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Aliases for SLC34A1 Gene

Aliases for SLC34A1 Gene

  • Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 1 2 3
  • SLC17A2 3 4 6
  • NPT2 3 4 6
  • Solute Carrier Family 34 (Sodium Phosphate), Member 1 2 3
  • Na(+)-Dependent Phosphate Cotransporter 2A 3 4
  • Sodium-Phosphate Transport Protein 2A 3 4
  • Na+-Phosphate Cotransporter Type II 2 3
  • Sodium/Phosphate Cotransporter 2A 3 4
  • Solute Carrier Family 34 Member 1 3 4
  • Sodium/Phosphate Co-Transporter 2 3
  • Na(+)/Pi Cotransporter 2A 3 4
  • NaPi-2a 3 4
  • NPHLOP1 3 6
  • NAPI-3 3 4
  • FRTS2 3 6
  • Solute Carrier Family 17 (Sodium Phosphate), Member 2 3
  • Sodium-Dependent Phosphate Transport Protein 2A 3
  • Renal Sodium-Dependent Phosphate Transporter 3
  • Solute Carrier Family 17 (Sodium Phosphate) 2
  • Member 2 2
  • NPTIIa 3
  • SLC11 3

External Ids for SLC34A1 Gene

Previous HGNC Symbols for SLC34A1 Gene

  • NPT2
  • SLC17A2

Previous GeneCards Identifiers for SLC34A1 Gene

  • GC05P177184
  • GC05P177653
  • GC05P176747
  • GC05P176792
  • GC05P176744
  • GC05P176812
  • GC05P171732

Summaries for SLC34A1 Gene

Entrez Gene Summary for SLC34A1 Gene

  • This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for SLC34A1 Gene

SLC34A1 (Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 1) is a Protein Coding gene. Diseases associated with SLC34A1 include nephrolithiasis/osteoporosis, hypophosphatemic, 1 and fanconi renotubular syndrome 2. Among its related pathways are Osteoblast Signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and sodium-dependent phosphate transmembrane transporter activity. An important paralog of this gene is SLC34A2.

UniProtKB/Swiss-Prot for SLC34A1 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC34A1 Gene

Genomics for SLC34A1 Gene

Regulatory Elements for SLC34A1 Gene

Genomic Location for SLC34A1 Gene

177,379,235 bp from pter
177,398,848 bp from pter
19,614 bases
Plus strand

Genomic View for SLC34A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC34A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC34A1 Gene

Proteins for SLC34A1 Gene

  • Protein details for SLC34A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent phosphate transport protein 2A
    Protein Accession:
    Secondary Accessions:
    • B4DPE3

    Protein attributes for SLC34A1 Gene

    639 amino acids
    Molecular mass:
    68937 Da
    Quaternary structure:
    • Interacts via its C-terminal region with PDZK2 (By similarity). Interacts with SLC9A3R1.

    Alternative splice isoforms for SLC34A1 Gene


neXtProt entry for SLC34A1 Gene

Proteomics data for SLC34A1 Gene at MOPED

Post-translational modifications for SLC34A1 Gene

  • Glycosylation at Asn298, Asn323, and Asn330
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC34A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC34A1 Gene

Domains for SLC34A1 Gene

Gene Families for SLC34A1 Gene

Protein Domains for SLC34A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q06495
  • Belongs to the SLC34A transporter family.
genes like me logo Genes that share domains with SLC34A1: view

Function for SLC34A1 Gene

Molecular function for SLC34A1 Gene

GENATLAS Biochemistry: solute carrier family 34 (sodium/phosphate cotransport) member 1,expressed in kidney
UniProtKB/Swiss-Prot Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx

Gene Ontology (GO) - Molecular Function for SLC34A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17895247
GO:0015293 symporter activity IEA --
GO:0015321 sodium-dependent phosphate transmembrane transporter activity IDA 8327470
GO:0030165 PDZ domain binding IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with SLC34A1: view
genes like me logo Genes that share phenotypes with SLC34A1: view

Animal Models for SLC34A1 Gene

MGI Knock Outs for SLC34A1:

Animal Model Products

CRISPR Products

miRNA for SLC34A1 Gene

miRTarBase miRNAs that target SLC34A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC34A1 Gene

Localization for SLC34A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC34A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC34A1 Gene COMPARTMENTS Subcellular localization image for SLC34A1 gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for SLC34A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8327470
GO:0009986 cell surface IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC34A1: view

Pathways for SLC34A1 Gene

genes like me logo Genes that share pathways with SLC34A1: view

Gene Ontology (GO) - Biological Process for SLC34A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001822 kidney development IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006817 phosphate ion transport IDA 8327470
genes like me logo Genes that share ontologies with SLC34A1: view

Compounds for SLC34A1 Gene

(8) Novoseek inferred chemical compound relationships for SLC34A1 Gene

Compound -log(P) Hits PubMed IDs
foscarnet 78.5 5
calcitriol 62 2
1,25 dihydroxy vitamin d3 42.6 1
vitamin d 37.9 3
calcium 36.7 5
genes like me logo Genes that share compounds with SLC34A1: view

Transcripts for SLC34A1 Gene

Unigene Clusters for SLC34A1 Gene

Solute carrier family 34 (sodium phosphate), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC34A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC34A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC34A1 Gene

