Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC20A1 Gene

Aliases for SLC20A1 Gene

  • Solute Carrier Family 20 Member 1 2 3 4
  • Solute Carrier Family 20 (Phosphate Transporter), Member 1 2 3 5
  • Gibbon Ape Leukemia Virus Receptor 1 2 3 4
  • Leukemia Virus Receptor 1 Homolog 3 4
  • Glvr-1 3 4
  • Pit-1 3 4
  • GLVR1 3 4
  • PIT1 3 4
  • Phosphate Transporter 1 4

External Ids for SLC20A1 Gene

Previous HGNC Symbols for SLC20A1 Gene

  • GLVR1

Previous GeneCards Identifiers for SLC20A1 Gene

  • GC02P110609
  • GC02P111324
  • GC02P113310
  • GC02P113498
  • GC02P113119
  • GC02P113403
  • GC02P105859
  • GC02P112653
  • GC02P112661

Summaries for SLC20A1 Gene

Entrez Gene Summary for SLC20A1 Gene

  • The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

GeneCards Summary for SLC20A1 Gene

SLC20A1 (Solute Carrier Family 20 Member 1) is a Protein Coding gene. Diseases associated with SLC20A1 include Leukemia and Isolated Growth Hormone Deficiency. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include signal transducer activity and sodium:phosphate symporter activity. An important paralog of this gene is SLC20A2.

UniProtKB/Swiss-Prot for SLC20A1 Gene

  • Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).

Gene Wiki entry for SLC20A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC20A1 Gene

Genomics for SLC20A1 Gene

Regulatory Elements for SLC20A1 Gene

Enhancers for SLC20A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC20A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC20A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC20A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC20A1 Gene

Chromosome:
2
Start:
112,645,857 bp from pter
End:
112,663,827 bp from pter
Size:
17,971 bases
Orientation:
Plus strand

Genomic View for SLC20A1 Gene

Genes around SLC20A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC20A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC20A1 Gene

Proteins for SLC20A1 Gene

  • Protein details for SLC20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM9-S20A1_HUMAN
    Recommended name:
    Sodium-dependent phosphate transporter 1
    Protein Accession:
    Q8WUM9
    Secondary Accessions:
    • Q08344
    • Q6DHX8
    • Q9UQ82

    Protein attributes for SLC20A1 Gene

    Size:
    679 amino acids
    Molecular mass:
    73700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC20A1 Gene

Proteomics data for SLC20A1 Gene at MOPED

Post-translational modifications for SLC20A1 Gene

  • Ubiquitination at Lys 389 and Lys 394
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC20A1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC20A1 (SLC20A1)

No data available for DME Specific Peptides for SLC20A1 Gene

Domains & Families for SLC20A1 Gene

Gene Families for SLC20A1 Gene

Protein Domains for SLC20A1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WUM9

UniProtKB/Swiss-Prot:

S20A1_HUMAN :
  • Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
  • Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
Domain:
  • Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
Family:
  • Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
genes like me logo Genes that share domains with SLC20A1: view

Function for SLC20A1 Gene

Molecular function for SLC20A1 Gene

GENATLAS Biochemistry:
solute carrier family 20,member 1 (phosphate transport),putatively involved in the regulation of Pi handling in bone forming cells
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=24.1 uM for phosphate {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate) {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Note=With an increase in pH, a decrease in phosphate uptake is observed.; pH dependence: Optimum pH is 6.5 and 7.5. {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748};
UniProtKB/Swiss-Prot Function:
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
UniProtKB/Swiss-Prot Induction:
By phosphate deprivation as well as by IL8/interleukin-8 in hypertrophic chondrocytes.

Gene Ontology (GO) - Molecular Function for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8041748
GO:0005315 inorganic phosphate transmembrane transporter activity IEA,IBA --
GO:0015321 sodium-dependent phosphate transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC20A1: view
genes like me logo Genes that share phenotypes with SLC20A1: view

Animal Models for SLC20A1 Gene

MGI Knock Outs for SLC20A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC20A1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC20A1 Gene

Localization for SLC20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC20A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC20A1 Gene COMPARTMENTS Subcellular localization image for SLC20A1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 8041748
genes like me logo Genes that share ontologies with SLC20A1: view

Pathways & Interactions for SLC20A1 Gene

genes like me logo Genes that share pathways with SLC20A1: view

Gene Ontology (GO) - Biological Process for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8041748
GO:0006817 phosphate ion transport IEA --
GO:0007165 signal transduction IMP 12761501
GO:0035435 phosphate ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC20A1: view

No data available for SIGNOR curated interactions for SLC20A1 Gene

Drugs & Compounds for SLC20A1 Gene

(3) Drugs for SLC20A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SLC20A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC20A1: view

Transcripts for SLC20A1 Gene

Unigene Clusters for SLC20A1 Gene

Solute carrier family 20 (phosphate transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - - - - - -
SP9:
SP10:

