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Aliases for SLC19A1 Gene

Aliases for SLC19A1 Gene

  • Solute Carrier Family 19 (Folate Transporter), Member 1 2 3
  • FOLT 3 4 6
  • Solute Carrier Family 19 Member 1 3 4
  • Reduced Folate Carrier Protein 3 4
  • Placental Folate Transporter 3 4
  • Intestinal Folate Carrier 1 3 4
  • IFC-1 3 4
  • RFC1 3 4
  • RFC 3 4
  • Folate Transporter 1 3
  • FLOT1 4
  • CHMD 3
  • IFC1 3
  • REFC 3

External Ids for SLC19A1 Gene

Summaries for SLC19A1 Gene

Entrez Gene Summary for SLC19A1 Gene

  • The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for SLC19A1 Gene

SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include methotrexate dose selection and choriocarcinoma. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include folic acid binding and reduced folate carrier activity. An important paralog of this gene is SLC19A2.

UniProtKB/Swiss-Prot for SLC19A1 Gene

  • Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump

Gene Wiki entry for SLC19A1 Gene

PharmGKB "VIP" Summary for SLC19A1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for SLC19A1 Gene

Genomics for SLC19A1 Gene

Genomic Location for SLC19A1 Gene

Start:
45,493,572 bp from pter
End:
45,544,411 bp from pter
Size:
50,840 bases
Orientation:
Minus strand

Genomic View for SLC19A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC19A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC19A1 Gene

Regulatory Elements for SLC19A1 Gene

Proteins for SLC19A1 Gene

  • Protein details for SLC19A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41440-S19A1_HUMAN
    Recommended name:
    Folate transporter 1
    Protein Accession:
    P41440
    Secondary Accessions:
    • B2R7U8
    • B7Z8C3
    • E9PFY4
    • O00553
    • O60227
    • Q13026
    • Q9BTX8

    Protein attributes for SLC19A1 Gene

    Size:
    591 amino acids
    Molecular mass:
    64868 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC19A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC19A1 Gene

Proteomics data for SLC19A1 Gene at MOPED

Post-translational modifications for SLC19A1 Gene

No data available for DME Specific Peptides for SLC19A1 Gene

Domains for SLC19A1 Gene

Gene Families for SLC19A1 Gene

Protein Domains for SLC19A1 Gene

UniProtKB/Swiss-Prot:

S19A1_HUMAN
Family:
  • Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.:
    • P41440
genes like me logo Genes that share domains with SLC19A1: view

Function for SLC19A1 Gene

Molecular function for SLC19A1 Gene

GENATLAS Biochemistry: solute carrier family 19,member A1,folate transporter,expressed in placenta,testis,with two alternative non coding exons
UniProtKB/Swiss-Prot Function: Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump

Gene Ontology (GO) - Molecular Function for SLC19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
GO:0008517 folic acid transporter activity IEA --
GO:0015350 methotrexate transporter activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with SLC19A1: view
genes like me logo Genes that share phenotypes with SLC19A1: view

Animal Models for SLC19A1 Gene

MGI Knock Outs for SLC19A1:

miRNA for SLC19A1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC19A1 Gene

Localization for SLC19A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC19A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC19A1 Gene COMPARTMENTS Subcellular localization image for SLC19A1 gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 8276792
genes like me logo Genes that share ontologies with SLC19A1: view

Pathways for SLC19A1 Gene

SuperPathways for SLC19A1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Telomere C-strand (Lagging Strand) Synthesis
3 DNA Repair
4 CDK-mediated phosphorylation and removal of Cdc6
.78
5 Global Genomic NER (GG-NER)
genes like me logo Genes that share pathways with SLC19A1: view

Pathways by source for SLC19A1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SLC19A1 Gene
1 Cell Signaling Technology pathway for SLC19A1 Gene

Interacting Proteins for SLC19A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308895%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000308895 for SLC19A1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for SLC19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006810 transport --
GO:0008152 metabolic process --
GO:0015884 folic acid transport IEA --
genes like me logo Genes that share ontologies with SLC19A1: view

Compounds for SLC19A1 Gene

(1) HMDB Compounds for SLC19A1 Gene

Compound Synonyms Cas Number PubMed IDs
Folic acid
  • Acifolic
59-30-3

(2) IUPHAR Ligand for SLC19A1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]folic acid None None
[3H]methotrexate None None

(51) Novoseek inferred chemical compound relationships for SLC19A1 Gene

Compound -log(P) Hits PubMed IDs
folate 94.9 278
pt523 93.5 20
zd9331 92.6 12
tomudex 92.5 15
1843u89 89.5 4

(8) PharmGKB related drug/compound annotations for SLC19A1 Gene

genes like me logo Genes that share compounds with SLC19A1: view

Transcripts for SLC19A1 Gene

Unigene Clusters for SLC19A1 Gene

Solute carrier family 19 (folate transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC19A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7:
SP8: - - - -
SP9:

Relevant External Links for SLC19A1 Gene

GeneLoc Exon Structure for
SLC19A1
ECgene alternative splicing isoforms for
SLC19A1

Expression for SLC19A1 Gene

mRNA expression in normal human tissues for SLC19A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC19A1 Gene

This gene is overexpressed in Whole Blood (13.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC19A1 Gene

SOURCE GeneReport for Unigene cluster for SLC19A1 Gene Hs.84190

mRNA Expression by UniProt/SwissProt for SLC19A1 Gene

P41440-S19A1_HUMAN
Tissue specificity: Placenta, liver, and to a much smaller extent, in lung
genes like me logo Genes that share expressions with SLC19A1: view

