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Aliases for SLC22A3 Gene

Aliases for SLC22A3 Gene

  • Solute Carrier Family 22 (Organic Cation Transporter), Member 3 2 3
  • EMT 3 4 6
  • Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3 2 3
  • Extraneuronal Monoamine Transporter 3 4
  • Organic Cation Transporter 3 3 4
  • EMTH 3 4
  • OCT3 3 4
  • Solute Carrier Family 22 Member 3 3
  • EMT Organic Cation Transporter 3 3

External Ids for SLC22A3 Gene

Summaries for SLC22A3 Gene

Entrez Gene Summary for SLC22A3 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A3 Gene

SLC22A3 (Solute Carrier Family 22 (Organic Cation Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include organic cation transmembrane transporter activity and toxin transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A3 Gene

  • Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Wiki entry for SLC22A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A3 Gene

Genomics for SLC22A3 Gene

Genomic Location for SLC22A3 Gene

Start:
160,348,268 bp from pter
End:
160,452,581 bp from pter
Size:
104,314 bases
Orientation:
Plus strand

Genomic View for SLC22A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A3 Gene

Regulatory Elements for SLC22A3 Gene

Proteins for SLC22A3 Gene

  • Protein details for SLC22A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75751-S22A3_HUMAN
    Recommended name:
    Solute carrier family 22 member 3
    Protein Accession:
    O75751
    Secondary Accessions:
    • Q5SYN6
    • Q9UP02

    Protein attributes for SLC22A3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A3 Gene

Proteomics data for SLC22A3 Gene at MOPED

Post-translational modifications for SLC22A3 Gene

  • Glycosylation at Asn72, Asn99, Asn119, and Asn322

Other Protein References for SLC22A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A3 Gene

Domains for SLC22A3 Gene

Gene Families for SLC22A3 Gene

Protein Domains for SLC22A3 Gene

Graphical View of Domain Structure for InterPro Entry

O75751

UniProtKB/Swiss-Prot:

S22A3_HUMAN
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.:
    • O75751
genes like me logo Genes that share domains with SLC22A3: view

Function for SLC22A3 Gene

Molecular function for SLC22A3 Gene

GENATLAS Biochemistry: solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2
UniProtKB/Swiss-Prot Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Ontology (GO) - Molecular Function for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005329 dopamine transmembrane transporter activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0015075 ion transmembrane transporter activity --
GO:0015101 organic cation transmembrane transporter activity IDA 10966924
GO:0015651 quaternary ammonium group transmembrane transporter activity IDA 10966924
genes like me logo Genes that share ontologies with SLC22A3: view
genes like me logo Genes that share phenotypes with SLC22A3: view

Animal Models for SLC22A3 Gene

MGI Knock Outs for SLC22A3:

miRNA for SLC22A3 Gene

miRTarBase miRNAs that target SLC22A3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC22A3 Gene

Localization for SLC22A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A3 Gene COMPARTMENTS Subcellular localization image for SLC22A3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9933568
GO:0016020 membrane TAS 9933568
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC22A3: view

Pathways for SLC22A3 Gene

genes like me logo Genes that share pathways with SLC22A3: view

Gene Ontology (GO) - Biological Process for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006855 drug transmembrane transport TAS --
GO:0015695 organic cation transport IDA 10966924
GO:0015697 quaternary ammonium group transport IDA 10966924
GO:0015844 monoamine transport --
GO:0015872 dopamine transport IEA --
genes like me logo Genes that share ontologies with SLC22A3: view

Compounds for SLC22A3 Gene

(28) Drugbank Compounds for SLC22A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adefovir Dipivoxil
  • Adefovir
142340-99-6 transporter substrate
Agmatine
306-60-5 transporter substrate
Amphetamine
  • (+/-)-Benzedrine
300-62-9 transporter inhibitor
Choline
  • Bilineurine
62-49-7 transporter inhibitor
Cimetidine
51481-61-9 transporter substrate inhibitor

(28) Novoseek inferred chemical compound relationships for SLC22A3 Gene

Compound -log(P) Hits PubMed IDs
sarcnu 92.4 13
moxa 89.2 3
1 methyl 4 phenylpyridinium 85.7 13
tetraethylammonium 71.7 1
agmatine 71.4 5
genes like me logo Genes that share compounds with SLC22A3: view

Transcripts for SLC22A3 Gene

Unigene Clusters for SLC22A3 Gene

Solute carrier family 22 (extraneuronal monoamine transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for SLC22A3 Gene

GeneLoc Exon Structure for
SLC22A3
ECgene alternative splicing isoforms for
SLC22A3

Expression for SLC22A3 Gene

mRNA expression in normal human tissues for SLC22A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A3 Gene

