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Aliases for SNAPC3 Gene

Aliases for SNAPC3 Gene

  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kDa 2 3
  • SNAP50 3 4 6
  • Proximal Sequence Element-Binding Transcription Factor Subunit Beta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 3, 50kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 3 3 4
  • SnRNA-Activating Protein Complex 50 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Beta 3 4
  • SNAPc 50 KDa Subunit 3 4
  • PTF Subunit Beta 3 4
  • SNAPc Subunit 3 3 4
  • SnRNA-Activating Protein Complex Subunit 3 3
  • PTFbeta 3

External Ids for SNAPC3 Gene

Previous GeneCards Identifiers for SNAPC3 Gene

  • GC09P015588
  • GC09P015404

Summaries for SNAPC3 Gene

GeneCards Summary for SNAPC3 Gene

SNAPC3 (Small Nuclear RNA Activating Complex, Polypeptide 3, 50kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for SNAPC3 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC3 Gene

Genomics for SNAPC3 Gene

Regulatory Elements for SNAPC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNAPC3 Gene

Start:
15,422,696 bp from pter
End:
15,465,953 bp from pter
Size:
43,258 bases
Orientation:
Plus strand

Genomic View for SNAPC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC3 Gene

Proteins for SNAPC3 Gene

  • Protein details for SNAPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92966-SNPC3_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 3
    Protein Accession:
    Q92966
    Secondary Accessions:
    • D3DRI8
    • Q2VPI6
    • Q5T285

    Protein attributes for SNAPC3 Gene

    Size:
    411 amino acids
    Molecular mass:
    46753 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.

neXtProt entry for SNAPC3 Gene

Proteomics data for SNAPC3 Gene at MOPED

Post-translational modifications for SNAPC3 Gene

  • Ubiquitination at Lys110, Lys244, Lys287, and Lys395
  • Modification sites at PhosphoSitePlus

Other Protein References for SNAPC3 Gene

No data available for DME Specific Peptides for SNAPC3 Gene

Domains for SNAPC3 Gene

Protein Domains for SNAPC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92966

UniProtKB/Swiss-Prot:

SNPC3_HUMAN :
  • Q92966
Family:
  • Belongs to the SNAPC3/SRD2 family.
genes like me logo Genes that share domains with SNAPC3: view

No data available for Gene Families for SNAPC3 Gene

Function for SNAPC3 Gene

Molecular function for SNAPC3 Gene

UniProtKB/Swiss-Prot Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Ontology (GO) - Molecular Function for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SNAPC3: view

Phenotypes for SNAPC3 Gene

GenomeRNAi human phenotypes for SNAPC3:
genes like me logo Genes that share phenotypes with SNAPC3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNAPC3 Gene

Localization for SNAPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC3 Gene COMPARTMENTS Subcellular localization image for SNAPC3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNAPC3: view

Pathways for SNAPC3 Gene

genes like me logo Genes that share pathways with SNAPC3: view

Gene Ontology (GO) - Biological Process for SNAPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7715707
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0009301 snRNA transcription TAS 7715707
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNAPC3: view

Compounds for SNAPC3 Gene

(1) Novoseek inferred chemical compound relationships for SNAPC3 Gene

Compound -log(P) Hits PubMed IDs
s-napc 97.8 5
genes like me logo Genes that share compounds with SNAPC3: view

Transcripts for SNAPC3 Gene

Unigene Clusters for SNAPC3 Gene

Small nuclear RNA activating complex, polypeptide 3, 50kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAPC3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SNAPC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SNAPC3 Gene

GeneLoc Exon Structure for
SNAPC3
ECgene alternative splicing isoforms for
SNAPC3

Expression for SNAPC3 Gene

mRNA expression in normal human tissues for SNAPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAPC3 Gene

SOURCE GeneReport for Unigene cluster for SNAPC3 Gene Hs.546299

genes like me logo Genes that share expressions with SNAPC3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNAPC3 Gene

Orthologs for SNAPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC3 35
  • 99.76 (n)
  • 100 (a)
SNAPC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC3 35
  • 88.78 (n)
  • 87.96 (a)
SNAPC3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC3 35
  • 90.19 (n)
  • 91 (a)
SNAPC3 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc3 35
  • 84.4 (n)
  • 86.21 (a)
Snapc3 16
Snapc3 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAPC3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc3 35
  • 83.91 (n)
  • 86.45 (a)
chicken
(Gallus gallus)
Aves SNAPC3 35
  • 70.88 (n)
  • 70.43 (a)
SNAPC3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC3 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23738 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snapc3 35
  • 70.26 (n)
  • 70.35 (a)
Str.4306 35
zebrafish
(Danio rerio)
Actinopterygii snapc3 35
  • 60.22 (n)
  • 54.22 (a)
snapc3 36
  • 51 (a)
OneToOne
zgc56295 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003852 35
  • 43.09 (n)
  • 36.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pbp49 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snpc-3.1 36
  • 20 (a)
OneToMany
snpc-3.2 36
  • 20 (a)
OneToMany
snpc-3.3 36
  • 18 (a)
OneToMany
snpc-3.4 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10344 36
  • 45 (a)
OneToOne
Species with no ortholog for SNAPC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAPC3 Gene

ENSEMBL:
Gene Tree for SNAPC3 (if available)
TreeFam:
Gene Tree for SNAPC3 (if available)

Paralogs for SNAPC3 Gene

No data available for Paralogs for SNAPC3 Gene

Variants for SNAPC3 Gene

Sequence variations from dbSNP and Humsavar for SNAPC3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12093 -- 15,461,508(-) TTTGA(A/G)TAAAT utr-variant-3-prime, intron-variant
rs12859 -- 15,461,473(+) ACTTT(A/C)TTTAT utr-variant-3-prime, intron-variant
rs878379 -- 15,443,588(-) TTTTT(C/T)ttttt intron-variant
rs907075 -- 15,443,660(-) GTTTT(C/G)ACCCT intron-variant
rs907076 -- 15,443,432(-) CAAGA(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC3 Gene

Variant ID Type Subtype PubMed ID
nsv517975 CNV Loss 19592680
nsv892625 CNV Gain 21882294
nsv892626 CNV Loss 21882294
nsv892627 CNV Gain 21882294
nsv831520 CNV Loss 17160897
nsv892628 CNV Gain 21882294

Relevant External Links for SNAPC3 Gene

HapMap Linkage Disequilibrium report
SNAPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC3 Gene

Disorders for SNAPC3 Gene

No disorders were found for SNAPC3 Gene.

No data available for UniProtKB/Swiss-Prot for SNAPC3 Gene

Publications for SNAPC3 Gene

  1. Cloning and characterization of SNAP50, a subunit of the snRNA- activating protein complex SNAPc. (PMID: 9003788) Henry R.W. … Hernandez N. (EMBO J. 1996) 2 3 4 23
  2. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley C.S. … Henry R.W. (J. Biol. Chem. 2003) 3 4 23
  3. Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III. (PMID: 8816454) Bai L. … Roeder R.G. (Mol. Cell. Biol. 1996) 3 4
  4. A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PMID: 11056176) Ma B. … Hernandez N. (J. Biol. Chem. 2001) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for SNAPC3 Gene

Sources for SNAPC3 Gene

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