Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLN Gene

Aliases for SLN Gene

  • Sarcolipin 2 3

External Ids for SLN Gene

Previous GeneCards Identifiers for SLN Gene

  • GC11M109772
  • GC11M108934
  • GC11M107612
  • GC11M107115
  • GC11M107083
  • GC11M103503

Summaries for SLN Gene

Entrez Gene Summary for SLN Gene

  • Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLN Gene

SLN (Sarcolipin) is a Protein Coding gene. Diseases associated with SLN include familial atrial fibrillation. GO annotations related to this gene include ATPase binding and enzyme regulator activity.

UniProtKB/Swiss-Prot for SLN Gene

  • Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.

Gene Wiki entry for SLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLN Gene

Genomics for SLN Gene

Regulatory Elements for SLN Gene

Genomic Location for SLN Gene

Chromosome:
11
Start:
107,707,375 bp from pter
End:
107,719,693 bp from pter
Size:
12,319 bases
Orientation:
Minus strand

Genomic View for SLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLN Gene

Proteins for SLN Gene

  • Protein details for SLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00631-SARCO_HUMAN
    Recommended name:
    Sarcolipin
    Protein Accession:
    O00631
    Secondary Accessions:
    • Q6ICV3

    Protein attributes for SLN Gene

    Size:
    31 amino acids
    Molecular mass:
    3762 Da
    Quaternary structure:
    • Interacts with calcium ATPase ATP2A1/SERCA1

    Three dimensional structures from OCA and Proteopedia for SLN Gene

neXtProt entry for SLN Gene

Proteomics data for SLN Gene at MOPED

Post-translational modifications for SLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLN Gene

Domains & Families for SLN Gene

Protein Domains for SLN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00631

UniProtKB/Swiss-Prot:

SARCO_HUMAN :
  • Belongs to the sarcolipin family.
Family:
  • Belongs to the sarcolipin family.
genes like me logo Genes that share domains with SLN: view

No data available for Gene Families for SLN Gene

Function for SLN Gene

Molecular function for SLN Gene

GENATLAS Biochemistry:
sarcolipin,low molecular weight proteolipid associated with the fast-twitch skeletal muscle sarcoplasmic reticulum Ca++ ATPase (ATP2A1),phospholamban homolog
UniProtKB/Swiss-Prot Function:
Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.

Gene Ontology (GO) - Molecular Function for SLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS 12032137
GO:0005515 protein binding IPI 25416956
GO:0030234 enzyme regulator activity --
GO:0051117 ATPase binding ISS 12032137
genes like me logo Genes that share ontologies with SLN: view
genes like me logo Genes that share phenotypes with SLN: view

Animal Models for SLN Gene

MGI Knock Outs for SLN:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLN Gene

Localization for SLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLN Gene

Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLN Gene COMPARTMENTS Subcellular localization image for SLN gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 9367679
GO:0016529 sarcoplasmic reticulum IDA 9575189
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SLN: view

Pathways & Interactions for SLN Gene

SuperPathways for SLN Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport NAS 9367679
GO:0043086 negative regulation of catalytic activity ISS 12032137
GO:0043242 negative regulation of protein complex disassembly ISS 12032137
GO:0051924 regulation of calcium ion transport ISS --
GO:0070296 sarcoplasmic reticulum calcium ion transport ISS --
genes like me logo Genes that share ontologies with SLN: view

No data available for Pathways by source and SIGNOR curated interactions for SLN Gene

Drugs & Compounds for SLN Gene

(8) Drugs for SLN Gene - From: ClinicalTrials, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Perflutren Approved Pharma 66
Calcium Nutra 0
Definity Pharma 66
Fluorophosphate Pharma 33
FS 069 Pharma 21

(1) Additional Compounds for SLN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
genes like me logo Genes that share compounds with SLN: view

Transcripts for SLN Gene

mRNA/cDNA for SLN Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(153) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLN Gene

Sarcolipin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLN Gene

No ASD Table

Relevant External Links for SLN Gene

GeneLoc Exon Structure for
SLN
ECgene alternative splicing isoforms for
SLN

Expression for SLN Gene

mRNA expression in normal human tissues for SLN Gene

mRNA differential expression in normal tissues according to GTEx for SLN Gene

This gene is overexpressed in Muscle - Skeletal (x37.0) and Heart - Atrial Appendage (x13.1).

SOURCE GeneReport for Unigene cluster for SLN Gene Hs.334629

genes like me logo Genes that share expression patterns with SLN: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLN Gene

Orthologs for SLN Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SLN Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sln 16
chimpanzee
(Pan troglodytes)
Mammalia SLN 36
  • 100 (a)
OneToOne
Species with no ortholog for SLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLN Gene

ENSEMBL:
Gene Tree for SLN (if available)
TreeFam:
Gene Tree for SLN (if available)

Paralogs for SLN Gene

No data available for Paralogs for SLN Gene

Variants for SLN Gene

Sequence variations from dbSNP and Humsavar for SLN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs498980 -- 107,707,730(+) CCCTC(A/G)GATGG utr-variant-3-prime
rs522691 -- 107,708,030(+) AAAAC(A/C)CAAGG intron-variant
rs525599 -- 107,711,748(+) AAAAA(A/C)ATTTT intron-variant
rs583362 -- 107,707,995(-) GAGGA(C/G)AAGCC utr-variant-5-prime
rs585507 -- 107,707,551(-) AAACT(A/G)GATTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLN Gene

Variant ID Type Subtype PubMed ID
esv2750979 CNV Gain 17911159
nsv898378 CNV Gain 21882294

Variation tolerance for SLN Gene

Residual Variation Intolerance Score: 69.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLN Gene

HapMap Linkage Disequilibrium report
SLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLN Gene

Disorders for SLN Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLN Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association
Search SLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLN

Genetic Association Database (GAD)
SLN
Human Genome Epidemiology (HuGE) Navigator
SLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLN
genes like me logo Genes that share disorders with SLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLN Gene

Publications for SLN Gene

  1. Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. (PMID: 9367679) Odermatt A. … Maclennan D.H. (Genomics 1997) 2 23 67
  2. The decay phase of Ca2+ transients in skeletal muscle: regulation and physiology. (PMID: 19448701) Tupling A.R. (Appl Physiol Nutr Metab 2009) 23 67
  3. The role of sarcolipin and ATP in the transport of phosphate ion into the sarcoplasmic reticulum. (PMID: 19917222) Becucci L. … Veglia G. (Biophys. J. 2009) 23 67
  4. Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice. (PMID: 19204867) Vasu V.T. … Gohil K. (Free Radic. Res. 2009) 23 67
  5. Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy. (PMID: 19525500) Nef H.M. … ElsAosser A. (Eur. Heart J. 2009) 23 67

Products for SLN Gene

Sources for SLN Gene

Back to Top

Content