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Aliases for CAPRIN2 Gene

Aliases for CAPRIN2 Gene

  • Caprin Family Member 2 2 3 5
  • Cytoplasmic Activation/Proliferation-Associated Protein 2 3 4
  • Gastric Cancer Multidrug Resistance-Associated Protein 3 4
  • C1q Domain-Containing Protein 1 3 4
  • RNA Granule Protein 140 3 4
  • C1QDC1 3 4
  • RNG140 3 4
  • EEG1 3 4
  • C1q Domain Containing 1 2
  • Protein EEG-1 4
  • KIAA1873 4
  • EEG-1 3

External Ids for CAPRIN2 Gene

Previous HGNC Symbols for CAPRIN2 Gene

  • C1QDC1

Previous GeneCards Identifiers for CAPRIN2 Gene

  • GC12M030754
  • GC12M030862
  • GC12M030627

Summaries for CAPRIN2 Gene

Entrez Gene Summary for CAPRIN2 Gene

  • The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for CAPRIN2 Gene

CAPRIN2 (Caprin Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and receptor binding. An important paralog of this gene is C1QL4.

UniProtKB/Swiss-Prot for CAPRIN2 Gene

  • May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Gene Wiki entry for CAPRIN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPRIN2 Gene

Genomics for CAPRIN2 Gene

Regulatory Elements for CAPRIN2 Gene

Enhancers for CAPRIN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPRIN2 Gene

Chromosome:
12
Start:
30,709,552 bp from pter
End:
30,823,235 bp from pter
Size:
113,684 bases
Orientation:
Minus strand

Genomic View for CAPRIN2 Gene

Genes around CAPRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPRIN2 Gene

Proteins for CAPRIN2 Gene

  • Protein details for CAPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMN6-CAPR2_HUMAN
    Recommended name:
    Caprin-2
    Protein Accession:
    Q6IMN6
    Secondary Accessions:
    • E4NKG2
    • Q149P6
    • Q149P7
    • Q6IMN5
    • Q7Z371
    • Q8TE70
    • Q8TE71
    • Q96RN6
    • Q9H667
    • Q9HAL4

    Protein attributes for CAPRIN2 Gene

    Size:
    1127 amino acids
    Molecular mass:
    125925 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK83153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAPRIN2 Gene

    Alternative splice isoforms for CAPRIN2 Gene

neXtProt entry for CAPRIN2 Gene

Proteomics data for CAPRIN2 Gene at MOPED

Post-translational modifications for CAPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPRIN2 Gene

Domains & Families for CAPRIN2 Gene

Protein Domains for CAPRIN2 Gene

Suggested Antigen Peptide Sequences for CAPRIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IMN6

UniProtKB/Swiss-Prot:

CAPR2_HUMAN :
  • Contains 1 C1q domain.
  • Belongs to the caprin family.
Domain:
  • Contains 1 C1q domain.
Family:
  • Belongs to the caprin family.
genes like me logo Genes that share domains with CAPRIN2: view

No data available for Gene Families for CAPRIN2 Gene

Function for CAPRIN2 Gene

Molecular function for CAPRIN2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.

Phenotypes for CAPRIN2 Gene

GenomeRNAi human phenotypes for CAPRIN2:
genes like me logo Genes that share phenotypes with CAPRIN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CAPRIN2

CRISPR Products

miRNA for CAPRIN2 Gene

miRTarBase miRNAs that target CAPRIN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPRIN2 Gene

Localization for CAPRIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Isoform 1: Cytoplasm.
Isoform 2: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
Isoform 5: Mitochondrion. Note=Colocalizes with aggregated mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPRIN2 Gene COMPARTMENTS Subcellular localization image for CAPRIN2 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with CAPRIN2: view

Pathways & Interactions for CAPRIN2 Gene

SuperPathways for CAPRIN2 Gene

No Data Available

Interacting Proteins for CAPRIN2 Gene

SIGNOR curated interactions for CAPRIN2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CAPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032092 positive regulation of protein binding IDA 18762581
GO:0061003 positive regulation of dendritic spine morphogenesis ISS --
GO:0090263 positive regulation of canonical Wnt signaling pathway IDA 18762581
genes like me logo Genes that share ontologies with CAPRIN2: view

