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Aliases for SUMO3 Gene

Aliases for SUMO3 Gene

  • Small Ubiquitin-Like Modifier 3 2 3 5
  • SUMO-3 3 4
  • SMT3H1 3 4
  • Smt3A 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 1 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 1 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 3 3
  • Small Ubiquitin-Related Modifier 3 3
  • Ubiquitin-Like Protein SMT3B 3
  • Ubiquitin-Like Protein SMT3A 4
  • SMT3 Homolog 1 4
  • SUMO-2 4
  • SMT3B 3

External Ids for SUMO3 Gene

Previous HGNC Symbols for SUMO3 Gene

  • SMT3H1

Previous GeneCards Identifiers for SUMO3 Gene

  • GC21M045083
  • GC21M045049
  • GC21M046191
  • GC21M031598
  • GC21M046548
  • GC21M046735

Summaries for SUMO3 Gene

Entrez Gene Summary for SUMO3 Gene

  • This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

GeneCards Summary for SUMO3 Gene

SUMO3 (Small Ubiquitin-Like Modifier 3) is a Protein Coding gene. Among its related pathways are HIF Repressor Pathways and SUMOylation. GO annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot for SUMO3 Gene

  • Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO3 Gene

Genomics for SUMO3 Gene

Regulatory Elements for SUMO3 Gene

Enhancers for SUMO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SUMO3 on UCSC Golden Path with GeneCards custom track

Promoters for SUMO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SUMO3 Gene

Chromosome:
21
Start:
44,805,617 bp from pter
End:
44,818,779 bp from pter
Size:
13,163 bases
Orientation:
Minus strand

Genomic View for SUMO3 Gene

Genes around SUMO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO3 Gene

Proteins for SUMO3 Gene

  • Protein details for SUMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55854-SUMO3_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 3
    Protein Accession:
    P55854
    Secondary Accessions:
    • B2R5X4
    • B4DUW4
    • Q53HI9
    • Q6FGD4
    • Q9BWR4

    Protein attributes for SUMO3 Gene

    Size:
    103 amino acids
    Molecular mass:
    11637 Da
    Quaternary structure:
    • Covalently attached to a number of proteins. Interacts with ARNTL/BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.

    Three dimensional structures from OCA and Proteopedia for SUMO3 Gene

    Alternative splice isoforms for SUMO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO3 Gene

Post-translational modifications for SUMO3 Gene

  • Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
  • Polymeric chains can be formed through Lys-11 cross-linking.
  • Ubiquitination at Lys 5, Lys 7, and Lys 20
  • Modification sites at PhosphoSitePlus

Other Protein References for SUMO3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUMO3 (SUMO3)

No data available for DME Specific Peptides for SUMO3 Gene

Domains & Families for SUMO3 Gene

Protein Domains for SUMO3 Gene

Suggested Antigen Peptide Sequences for SUMO3 Gene

Graphical View of Domain Structure for InterPro Entry

P55854

UniProtKB/Swiss-Prot:

SUMO3_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the ubiquitin family. SUMO subfamily.
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO3: view

No data available for Gene Families for SUMO3 Gene

Function for SUMO3 Gene

Molecular function for SUMO3 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Ontology (GO) - Molecular Function for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17000644
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with SUMO3: view
genes like me logo Genes that share phenotypes with SUMO3: view

Animal Models for SUMO3 Gene

MGI Knock Outs for SUMO3:

Animal Model Products

CRISPR Products

miRNA for SUMO3 Gene

miRTarBase miRNAs that target SUMO3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SUMO3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO3 Gene

Localization for SUMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO3 Gene

Cytoplasm. Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO3 Gene COMPARTMENTS Subcellular localization image for SUMO3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore TAS 9119407
GO:0005634 nucleus IDA 21965678
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with SUMO3: view

Pathways & Interactions for SUMO3 Gene

genes like me logo Genes that share pathways with SUMO3: view

Pathways by source for SUMO3 Gene

1 KEGG pathway for SUMO3 Gene
2 R&D Systems pathways for SUMO3 Gene
2 Qiagen pathways for SUMO3 Gene

Gene Ontology (GO) - Biological Process for SUMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation TAS --
GO:0070911 global genome nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with SUMO3: view

