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Aliases for SLC20A1 Gene

Aliases for SLC20A1 Gene

  • Solute Carrier Family 20 Member 1 2 3 4 5
  • Gibbon Ape Leukemia Virus Receptor 1 2 3 4
  • Solute Carrier Family 20 (Phosphate Transporter), Member 1 2 3
  • Leukemia Virus Receptor 1 Homolog 3 4
  • Glvr-1 3 4
  • Pit-1 3 4
  • GLVR1 3 4
  • PIT1 3 4
  • Sodium-Dependent Phosphate Transporter 1 3
  • Phosphate Transporter 1 4

External Ids for SLC20A1 Gene

Previous HGNC Symbols for SLC20A1 Gene

  • GLVR1

Previous GeneCards Identifiers for SLC20A1 Gene

  • GC02P110609
  • GC02P111324
  • GC02P113310
  • GC02P113498
  • GC02P113119
  • GC02P113403
  • GC02P105859
  • GC02P112653
  • GC02P112661
  • GC02P112668
  • GC02P112716
  • GC02P112866
  • GC02P112917

Summaries for SLC20A1 Gene

Entrez Gene Summary for SLC20A1 Gene

  • The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

GeneCards Summary for SLC20A1 Gene

SLC20A1 (Solute Carrier Family 20 Member 1) is a Protein Coding gene. Diseases associated with SLC20A1 include Leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. GO annotations related to this gene include signal transducer activity and sodium:phosphate symporter activity. An important paralog of this gene is SLC20A2.

UniProtKB/Swiss-Prot for SLC20A1 Gene

  • Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).

Gene Wiki entry for SLC20A1 Gene

Additional gene information for SLC20A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC20A1 Gene

Genomics for SLC20A1 Gene

Regulatory Elements for SLC20A1 Gene

Enhancers for SLC20A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H112690 2 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +46.4 46371 3 HDGF FOXA2 MLX ARID4B FEZF1 ZNF766 ZNF143 FOS SP3 NFYC IL1RN FLJ42351 IL36B SLC20A1 IL1B ENSG00000243389 CHCHD5 ENSG00000207383 IL36G IL1A
GH02H112705 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +61.7 61721 4 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 IL1B ENSG00000243389 IL1RN FLJ42351 SLC20A1 IL36B ENSG00000207383 CHCHD5 CDK8P2 IL36G
GH02H112682 1.5 Ensembl ENCODE dbSUPER 12.8 +38.2 38173 3 ATF1 ARNT TCF12 ZNF121 ZNF766 GATA2 ELK1 ATF7 NCOA1 ZNF592 FLJ42351 NT5DC4 SLC20A1 ENSG00000243389 CHCHD5 ENSG00000207383 IL37 RGPD8 LOC102724955
GH02H112699 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +54.8 54755 2 PKNOX1 MAX BMI1 CEBPG RELA ATF7 NFE2 RUNX3 IKZF2 SMARCE1 IL1RN NT5DC4 FLJ42351 SLC20A1 IL36B ENSG00000243389 CHCHD5 ENSG00000207383 IL1B IL1A
GH02H112802 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +158.8 158758 3 PKNOX1 FOXA2 ATF1 ARID4B TCF12 FOS ATF7 RUNX3 MXD4 JUNB IL1B CKAP2L IL37 SLC20A1 FLJ42351 IL1A IL36G IL1RN GC02M112788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC20A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC20A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121958 243 2201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 PAF1

Genomic Location for SLC20A1 Gene

Chromosome:
2
Start:
112,645,857 bp from pter
End:
112,663,827 bp from pter
Size:
17,971 bases
Orientation:
Plus strand

Genomic View for SLC20A1 Gene

Genes around SLC20A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC20A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC20A1 Gene

Proteins for SLC20A1 Gene

  • Protein details for SLC20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM9-S20A1_HUMAN
    Recommended name:
    Sodium-dependent phosphate transporter 1
    Protein Accession:
    Q8WUM9
    Secondary Accessions:
    • Q08344
    • Q6DHX8
    • Q9UQ82

    Protein attributes for SLC20A1 Gene

    Size:
    679 amino acids
    Molecular mass:
    73700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC20A1 Gene

Post-translational modifications for SLC20A1 Gene

  • Ubiquitination at Lys389 and isoforms=394
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC20A1 Gene

Domains & Families for SLC20A1 Gene

Gene Families for SLC20A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC20A1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WUM9

UniProtKB/Swiss-Prot:

S20A1_HUMAN :
  • Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
  • Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
Domain:
  • Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
Family:
  • Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
genes like me logo Genes that share domains with SLC20A1: view

Function for SLC20A1 Gene

Molecular function for SLC20A1 Gene

GENATLAS Biochemistry:
solute carrier family 20,member 1 (phosphate transport),putatively involved in the regulation of Pi handling in bone forming cells
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=24.1 uM for phosphate {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate) {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Note=With an increase in pH, a decrease in phosphate uptake is observed.; pH dependence: Optimum pH is 6.5 and 7.5. {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748};
UniProtKB/Swiss-Prot Function:
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
UniProtKB/Swiss-Prot Induction:
By phosphate deprivation as well as by IL8/interleukin-8 in hypertrophic chondrocytes.

