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Aliases for SUMO2 Gene

Aliases for SUMO2 Gene

  • Small Ubiquitin-Like Modifier 2 2 3 5
  • Ubiquitin-Like Protein SMT3B 3 4
  • SMT3 Homolog 2 3 4
  • SMT3H2 3 4
  • HSMT3 3 4
  • SMT3B 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 2 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • Small Ubiquitin-Related Modifier 2 3
  • Ubiquitin-Like Protein SMT3A 3
  • Sentrin 2 3
  • Sentrin-2 4
  • SUMO-2 4
  • SUMO-3 4
  • SUMO3 3
  • Smt3A 3

External Ids for SUMO2 Gene

Previous HGNC Symbols for SUMO2 Gene

  • SMT3H2

Previous GeneCards Identifiers for SUMO2 Gene

  • GC17M073761
  • GC17M070675
  • GC17M073163
  • GC17M068573

Summaries for SUMO2 Gene

Entrez Gene Summary for SUMO2 Gene

  • This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO2 Gene

SUMO2 (Small Ubiquitin-Like Modifier 2) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and DNA Double-Strand Break Repair. GO annotations related to this gene include poly(A) RNA binding and SUMO transferase activity. An important paralog of this gene is SUMO3.

UniProtKB/Swiss-Prot for SUMO2 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO2 Gene

Additional gene information for SUMO2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO2 Gene

Genomics for SUMO2 Gene

Regulatory Elements for SUMO2 Gene

Enhancers for SUMO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075776 2.4 ENCODE dbSUPER 10.2 -595.5 -595524 4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 UNK NUP85 SRSF2 ENSG00000267342 NT5C ENSG00000266980 MFSD11 METTL23 TRIM65 GGA3
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +91.5 91508 11 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H075031 1.8 FANTOM5 ENCODE dbSUPER 10.4 +148.4 148383 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC NUP85 UNK ENSG00000266980 GGA3 NT5C TRIM65 ENSG00000267342 KCTD2 ATP5H RN7SL573P
GH17H074203 1.4 ENCODE dbSUPER 10.4 +977.9 977853 4 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 RCOR2 NAT9 RN7SL573P NT5C ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935 KCTD2 SUMO2 RPL38
GH17H075046 1.4 ENCODE dbSUPER 10.3 +135.6 135553 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 NUP85 UNK ENSG00000266980 ENSG00000267342 ATP5H GGA3 NT5C KCTD2 RN7SL573P NAT9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUMO2 on UCSC Golden Path with GeneCards custom track

Promoters for SUMO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098334 803 2401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 FOS

Transcription factor binding sites by QIAGEN in the SUMO2 gene promoter:

Genomic Location for SUMO2 Gene

Chromosome:
17
Start:
75,165,586 bp from pter
End:
75,183,003 bp from pter
Size:
17,418 bases
Orientation:
Minus strand

Genomic View for SUMO2 Gene

Genes around SUMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO2 Gene

Proteins for SUMO2 Gene

  • Protein details for SUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61956-SUMO2_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 2
    Protein Accession:
    P61956
    Secondary Accessions:
    • B2R4I2
    • P55855
    • Q32Q42
    • Q6IPZ6
    • Q96HK1

    Protein attributes for SUMO2 Gene

    Size:
    95 amino acids
    Molecular mass:
    10871 Da
    Quaternary structure:
    • Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1. Interacts with Epstein-barr virus BGLF4.

    Three dimensional structures from OCA and Proteopedia for SUMO2 Gene

    Alternative splice isoforms for SUMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO2 Gene

Post-translational modifications for SUMO2 Gene

  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo Lys-6-, Lys-11-, Lys-48- and Lys-63-linked polyubiquitination by RNF4.
  • Ubiquitination at Lys5, posLast=77, and Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for SUMO2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUMO2 (SUMO2)

Assay Products

  • Cloud-Clone Corp. Assay Kits for SUMO2

No data available for DME Specific Peptides for SUMO2 Gene

Domains & Families for SUMO2 Gene

Gene Families for SUMO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SUMO2 Gene

Suggested Antigen Peptide Sequences for SUMO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61956

UniProtKB/Swiss-Prot:

SUMO2_HUMAN :
  • Belongs to the ubiquitin family. SUMO subfamily.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO2: view

Function for SUMO2 Gene

Molecular function for SUMO2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Phenotypes From GWAS Catalog for SUMO2 Gene

Gene Ontology (GO) - Molecular Function for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding IPI 17081986
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 15383276
GO:0019789 SUMO transferase activity IEA --
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with SUMO2: view
genes like me logo Genes that share phenotypes with SUMO2: view

