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Aliases for SUMO2 Gene

Aliases for SUMO2 Gene

  • Small Ubiquitin-Like Modifier 2 2 3 5
  • Ubiquitin-Like Protein SMT3B 3 4
  • SMT3 Homolog 2 3 4
  • SMT3H2 3 4
  • HSMT3 3 4
  • SMT3B 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 2 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • Ubiquitin-Like Protein SMT3A 3
  • Sentrin 2 3
  • Sentrin-2 4
  • SUMO-2 4
  • SUMO-3 4
  • SUMO3 3
  • Smt3A 3

External Ids for SUMO2 Gene

Previous HGNC Symbols for SUMO2 Gene

  • SMT3H2

Previous GeneCards Identifiers for SUMO2 Gene

  • GC17M073761
  • GC17M070675
  • GC17M073163
  • GC17M068573

Summaries for SUMO2 Gene

Entrez Gene Summary for SUMO2 Gene

  • This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO2 Gene

SUMO2 (Small Ubiquitin-Like Modifier 2) is a Protein Coding gene. Diseases associated with SUMO2 include setx. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. GO annotations related to this gene include poly(A) RNA binding and SUMO transferase activity. An important paralog of this gene is SUMO4.

UniProtKB/Swiss-Prot for SUMO2 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO2 Gene

Genomics for SUMO2 Gene

Regulatory Elements for SUMO2 Gene

Promoters for SUMO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUMO2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SUMO2 gene promoter:

Genomic Location for SUMO2 Gene

Chromosome:
17
Start:
75,165,586 bp from pter
End:
75,183,003 bp from pter
Size:
17,418 bases
Orientation:
Minus strand

Genomic View for SUMO2 Gene

Genes around SUMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO2 Gene

Proteins for SUMO2 Gene

  • Protein details for SUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61956-SUMO2_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 2
    Protein Accession:
    P61956
    Secondary Accessions:
    • B2R4I2
    • P55855
    • Q32Q42
    • Q6IPZ6
    • Q96HK1

    Protein attributes for SUMO2 Gene

    Size:
    95 amino acids
    Molecular mass:
    10871 Da
    Quaternary structure:
    • Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1. Interacts with Epstein-barr virus BGLF4.

    Three dimensional structures from OCA and Proteopedia for SUMO2 Gene

    Alternative splice isoforms for SUMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO2 Gene

Proteomics data for SUMO2 Gene at MOPED

Post-translational modifications for SUMO2 Gene

  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo Lys-6-, Lys-11-, Lys-48- and Lys-63-linked polyubiquitination by RNF4.
  • Ubiquitination at Lys 5, Lys 7, and Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for SUMO2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUMO2 (SUMO2)

No data available for DME Specific Peptides for SUMO2 Gene

Domains & Families for SUMO2 Gene

Protein Domains for SUMO2 Gene

Suggested Antigen Peptide Sequences for SUMO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61956

UniProtKB/Swiss-Prot:

SUMO2_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the ubiquitin family. SUMO subfamily.
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO2: view

No data available for Gene Families for SUMO2 Gene

Function for SUMO2 Gene

Molecular function for SUMO2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
genes like me logo Genes that share phenotypes with SUMO2: view

Animal Models for SUMO2 Gene

MGI Knock Outs for SUMO2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SUMO2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO2 Gene

Localization for SUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO2 Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO2 Gene COMPARTMENTS Subcellular localization image for SUMO2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IDA 22406621
genes like me logo Genes that share ontologies with SUMO2: view

Pathways & Interactions for SUMO2 Gene

genes like me logo Genes that share pathways with SUMO2: view

Gene Ontology (GO) - Biological Process for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IEA,TAS --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 18408734
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SUMO2: view

