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Aliases for SNRPD2 Gene

Aliases for SNRPD2 Gene

  • Small Nuclear Ribonucleoprotein D2 Polypeptide 16.5kDa 2 3
  • SnRNP Core Protein D2 2 3 4
  • SNRPD1 3 4
  • Sm-D2 3 4
  • Small Nuclear Ribonucleoprotein D2 Polypeptide (16.5kD) 2
  • Small Nuclear Ribonucleoprotein Sm D2 3
  • SMD2 3

External Ids for SNRPD2 Gene

Previous HGNC Symbols for SNRPD2 Gene

  • SNRPD1

Previous GeneCards Identifiers for SNRPD2 Gene

  • GC19M046834
  • GC19M046581
  • GC19M050866
  • GC19M050882
  • GC19M046190
  • GC19M042619

Summaries for SNRPD2 Gene

Entrez Gene Summary for SNRPD2 Gene

  • The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for SNRPD2 Gene

SNRPD2 (Small Nuclear Ribonucleoprotein D2 Polypeptide 16.5kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and EGFR1 Signaling Pathway.

UniProtKB/Swiss-Prot for SNRPD2 Gene

  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.

Gene Wiki entry for SNRPD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPD2 Gene

Genomics for SNRPD2 Gene

Regulatory Elements for SNRPD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNRPD2 Gene

Start:
45,687,454 bp from pter
End:
45,692,569 bp from pter
Size:
5,116 bases
Orientation:
Minus strand

Genomic View for SNRPD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPD2 Gene

Proteins for SNRPD2 Gene

  • Protein details for SNRPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62316-SMD2_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein Sm D2
    Protein Accession:
    P62316
    Secondary Accessions:
    • A8K797
    • J3KPM5
    • P43330

    Protein attributes for SNRPD2 Gene

    Size:
    118 amino acids
    Molecular mass:
    13527 Da
    Quaternary structure:
    • U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
    Miscellaneous:
    • In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity

    Three dimensional structures from OCA and Proteopedia for SNRPD2 Gene

    Alternative splice isoforms for SNRPD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRPD2 Gene

Proteomics data for SNRPD2 Gene at MOPED

Post-translational modifications for SNRPD2 Gene

  • Ubiquitination at Lys98
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPD2 Gene

No data available for DME Specific Peptides for SNRPD2 Gene

Domains for SNRPD2 Gene

Protein Domains for SNRPD2 Gene

Suggested Antigen Peptide Sequences for SNRPD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62316

UniProtKB/Swiss-Prot:

SMD2_HUMAN :
  • P62316
Family:
  • Belongs to the snRNP core protein family.
genes like me logo Genes that share domains with SNRPD2: view

No data available for Gene Families for SNRPD2 Gene

Function for SNRPD2 Gene

Molecular function for SNRPD2 Gene

UniProtKB/Swiss-Prot Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.

Gene Ontology (GO) - Molecular Function for SNRPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11714716
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SNRPD2: view
genes like me logo Genes that share phenotypes with SNRPD2: view

Animal Model Products

CRISPR Products

miRNA for SNRPD2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRPD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPD2 Gene

Localization for SNRPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPD2 Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPD2 Gene COMPARTMENTS Subcellular localization image for SNRPD2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for SNRPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex TAS 1701240
GO:0005685 U1 snRNP IDA 21113136
GO:0005687 U4 snRNP IDA 21516107
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SNRPD2: view

Pathways for SNRPD2 Gene

genes like me logo Genes that share pathways with SNRPD2: view

Pathways by source for SNRPD2 Gene

Gene Ontology (GO) - Biological Process for SNRPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly TAS 7527560
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNRPD2: view

Transcripts for SNRPD2 Gene

Unigene Clusters for SNRPD2 Gene

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRPD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - -

Relevant External Links for SNRPD2 Gene

GeneLoc Exon Structure for
SNRPD2
ECgene alternative splicing isoforms for
SNRPD2

