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Aliases for CAPRIN2 Gene

Aliases for CAPRIN2 Gene

  • Caprin Family Member 2 2 3 5
  • Cytoplasmic Activation/Proliferation-Associated Protein 2 3 4
  • Gastric Cancer Multidrug Resistance-Associated Protein 3 4
  • C1q Domain-Containing Protein 1 3 4
  • RNA Granule Protein 140 3 4
  • C1QDC1 3 4
  • RNG140 3 4
  • EEG1 3 4
  • C1q Domain Containing 1 2
  • Protein EEG-1 4
  • Caprin-2 3
  • KIAA1873 4
  • EEG-1 3

External Ids for CAPRIN2 Gene

Previous HGNC Symbols for CAPRIN2 Gene

  • C1QDC1

Previous GeneCards Identifiers for CAPRIN2 Gene

  • GC12M030754
  • GC12M030862
  • GC12M030627

Summaries for CAPRIN2 Gene

Entrez Gene Summary for CAPRIN2 Gene

  • The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for CAPRIN2 Gene

CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and receptor binding. An important paralog of this gene is CAPRIN1.

UniProtKB/Swiss-Prot for CAPRIN2 Gene

  • Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).

Gene Wiki entry for CAPRIN2 Gene

Additional gene information for CAPRIN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPRIN2 Gene

Genomics for CAPRIN2 Gene

Regulatory Elements for CAPRIN2 Gene

Enhancers for CAPRIN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H031726 1.4 ENCODE dbSUPER 15.3 -905.2 -905243 3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 DDX11 SINHCAF LOC100420981 FLJ13224 KIAA1551 DDX11-AS1 CAPRIN2 H3F3C ENSG00000256984 BICD1
GH12H030753 1.1 ENCODE 17.3 +68.4 68394 2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CAPRIN2 LOC645485 IPO8
GH12H030850 1.3 Ensembl ENCODE 14.2 -28.2 -28248 1 PKNOX1 ATF1 FOXA2 FEZF1 ZNF2 GLIS2 FOS ATF7 SP3 TSHZ1 CAPRIN2 IPO8 DDX11-AS1 DDX11 GC12M030845 PPIAP44
GH12H031758 0.8 ENCODE 18.4 -935.2 -935247 0 ZSCAN5A PKNOX1 KLF1 ZNF473 INSM2 ZNF223 KLF17 SALL2 ZNF155 CTBP1 LOC100420981 DNM1L BICD1 DDX11 CAPRIN2 DDX11-AS1 ENSG00000252204 AMN1 LOC105369724 H3F3C
GH12H031360 0.9 dbSUPER 14 -537.5 -537521 0 ZFP64 FEZF1 ZNF354C KLF7 ZNF202 ZNF654 ZNF680 ZC3H11A REST ZNF623 IPO8 DDX11-AS1 DDX11 SINHCAF FLJ13224 BICD1 CAPRIN2 RNU6-618P DENND5B-AS1 DENND5B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPRIN2 Gene

Chromosome:
12
Start:
30,709,552 bp from pter
End:
30,823,235 bp from pter
Size:
113,684 bases
Orientation:
Minus strand

Genomic View for CAPRIN2 Gene

Genes around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN2 Gene

Proteins for CAPRIN2 Gene

  • Protein details for CAPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMN6-CAPR2_HUMAN
    Recommended name:
    Caprin-2
    Protein Accession:
    Q6IMN6
    Secondary Accessions:
    • E4NKG2
    • Q149P6
    • Q149P7
    • Q6IMN5
    • Q7Z371
    • Q8TE70
    • Q8TE71
    • Q96RN6
    • Q9H667
    • Q9HAL4

    Protein attributes for CAPRIN2 Gene

    Size:
    1127 amino acids
    Molecular mass:
    125925 Da
    Quaternary structure:
    • Homotrimer; via C1q domain (PubMed:25331957). Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587). Interacts with LRP5 (PubMed:18762581). Interacts with LRP6 (PubMed:18762581, PubMed:25331957).
    SequenceCaution:
    • Sequence=AAK83153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPRIN2 Gene

    Alternative splice isoforms for CAPRIN2 Gene

neXtProt entry for CAPRIN2 Gene

Post-translational modifications for CAPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPRIN2 Gene

Domains & Families for CAPRIN2 Gene

Gene Families for CAPRIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAPRIN2 Gene

Suggested Antigen Peptide Sequences for CAPRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IMN6

UniProtKB/Swiss-Prot:

CAPR2_HUMAN :
  • The C1q domain is essential for the function in Wnt signaling.
  • Belongs to the caprin family.
Domain:
  • The C1q domain is essential for the function in Wnt signaling.
Family:
  • Belongs to the caprin family.
genes like me logo Genes that share domains with CAPRIN2: view

Function for CAPRIN2 Gene

Molecular function for CAPRIN2 Gene

UniProtKB/Swiss-Prot Function:
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).