This gene is overexpressed in Artery - Aorta (6.5), Muscle - Skeletal (6.0), Nerve - Tibial (4.9), and Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC22A3 Gene

SOURCE GeneReport for Unigene cluster for SLC22A3 Gene Hs.567337

mRNA Expression by UniProt/SwissProt for SLC22A3 Gene

O75751-S22A3_HUMAN
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.
genes like me logo Genes that share expressions with SLC22A3: view

Orthologs for SLC22A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A3 35
  • 99.52 (n)
  • 99.64 (a)
SLC22A3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A3 35
  • 89.49 (n)
  • 93.87 (a)
SLC22A3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A3 35
  • 89.27 (n)
  • 92.36 (a)
SLC22A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a3 35
  • 85 (n)
  • 87.3 (a)
Slc22a3 16
Slc22a3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a3 35
  • 85.48 (n)
  • 87.11 (a)
chicken
(Gallus gallus)
Aves SLC22A3 35
  • 72.47 (n)
  • 75 (a)
SLC22A3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A3 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SLC22A3 36
  • 44 (a)
OneToOne
zgc:175176 35
  • 54.41 (n)
  • 47.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4630 36
  • 29 (a)
ManyToMany
CG7442 36
  • 27 (a)
ManyToMany
CG7458 36
  • 27 (a)
ManyToMany
CG3790 37
  • 29 (a)
CG17751 37
  • 27 (a)
CG8654 37
  • 38 (a)
CG16727 37
  • 24 (a)
CG5592 37
  • 27 (a)
CG7458 37
  • 28 (a)
CG13610 37
  • 30 (a)
CG7084 37
  • 24 (a)
CG14857 37
  • 25 (a)
CG6126 37
  • 29 (a)
CG17752 37
  • 26 (a)
CG9317 37
  • 30 (a)
CG7442 37
  • 28 (a)
CG6231 37
  • 26 (a)
Orct 37
  • 31 (a)
CG6600 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea F52F12.1a 37
  • 29 (a)
K05F1.6 37
  • 27 (a)
oct-1 37
  • 29 (a)
Y82E9BR.16 37
  • 26 (a)
ZK455.8a 37
  • 26 (a)
B0252.3 37
  • 27 (a)
ZK455.8b 37
  • 26 (a)
Species with no ortholog for SLC22A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A3 Gene

ENSEMBL:
Gene Tree for SLC22A3 (if available)
TreeFam:
Gene Tree for SLC22A3 (if available)

Paralogs for SLC22A3 Gene

Selected SIMAP similar genes for SLC22A3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC22A3 Gene

genes like me logo Genes that share paralogs with SLC22A3: view

Variants for SLC22A3 Gene

Sequence variations from dbSNP and Humsavar for SLC22A3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs316235 -- 160,402,074(+) agcca(A/G)ctaaa intron-variant
rs316236 -- 160,402,600(+) aagtt(C/T)taatg intron-variant
rs316237 -- 160,402,658(+) aacat(A/G)tatta intron-variant
rs316238 -- 160,402,863(+) aaaac(A/G)ctcaa intron-variant
rs316239 -- 160,404,635(+) gccaa(C/T)gcagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A3 Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
nsv886810 CNV Gain 21882294
essv6642 CNV CNV 17122850
essv24539 CNV CNV 17122850

Relevant External Links for SLC22A3 Gene

HapMap Linkage Disequilibrium report
SLC22A3
Human Gene Mutation Database (HGMD)
SLC22A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A3 Gene

Disorders for SLC22A3 Gene

(2) Novoseek inferred disease relationships for SLC22A3 Gene

Disease -log(P) Hits PubMed IDs
glioma 44.2 8
tumors 0 4

Relevant External Links for SLC22A3

Genetic Association Database (GAD)
SLC22A3
Human Genome Epidemiology (HuGE) Navigator
SLC22A3
genes like me logo Genes that share disorders with SLC22A3: view

No data available for UniProtKB/Swiss-Prot for SLC22A3 Gene

Publications for SLC22A3 Gene

  1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PMID: 10966924) Wu X. … Ganapathy V. (Am. J. Physiol. 2000) 3 4 23 25
  2. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PMID: 19591196) Nies A.T. … Schaeffeler E. (Hepatology 2009) 3 23 48
  3. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PMID: 17010131) Aoyama N. … Ozaki N. (Alcohol. Clin. Exp. Res. 2006) 3 23 48
  4. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PMID: 9933568) Verhaagh S. … Zwart R. (Genomics 1999) 2 3 4
  5. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. (PMID: 10196521) Gruendemann D. … Schoemig E. (Nat. Neurosci. 1998) 3 4 25

Products for SLC22A3 Gene

Sources for SLC22A3 Gene

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