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Aliases for SNAPC1 Gene

Aliases for SNAPC1 Gene

  • Small Nuclear RNA Activating Complex, Polypeptide 1, 43kDa 2 3
  • SNAP43 3 4 6
  • Proximal Sequence Element-Binding Transcription Factor Subunit Gamma 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 1, 43kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 1 3 4
  • SnRNA-Activating Protein Complex 43 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Gamma 3 4
  • SNAPc 43 KDa Subunit 3 4
  • PTF Subunit Gamma 3 4
  • SNAPc Subunit 1 3 4
  • SnRNA-Activating Protein Complex Subunit 1 3
  • PTFgamma 3

External Ids for SNAPC1 Gene

Summaries for SNAPC1 Gene

GeneCards Summary for SNAPC1 Gene

SNAPC1 (Small Nuclear RNA Activating Complex, Polypeptide 1, 43kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for SNAPC1 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC1 Gene

Genomics for SNAPC1 Gene

Genomic Location for SNAPC1 Gene

Start:
61,762,357 bp from pter
End:
61,796,428 bp from pter
Size:
34,072 bases
Orientation:
Plus strand

Genomic View for SNAPC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC1 Gene

Regulatory Elements for SNAPC1 Gene

Proteins for SNAPC1 Gene

  • Protein details for SNAPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16533-SNPC1_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 1
    Protein Accession:
    Q16533
    Secondary Accessions:

    Protein attributes for SNAPC1 Gene

    Size:
    368 amino acids
    Molecular mass:
    42994 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP.

neXtProt entry for SNAPC1 Gene

Proteomics data for SNAPC1 Gene at MOPED

Post-translational modifications for SNAPC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys142

Other Protein References for SNAPC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAPC1 Gene

Domains for SNAPC1 Gene

Protein Domains for SNAPC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SNAPC1 Gene

Function for SNAPC1 Gene

Molecular function for SNAPC1 Gene

GENATLAS Biochemistry: small nuclear activating protein complex,polypeptide 1,43kDa,TBP associated factor (TAF) binding to the proximal sequence element PSE,required for transcription of SNRN genes by polymerases II and III,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Ontology (GO) - Molecular Function for SNAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SNAPC1: view

Phenotypes for SNAPC1 Gene

GenomeRNAi human phenotypes for SNAPC1:
genes like me logo Genes that share phenotypes with SNAPC1: view

miRNA for SNAPC1 Gene

miRTarBase miRNAs that target SNAPC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNAPC1 Gene

Localization for SNAPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC1 Gene COMPARTMENTS Subcellular localization image for SNAPC1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SNAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SNAPC1: view

Pathways for SNAPC1 Gene

genes like me logo Genes that share pathways with SNAPC1: view

Gene Ontology (GO) - Biological Process for SNAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNAPC1: view

Transcripts for SNAPC1 Gene

mRNA/cDNA for SNAPC1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(611) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAPC1 Gene

Small nuclear RNA activating complex, polypeptide 1, 43kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -

Relevant External Links for SNAPC1 Gene

GeneLoc Exon Structure for
SNAPC1
ECgene alternative splicing isoforms for
SNAPC1

Expression for SNAPC1 Gene

mRNA expression in normal human tissues for SNAPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAPC1 Gene

SOURCE GeneReport for Unigene cluster for SNAPC1 Gene Hs.179312

genes like me logo Genes that share expressions with SNAPC1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNAPC1 Gene

Orthologs for SNAPC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC1 35
  • 99.46 (n)
  • 99.46 (a)
SNAPC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC1 35
  • 88.25 (n)
  • 83.33 (a)
SNAPC1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC1 35
  • 91.67 (n)
  • 89.13 (a)
SNAPC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc1 35
  • 80.51 (n)
  • 78.69 (a)
Snapc1 16
Snapc1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAPC1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc1 35
  • 79.08 (n)
  • 79.89 (a)
chicken
(Gallus gallus)
Aves SNAPC1 35
  • 66.02 (n)
  • 60 (a)
SNAPC1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC1 36
  • 44 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13170 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snapc1 35
  • 61.19 (n)
  • 53.2 (a)
Str.10031 35
zebrafish
(Danio rerio)
Actinopterygii snapc1a 36
  • 35 (a)
OneToMany
snapc1b 35
  • 55.68 (n)
  • 48.52 (a)
snapc1b 36
  • 39 (a)
OneToMany
zgc55475 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for SNAPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC1 Gene

ENSEMBL:
Gene Tree for SNAPC1 (if available)
TreeFam:
Gene Tree for SNAPC1 (if available)

Paralogs for SNAPC1 Gene

Pseudogenes.org Pseudogenes for SNAPC1 Gene

genes like me logo Genes that share paralogs with SNAPC1: view

No data available for Paralogs for SNAPC1 Gene

Variants for SNAPC1 Gene

Sequence variations from dbSNP and Humsavar for SNAPC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1152572 -- 61,783,593(-) gcgcc(A/C)ctgca intron-variant
rs1152573 -- 61,794,607(+) GTTTC(A/G)CCATG intron-variant
rs1254677 -- 61,767,088(-) AAAAA(C/T)ATGGT intron-variant
rs1254678 -- 61,764,496(-) TCTTA(C/T)GCAAT intron-variant
rs1254679 -- 61,774,442(-) GACAA(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC1 Gene

Variant ID Type Subtype PubMed ID
nsv902008 CNV Loss 21882294
nsv1300 CNV Loss 18451855
nsv1301 CNV Insertion 18451855

Relevant External Links for SNAPC1 Gene

HapMap Linkage Disequilibrium report
SNAPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC1 Gene

Disorders for SNAPC1 Gene

No disorders were found for SNAPC1 Gene.

No data available for UniProtKB/Swiss-Prot for SNAPC1 Gene

Publications for SNAPC1 Gene

  1. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. (PMID: 7715707) Henry R.W. … Hernandez N. (Nature 1995) 3 4 23
  2. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley C.S. … Henry R.W. (J. Biol. Chem. 2003) 3 4 23
  3. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. (PMID: 8524284) Yoon J.B. … Roeder R.G. (Mol. Cell. Biol. 1996) 3 4
  4. The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR. (PMID: 9644240) Maeng J.H. … Yoon J.B. (J. Biochem. 1998) 2 3
  5. A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PMID: 11056176) Ma B. … Hernandez N. (J. Biol. Chem. 2001) 3 4

Products for SNAPC1 Gene

Sources for SNAPC1 Gene

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