No data available for SIGNOR curated interactions for SUMO2 Gene

Drugs & Compounds for SUMO2 Gene

No Compound Related Data Available

Transcripts for SUMO2 Gene

mRNA/cDNA for SUMO2 Gene

Unigene Clusters for SUMO2 Gene

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO2 Gene

No ASD Table

Relevant External Links for SUMO2 Gene

GeneLoc Exon Structure for
SUMO2
ECgene alternative splicing isoforms for
SUMO2

Expression for SUMO2 Gene

mRNA expression in normal human tissues for SUMO2 Gene

Protein differential expression in normal tissues from HIPED for SUMO2 Gene

This gene is overexpressed in Tlymphocyte (7.0), Oral epithelium (6.9), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUMO2 Gene



SOURCE GeneReport for Unigene cluster for SUMO2 Gene Hs.380973

mRNA Expression by UniProt/SwissProt for SUMO2 Gene

P61956-SUMO2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with SUMO2: view

Protein tissue co-expression partners for SUMO2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUMO2 Gene

Orthologs for SUMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUMO2 35
  • 97.19 (n)
  • 100 (a)
-- 36
  • 46 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SUMO2 35
  • 97.89 (n)
  • 100 (a)
-- 36
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sumo2 35
  • 95.79 (n)
  • 100 (a)
Sumo2 16
chimpanzee
(Pan troglodytes)
Mammalia SUMO2 35
  • 99.65 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Sumo2 35
  • 95.79 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUMO2 35
  • 91.58 (n)
  • 100 (a)
SUMO2 36
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5818 35
sumo2 35
  • 84.91 (n)
  • 95.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia smt3h2-prov 35
zebrafish
(Danio rerio)
Actinopterygii sumo2b 35
  • 81.72 (n)
  • 98.92 (a)
sumo3b 36
  • 95 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001701 35
  • 67.03 (n)
  • 69.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta smt3 36
  • 73 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 36
  • 73 (a)
OneToMany
Species with no ortholog for SUMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO2 Gene

ENSEMBL:
Gene Tree for SUMO2 (if available)
TreeFam:
Gene Tree for SUMO2 (if available)

Paralogs for SUMO2 Gene

Paralogs for SUMO2 Gene

(4) SIMAP similar genes for SUMO2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SUMO2: view

Variants for SUMO2 Gene

Sequence variations from dbSNP and Humsavar for SUMO2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17850328 - 75,181,164(+) ATGAT(C/T)GTTGT reference, missense
rs8420 -- 75,168,223(-) GTTTT(C/T)TCTAT utr-variant-3-prime
rs13692 -- 75,168,048(+) GAGAA(A/C/G)GGGGG utr-variant-3-prime
rs1471453 -- 75,181,349(-) TTTCC(G/T)CTTTC intron-variant
rs899323 -- 75,173,799(-) TTTTG(G/T)CCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO2 Gene

Variant ID Type Subtype PubMed ID
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
nsv908758 CNV Loss 21882294
nsv908759 CNV Loss 21882294
nsv2141 CNV Loss 18451855

Variation tolerance for SUMO2 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO2 Gene

HapMap Linkage Disequilibrium report
SUMO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO2 Gene

Disorders for SUMO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUMO2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
setx
- elite association - COSMIC cancer census association via MalaCards
Search SUMO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUMO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO2
genes like me logo Genes that share disorders with SUMO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO2 Gene

Publications for SUMO2 Gene

  1. Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. (PMID: 8630065) Mannen H. … Li S.S.-L. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 67
  2. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PMID: 19394292) Ouyang J. … Gill G. (Mol. Cell 2009) 3 23
  3. In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. (PMID: 17938407) Matic I. … Vertegaal A.C. (Mol. Cell Proteomics 2008) 3 23
  4. Repression of SOX6 transcriptional activity by SUMO modification. (PMID: 16442531) Fernandez-Lloris R. … Ventura F. (FEBS Lett. 2006) 3 23
  5. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PMID: 17000644) Vertegaal A.C. … Lamond A.I. (Mol. Cell Proteomics 2006) 3 23

Products for SUMO2 Gene

Sources for SUMO2 Gene

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