Phenotypes From GWAS Catalog for CAPRIN2 Gene

Gene Ontology (GO) - Molecular Function for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005102 receptor binding IPI 18762581
GO:0005515 protein binding IPI 18762581
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Phenotypes for CAPRIN2 Gene

MGI mutant phenotypes for CAPRIN2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CAPRIN2:
genes like me logo Genes that share phenotypes with CAPRIN2: view

Animal Models for CAPRIN2 Gene

MGI Knock Outs for CAPRIN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPRIN2

CRISPR Products

miRNA for CAPRIN2 Gene

miRTarBase miRNAs that target CAPRIN2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPRIN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPRIN2 Gene

Localization for CAPRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Isoform 1: Cytoplasm.
Isoform 2: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
Isoform 5: Mitochondrion. Note=Colocalizes with aggregated mitochondria.
Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPRIN2 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 14593112
GO:0005739 mitochondrion IDA,IEA 14593112
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Pathways & Interactions for CAPRIN2 Gene

SuperPathways for CAPRIN2 Gene

No Data Available

SIGNOR curated interactions for CAPRIN2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 14593112
GO:0032092 positive regulation of protein binding IDA 18762581
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 18762581
genes like me logo Genes that share ontologies with CAPRIN2: view

No data available for Pathways by source for CAPRIN2 Gene

Drugs & Compounds for CAPRIN2 Gene

No Compound Related Data Available

Transcripts for CAPRIN2 Gene

Unigene Clusters for CAPRIN2 Gene

Caprin family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPRIN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19: - - - - - - - -
SP20: - - - - - - -
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - - -

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - -
SP15: - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for CAPRIN2 Gene

GeneLoc Exon Structure for
CAPRIN2
ECgene alternative splicing isoforms for
CAPRIN2

Expression for CAPRIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPRIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPRIN2 Gene

This gene is overexpressed in Plasma (53.1) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPRIN2 Gene



Protein tissue co-expression partners for CAPRIN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPRIN2 Gene:

CAPRIN2

SOURCE GeneReport for Unigene cluster for CAPRIN2 Gene:

Hs.234355

mRNA Expression by UniProt/SwissProt for CAPRIN2 Gene:

Q6IMN6-CAPR2_HUMAN
Tissue specificity: Detected in all tissues tested with highest levels of expression in brain and spleen.

Evidence on tissue expression from TISSUES for CAPRIN2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with CAPRIN2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPRIN2 Gene

Orthologs for CAPRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN2 33 34
  • 99.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN2 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN2 33 34
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia CAPRIN2 33 34
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Caprin2 33 16 34
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia Caprin2 33
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPRIN2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPRIN2 33 34
  • 73.17 (n)
lizard
(Anolis carolinensis)
Reptilia CAPRIN2 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin2 33
  • 59.25 (n)
Str.17842 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3769 33
zebrafish
(Danio rerio)
Actinopterygii caprin2 33 34
  • 52.89 (n)
wufj80b02 33
fruit fly
(Drosophila melanogaster)
Insecta Capr 34
  • 20 (a)
OneToMany
Species where no ortholog for CAPRIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN2 Gene

ENSEMBL:
Gene Tree for CAPRIN2 (if available)
TreeFam:
Gene Tree for CAPRIN2 (if available)

Paralogs for CAPRIN2 Gene

genes like me logo Genes that share paralogs with CAPRIN2: view

Variants for CAPRIN2 Gene

Sequence variations from dbSNP and Humsavar for CAPRIN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000032084 -- 30,722,620(+) TTAAG(C/G)CTGAG intron-variant
rs1000054884 -- 30,746,092(+) AACTT(G/T)AAAGA intron-variant
rs1000119305 -- 30,752,974(+) CAGCA(A/G)TTATA intron-variant, upstream-variant-2KB
rs1000222894 -- 30,732,918(+) CAAAC(G/T)ATTTT intron-variant
rs1000269264 -- 30,739,912(+) AAATA(C/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN2 Gene

Variant ID Type Subtype PubMed ID
esv2745706 CNV deletion 23290073
esv3629022 CNV loss 21293372
nsv832361 CNV loss 17160897

Variation tolerance for CAPRIN2 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPRIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Disorders for CAPRIN2 Gene

Relevant External Links for CAPRIN2

Genetic Association Database (GAD)
CAPRIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPRIN2

No disorders were found for CAPRIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPRIN2 Gene

Publications for CAPRIN2 Gene

  1. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B … Schrader JW (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 60
  2. Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation. (PMID: 27821587) Wang X … Li L (The Journal of biological chemistry 2016) 3 4 60
  3. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. (PMID: 25331957) Miao H … Li L (The Journal of biological chemistry 2014) 3 4 60
  4. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. (PMID: 20516077) Shiina N … Tokunaga M (The Journal of biological chemistry 2010) 3 4 60
  5. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. (PMID: 18762581) Ding Y … Li L (The Journal of cell biology 2008) 3 4 60

Products for CAPRIN2 Gene

Sources for CAPRIN2 Gene

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