No data available for SIGNOR curated interactions for SUMO3 Gene

Drugs & Compounds for SUMO3 Gene

No Compound Related Data Available

Transcripts for SUMO3 Gene

Unigene Clusters for SUMO3 Gene

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SUMO3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - - - - -
SP14:

ExUns: 10f · 10g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SUMO3 Gene

GeneLoc Exon Structure for
SUMO3
ECgene alternative splicing isoforms for
SUMO3

Expression for SUMO3 Gene

mRNA expression in normal human tissues for SUMO3 Gene

Protein differential expression in normal tissues from HIPED for SUMO3 Gene

This gene is overexpressed in Oral epithelium (8.1), Frontal cortex (7.9), and Fetal ovary (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUMO3 Gene



Protein tissue co-expression partners for SUMO3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUMO3 Gene:

SUMO3

SOURCE GeneReport for Unigene cluster for SUMO3 Gene:

Hs.474005

mRNA Expression by UniProt/SwissProt for SUMO3 Gene:

P55854-SUMO3_HUMAN
Tissue specificity: Expressed predominantly in liver.
genes like me logo Genes that share expression patterns with SUMO3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUMO3 Gene

Orthologs for SUMO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUMO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO3 35
  • 100 (a)
OneToOne
SUMO3 34
  • 99.68 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4933411G06Rik 35
  • 34 (a)
ManyToMany
Sumo3 16
Sumo3 34
  • 90.94 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
ManyToMany
SUMO3 34
  • 91.3 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Sumo3 34
  • 90.68 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves SUMO3 35
  • 97 (a)
ManyToMany
SUMO3 34
  • 90.32 (n)
  • 97.85 (a)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 98 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64297 34
tropical clawed frog
(Silurana tropicalis)
Amphibia sumo3 34
  • 84.23 (n)
  • 98.92 (a)
zebrafish
(Danio rerio)
Actinopterygii sumo2a 35
  • 68 (a)
ManyToMany
wufa94a11 34
sumo3b 34
  • 84.06 (n)
  • 98.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta smt3 35
  • 74 (a)
OneToMany
smt3 34
  • 75.56 (n)
  • 74.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000852 34
  • 72.84 (n)
  • 74.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 35
  • 43 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.24729 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 35
  • 72 (a)
OneToMany
Species where no ortholog for SUMO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO3 Gene

ENSEMBL:
Gene Tree for SUMO3 (if available)
TreeFam:
Gene Tree for SUMO3 (if available)

Paralogs for SUMO3 Gene

Paralogs for SUMO3 Gene

(6) SIMAP similar genes for SUMO3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SUMO3: view

Variants for SUMO3 Gene

Sequence variations from dbSNP and Humsavar for SUMO3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1051311 - 44,814,014(-) ACACG(C/T)CGCTG reference, missense
rs235292 -- 44,805,750(+) AACAT(G/T)TCAGC utr-variant-3-prime
rs235293 -- 44,809,015(+) GAAGT(C/T)GCCCT intron-variant
rs235334 -- 44,815,259(-) CATGG(A/G)TGCAG intron-variant
rs235335 -- 44,815,992(-) GTGGA(C/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO3 Gene

Variant ID Type Subtype PubMed ID
esv3647135 CNV loss 21293372
esv3647136 CNV loss 21293372
nsv1058550 CNV loss 25217958
nsv1071763 CNV deletion 25765185
nsv3540 CNV insertion 18451855
nsv459298 CNV loss 19166990
nsv587813 CNV loss 21841781

Variation tolerance for SUMO3 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUMO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO3 Gene

Disorders for SUMO3 Gene

Relevant External Links for SUMO3

Genetic Association Database (GAD)
SUMO3
Human Genome Epidemiology (HuGE) Navigator
SUMO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO3

No disorders were found for SUMO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUMO3 Gene

Publications for SUMO3 Gene

  1. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PMID: 9119407) Lapenta V. … Brahe C. (Genomics 1997) 2 3 4 22 65
  2. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D. … Lima C.D. (Structure 2004) 3 4 22 65
  3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su H.-L. … Li S.S.-L. (Gene 2002) 3 4 22 65
  4. A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. (PMID: 24105744) Richard P. … Manley J.L. (Genes Dev. 2013) 3 4 65
  5. SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L. … Kumar R. (J. Biol. Chem. 2011) 3 4 65

Products for SUMO3 Gene

Sources for SUMO3 Gene

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