Orthologs for SLC19A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC19A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC19A1 36
  • 99.15 (n)
  • 99.15 (a)
SLC19A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC19A1 36
  • 79.38 (n)
  • 73.49 (a)
SLC19A1 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC19A1 36
  • 82.4 (n)
  • 76.28 (a)
SLC19A1 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc19a1 36
  • 73.87 (n)
  • 68.69 (a)
Slc19a1 16
Slc19a1 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC19A1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC19A1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc19a1 36
  • 73.89 (n)
  • 67.2 (a)
chicken
(Gallus gallus)
Aves SLC19A1 36
  • 71.76 (n)
  • 64.95 (a)
SLC19A1 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC19A1 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc19a1 36
  • 60.66 (n)
  • 62.64 (a)
zebrafish
(Danio rerio)
Actinopterygii im:7144090 36
  • 61.06 (n)
  • 61.36 (a)
SLC19A1 37
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14694 37
  • 29 (a)
ManyToMany
CG17036 37
  • 31 (a)
ManyToMany
CG6574 37
  • 33 (a)
ManyToMany
CG6574 38
  • 34 (a)
CG14694 38
  • 30 (a)
CG17036 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea folt-1 37
  • 30 (a)
ManyToMany
folt-2 37
  • 30 (a)
ManyToMany
folt-3 37
  • 31 (a)
ManyToMany
C50E3.11 38
  • 28 (a)
C06H2.4 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for SLC19A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC19A1 Gene

ENSEMBL:
Gene Tree for SLC19A1 (if available)
TreeFam:
Gene Tree for SLC19A1 (if available)

Paralogs for SLC19A1 Gene

Paralogs for SLC19A1 Gene

Selected SIMAP similar genes for SLC19A1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SLC19A1: view

Variants for SLC19A1 Gene

Sequence variations from dbSNP and Humsavar for SLC19A1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs12659 -- 45,531,642(-) AATCC(C/T)GGCCC synonymous-codon, reference
rs762782 -- 45,541,205(-) TTTGG(A/T)GGATT intron-variant
rs914231 -- 45,532,180(+) CCAGG(C/T)GTTAG intron-variant
rs914232 -- 45,532,836(+) AAGCT(C/T)CTTCC intron-variant
rs965933 -- 45,527,173(+) AGAGC(A/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC19A1 Gene

Variant ID Type Subtype PubMed ID
dgv4785n71 CNV Loss 21882294
nsv914027 CNV Loss 21882294
dgv4791n71 CNV Loss 21882294
dgv4793n71 CNV Loss 21882294
nsv516407 CNV Loss 19592680
nsv914048 CNV Loss 21882294
nsv834111 CNV Loss 17160897
dgv4795n71 CNV Loss 21882294
dgv4797n71 CNV Loss 21882294
dgv4798n71 CNV Loss 21882294
nsv914060 CNV Loss 21882294
nsv914061 CNV Gain 21882294
dgv4799n71 CNV Loss 21882294
dgv4800n71 CNV Loss 21882294
nsv914066 CNV Gain 21882294
nsv459308 CNV Loss 19166990
dgv4801n71 CNV Loss 21882294
nsv834112 CNV Gain 17160897
nsv914071 CNV Loss 21882294
dgv4802n71 CNV Loss 21882294
dgv4803n71 CNV Loss 21882294
esv2723788 CNV Deletion 23290073
nsv914076 CNV Loss 21882294
esv2723789 CNV Deletion 23290073
esv2723790 CNV Deletion 23290073
esv2723791 CNV Deletion 23290073
nsv187444 CNV Loss 16902084
esv2723792 CNV Deletion 23290073
esv2723793 CNV Deletion 23290073
esv1055733 CNV Insertion 17803354
nsv3542 CNV Insertion 18451855

Relevant External Links for SLC19A1 Gene

HapMap Linkage Disequilibrium report
SLC19A1
Human Gene Mutation Database (HGMD)
SLC19A1

Disorders for SLC19A1 Gene

(1) University of Copenhagen DISEASES for SLC19A1 Gene

(35) Novoseek inferred disease relationships for SLC19A1 Gene

Disease -log(P) Hits PubMed IDs
thiamine-responsive megaloblastic anemia syndrome 77.3 1
folate deficiency 75 7
neural tube defects 71.3 6
lymphoblastic leukemia acute childhood 67.6 8
leukemia l1210 58.3 6

Relevant External Links for SLC19A1

Genetic Association Database (GAD)
SLC19A1
Human Genome Epidemiology (HuGE) Navigator
SLC19A1
genes like me logo Genes that share disorders with SLC19A1: view

No data available for UniProtKB/Swiss-Prot for SLC19A1 Gene

Publications for SLC19A1 Gene

  1. Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. (PMID: 10347183) Ferguson P.L. … Flintoff W.F. (J. Biol. Chem. 1999) 3 4 23
  2. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. (PMID: 7615551) Wong S.C. … Matherly L.H. (J. Biol. Chem. 1995) 3 4 23
  3. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate- resistant human breast cancer cells. (PMID: 7641195) Moscow J.A. … Cowan K.H. (Cancer Res. 1995) 3 4 23
  4. Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. (PMID: 11857541) Shaw G.M. … Finnell R.H. (Am. J. Med. Genet. 2002) 3 23 49
  5. Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. (PMID: 12411325) LaverdiA"re C. … Krajinovic M. (Blood 2002) 3 23 49

Products for SLC19A1 Gene

Sources for SLC19A1 Gene

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