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Aliases for LYNX1 Gene

Aliases for LYNX1 Gene

  • Ly6/Neurotoxin 1 2 3
  • Secreted Ly-6/UPAR Domain-Containing Protein 2 3 4
  • Secreted Ly-6/UPAR-Related Protein 2 3 4
  • SLURP-2 3 4
  • SLURP2 3 4
  • Secreted Ly6/UPAR Related Protein 2 3
  • Ly-6 Neurotoxin-Like Protein 1 3
  • Ly-6/Neurotoxin-Like Protein 1 3

External Ids for LYNX1 Gene

Summaries for LYNX1 Gene

Entrez Gene Summary for LYNX1 Gene

  • This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for LYNX1 Gene

LYNX1 (Ly6/Neurotoxin 1) is a Protein Coding gene. Diseases associated with LYNX1 include psoriasis.

UniProtKB/Swiss-Prot for LYNX1 Gene

  • Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYNX1 Gene

Genomics for LYNX1 Gene

Genomic Location for LYNX1 Gene

Start:
142,764,334 bp from pter
End:
142,778,224 bp from pter
Size:
13,891 bases
Orientation:
Minus strand

Genomic View for LYNX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYNX1 Gene

Regulatory Elements for LYNX1 Gene

Proteins for LYNX1 Gene

  • Protein details for LYNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZG9-LYNX1_HUMAN
    Recommended name:
    Ly-6/neurotoxin-like protein 1
    Protein Accession:
    Q9BZG9
    Secondary Accessions:
    • D3DWI7
    • G3XAC2
    • Q86SR0

    Protein attributes for LYNX1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14026 Da
    Quaternary structure:
    • Isoform 2 interacts with nAChRs, including alpha(4)beta(2) (CHRNA4/CHRNB2) and alpha(7) (CHRNA7) (By similarity). Competes with alpha-bungarotoxin for nAChR alpha(7) binding. Isoform 3 may interact with heteropentameric nAChRs expressed by keratinocytes.
    Miscellaneous:
    • Isoform 2 is considered to be an endogenous "prototoxin", that shares a N-terminal three-finger structure with snake alpha-neurotoxins

    Three dimensional structures from OCA and Proteopedia for LYNX1 Gene

    Alternative splice isoforms for LYNX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LYNX1 Gene

Proteomics data for LYNX1 Gene at MOPED

Post-translational modifications for LYNX1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LYNX1 Gene

Domains for LYNX1 Gene

Protein Domains for LYNX1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

LYNX1_HUMAN
Domain:
  • Contains 1 UPAR/Ly6 domain.:
    • Q9BZG9
genes like me logo Genes that share domains with LYNX1: view

No data available for Gene Families for LYNX1 Gene

Function for LYNX1 Gene

Molecular function for LYNX1 Gene

UniProtKB/Swiss-Prot Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.
genes like me logo Genes that share phenotypes with LYNX1: view

Animal Models for LYNX1 Gene

MGI Knock Outs for LYNX1:

miRNA for LYNX1 Gene

miRTarBase miRNAs that target LYNX1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for LYNX1 Gene

Localization for LYNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYNX1 Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, dendrite. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000250}.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYNX1 Gene COMPARTMENTS Subcellular localization image for LYNX1 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LYNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030425 dendrite IEA --
GO:0031225 anchored component of membrane IEA --
GO:0042995 cell projection --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LYNX1: view

Pathways for LYNX1 Gene

SuperPathways for LYNX1 Gene

No Data Available

Interacting Proteins for LYNX1 Gene

Selected Interacting proteins: Q9BZG9-LYNX1_HUMAN for LYNX1 Gene via I2D

Symbol External ID(s) Details
PLSCR1

Gene Ontology (GO) - Biological Process for LYNX1 Gene

None

No data available for Pathways by source for LYNX1 Gene

Transcripts for LYNX1 Gene

Unigene Clusters for LYNX1 Gene

Ly6/neurotoxin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LYNX1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6: - -
SP7: -

Relevant External Links for LYNX1 Gene

GeneLoc Exon Structure for
LYNX1
ECgene alternative splicing isoforms for
LYNX1

Expression for LYNX1 Gene

mRNA expression in normal human tissues for LYNX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYNX1 Gene

