Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAK2 Gene

Aliases for TRAK2 Gene

  • Trafficking Protein, Kinesin Binding 2 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 3 2 3
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 98 2 3
  • Gamma-Aminobutyric Acid(A) Receptor-Interacting Factor 2 3
  • ALS2CR3 3 4
  • Milton Homolog 2 (Drosophila) 2
  • Milton Homolog 2 3
  • KIAA0549 4
  • CALS-C 3
  • GRIF-1 3
  • GRIF1 3
  • MILT2 3
  • OIP98 3

External Ids for TRAK2 Gene

Previous HGNC Symbols for TRAK2 Gene

  • ALS2CR3

Previous GeneCards Identifiers for TRAK2 Gene

  • GC02M202068
  • GC02M201950
  • GC02M202241
  • GC02M194090

Summaries for TRAK2 Gene

GeneCards Summary for TRAK2 Gene

TRAK2 (Trafficking Protein, Kinesin Binding 2) is a Protein Coding gene. Diseases associated with TRAK2 include Amyotrophic Lateral Sclerosis 2, Juvenile. Among its related pathways are Circadian entrainment and Metabolism. GO annotations related to this gene include receptor binding and GABA receptor binding. An important paralog of this gene is HAP1.

UniProtKB/Swiss-Prot for TRAK2 Gene

  • May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Gene Wiki entry for TRAK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK2 Gene

Genomics for TRAK2 Gene

Regulatory Elements for TRAK2 Gene

Enhancers for TRAK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAK2 Gene

Chromosome:
2
Start:
201,377,207 bp from pter
End:
201,451,611 bp from pter
Size:
74,405 bases
Orientation:
Minus strand

Genomic View for TRAK2 Gene

Genes around TRAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK2 Gene

Proteins for TRAK2 Gene

  • Protein details for TRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60296-TRAK2_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 2
    Protein Accession:
    O60296
    Secondary Accessions:
    • E7EV21
    • Q8WVH7
    • Q96NS2
    • Q9C0K5
    • Q9C0K6

    Protein attributes for TRAK2 Gene

    Size:
    914 amino acids
    Molecular mass:
    101419 Da
    Quaternary structure:
    • Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

    Alternative splice isoforms for TRAK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK2 Gene

Proteomics data for TRAK2 Gene at MOPED

Post-translational modifications for TRAK2 Gene

Other Protein References for TRAK2 Gene

No data available for DME Specific Peptides for TRAK2 Gene

Domains & Families for TRAK2 Gene

Protein Domains for TRAK2 Gene

Suggested Antigen Peptide Sequences for TRAK2 Gene

Graphical View of Domain Structure for InterPro Entry

O60296

UniProtKB/Swiss-Prot:

TRAK2_HUMAN :
  • Contains 1 HAP1 N-terminal domain.
Domain:
  • Contains 1 HAP1 N-terminal domain.
genes like me logo Genes that share domains with TRAK2: view

No data available for Gene Families for TRAK2 Gene

Function for TRAK2 Gene

Molecular function for TRAK2 Gene

UniProtKB/Swiss-Prot Function:
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Gene Ontology (GO) - Molecular Function for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050811 GABA receptor binding NAS 15644324
genes like me logo Genes that share ontologies with TRAK2: view
genes like me logo Genes that share phenotypes with TRAK2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAK2 Gene

Localization for TRAK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK2 Gene

Cytoplasm. Early endosome. Mitochondrion. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAK2 Gene COMPARTMENTS Subcellular localization image for TRAK2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 3
endosome 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 12034717
GO:0005739 mitochondrion ISS --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with TRAK2: view

Pathways & Interactions for TRAK2 Gene

SuperPathways for TRAK2 Gene

Superpath Contained pathways
1 Circadian entrainment
2 Metabolism
genes like me logo Genes that share pathways with TRAK2: view

Pathways by source for TRAK2 Gene

2 KEGG pathways for TRAK2 Gene

Gene Ontology (GO) - Biological Process for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
genes like me logo Genes that share ontologies with TRAK2: view

No data available for SIGNOR curated interactions for TRAK2 Gene

Drugs & Compounds for TRAK2 Gene

(2) Additional Compounds for TRAK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAK2: view

Transcripts for TRAK2 Gene

Unigene Clusters for TRAK2 Gene

Trafficking protein, kinesin binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

ExUns: 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TRAK2 Gene

GeneLoc Exon Structure for
TRAK2
ECgene alternative splicing isoforms for
TRAK2

Expression for TRAK2 Gene

mRNA expression in normal human tissues for TRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for TRAK2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.9).

