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Aliases for SNAPC3 Gene

Aliases for SNAPC3 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 3 2 3 5
  • Proximal Sequence Element-Binding Transcription Factor Subunit Beta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 3 3 4
  • SnRNA-Activating Protein Complex 50 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Beta 3 4
  • SNAPc 50 KDa Subunit 3 4
  • PTF Subunit Beta 3 4
  • SNAPc Subunit 3 3 4
  • SNAP50 3 4
  • PTFbeta 3

External Ids for SNAPC3 Gene

Previous GeneCards Identifiers for SNAPC3 Gene

  • GC09P015588
  • GC09P015404

Summaries for SNAPC3 Gene

GeneCards Summary for SNAPC3 Gene

SNAPC3 (Small Nuclear RNA Activating Complex Polypeptide 3) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance.

UniProtKB/Swiss-Prot for SNAPC3 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC3 Gene

Genomics for SNAPC3 Gene

Regulatory Elements for SNAPC3 Gene

Promoters for SNAPC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNAPC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNAPC3 Gene

Chromosome:
9
Start:
15,422,696 bp from pter
End:
15,466,751 bp from pter
Size:
44,056 bases
Orientation:
Plus strand

Genomic View for SNAPC3 Gene

Genes around SNAPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC3 Gene

Proteins for SNAPC3 Gene

  • Protein details for SNAPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92966-SNPC3_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 3
    Protein Accession:
    Q92966
    Secondary Accessions:
    • D3DRI8
    • Q2VPI6
    • Q5T285

    Protein attributes for SNAPC3 Gene

    Size:
    411 amino acids
    Molecular mass:
    46753 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.

neXtProt entry for SNAPC3 Gene

Proteomics data for SNAPC3 Gene at MOPED

Post-translational modifications for SNAPC3 Gene

  • Ubiquitination at Lys 110, Lys 244, Lys 287, and Lys 395
  • Modification sites at PhosphoSitePlus

Other Protein References for SNAPC3 Gene

Antibody Products

No data available for DME Specific Peptides for SNAPC3 Gene

Domains & Families for SNAPC3 Gene

Gene Families for SNAPC3 Gene

Protein Domains for SNAPC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92966

UniProtKB/Swiss-Prot:

SNPC3_HUMAN :
  • Belongs to the SNAPC3/SRD2 family.
Family:
  • Belongs to the SNAPC3/SRD2 family.
genes like me logo Genes that share domains with SNAPC3: view

Function for SNAPC3 Gene

Molecular function for SNAPC3 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
genes like me logo Genes that share phenotypes with SNAPC3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC3 Gene

Localization for SNAPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC3 Gene COMPARTMENTS Subcellular localization image for SNAPC3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SNAPC3 Gene

Pathways & Interactions for SNAPC3 Gene

genes like me logo Genes that share pathways with SNAPC3: view

Gene Ontology (GO) - Biological Process for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 7715707
GO:0006383 transcription from RNA polymerase III promoter TAS 7715707
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNAPC3: view

No data available for SIGNOR curated interactions for SNAPC3 Gene

Drugs & Compounds for SNAPC3 Gene

(1) Additional Compounds for SNAPC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAPC3: view

Transcripts for SNAPC3 Gene

Unigene Clusters for SNAPC3 Gene

Small nuclear RNA activating complex, polypeptide 3, 50kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SNAPC3 Gene

GeneLoc Exon Structure for
SNAPC3
ECgene alternative splicing isoforms for
SNAPC3

Expression for SNAPC3 Gene

mRNA expression in normal human tissues for SNAPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNAPC3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAPC3 Gene



SOURCE GeneReport for Unigene cluster for SNAPC3 Gene Hs.546299

genes like me logo Genes that share expression patterns with SNAPC3: view

Protein tissue co-expression partners for SNAPC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNAPC3 Gene

Orthologs for SNAPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC3 36
  • 100 (a)
OneToOne
SNAPC3 35
  • 99.76 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SNAPC3 35
  • 88.78 (n)
  • 87.96 (a)
SNAPC3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC3 36
  • 63 (a)
OneToOne
SNAPC3 35
  • 90.19 (n)
  • 91 (a)
mouse
(Mus musculus)
Mammalia Snapc3 36
  • 85 (a)
OneToOne
Snapc3 16
Snapc3 35
  • 84.4 (n)
  • 86.21 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAPC3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc3 35
  • 83.91 (n)
  • 86.45 (a)
chicken
(Gallus gallus)
Aves SNAPC3 35
  • 70.88 (n)
  • 70.43 (a)
SNAPC3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC3 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23738 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snapc3 35
  • 70.26 (n)
  • 70.35 (a)
Str.4306 35
zebrafish
(Danio rerio)
Actinopterygii snapc3 36
  • 51 (a)
OneToOne
snapc3 35
  • 60.22 (n)
  • 54.22 (a)
zgc56295 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003852 35
  • 43.09 (n)
  • 36.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pbp49 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snpc-3.1 36
  • 20 (a)
OneToMany
snpc-3.2 36
  • 20 (a)
OneToMany
snpc-3.3 36
  • 18 (a)
OneToMany
snpc-3.4 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10344 36
  • 45 (a)
OneToOne
Species with no ortholog for SNAPC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAPC3 Gene

ENSEMBL:
Gene Tree for SNAPC3 (if available)
TreeFam:
Gene Tree for SNAPC3 (if available)

Paralogs for SNAPC3 Gene

No data available for Paralogs for SNAPC3 Gene

Variants for SNAPC3 Gene

Sequence variations from dbSNP and Humsavar for SNAPC3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3087653 - 15,459,823(+) GGGGG(A/C)ATTCC nc-transcript-variant, reference, missense
rs907075 -- 15,443,660(-) GTTTT(C/G)ACCCT intron-variant
rs907076 -- 15,443,432(-) CAAGA(A/G)AAAAT intron-variant
rs1397214 -- 15,421,172(+) tgaac(C/G)tgtta upstream-variant-2KB
rs1057642 -- 15,461,991(+) AACCC(G/T)AAAAT intron-variant, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNAPC3 Gene

Variant ID Type Subtype PubMed ID
nsv517975 CNV Loss 19592680
nsv892625 CNV Gain 21882294
nsv892626 CNV Loss 21882294
nsv892627 CNV Gain 21882294
nsv831520 CNV Loss 17160897
nsv892628 CNV Gain 21882294

Variation tolerance for SNAPC3 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAPC3 Gene

HapMap Linkage Disequilibrium report
SNAPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC3 Gene

Disorders for SNAPC3 Gene

Relevant External Links for SNAPC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAPC3

No disorders were found for SNAPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC3 Gene

Publications for SNAPC3 Gene

  1. Cloning and characterization of SNAP50, a subunit of the snRNA- activating protein complex SNAPc. (PMID: 9003788) Henry R.W. … Hernandez N. (EMBO J. 1996) 2 3 4 23 67
  2. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley C.S. … Henry R.W. (J. Biol. Chem. 2003) 3 23
  3. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. (PMID: 7715707) Henry R.W. … Hernandez N. (Nature 1995) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SNAPC3 Gene

Sources for SNAPC3 Gene

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