Expression for SNRPD2 Gene

mRNA expression in normal human tissues for SNRPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPD2 Gene

SOURCE GeneReport for Unigene cluster for SNRPD2 Gene Hs.515472

genes like me logo Genes that share expressions with SNRPD2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPD2 Gene

Orthologs for SNRPD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPD2 35
  • 99.15 (n)
  • 100 (a)
SNRPD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPD2 35
  • 93.22 (n)
  • 100 (a)
SNRPD2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPD2 35
  • 93.22 (n)
  • 100 (a)
SNRPD2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5449 36
  • 95 (a)
OneToOne
Snrpd2 35
  • 91.24 (n)
  • 100 (a)
Snrpd2 16
oppossum
(Monodelphis domestica)
Mammalia SNRPD2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPD2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpd2 35
  • 91.81 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia SNRPD2 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4271 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpd2 35
  • 80.23 (n)
  • 99.15 (a)
Str.10758 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.778 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12513 35
snrpd2 35
  • 84.18 (n)
  • 99.15 (a)
snrpd2 36
  • 99 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003936 35
  • 74.78 (n)
  • 88.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta SmD2 35
  • 79.71 (n)
  • 89.57 (a)
SmD2 36
  • 87 (a)
OneToOne
CG1249 37
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea snr-4 35
  • 71.05 (n)
  • 81.58 (a)
snr-4 36
  • 79 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR277W 35
  • 56.19 (n)
  • 58.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMD2 35
  • 55.35 (n)
  • 55.66 (a)
SMD2 36
  • 54 (a)
OneToOne
SMD2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09284g 35
  • 58.42 (n)
  • 53.61 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3324 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62840 35
  • 74.44 (n)
  • 87.78 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2981 35
rice
(Oryza sativa)
Liliopsida Os.24812 35
Os05g0314100 35
  • 75.56 (n)
  • 88.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03778 35
  • 63.24 (n)
  • 64.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes smd2 35
  • 57.27 (n)
  • 69.09 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4211 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
OneToOne
Species with no ortholog for SNRPD2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRPD2 Gene

ENSEMBL:
Gene Tree for SNRPD2 (if available)
TreeFam:
Gene Tree for SNRPD2 (if available)

Paralogs for SNRPD2 Gene

Selected SIMAP similar genes for SNRPD2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SNRPD2 Gene

genes like me logo Genes that share paralogs with SNRPD2: view

No data available for Paralogs for SNRPD2 Gene

Variants for SNRPD2 Gene

Sequence variations from dbSNP and Humsavar for SNRPD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs759288 -- 45,687,957(+) ATAAT(C/G)ACGTT intron-variant
rs1802704 -- 45,687,548(-) GGGGC(A/C/T)GCCTG utr-variant-3-prime
rs1802706 -- 45,687,672(-) CCAAG(A/G)GTGGC reference, missense
rs1802707 -- 45,688,425(-) CGCAA(C/T)AATAA reference, synonymous-codon
rs1964272 -- 45,687,010(+) cgccc(A/G)gccAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNRPD2 Gene

Variant ID Type Subtype PubMed ID
nsv912159 CNV Loss 21882294
dgv3954n71 CNV Loss 21882294
dgv3955n71 CNV Loss 21882294

Relevant External Links for SNRPD2 Gene

HapMap Linkage Disequilibrium report
SNRPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPD2 Gene

Disorders for SNRPD2 Gene

No disorders were found for SNRPD2 Gene.

No data available for UniProtKB/Swiss-Prot for SNRPD2 Gene

Publications for SNRPD2 Gene

  1. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction. (PMID: 7527560) Lehmeier T. … Luehrmann R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5. (PMID: 1701240) Lehmeier T. … LA1hrmann R. (Nucleic Acids Res. 1990) 2 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SNRPD2 Gene

Sources for SNRPD2 Gene

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