Aliases for BNIP2 Gene
Aliases for BNIP2 Gene
External Ids for BNIP2 Gene
- HGNC: 1083
- Entrez Gene: 663
- Ensembl: ENSG00000140299
- OMIM: 603292
- UniProtKB: Q12982
Previous GeneCards Identifiers for BNIP2 Gene
- GC15M055513
- GC15M053003
- GC15M057534
- GC15M057671
- GC15M057742
- GC15M059951
- GC15M036777
Summaries for BNIP2 Gene
-
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for BNIP2 Gene
BNIP2 (BCL2 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Myogenesis and G-protein signaling_Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is PRUNE2.
UniProtKB/Swiss-Prot for BNIP2 Gene
-
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP2 Gene
Genomics for BNIP2 Gene
GeneHancer (GH) Regulatory Elements for BNIP2 Gene
Regulatory Element Products
Genomic Locations for BNIP2 Gene
- chr15:59,659,146-59,689,534
- (GRCh38/hg38)
- Size:
- 30,389 bases
- Orientation:
- Minus strand
- chr15:59,951,345-59,981,733
- (GRCh37/hg19)
Genomic View for BNIP2 Gene
- Cytogenetic band:
-
- 15q22.2 by Ensembl
- 15q22.2 by Entrez Gene
- 15q22.2 by HGNC


RefSeq DNA sequence for BNIP2 Gene
Proteins for BNIP2 Gene
-
Protein details for BNIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12982-BNIP2_HUMAN
- Recommended name:
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
- Protein Accession:
- Q12982
- B4DS94
Protein attributes for BNIP2 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 36018 Da
- Quaternary structure:
- No Data Available
Protein Expression for BNIP2 Gene
Post-translational modifications for BNIP2 Gene
- Ubiquitination at posLast=219219, Lys228, and Lys267
Other Protein References for BNIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for BNIP2
-
Abcam antibodies for BNIP2
- Invitrogen Antibodies for BNIP2
- GeneTex BNIP2 antibody for BNIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BNIP2
Protein Products
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OriGene Purified Proteins for BNIP2
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-
Abcam proteins for BNIP2
Assay Products
No data available for DME Specific Peptides for BNIP2 Gene
Domains & Families for BNIP2 Gene
Gene Families for BNIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BNIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BNIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BNIP2 Gene
Function for BNIP2 Gene
Molecular function for BNIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
Phenotypes From GWAS Catalog for BNIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | TAS | 10799524 |
GO:0005509 | calcium ion binding | TAS | 7954800 |
GO:0005515 | protein binding | IPI | 7954800 |
GO:0042802 | identical protein binding | IBA | -- |
Phenotypes for BNIP2 Gene
- MGI mutant phenotypes for BNIP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BNIP2:
Animal Models for BNIP2 Gene
- MGI Knock Outs for BNIP2:
-
- Bnip2 tm1b(EUCOMM)Wtsi
Animal Model Products
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-
-
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-
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CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for BNIP2 Gene
- miRTarBase miRNAs that target BNIP2
-
- hsa-mir-20a-5p (MIRT005481)
- hsa-mir-130b-3p (MIRT020114)
- hsa-mir-132-3p (MIRT021762)
- hsa-mir-93-5p (MIRT027996)
- hsa-mir-877-3p (MIRT037172)
- hsa-mir-4280 (MIRT140479)
- hsa-mir-21-5p (MIRT441107)
- hsa-mir-106b-5p (MIRT441108)
- hsa-mir-138-2-3p (MIRT503112)
- hsa-mir-885-5p (MIRT503113)
- hsa-mir-6507-3p (MIRT503114)
- hsa-mir-194-5p (MIRT503115)
- hsa-mir-143-5p (MIRT507953)
- hsa-mir-8075 (MIRT507954)
- hsa-mir-6499-3p (MIRT507955)
- hsa-mir-4502 (MIRT507956)
- hsa-mir-519c-3p (MIRT507957)
- hsa-mir-519b-3p (MIRT507958)
- hsa-mir-519a-3p (MIRT507959)
- hsa-mir-548t-5p (MIRT507960)
- hsa-mir-548az-5p (MIRT507961)
- hsa-mir-106a-5p (MIRT507962)
- hsa-mir-526b-3p (MIRT507963)
- hsa-mir-519d-3p (MIRT507964)
- hsa-mir-20b-5p (MIRT507965)
- hsa-mir-17-5p (MIRT507966)
- hsa-mir-921 (MIRT514030)
- hsa-mir-4641 (MIRT514031)
- hsa-mir-4693-3p (MIRT514032)
- hsa-mir-371b-3p (MIRT514033)
- hsa-mir-3174 (MIRT514034)
- hsa-mir-4796-3p (MIRT514035)
- hsa-mir-548ah-5p (MIRT514036)
- hsa-mir-3609 (MIRT514037)
- hsa-mir-548e-5p (MIRT514038)
- hsa-mir-3691-3p (MIRT559184)
- hsa-mir-34a-5p (MIRT734022)
- hsa-mir-1247-3p (MIRT761519)
- hsa-mir-1827 (MIRT763015)
- hsa-mir-2467-3p (MIRT764068)
- hsa-mir-3612 (MIRT765886)
- hsa-mir-377-5p (MIRT767361)
- hsa-mir-4257 (MIRT768106)
- hsa-mir-455-3p (MIRT770274)
- hsa-mir-6086 (MIRT775492)
- hsa-mir-650 (MIRT776644)
- hsa-mir-6516-5p (MIRT777069)
- hsa-mir-6807-5p (MIRT779554)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for BNIP2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BNIP2 gene related products
- orf clones - Search results for available BNIP2 gene related products
- Applied Biological Materials Clones for BNIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for BNIP2
-
ViGene Biosciences adenoviral particle packaged cDNA for BNIP2 gene
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ViGene Biosciences lentiviral particle packaged cDNA for BNIP2 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNIP2 Gene
Localization for BNIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BNIP2 Gene
- Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005635 | nuclear envelope | IDA | 7954800 |
