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Aliases for CAPRIN2 Gene

Aliases for CAPRIN2 Gene

  • Caprin Family Member 2 2 3
  • C1QDC1 3 4 6
  • EEG1 3 4 6
  • Cytoplasmic Activation/Proliferation-Associated Protein 2 3 4
  • Gastric Cancer Multidrug Resistance-Associated Protein 3 4
  • C1q Domain-Containing Protein 1 3 4
  • RNA Granule Protein 140 3 4
  • KIAA1873 4 6
  • RNG140 3 4
  • C1q Domain Containing 1 2
  • Protein EEG-1 4
  • Caprin-2 3
  • EEG-1 3

External Ids for CAPRIN2 Gene

Previous HGNC Symbols for CAPRIN2 Gene

  • C1QDC1

Previous GeneCards Identifiers for CAPRIN2 Gene

  • GC12M030754
  • GC12M030862
  • GC12M030627

Summaries for CAPRIN2 Gene

Entrez Gene Summary for CAPRIN2 Gene

  • The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for CAPRIN2 Gene

CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and receptor binding. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CAPRIN2 Gene

  • May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Gene Wiki entry for CAPRIN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPRIN2 Gene

Genomics for CAPRIN2 Gene

Genomic Location for CAPRIN2 Gene

Start:
30,709,552 bp from pter
End:
30,754,951 bp from pter
Size:
45,400 bases
Orientation:
Minus strand

Genomic View for CAPRIN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN2 Gene

No data available for Regulatory Elements for CAPRIN2 Gene

Proteins for CAPRIN2 Gene

  • Protein details for CAPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMN6-CAPR2_HUMAN
    Recommended name:
    Caprin-2
    Protein Accession:
    Q6IMN6
    Secondary Accessions:
    • E4NKG2
    • Q149P6
    • Q149P7
    • Q6IMN5
    • Q7Z371
    • Q8TE70
    • Q8TE71
    • Q96RN6
    • Q9H667
    • Q9HAL4

    Protein attributes for CAPRIN2 Gene

    Size:
    1127 amino acids
    Molecular mass:
    125925 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK83153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPRIN2 Gene

    Alternative splice isoforms for CAPRIN2 Gene

neXtProt entry for CAPRIN2 Gene

Proteomics data for CAPRIN2 Gene at MOPED

Post-translational modifications for CAPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPRIN2 Gene

Domains for CAPRIN2 Gene

Protein Domains for CAPRIN2 Gene

Suggested Antigen Peptide Sequences for CAPRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IMN6

UniProtKB/Swiss-Prot:

CAPR2_HUMAN :
  • Q6IMN6
Domain:
  • Contains 1 C1q domain.
Family:
  • Belongs to the caprin family.
genes like me logo Genes that share domains with CAPRIN2: view

No data available for Gene Families for CAPRIN2 Gene

Function for CAPRIN2 Gene

Molecular function for CAPRIN2 Gene

UniProtKB/Swiss-Prot Function: May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Gene Ontology (GO) - Molecular Function for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003723 RNA binding IEA --
GO:0003824 catalytic activity --
GO:0005102 receptor binding IPI 18762581
GO:0005515 protein binding IPI 18762581
genes like me logo Genes that share ontologies with CAPRIN2: view

miRNA for CAPRIN2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPRIN2 Gene

Localization for CAPRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Isoform 1: Cytoplasm.
Isoform 2: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
Isoform 5: Mitochondrion. Note=Colocalizes with aggregated mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPRIN2 Gene COMPARTMENTS Subcellular localization image for CAPRIN2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 14593112
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Pathways for CAPRIN2 Gene

SuperPathways for CAPRIN2 Gene

No Data Available

Interacting Proteins for CAPRIN2 Gene

Gene Ontology (GO) - Biological Process for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation IEA --
GO:0030308 negative regulation of cell growth IDA 14593112
GO:0032092 positive regulation of protein binding IDA 18762581
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 18762581
GO:0044237 cellular metabolic process --
genes like me logo Genes that share ontologies with CAPRIN2: view

