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Aliases for SUMO3 Gene

Aliases for SUMO3 Gene

  • Small Ubiquitin-Like Modifier 3 2 3
  • SMT3H1 3 4 6
  • SUMO-3 3 4
  • SMT3A 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 1 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 1 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 3
  • Small Ubiquitin-Related Modifier 3 3
  • Ubiquitin-Like Protein SMT3B 3
  • Ubiquitin-Like Protein SMT3A 4
  • SMT3 Homolog 1 4
  • SUMO-2 4
  • Smt3B 3

External Ids for SUMO3 Gene

Previous Symbols for SUMO3 Gene

  • SMT3H1

Summaries for SUMO3 Gene

Entrez Gene Summary for SUMO3 Gene

  • This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

GeneCards Summary for SUMO3 Gene

SUMO3 (Small Ubiquitin-Like Modifier 3) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO4.

UniProtKB/Swiss-Prot for SUMO3 Gene

  • Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO3 Gene

Genomics for SUMO3 Gene

Genomic Location for SUMO3 Gene

Start:
44,805,617 bp from pter
End:
44,818,779 bp from pter
Size:
13,163 bases
Orientation:
Minus strand

Genomic View for SUMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO3 Gene

Regulatory Elements for SUMO3 Gene

Proteins for SUMO3 Gene

  • Protein details for SUMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55854-SUMO3_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 3
    Protein Accession:
    P55854
    Secondary Accessions:
    • B2R5X4
    • B4DUW4
    • Q53HI9
    • Q6FGD4
    • Q9BWR4

    Protein attributes for SUMO3 Gene

    Size:
    103 amino acids
    Molecular mass:
    11637 Da
    Quaternary structure:
    • Covalently attached to a number of proteins. Interacts with ARNTL/BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.

    Three dimensional structures from OCA and Proteopedia for SUMO3 Gene

    Alternative splice isoforms for SUMO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO3 Gene

Proteomics data for SUMO3 Gene at MOPED

Post-translational modifications for SUMO3 Gene

  • Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function
  • Polymeric chains can be formed through Lys-11 cross-linking
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys7, Lys20, Lys32, Lys34, Lys41, and Lys44

Other Protein References for SUMO3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SUMO3 Gene

Domains for SUMO3 Gene

Protein Domains for SUMO3 Gene

UniProtKB/Swiss-Prot:

SUMO3_HUMAN
Domain:
  • Contains 1 ubiquitin-like domain.:
    • P55854
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.:
    • P55854
genes like me logo Genes that share domains with SUMO3: view

No data available for Gene Families for SUMO3 Gene

Function for SUMO3 Gene

Molecular function for SUMO3 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Ontology (GO) - Molecular Function for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17000644
GO:0019789 SUMO transferase activity IEA --
genes like me logo Genes that share ontologies with SUMO3: view

Phenotypes for SUMO3 Gene

MGI mutant phenotypes for SUMO3:
inferred from 1 alleles
GenomeRNAi human phenotypes for SUMO3:
genes like me logo Genes that share phenotypes with SUMO3: view

miRNA for SUMO3 Gene

miRTarBase miRNAs that target SUMO3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUMO3 Gene

Localization for SUMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO3 Gene

Cytoplasm. Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO3 Gene COMPARTMENTS Subcellular localization image for SUMO3 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore TAS 9119407
GO:0005634 nucleus IDA 21965678
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016604 nuclear body --
genes like me logo Genes that share ontologies with SUMO3: view

Pathways for SUMO3 Gene

genes like me logo Genes that share pathways with SUMO3: view

Pathways by source for SUMO3 Gene

2 Qiagen pathways for SUMO3 Gene
1 Cell Signaling Technology pathway for SUMO3 Gene
1 BioSystems pathway for SUMO3 Gene

Gene Ontology (GO) - Biological Process for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation TAS --
GO:0034504 protein localization to nucleus IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with SUMO3: view

