External Ids for SLN Gene
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLN Gene
SLN (Sarcolipin) is a Protein Coding gene. Diseases associated with SLN include long qt syndrome. GO annotations related to this gene include enzyme inhibitor activity and ATPase binding.
UniProtKB/Swiss-Prot for SLN Gene
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.