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Aliases for SNRPG Gene

Aliases for SNRPG Gene

  • Small Nuclear Ribonucleoprotein Polypeptide G 2 3
  • Sm Protein G 3 4
  • SnRNP-G 3 4
  • Sm-G 3 4
  • SMG 3 4
  • Small Nuclear Ribonucleoprotein G 3
  • PBSCG 4

External Ids for SNRPG Gene

Previous GeneCards Identifiers for SNRPG Gene

  • GC02M070518
  • GC02M070719
  • GC02M070483
  • GC02M070420
  • GC02M070362
  • GC02M070508
  • GC02M070245

Summaries for SNRPG Gene

GeneCards Summary for SNRPG Gene

SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SNRPG Gene

  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.

Gene Wiki entry for SNRPG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPG Gene

Genomics for SNRPG Gene

Regulatory Elements for SNRPG Gene

Genomic Location for SNRPG Gene

Start:
70,281,362 bp from pter
End:
70,293,771 bp from pter
Size:
12,410 bases
Orientation:
Minus strand

Genomic View for SNRPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPG Gene

Proteins for SNRPG Gene

  • Protein details for SNRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62308-RUXG_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein G
    Protein Accession:
    P62308
    Secondary Accessions:
    • D6W5G6
    • Q15357
    • Q6IB86

    Protein attributes for SNRPG Gene

    Size:
    76 amino acids
    Molecular mass:
    8496 Da
    Quaternary structure:
    • U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1.

    Three dimensional structures from OCA and Proteopedia for SNRPG Gene

neXtProt entry for SNRPG Gene

Proteomics data for SNRPG Gene at MOPED

Post-translational modifications for SNRPG Gene

  • Ubiquitination at Lys10, Lys11, and Lys20
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPG Gene

No data available for DME Specific Peptides for SNRPG Gene

Domains for SNRPG Gene

Protein Domains for SNRPG Gene

Suggested Antigen Peptide Sequences for SNRPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62308

UniProtKB/Swiss-Prot:

RUXG_HUMAN :
  • P62308
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with SNRPG: view

No data available for Gene Families for SNRPG Gene

Function for SNRPG Gene

Molecular function for SNRPG Gene

UniProtKB/Swiss-Prot Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.

Gene Ontology (GO) - Molecular Function for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12165861
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SNRPG: view
genes like me logo Genes that share phenotypes with SNRPG: view

Animal Model Products

CRISPR Products

miRNA for SNRPG Gene

miRTarBase miRNAs that target SNRPG

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPG Gene

Localization for SNRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPG Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPG Gene COMPARTMENTS Subcellular localization image for SNRPG gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex TAS 7744013
GO:0005683 U7 snRNP IDA 11574479
GO:0005685 U1 snRNP IDA 21113136
GO:0005687 U4 snRNP IDA 21516107
genes like me logo Genes that share ontologies with SNRPG: view

Pathways for SNRPG Gene

genes like me logo Genes that share pathways with SNRPG: view

Gene Ontology (GO) - Biological Process for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly NAS 7744013
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with SNRPG: view

Transcripts for SNRPG Gene

Unigene Clusters for SNRPG Gene

Small nuclear ribonucleoprotein polypeptide G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRPG

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPG Gene

No ASD Table

Relevant External Links for SNRPG Gene

GeneLoc Exon Structure for
SNRPG
ECgene alternative splicing isoforms for
SNRPG

Expression for SNRPG Gene

mRNA expression in normal human tissues for SNRPG Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNRPG Gene

SOURCE GeneReport for Unigene cluster for SNRPG Gene Hs.465167

genes like me logo Genes that share expressions with SNRPG: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPG Gene

Orthologs for SNRPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614811 35
  • 97.75 (n)
  • 94.59 (a)
SNRPG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPG 35
  • 97.81 (n)
  • 100 (a)
SNRPG 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPG 35
  • 93.86 (n)
  • 100 (a)
SNRPG 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrpg 16
Snrpg 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRPG 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpgl2 35
  • 85.53 (n)
  • 92.11 (a)
chicken
(Gallus gallus)
Aves FAM136A 35
  • 81.14 (n)
  • 97.37 (a)
SNRPG 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPG 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpg 35
  • 78.95 (n)
  • 90.79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.812 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14228 35
SNRPG 36
  • 89 (a)
OneToOne
zgc:103688 35
  • 77.19 (n)
  • 89.47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002706 35
  • 67.98 (n)
  • 77.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta SmG 35
  • 62.72 (n)
  • 72.37 (a)
SmG 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snr-7 35
  • 59.21 (n)
  • 65.79 (a)
snr-7 36
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMX2 36
  • 49 (a)
OneToOne
SMX2 38
Species with no ortholog for SNRPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRPG Gene

ENSEMBL:
Gene Tree for SNRPG (if available)
TreeFam:
Gene Tree for SNRPG (if available)

Paralogs for SNRPG Gene

Selected SIMAP similar genes for SNRPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNRPG: view

No data available for Paralogs for SNRPG Gene

Variants for SNRPG Gene

Sequence variations from dbSNP and Humsavar for SNRPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15656 -- 70,293,714(+) TCCCG(A/C/G/T)TGTAG utr-variant-5-prime
rs1961833 -- 70,291,653(-) TTCCT(C/T)TGCTT intron-variant
rs2272531 -- 70,281,741(+) ACTAT(A/G)ATGAT intron-variant
rs2272532 -- 70,293,366(+) GGGCC(A/G)GACCG intron-variant
rs2272533 -- 70,293,488(+) GGATC(C/T)CGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPG Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680
esv2523050 CNV Deletion 19546169

Relevant External Links for SNRPG Gene

HapMap Linkage Disequilibrium report
SNRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPG Gene

Disorders for SNRPG Gene

No disorders were found for SNRPG Gene.

No data available for UniProtKB/Swiss-Prot for SNRPG Gene

Publications for SNRPG Gene

  1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PMID: 7744013) Hermann H. … Luehrmann R. (EMBO J. 1995) 2 3 4
  2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 4 23
  3. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. (PMID: 1387914) Heinrichs V. … LA1hrmann R. (J. Mol. Biol. 1992) 3 23
  4. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PMID: 11574479) Pillai R.S. … Mueller B. (EMBO J. 2001) 3 4
  5. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4

Products for SNRPG Gene

Sources for SNRPG Gene

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