Relevant External Links for SLC20A1 Gene

GeneLoc Exon Structure for
SLC20A1
ECgene alternative splicing isoforms for
SLC20A1

Expression for SLC20A1 Gene

mRNA expression in normal human tissues for SLC20A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC20A1 Gene

This gene is overexpressed in Breast (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC20A1 Gene



SOURCE GeneReport for Unigene cluster for SLC20A1 Gene Hs.187946

mRNA Expression by UniProt/SwissProt for SLC20A1 Gene

Q8WUM9-S20A1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SLC20A1: view

Protein tissue co-expression partners for SLC20A1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SLC20A1 Gene

Orthologs for SLC20A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC20A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC20A1 35
  • 90.05 (n)
  • 95.57 (a)
SLC20A1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC20A1 35
  • 92.77 (n)
  • 96.02 (a)
SLC20A1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc20a1 35
  • 89.63 (n)
  • 92.87 (a)
Slc20a1 16
Slc20a1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC20A1 35
  • 99.61 (n)
  • 99.41 (a)
SLC20A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc20a1 35
  • 89.48 (n)
  • 92.87 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC20A1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC20A1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC20A1 35
  • 75.08 (n)
  • 85.64 (a)
SLC20A1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc20a1 35
  • 74.11 (n)
  • 80.74 (a)
Str.10938 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68496 35
zebrafish
(Danio rerio)
Actinopterygii slc20a1b 35
  • 66.93 (n)
  • 73.25 (a)
wufa05g12 35
slc20a1a 36
  • 64 (a)
OneToMany
slc20a1b 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5974 35
fruit fly
(Drosophila melanogaster)
Insecta CG7628 37
  • 53 (a)
CG42575 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0222.2 37
  • 40 (a)
B0222.3 37
  • 42 (a)
C48A7.2 37
  • 57 (a)
F09G2.3 37
  • 43 (a)
W05H5.3 37
  • 37 (a)
C48A7.2 35
  • 53.57 (n)
  • 49.21 (a)
pitr-1 36
  • 40 (a)
ManyToMany
pitr-2 36
  • 42 (a)
ManyToMany
pitr-3 36
  • 44 (a)
ManyToMany
pitr-4 36
  • 30 (a)
ManyToMany
pitr-5 36
  • 41 (a)
ManyToMany
pitr-6 36
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO89 36
  • 29 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.4001 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2670 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
CSA.3671 36
  • 43 (a)
ManyToMany
Species with no ortholog for SLC20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SLC20A1 Gene

ENSEMBL:
Gene Tree for SLC20A1 (if available)
TreeFam:
Gene Tree for SLC20A1 (if available)

Paralogs for SLC20A1 Gene

Paralogs for SLC20A1 Gene

(1) SIMAP similar genes for SLC20A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC20A1 Gene

genes like me logo Genes that share paralogs with SLC20A1: view

Variants for SLC20A1 Gene

Sequence variations from dbSNP and Humsavar for SLC20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs885346 -- 112,657,973(-) TTCAA(A/C)TTGCT intron-variant
rs885347 -- 112,657,779(-) ATGTG(C/T)GTTTG intron-variant
rs1053652 -- 112,652,260(+) GGTTG(C/G)CGTAC intron-variant
rs5833453 -- 112,656,748(+) CAGTT(-/A)ACGAT intron-variant
rs5833454 -- 112,660,699(+) TGTCA(-/G/GT)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC20A1 Gene

Variant ID Type Subtype PubMed ID
nsv458997 CNV Gain 19166990
nsv470480 CNV Gain 18288195

Variation tolerance for SLC20A1 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC20A1 Gene

Disorders for SLC20A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC20A1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
leukemia
isolated growth hormone deficiency
  • dwarfism, growth hormone deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC20A1

Genetic Association Database (GAD)
SLC20A1
Human Genome Epidemiology (HuGE) Navigator
SLC20A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC20A1
genes like me logo Genes that share disorders with SLC20A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC20A1 Gene

Publications for SLC20A1 Gene

  1. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. (PMID: 8041748) Kavanaugh M.P. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 67
  2. Clinical outcome and mechanism of soft tissue calcification in Werner syndrome. (PMID: 18729813) Honjo S. … Saito Y. (Rejuvenation Res 2008) 3 23
  3. Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. (PMID: 16790504) Boettger P. … Pedersen L. (Am. J. Physiol. 2006) 2 3
  4. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. (PMID: 16527991) Li X. … Giachelli C.M. (Circ. Res. 2006) 3 23
  5. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. (PMID: 15641067) Cecil D.L. … Liu-Bryan R. (Arthritis Rheum. 2005) 3 23

Products for SLC20A1 Gene

Sources for SLC20A1 Gene

Content