Protein differential expression in normal tissues from HIPED for TRAK2 Gene

This gene is overexpressed in Neutrophil (32.5), Plasma (12.3), Blymphocyte (10.3), and Monocytes (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAK2 Gene



SOURCE GeneReport for Unigene cluster for TRAK2 Gene Hs.152774

mRNA Expression by UniProt/SwissProt for TRAK2 Gene

O60296-TRAK2_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart.
genes like me logo Genes that share expression patterns with TRAK2: view

Protein tissue co-expression partners for TRAK2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRAK2 Gene

Orthologs for TRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAK2 35
  • 89.77 (n)
  • 90.02 (a)
TRAK2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAK2 35
  • 91.23 (n)
  • 92.18 (a)
TRAK2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trak2 35
  • 85.45 (n)
  • 87.72 (a)
Trak2 16
Trak2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAK2 35
  • 99.31 (n)
  • 99.23 (a)
TRAK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trak2 35
  • 84.98 (n)
  • 86.95 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAK2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAK2 35
  • 73.27 (n)
  • 74.92 (a)
TRAK2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAK2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trak2 35
  • 63.21 (n)
  • 61.8 (a)
zebrafish
(Danio rerio)
Actinopterygii trak2 35
  • 59.47 (n)
  • 60 (a)
wufj21g01 35
trak2 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta milt 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 36
  • 21 (a)
OneToMany
Species with no ortholog for TRAK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK2 Gene

ENSEMBL:
Gene Tree for TRAK2 (if available)
TreeFam:
Gene Tree for TRAK2 (if available)

Paralogs for TRAK2 Gene

Paralogs for TRAK2 Gene

(3) SIMAP similar genes for TRAK2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRAK2 Gene

genes like me logo Genes that share paralogs with TRAK2: view

Variants for TRAK2 Gene

Sequence variations from dbSNP and Humsavar for TRAK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13022344 - 201,399,433(+) TAAGA(C/T)ATGGT reference, missense, utr-variant-5-prime
rs2244438 - 201,387,816(+) TCTCT(A/G)TCGGG reference, missense
rs34594680 - 201,380,700(+) GACCA(A/T)TTTCT reference, missense
rs1558636 -- 201,377,070(+) TGTTT(A/G)TTATT downstream-variant-500B
rs1558637 -- 201,398,651(+) TTCAC(G/T)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK2 Gene

Variant ID Type Subtype PubMed ID
nsv875708 CNV Gain 21882294
esv272558 CNV Insertion 20981092
esv267788 CNV Insertion 20981092
esv28629 CNV Loss 19812545
esv1007085 CNV Insertion 20482838

Variation tolerance for TRAK2 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAK2 Gene

Human Gene Mutation Database (HGMD)
TRAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK2 Gene

Disorders for TRAK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAK2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 2, juvenile
  • als2
- elite association - COSMIC cancer census association via MalaCards
Search TRAK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAK2

Genetic Association Database (GAD)
TRAK2
Human Genome Epidemiology (HuGE) Navigator
TRAK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAK2
genes like me logo Genes that share disorders with TRAK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAK2 Gene

Publications for TRAK2 Gene

  1. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S. … Hayden M.R. (Genomics 2001) 2 3 4 67
  2. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. (PMID: 20230862) Koutsopoulos O.S. … Ryan M.T. (Biochim. Biophys. Acta 2010) 2 3
  3. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. (PMID: 16380713) Gilbert S.L. … Lahn B.T. (Nat. Genet. 2006) 2 3
  4. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1. (PMID: 16895905) Grishin A. … Zaks-Makhina E. (J. Biol. Chem. 2006) 3 23

Products for TRAK2 Gene

Sources for TRAK2 Gene

Content