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Aliases for SNRPB2 Gene

Aliases for SNRPB2 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide B2 2 3
  • Small Nuclear Ribonucleoprotein Polypeptide B 2 3 5
  • U2 SnRNP B 3 4
  • Msl1 3
  • U2B 3

External Ids for SNRPB2 Gene

Previous GeneCards Identifiers for SNRPB2 Gene

  • GC20P016698
  • GC20P016705

Summaries for SNRPB2 Gene

Entrez Gene Summary for SNRPB2 Gene

  • The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNRPB2 Gene

SNRPB2 (Small Nuclear Ribonucleoprotein Polypeptide B2) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and snRNA binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot for SNRPB2 Gene

  • Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein.

Gene Wiki entry for SNRPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPB2 Gene

Genomics for SNRPB2 Gene

Regulatory Elements for SNRPB2 Gene

Promoters for SNRPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRPB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRPB2 Gene

Chromosome:
20
Start:
16,729,961 bp from pter
End:
16,742,563 bp from pter
Size:
12,603 bases
Orientation:
Plus strand

Genomic View for SNRPB2 Gene

Genes around SNRPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPB2 Gene

Proteins for SNRPB2 Gene

  • Protein details for SNRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08579-RU2B_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein B
    Protein Accession:
    P08579
    Secondary Accessions:
    • B2R7J3
    • D3DW21
    • Q9UJD4

    Protein attributes for SNRPB2 Gene

    Size:
    225 amino acids
    Molecular mass:
    25486 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1.
    Miscellaneous:
    • Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

    Three dimensional structures from OCA and Proteopedia for SNRPB2 Gene

neXtProt entry for SNRPB2 Gene

Proteomics data for SNRPB2 Gene at MOPED

Post-translational modifications for SNRPB2 Gene

  • Ubiquitination at Lys 57, Lys 77, Lys 85, Lys 93, and Lys 219
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPB2 Gene

Domains & Families for SNRPB2 Gene

Gene Families for SNRPB2 Gene

Protein Domains for SNRPB2 Gene

Suggested Antigen Peptide Sequences for SNRPB2 Gene

Graphical View of Domain Structure for InterPro Entry

P08579

UniProtKB/Swiss-Prot:

RU2B_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM U1 A/B family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM U1 A/B family.
genes like me logo Genes that share domains with SNRPB2: view

Function for SNRPB2 Gene

Molecular function for SNRPB2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein.

Gene Ontology (GO) - Molecular Function for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SNRPB2: view
genes like me logo Genes that share phenotypes with SNRPB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SNRPB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPB2 Gene

Localization for SNRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPB2 Gene COMPARTMENTS Subcellular localization image for SNRPB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005686 U2 snRNP IDA 2951739
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNRPB2: view

Pathways & Interactions for SNRPB2 Gene

genes like me logo Genes that share pathways with SNRPB2: view

Pathways by source for SNRPB2 Gene

1 KEGG pathway for SNRPB2 Gene

Gene Ontology (GO) - Biological Process for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with SNRPB2: view

No data available for SIGNOR curated interactions for SNRPB2 Gene

Drugs & Compounds for SNRPB2 Gene

No Compound Related Data Available

Transcripts for SNRPB2 Gene

mRNA/cDNA for SNRPB2 Gene

Unigene Clusters for SNRPB2 Gene

Small nuclear ribonucleoprotein polypeptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SNRPB2 Gene

GeneLoc Exon Structure for
SNRPB2
ECgene alternative splicing isoforms for
SNRPB2

Expression for SNRPB2 Gene

mRNA expression in normal human tissues for SNRPB2 Gene

Protein differential expression in normal tissues from HIPED for SNRPB2 Gene

This gene is overexpressed in CD8 Tcells (7.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPB2 Gene



SOURCE GeneReport for Unigene cluster for SNRPB2 Gene Hs.280378

genes like me logo Genes that share expression patterns with SNRPB2: view

Protein tissue co-expression partners for SNRPB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPB2 Gene

Orthologs for SNRPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPB2 35
  • 99.11 (n)
  • 99.56 (a)
SNRPB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPB2 36
  • 97 (a)
OneToOne
SNRPB2 35
  • 93.58 (n)
  • 99.08 (a)
dog
(Canis familiaris)
Mammalia SNRPB2 35
  • 93.63 (n)
  • 98.67 (a)
-- 36
  • 89 (a)
OneToMany
SNRPB2 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Snrpb2 16
Snrpb2 36
  • 96 (a)
OneToOne
Snrpb2 35
  • 89.63 (n)
  • 96 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRPB2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPB2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpb2 35
  • 90.67 (n)
  • 96.89 (a)
chicken
(Gallus gallus)
Aves SNRPB2 36
  • 88 (a)
OneToOne
SNRPB2 35
  • 79.41 (n)
  • 90.22 (a)
lizard
(Anolis carolinensis)
Reptilia SNRPB2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpb2 35
  • 74.14 (n)
  • 83.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8470 35
zebrafish
(Danio rerio)
Actinopterygii snrpb2 36
  • 80 (a)
OneToOne
Dr.14007 35
snrpb2 35
  • 71.67 (n)
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta snf 36
  • 68 (a)
OneToMany
snf 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rnp-3 35
  • 54.72 (n)
  • 50 (a)
rnp-2 36
  • 48 (a)
ManyToMany
rnp-3 36
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 36
  • 23 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1622 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06960 35
  • 59.39 (n)
  • 56.36 (a)
rice
(Oryza sativa)
Liliopsida Os03g0298800 35
  • 60.61 (n)
  • 54.55 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9408 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 36
  • 52 (a)
OneToMany
Species with no ortholog for SNRPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPB2 Gene

ENSEMBL:
Gene Tree for SNRPB2 (if available)
TreeFam:
Gene Tree for SNRPB2 (if available)

Paralogs for SNRPB2 Gene

Paralogs for SNRPB2 Gene

(1) SIMAP similar genes for SNRPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRPB2: view

Variants for SNRPB2 Gene

Sequence variations from dbSNP and Humsavar for SNRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035487 A colorectal cancer sample
rs1804873 -- 16,741,008(+) TAACA(C/T)TTGGG utr-variant-3-prime
rs2073054 -- 16,730,285(-) ACCTT(C/T)GCCCA intron-variant
rs2073055 -- 16,730,146(-) TTCGT(A/C)CGCTC intron-variant, utr-variant-5-prime
rs1131480 -- 16,731,677(+) TTTAC(G/T)GTCTC utr-variant-5-prime

Variation tolerance for SNRPB2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPB2 Gene

HapMap Linkage Disequilibrium report
SNRPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNRPB2 Gene

Disorders for SNRPB2 Gene

Relevant External Links for SNRPB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPB2

No disorders were found for SNRPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPB2 Gene

Publications for SNRPB2 Gene

  1. Analysis of a cDNA clone expressing a human autoimmune antigen: full- length sequence of the U2 small nuclear RNA-associated B' antigen. (PMID: 2951739) Habets W.J. … van Venrooij W.J. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for SNRPB2 Gene

Sources for SNRPB2 Gene

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