No data available for Pathways by source for CAPRIN2 Gene

Transcripts for CAPRIN2 Gene

Unigene Clusters for CAPRIN2 Gene

Caprin family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19: - - - - - - - -
SP20: - - - - - - -
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - - -

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - -
SP15: - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for CAPRIN2 Gene

GeneLoc Exon Structure for
CAPRIN2
ECgene alternative splicing isoforms for
CAPRIN2

Expression for CAPRIN2 Gene

mRNA expression in normal human tissues for CAPRIN2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CAPRIN2 Gene

SOURCE GeneReport for Unigene cluster for CAPRIN2 Gene Hs.234355

mRNA Expression by UniProt/SwissProt for CAPRIN2 Gene

Q6IMN6-CAPR2_HUMAN
Tissue specificity: Detected in all tissues tested with highest levels of expression in brain and spleen.
genes like me logo Genes that share expressions with CAPRIN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAPRIN2 Gene

Orthologs for CAPRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN2 35
  • 99.65 (n)
  • 99.65 (a)
CAPRIN2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPRIN2 35
  • 93.56 (n)
  • 92.3 (a)
CAPRIN2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN2 35
  • 93.98 (n)
  • 93.95 (a)
CAPRIN2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caprin2 35
  • 85.33 (n)
  • 82.38 (a)
Caprin2 16
Caprin2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPRIN2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caprin2 35
  • 82.79 (n)
  • 80.04 (a)
chicken
(Gallus gallus)
Aves CAPRIN2 35
  • 73.17 (n)
  • 73.23 (a)
CAPRIN2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPRIN2 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3769 35
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin2 35
  • 59.25 (n)
  • 54.79 (a)
Str.17842 35
zebrafish
(Danio rerio)
Actinopterygii caprin2 35
  • 52.89 (n)
  • 50.47 (a)
caprin2 36
  • 43 (a)
OneToOne
wufj80b02 35
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 20 (a)
OneToMany
Species with no ortholog for CAPRIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN2 Gene

ENSEMBL:
Gene Tree for CAPRIN2 (if available)
TreeFam:
Gene Tree for CAPRIN2 (if available)

Paralogs for CAPRIN2 Gene

genes like me logo Genes that share paralogs with CAPRIN2: view

Variants for CAPRIN2 Gene

Sequence variations from dbSNP and Humsavar for CAPRIN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7032 -- 30,709,719(+) CAGAT(A/T)AGTGC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs13656 -- 30,715,068(-) AATGT(A/G)TTTCC synonymous-codon, reference, nc-transcript-variant
rs33132 -- 30,736,359(-) ATATG(A/G)TGGAA intron-variant
rs718368 -- 30,718,569(+) CTTAA(C/T)TGCAA intron-variant
rs1044833 -- 30,710,471(-) AAACA(G/T)CAGGG splice-acceptor-variant, reference, missense, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN2 Gene

Variant ID Type Subtype PubMed ID
nsv832361 CNV Loss 17160897
esv2745706 CNV Deletion 23290073

Relevant External Links for CAPRIN2 Gene

HapMap Linkage Disequilibrium report
CAPRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Disorders for CAPRIN2 Gene

(1) University of Copenhagen DISEASES for CAPRIN2 Gene

Relevant External Links for CAPRIN2

Genetic Association Database (GAD)
CAPRIN2
genes like me logo Genes that share disorders with CAPRIN2: view

No data available for UniProtKB/Swiss-Prot for CAPRIN2 Gene

Publications for CAPRIN2 Gene

  1. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B. … Schrader J.W. (J. Immunol. 2004) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3
  3. Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. (PMID: 14593112) Aerbajinai W. … Miller J.L. (J. Biol. Chem. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. (PMID: 20516077) Shiina N. … Tokunaga M. (J. Biol. Chem. 2010) 3 4

Products for CAPRIN2 Gene

Sources for CAPRIN2 Gene

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