Animal Models for SUMO2 Gene

MGI Knock Outs for SUMO2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SUMO2
  • Applied Biological Materials Clones for SUMO2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO2 Gene

Localization for SUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO2 Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUMO2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21965678
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IDA,IEA 22406621
genes like me logo Genes that share ontologies with SUMO2: view

Pathways & Interactions for SUMO2 Gene

genes like me logo Genes that share pathways with SUMO2: view

Pathways by source for SUMO2 Gene

Gene Ontology (GO) - Biological Process for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation TAS,IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 18408734
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0070911 global genome nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with SUMO2: view

No data available for SIGNOR curated interactions for SUMO2 Gene

Drugs & Compounds for SUMO2 Gene

No Compound Related Data Available

Transcripts for SUMO2 Gene

mRNA/cDNA for SUMO2 Gene

Unigene Clusters for SUMO2 Gene

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SUMO2
  • Applied Biological Materials Clones for SUMO2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO2 Gene

No ASD Table

Relevant External Links for SUMO2 Gene

GeneLoc Exon Structure for
SUMO2
ECgene alternative splicing isoforms for
SUMO2

Expression for SUMO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUMO2 Gene

Protein differential expression in normal tissues from HIPED for SUMO2 Gene

This gene is overexpressed in Tlymphocyte (7.0), Oral epithelium (6.9), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUMO2 Gene



Protein tissue co-expression partners for SUMO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUMO2 Gene:

SUMO2

SOURCE GeneReport for Unigene cluster for SUMO2 Gene:

Hs.380973

mRNA Expression by UniProt/SwissProt for SUMO2 Gene:

P61956-SUMO2_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for SUMO2 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(4.7)
  • Bone(4.4)
  • Bone marrow(4.3)
  • Intestine(3.8)
  • Liver(3.7)
  • Pancreas(3.5)
  • Kidney(3.3)
  • Eye(3.1)
  • Blood(2.9)
  • Muscle(2.8)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with SUMO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO2 Gene

Orthologs for SUMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO2 33
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SUMO2 33
  • 97.89 (n)
-- 34
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SUMO2 33
  • 97.19 (n)
-- 34
  • 46 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sumo2 33 16
  • 95.79 (n)
rat
(Rattus norvegicus)
Mammalia Sumo2 33
  • 95.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUMO2 33 34
  • 91.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sumo2 33
  • 84.91 (n)
Str.5818 33
African clawed frog
(Xenopus laevis)
Amphibia smt3h2-prov 33
zebrafish
(Danio rerio)
Actinopterygii sumo3b 34
  • 95 (a)
ManyToMany
sumo2b 33
  • 81.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta smt3 34
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001701 33
  • 67.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 34
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 34
  • 73 (a)
OneToMany
Species where no ortholog for SUMO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO2 Gene

ENSEMBL:
Gene Tree for SUMO2 (if available)
TreeFam:
Gene Tree for SUMO2 (if available)

Paralogs for SUMO2 Gene

Paralogs for SUMO2 Gene

(4) SIMAP similar genes for SUMO2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SUMO2: view

Variants for SUMO2 Gene

Sequence variations from dbSNP and Humsavar for SUMO2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000020841 -- 75,171,011(+) ACTAA(A/G)CAGCA intron-variant
rs1000021233 -- 75,167,960(+) TTGTT(G/T)TTTTT utr-variant-3-prime
rs1000339637 -- 75,171,400(+) TCCCA(C/G)CTACT intron-variant
rs1000621831 -- 75,169,653(+) GCTGG(C/G)ATTAT intron-variant
rs1000727418 -- 75,168,445(+) AAGTT(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO2 Gene

Variant ID Type Subtype PubMed ID
nsv1113889 CNV deletion 24896259
nsv2141 CNV deletion 18451855
nsv470602 CNV loss 18288195
nsv960527 CNV duplication 23825009

Variation tolerance for SUMO2 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUMO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO2 Gene

Disorders for SUMO2 Gene

Relevant External Links for SUMO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO2

No disorders were found for SUMO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUMO2 Gene

Publications for SUMO2 Gene

  1. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PMID: 15479240) Huang WC … Wang AH (European journal of biochemistry 2004) 3 4 22 60
  2. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D … Lima CD (Structure (London, England : 1993) 2004) 3 4 22 60
  3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL … Li SS (Gene 2002) 3 4 22 60
  4. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PMID: 11451954) Tatham MH … Hay RT (The Journal of biological chemistry 2001) 3 4 22 60
  5. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PMID: 9556629) Kamitani T … Yeh ET (The Journal of biological chemistry 1998) 3 4 22 60

Products for SUMO2 Gene

  • Addgene plasmids for SUMO2

Sources for SUMO2 Gene

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