No data available for Pathways by source for CAPRIN2 Gene

Drugs & Compounds for CAPRIN2 Gene

No Compound Related Data Available

Transcripts for CAPRIN2 Gene

Unigene Clusters for CAPRIN2 Gene

Caprin family member 2:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPRIN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19: - - - - - - - -
SP20: - - - - - - -
SP21:
SP22: -
SP23: - - - -
SP24:
SP25: - - -

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: -
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - -
SP15: - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21: - - - - - - - -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for CAPRIN2 Gene

GeneLoc Exon Structure for
CAPRIN2
ECgene alternative splicing isoforms for
CAPRIN2

Expression for CAPRIN2 Gene

mRNA expression in normal human tissues for CAPRIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAPRIN2 Gene

This gene is overexpressed in Plasma (53.1) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CAPRIN2 Gene



SOURCE GeneReport for Unigene cluster for CAPRIN2 Gene Hs.234355

mRNA Expression by UniProt/SwissProt for CAPRIN2 Gene

Q6IMN6-CAPR2_HUMAN
Tissue specificity: Detected in all tissues tested with highest levels of expression in brain and spleen.
genes like me logo Genes that share expression patterns with CAPRIN2: view

Protein tissue co-expression partners for CAPRIN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAPRIN2 Gene

Orthologs for CAPRIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPRIN2 35
  • 93.56 (n)
  • 92.3 (a)
CAPRIN2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPRIN2 35
  • 93.98 (n)
  • 93.95 (a)
CAPRIN2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caprin2 35
  • 85.33 (n)
  • 82.38 (a)
Caprin2 16
Caprin2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPRIN2 35
  • 99.65 (n)
  • 99.65 (a)
CAPRIN2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caprin2 35
  • 82.79 (n)
  • 80.04 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPRIN2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPRIN2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPRIN2 35
  • 73.17 (n)
  • 73.23 (a)
CAPRIN2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPRIN2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caprin2 35
  • 59.25 (n)
  • 54.79 (a)
Str.17842 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3769 35
zebrafish
(Danio rerio)
Actinopterygii caprin2 35
  • 52.89 (n)
  • 50.47 (a)
wufj80b02 35
caprin2 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Capr 36
  • 20 (a)
OneToMany
Species with no ortholog for CAPRIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPRIN2 Gene

ENSEMBL:
Gene Tree for CAPRIN2 (if available)
TreeFam:
Gene Tree for CAPRIN2 (if available)

Paralogs for CAPRIN2 Gene

genes like me logo Genes that share paralogs with CAPRIN2: view

Variants for CAPRIN2 Gene

Sequence variations from dbSNP and Humsavar for CAPRIN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2304630 - 30,728,875(+) CTGCA(A/C/T)GGAAG nc-transcript-variant, reference, missense
VAR_048445 -
rs12146709 - 30,735,067(+) CCCCT(C/T)TGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2304628 - 30,724,393(+) TAGCT(A/G)AAGGC nc-transcript-variant, reference, missense
rs7032 -- 30,709,719(+) CAGAT(A/T)AGTGC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAPRIN2 Gene

Variant ID Type Subtype PubMed ID
nsv832361 CNV Loss 17160897
esv2745706 CNV Deletion 23290073

Variation tolerance for CAPRIN2 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPRIN2 Gene

HapMap Linkage Disequilibrium report
CAPRIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPRIN2 Gene

Disorders for CAPRIN2 Gene

Relevant External Links for CAPRIN2

Genetic Association Database (GAD)
CAPRIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPRIN2

No disorders were found for CAPRIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPRIN2 Gene

Publications for CAPRIN2 Gene

  1. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. (PMID: 14764709) Grill B. … Schrader J.W. (J. Immunol. 2004) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. (PMID: 25331957) Miao H. … Li L. (J. Biol. Chem. 2014) 3
  5. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3

Products for CAPRIN2 Gene

Sources for CAPRIN2 Gene

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