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Aliases for SUMO2 Gene

Aliases for SUMO2 Gene

  • Small Ubiquitin-Like Modifier 2 2 3
  • Ubiquitin-Like Protein SMT3B 3 4
  • SMT3 Homolog 2 3 4
  • SMT3H2 3 4
  • Smt3B 3 4
  • HSMT3 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 2 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • Small Ubiquitin-Related Modifier 2 3
  • Ubiquitin-Like Protein SMT3A 3
  • Sentrin 2 3
  • Sentrin-2 4
  • SUMO-3 4
  • SUMO-2 4
  • SMT3A 3
  • SUMO3 3

External Ids for SUMO2 Gene

Previous Symbols for SUMO2 Gene

  • SMT3H2

Summaries for SUMO2 Gene

Entrez Gene Summary for SUMO2 Gene

  • This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO2 Gene

SUMO2 (Small Ubiquitin-Like Modifier 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is SUMO3.

UniProtKB/Swiss-Prot for SUMO2 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO2 Gene

Genomics for SUMO2 Gene

Genomic Location for SUMO2 Gene

Start:
75,165,586 bp from pter
End:
75,183,003 bp from pter
Size:
17,418 bases
Orientation:
Minus strand

Genomic View for SUMO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO2 Gene

Regulatory Elements for SUMO2 Gene

Transcription factor binding sites by QIAGEN in the SUMO2 gene promoter:

Proteins for SUMO2 Gene

  • Protein details for SUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61956-SUMO2_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 2
    Protein Accession:
    P61956
    Secondary Accessions:
    • B2R4I2
    • P55855
    • Q32Q42
    • Q6IPZ6
    • Q96HK1

    Protein attributes for SUMO2 Gene

    Size:
    95 amino acids
    Molecular mass:
    10871 Da
    Quaternary structure:
    • Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for SUMO2 Gene

    Alternative splice isoforms for SUMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO2 Gene

Proteomics data for SUMO2 Gene at MOPED

Post-translational modifications for SUMO2 Gene

  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function
  • Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo Lys-6-, Lys-11-, Lys-48- and Lys-63-linked polyubiquitination by RNF4.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys7, Lys21, Lys33, Lys35, Lys42, and Lys45

Other Protein References for SUMO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SUMO2 Gene

Domains for SUMO2 Gene

Protein Domains for SUMO2 Gene

UniProtKB/Swiss-Prot:

SUMO2_HUMAN
Domain:
  • Contains 1 ubiquitin-like domain.:
    • P61956
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.:
    • P61956
genes like me logo Genes that share domains with SUMO2: view

No data available for Gene Families for SUMO2 Gene

Function for SUMO2 Gene

Molecular function for SUMO2 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Ontology (GO) - Molecular Function for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383276
GO:0019789 SUMO transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 18408734
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SUMO2: view

Phenotypes for SUMO2 Gene

GenomeRNAi human phenotypes for SUMO2:
genes like me logo Genes that share phenotypes with SUMO2: view

miRNA for SUMO2 Gene

miRTarBase miRNAs that target SUMO2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUMO2 Gene

Localization for SUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO2 Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO2 Gene COMPARTMENTS Subcellular localization image for SUMO2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21965678
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IDA 22406621
genes like me logo Genes that share ontologies with SUMO2: view

Pathways for SUMO2 Gene

genes like me logo Genes that share pathways with SUMO2: view

Pathways by source for SUMO2 Gene

Gene Ontology (GO) - Biological Process for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation TAS --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 18408734
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SUMO2: view

Transcripts for SUMO2 Gene

mRNA/cDNA for SUMO2 Gene

Unigene Clusters for SUMO2 Gene

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO2 Gene

No ASD Table

Relevant External Links for SUMO2 Gene

GeneLoc Exon Structure for
SUMO2
ECgene alternative splicing isoforms for
SUMO2

Expression for SUMO2 Gene

mRNA expression in normal human tissues for SUMO2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUMO2 Gene

SOURCE GeneReport for Unigene cluster for SUMO2 Gene Hs.380973

mRNA Expression by UniProt/SwissProt for SUMO2 Gene

P61956-SUMO2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expressions with SUMO2: view

Orthologs for SUMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO2 36
  • 99.65 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 46 (a)
ManyToMany
SUMO2 36
  • 97.19 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 70 (a)
ManyToMany
SUMO2 36
  • 97.89 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Sumo2 36
  • 95.79 (n)
  • 100 (a)
Sumo2 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sumo2 36
  • 95.79 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SUMO2 36
  • 91.58 (n)
  • 100 (a)
SUMO2 37
  • 100 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia smt3h2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5818 36
sumo2 36
  • 84.91 (n)
  • 95.79 (a)
zebrafish
(Danio rerio)
Actinopterygii sumo2b 36
  • 81.72 (n)
  • 98.92 (a)
sumo3b 37
  • 95 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001701 36
  • 67.03 (n)
  • 69.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta smt3 37
  • 73 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 37
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 37
  • 73 (a)
OneToMany
Species with no ortholog for SUMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO2 Gene

ENSEMBL:
Gene Tree for SUMO2 (if available)
TreeFam:
Gene Tree for SUMO2 (if available)

Paralogs for SUMO2 Gene

Paralogs for SUMO2 Gene

Selected SIMAP similar genes for SUMO2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SUMO2: view

Variants for SUMO2 Gene

Sequence variations from dbSNP and Humsavar for SUMO2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs752824 -- 75,173,660(-) ctctt(A/T)acaaa intron-variant
rs899323 -- 75,173,799(-) TTTTG(G/T)CCTAG intron-variant
rs899324 -- 75,173,477(-) AAAAA(C/T)GACTT intron-variant
rs1471453 -- 75,181,349(-) TTTCC(G/T)CTTTC intron-variant
rs2035252 -- 75,171,819(-) GTGCT(A/G)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO2 Gene

Variant ID Type Subtype PubMed ID
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
nsv908758 CNV Loss 21882294
nsv908759 CNV Loss 21882294
nsv2141 CNV Loss 18451855

Relevant External Links for SUMO2 Gene

HapMap Linkage Disequilibrium report
SUMO2

Disorders for SUMO2 Gene

No disorders were found for SUMO2 Gene.

No data available for UniProtKB/Swiss-Prot for SUMO2 Gene

Publications for SUMO2 Gene

  1. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PMID: 9556629) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 1998) 3 4 23
  2. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su H.-L. … Li S.S.-L. (Gene 2002) 3 4 23
  3. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D. … Lima C.D. (Structure 2004) 3 4 23
  4. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PMID: 15479240) Huang W.-C. … Wang A.H.-J. (Eur. J. Biochem. 2004) 3 4 23
  5. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PMID: 11451954) Tatham M.H. … Hay R.T. (J. Biol. Chem. 2001) 3 4 23

Products for SUMO2 Gene

  • Addgene plasmids for SUMO2

Sources for SUMO2 Gene

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