Phenotypes From GWAS Catalog for SLC20A1 Gene

Gene Ontology (GO) - Molecular Function for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0004872 receptor activity TAS 8041748
GO:0005315 inorganic phosphate transmembrane transporter activity IBA,IEA --
GO:0005316 high-affinity inorganic phosphate:sodium symporter activity IEA --
GO:0005436 sodium:phosphate symporter activity TAS 8041748
genes like me logo Genes that share ontologies with SLC20A1: view
genes like me logo Genes that share phenotypes with SLC20A1: view

Animal Models for SLC20A1 Gene

MGI Knock Outs for SLC20A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC20A1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC20A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC20A1 Gene

Localization for SLC20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC20A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC20A1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8041748
GO:0016020 membrane IEA,TAS 8041748
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC20A1: view

Pathways & Interactions for SLC20A1 Gene

genes like me logo Genes that share pathways with SLC20A1: view

Interacting Proteins for SLC20A1 Gene

Gene Ontology (GO) - Biological Process for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8041748
GO:0006810 transport TAS 8041748
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006817 phosphate ion transport IEA --
genes like me logo Genes that share ontologies with SLC20A1: view

No data available for SIGNOR curated interactions for SLC20A1 Gene

Drugs & Compounds for SLC20A1 Gene

(5) Drugs for SLC20A1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Phosphate Approved Pharma Transporter, substrate 0
Sodium phosphate Approved Pharma Transporter, substrate 0

(2) Additional Compounds for SLC20A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC20A1: view

Transcripts for SLC20A1 Gene

Unigene Clusters for SLC20A1 Gene

Solute carrier family 20 (phosphate transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC20A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - - - - - -
SP9:
SP10:

Relevant External Links for SLC20A1 Gene

GeneLoc Exon Structure for
SLC20A1
ECgene alternative splicing isoforms for
SLC20A1

Expression for SLC20A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC20A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC20A1 Gene

This gene is overexpressed in Breast (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC20A1 Gene



Protein tissue co-expression partners for SLC20A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC20A1 Gene:

SLC20A1

SOURCE GeneReport for Unigene cluster for SLC20A1 Gene:

Hs.187946

mRNA Expression by UniProt/SwissProt for SLC20A1 Gene:

Q8WUM9-S20A1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SLC20A1 Gene

  • Kidney(4.4)
  • Skin(4.1)
  • Eye(4)
  • Liver(3.3)
  • Nervous system(3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with SLC20A1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC20A1 Gene

Orthologs for SLC20A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC20A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC20A1 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia SLC20A1 33 34
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia SLC20A1 33 34
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Slc20a1 33 16 34
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Slc20a1 33
  • 89.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC20A1 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC20A1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC20A1 33 34
  • 75.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc20a1 33
  • 74.11 (n)
Str.10938 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68496 33
zebrafish
(Danio rerio)
Actinopterygii slc20a1b 33 34
  • 66.93 (n)
slc20a1a 34
  • 64 (a)
OneToMany
wufa05g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5974 33
fruit fly
(Drosophila melanogaster)
Insecta CG7628 35
  • 53 (a)
CG42575 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C48A7.2 35 33
  • 53.57 (n)
pitr-3 34
  • 44 (a)
ManyToMany
F09G2.3 35
  • 43 (a)
B0222.3 35
  • 42 (a)
pitr-2 34
  • 42 (a)
ManyToMany
pitr-5 34
  • 41 (a)
ManyToMany
B0222.2 35
  • 40 (a)
pitr-1 34
  • 40 (a)
ManyToMany
W05H5.3 35
  • 37 (a)
pitr-6 34
  • 34 (a)
ManyToMany
pitr-4 34
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO89 34
  • 29 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.4001 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
ManyToMany
CSA.3671 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2670 33
Species where no ortholog for SLC20A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SLC20A1 Gene

ENSEMBL:
Gene Tree for SLC20A1 (if available)
TreeFam:
Gene Tree for SLC20A1 (if available)

Paralogs for SLC20A1 Gene

Paralogs for SLC20A1 Gene

(1) SIMAP similar genes for SLC20A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC20A1: view

Variants for SLC20A1 Gene

Sequence variations from dbSNP and Humsavar for SLC20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000154671 -- 112,652,083(+) TGTCA(G/T)TTCTA intron-variant
rs1000218492 -- 112,652,430(+) TGTGG(A/G)TATTG intron-variant
rs1000231411 -- 112,646,556(+) CCTCC(C/T)CCGCA intron-variant, upstream-variant-2KB
rs1000265554 -- 112,646,489(+) CGGGC(G/T)CGTGG intron-variant, upstream-variant-2KB
rs1000267899 -- 112,664,060(+) ACTTT(C/T)ATGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC20A1 Gene

Variant ID Type Subtype PubMed ID
nsv458997 CNV gain 19166990
nsv470480 CNV gain 18288195
nsv582708 CNV gain 21841781

Variation tolerance for SLC20A1 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC20A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC20A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC20A1 Gene

Disorders for SLC20A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC20A1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
leukemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC20A1

Genetic Association Database (GAD)
SLC20A1
Human Genome Epidemiology (HuGE) Navigator
SLC20A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC20A1
genes like me logo Genes that share disorders with SLC20A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC20A1 Gene

Publications for SLC20A1 Gene

  1. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. (PMID: 15641067) Cecil DL … Liu-Bryan R (Arthritis and rheumatism 2005) 3 4 22 60
  2. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. (PMID: 8041748) Kavanaugh MP … Miller AD (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 60
  3. GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. (PMID: 1531369) Johann SV … O'Hara B (Journal of virology 1992) 3 4 22 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Clinical outcome and mechanism of soft tissue calcification in Werner syndrome. (PMID: 18729813) Honjo S … Saito Y (Rejuvenation research 2008) 3 22 60

Products for SLC20A1 Gene

Sources for SLC20A1 Gene

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