No ASD Table

Relevant External Links for SLC34A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC34A1 Gene

mRNA expression in normal human tissues for SLC34A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC34A1 Gene

This gene is overexpressed in Kidney - Cortex (51.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC34A1 Gene

SOURCE GeneReport for Unigene cluster for SLC34A1 Gene Hs.936

mRNA Expression by UniProt/SwissProt for SLC34A1 Gene

Tissue specificity: Kidney and lung
genes like me logo Genes that share expressions with SLC34A1: view

In Situ Assay Products

Orthologs for SLC34A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC34A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC34A1 35
  • 99.37 (n)
  • 99.22 (a)
SLC34A1 36
  • 96 (a)
(Bos Taurus)
Mammalia SLC34A1 35
  • 88.21 (n)
  • 89.51 (a)
SLC34A1 36
  • 89 (a)
(Canis familiaris)
Mammalia SLC34A1 35
  • 88.63 (n)
  • 91.39 (a)
SLC34A1 36
  • 91 (a)
(Mus musculus)
Mammalia Slc34a1 35
  • 86.24 (n)
  • 91.21 (a)
Slc34a1 16
Slc34a1 36
  • 91 (a)
(Monodelphis domestica)
Mammalia SLC34A1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SLC34A1 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Slc34a1 35
  • 86.92 (n)
  • 91.21 (a)
(Gallus gallus)
Aves SLC34A1 35
  • 77.08 (n)
  • 77.88 (a)
SLC34A1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SLC34A1 36
  • 64 (a)
(Danio rerio)
Actinopterygii slc34a1a 35
  • 71.99 (n)
  • 74.36 (a)
slc34a1a 36
  • 58 (a)
slc34a1b 36
  • 69 (a)
slc34a2b 35
(Caenorhabditis elegans)
Secernentea ZK563.2 35
  • 43.11 (n)
  • 34.17 (a)
ZK563.2 36
  • 30 (a)
ZK563.2 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
-- 36
  • 46 (a)
-- 36
  • 49 (a)
-- 36
  • 41 (a)
Species with no ortholog for SLC34A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC34A1 Gene

Gene Tree for SLC34A1 (if available)
Gene Tree for SLC34A1 (if available)

Paralogs for SLC34A1 Gene

Paralogs for SLC34A1 Gene

Selected SIMAP similar genes for SLC34A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC34A1: view

Variants for SLC34A1 Gene

Sequence variations from dbSNP and Humsavar for SLC34A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3812035 -- 177,390,142(-) GTTGG(A/C)GTCAA utr-variant-3-prime, intron-variant
rs3812036 -- 177,386,403(-) CCAGC(A/G)TTGTC intron-variant
rs4076508 -- 177,398,773(+) TTCGG(C/T)ACCAC utr-variant-3-prime
rs4133135 -- 177,384,627(-) GCCAC(C/T)GCGCT intron-variant, upstream-variant-2KB
rs4246815 -- 177,399,337(+) GCAGG(G/T)ACCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC34A1 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv509103 CNV Insertion 20534489
nsv471057 CNV Loss 18288195
nsv883163 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv733n27 CNV Loss 19166990
dgv6381n71 CNV Loss 21882294
nsv883167 CNV Loss 21882294
esv2731189 CNV Deletion 23290073
esv2731190 CNV Deletion 23290073
esv4214 CNV Deletion 18987735
esv2675618 CNV Deletion 23128226
esv1007597 CNV Deletion 20482838
dgv6382n71 CNV Loss 21882294

Relevant External Links for SLC34A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC34A1 Gene

Disorders for SLC34A1 Gene

(2) OMIM Diseases for SLC34A1 Gene (182309)


  • Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1) [MIM:612286]: A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. {ECO:0000269 PubMed:12324554}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Fanconi renotubular syndrome 2 (FRTS2) [MIM:613388]: A disease due to a generalized dysfunction of the proximal kidney tubule resulting in decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. {ECO:0000269 PubMed:20335586}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for SLC34A1 Gene

(7) Novoseek inferred disease relationships for SLC34A1 Gene

Disease -log(P) Hits PubMed IDs
rickets hypophosphatemic 85.8 1
hypophosphatemia 83.1 1
hyperphosphatemia 82.3 4
hypercalciuria 67 3
calcification 63.3 13

Relevant External Links for SLC34A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC34A1: view

Publications for SLC34A1 Gene

  1. Expression cloning of human and rat renal cortex Na/Pi cotransport. (PMID: 8327470) Magagnin S. … Murer H. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Structure of murine and human renal type II Na+-phosphate cotransporter genes (Npt2 and NPT2). (PMID: 8693007) Hartmann C.M. … Tenenhouse H.S. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 23
  3. Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2. (PMID: 12674325) Chau H. … Tenenhouse H.S. (J. Bone Miner. Res. 2003) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Phosphate transport by the human renal cotransporter NaPi-3 expressed in HEK-293 cells. (PMID: 9530108) Timmer R.T. … Gunn R.B. (Am. J. Physiol. 1998) 3 23

Products for SLC34A1 Gene

Sources for SLC34A1 Gene

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