This gene is overexpressed in Brain - Cortex (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LYNX1 Gene

SOURCE GeneReport for Unigene cluster for LYNX1 Gene Hs.158665

mRNA Expression by UniProt/SwissProt for LYNX1 Gene

Q9BZG9-LYNX1_HUMAN
Tissue specificity: Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up-regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level).
genes like me logo Genes that share expressions with LYNX1: view

Orthologs for LYNX1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LYNX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYNX1 36
  • 98.56 (n)
  • 99.14 (a)
LYNX1 37
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LYNX1 36
  • 86.78 (n)
  • 90.52 (a)
dog
(Canis familiaris)
Mammalia LYNX1 37
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2300005B03Rik 37
  • 56 (a)
OneToOne
Lynx1 36
  • 80.75 (n)
  • 81.03 (a)
Lynx1 16
rat
(Rattus norvegicus)
Mammalia Lynx1 36
  • 79.31 (n)
  • 81.03 (a)
Species with no ortholog for LYNX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYNX1 Gene

ENSEMBL:
Gene Tree for LYNX1 (if available)
TreeFam:
Gene Tree for LYNX1 (if available)

Paralogs for LYNX1 Gene

Pseudogenes.org Pseudogenes for LYNX1 Gene

genes like me logo Genes that share paralogs with LYNX1: view

No data available for Paralogs for LYNX1 Gene

Variants for LYNX1 Gene

Sequence variations from dbSNP and Humsavar for LYNX1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs13362 -- 142,771,546(-) CCCCA(C/G)CCTTA intron-variant, utr-variant-3-prime, upstream-variant-2KB
rs892846 -- 142,774,337(-) GGTCC(C/G)CCGAG intron-variant, utr-variant-3-prime
rs892847 -- 142,774,331(-) CCGAG(G/T)CCTGG intron-variant, utr-variant-3-prime
rs892848 -- 142,774,252(-) TGGGG(A/G)TTGGG intron-variant, utr-variant-3-prime
rs1075542 -- 142,764,564(+) GGGGC(C/T)GTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LYNX1 Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV Deletion 23128226
dgv7910n71 CNV Loss 21882294
dgv7915n71 CNV Loss 21882294
nsv831485 CNV Loss 17160897
nsv891638 CNV Loss 21882294
nsv831486 CNV Gain 17160897
nsv891639 CNV Gain 21882294
dgv7917n71 CNV Loss 21882294
dgv7918n71 CNV Loss 21882294
nsv891646 CNV Loss 21882294
esv33000 CNV Gain 17666407
nsv824758 CNV Gain 20364138
esv2737931 CNV Deletion 23290073
nsv396254 CNV Loss 16902084
esv2737932 CNV Deletion 23290073
esv2737933 CNV Deletion 23290073
nsv824759 CNV Gain 20364138

Relevant External Links for LYNX1 Gene

HapMap Linkage Disequilibrium report
LYNX1

Disorders for LYNX1 Gene

(1) MalaCards Diseases for LYNX1 Gene

Search for LYNX1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for LYNX1 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 51.1 3

Relevant External Links for LYNX1

Genetic Association Database (GAD)
LYNX1
Human Genome Epidemiology (HuGE) Navigator
LYNX1
genes like me logo Genes that share disorders with LYNX1: view

No data available for UniProtKB/Swiss-Prot for LYNX1 Gene

Publications for LYNX1 Gene

  1. SLURP-2, a novel member of the human Ly-6 superfamily that is up- regulated in psoriasis vulgaris. (PMID: 12573258) Tsuji H. … Inoko H. (Genomics 2003) 2 3 4 23
  2. SLURP-2: a novel cholinergic signaling peptide in human mucocutaneous epithelium. (PMID: 16575903) Arredondo J. … Grando S.A. (J. Cell. Physiol. 2006) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1. (PMID: 21252236) Lyukmanova E.N. … Kirpichnikov M.P. (J. Biol. Chem. 2011) 3 4

Products for LYNX1 Gene

Sources for LYNX1 Gene

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