GO:0005737 | cytoplasm | IDA | 7954800 |
GO:0005814 | centriole | IEA | -- |
GO:0005829 | cytosol | IBA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BNIP2 Gene
Pathways & Interactions for BNIP2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Myogenesis |
1.00
|
1.00
|
2 | Developmental Biology | ||
3 | G-protein signaling_Regulation of CDC42 activity |
Pathways by source for BNIP2 Gene
3 Reactome pathways for BNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for BNIP2 Gene
Interacting Proteins for BNIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IPI | 7954800 |
GO:0007098 | centrosome cycle | IEA | -- |
GO:0043066 | negative regulation of apoptotic process | TAS | 7954800 |
GO:0043410 | positive regulation of MAPK cascade | IEA | -- |
GO:0043547 | positive regulation of GTPase activity | IEA | -- |
Transcripts for BNIP2 Gene
mRNA/cDNA for BNIP2 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BNIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BNIP2
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BNIP2
- GenScript: Design CRISPR guide RNA sequences for BNIP2
miRNA Products
- Search ViGene Biosciences for BNIP2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for BNIP2
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- genomics-online: shRNA clones - Search results for available BNIP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BNIP2 gene
Clone Products
- Sino Biological Human cDNA Clone for BNIP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BNIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BNIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BNIP2 gene related products
- orf clones - Search results for available BNIP2 gene related products
- Applied Biological Materials Clones for BNIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
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SP7: |
Expression for BNIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Bone (Muscoskeletal System)
- Blood (Hematopoietic System)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BNIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BNIP2 Gene:
BNIP2SOURCE GeneReport for Unigene cluster for BNIP2 Gene:
Hs.646490Evidence on tissue expression from TISSUES for BNIP2 Gene
- Nervous system(4.8)
- Liver(4.3)
- Blood(4.1)
- Eye(4.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for BNIP2
-
OriGene qPCR primer pairs and template standards for BNIP2
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No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP2 Gene
Orthologs for BNIP2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BNIP2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | BNIP2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | BNIP2 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | BNIP2 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Bnip2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Bnip2 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | BNIP2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | BNIP2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | BNIP2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | bnip2 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8459 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC100332015 33 |
|
||
bnip2 33 34 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG11593 35 34 |
|
- Species where no ortholog for BNIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BNIP2 Gene
(6) SIMAP similar genes for BNIP2 Gene using alignment to 4 proteins:
Variants for BNIP2 Gene
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000015947 | -- | 59,687,688(-) | C/T | intron_variant | |
rs1000030061 | -- | 59,666,425(-) | G/C | intron_variant | |
rs1000066852 | -- | 59,678,209(-) | A/T | intron_variant | |
rs1000219851 | -- | 59,685,447(-) | G/A | intron_variant | |
rs1000409896 | -- | 59,675,977(-) | A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3569653 | CNV | gain | 25503493 |
esv3636646 | CNV | gain | 21293372 |
esv3636647 | CNV | gain | 21293372 |
nsv1043693 | CNV | loss | 25217958 |
nsv1108960 | CNV | deletion | 24896259 |
nsv523274 | CNV | loss | 19592680 |
nsv527307 | CNV | gain | 19592680 |
nsv569605 | CNV | loss | 21841781 |
nsv7266 | OTHER | inversion | 18451855 |
nsv984080 | CNV | duplication | 23825009 |
Additional Variant Information for BNIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BNIP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIP2 Gene
Disorders for BNIP2 Gene
Additional Disease Information for BNIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BNIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP2 Gene
Publications for BNIP2 Gene
- Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd JM … Chinnadurai G (Cell 1994) 2 3 4 58
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
- Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
- BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PMID: 15652341) Zhou YT … Low BC (Experimental cell research 2005) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 68 available BNIP2 Antibodies ranked by validation data
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Sources for BNIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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