Transcripts for SUMO3 Gene

Unigene Clusters for SUMO3 Gene

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - - - - -
SP14:

ExUns: 10f · 10g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SUMO3 Gene

GeneLoc Exon Structure for
SUMO3
ECgene alternative splicing isoforms for
SUMO3

Expression for SUMO3 Gene

mRNA expression in normal human tissues for SUMO3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUMO3 Gene

SOURCE GeneReport for Unigene cluster for SUMO3 Gene Hs.474005

mRNA Expression by UniProt/SwissProt for SUMO3 Gene

P55854-SUMO3_HUMAN
Tissue specificity: Expressed predominantly in liver.
genes like me logo Genes that share expressions with SUMO3: view

Orthologs for SUMO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUMO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO3 36
  • 99.68 (n)
  • 100 (a)
SUMO3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 65 (a)
ManyToMany
SUMO3 36
  • 91.3 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 40 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933411G06Rik 37
  • 34 (a)
ManyToMany
Sumo3 36
  • 90.94 (n)
  • 100 (a)
Sumo3 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sumo3 36
  • 90.68 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves SUMO3 36
  • 90.32 (n)
  • 97.85 (a)
SUMO3 37
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 98 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64297 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sumo3 36
  • 84.23 (n)
  • 98.92 (a)
zebrafish
(Danio rerio)
Actinopterygii sumo2a 37
  • 68 (a)
ManyToMany
sumo3b 36
  • 84.06 (n)
  • 98.91 (a)
wufa94a11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000852 36
  • 72.84 (n)
  • 74.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta smt3 36
  • 75.56 (n)
  • 74.44 (a)
smt3 37
  • 74 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 37
  • 43 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.24729 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 37
  • 72 (a)
OneToMany
Species with no ortholog for SUMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO3 Gene

ENSEMBL:
Gene Tree for SUMO3 (if available)
TreeFam:
Gene Tree for SUMO3 (if available)

Paralogs for SUMO3 Gene

Paralogs for SUMO3 Gene

Selected SIMAP similar genes for SUMO3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SUMO3: view

Variants for SUMO3 Gene

Sequence variations from dbSNP and Humsavar for SUMO3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8645 -- 44,806,651(-) ACCCC(A/C)AAATT utr-variant-3-prime
rs180313 -- 44,807,883(+) GCTCT(C/T)AGCAG intron-variant
rs235292 -- 44,805,750(+) AACAT(G/T)TCAGC utr-variant-3-prime
rs235293 -- 44,809,015(+) GAAGT(C/T)GCCCT intron-variant
rs235334 -- 44,815,259(-) CATGG(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO3 Gene

Variant ID Type Subtype PubMed ID
dgv4775n71 CNV Loss 21882294
nsv913963 CNV Loss 21882294
nsv459298 CNV Loss 19166990
dgv4777n71 CNV Loss 21882294
nsv913966 CNV Loss 21882294
nsv3540 CNV Insertion 18451855

Relevant External Links for SUMO3 Gene

HapMap Linkage Disequilibrium report
SUMO3

Disorders for SUMO3 Gene

Relevant External Links for SUMO3

Genetic Association Database (GAD)
SUMO3
Human Genome Epidemiology (HuGE) Navigator
SUMO3
genes like me logo Genes that share disorders with SUMO3: view

No data available for UniProtKB/Swiss-Prot for SUMO3 Gene

Publications for SUMO3 Gene

  1. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PMID: 9119407) Lapenta V. … Brahe C. (Genomics 1997) 2 3 4 23
  2. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su H.-L. … Li S.S.-L. (Gene 2002) 3 4 23
  3. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D. … Lima C.D. (Structure 2004) 3 4 23
  4. Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. (PMID: 15940266) Fu C. … Yao X. (Oncogene 2005) 3 23
  5. The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. (PMID: 16934752) Liu G. … Warbrick E. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for SUMO3 Gene

  • Addgene plasmids for SUMO3

Sources for SUMO3 Gene

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