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Aliases for SLC17A1 Gene

Aliases for SLC17A1 Gene

  • Solute Carrier Family 17 Member 1 2 3 4
  • Solute Carrier Family 17 (Organic Anion Transporter), Member 1 2 3 5
  • Solute Carrier Family 17 (Sodium Phosphate), Member 1 2 3
  • Renal Sodium-Dependent Phosphate Transport Protein 1 3 4
  • Renal Na(+)-Dependent Phosphate Cotransporter 1 3 4
  • Renal Sodium-Phosphate Transport Protein 1 3 4
  • Sodium/Phosphate Cotransporter 1 3 4
  • Na(+)/PI Cotransporter 1 3 4
  • Na/Pi-4 3 4
  • NPT1 3 4
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 1 3
  • Sodium/Phosphate Type I Cotransporter 3
  • Sodium Phosphate Transporter 3
  • NAPI-1 3
  • NPT-1 3

External Ids for SLC17A1 Gene

Previous HGNC Symbols for SLC17A1 Gene

  • NPT1

Previous GeneCards Identifiers for SLC17A1 Gene

  • GC06M025840
  • GC06M025891

Summaries for SLC17A1 Gene

GeneCards Summary for SLC17A1 Gene

SLC17A1 (Solute Carrier Family 17 Member 1) is a Protein Coding gene. Diseases associated with SLC17A1 include gout. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. GO annotations related to this gene include symporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A1 Gene

  • Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.

Gene Wiki entry for SLC17A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A1 Gene

Genomics for SLC17A1 Gene

Regulatory Elements for SLC17A1 Gene

Genomic Location for SLC17A1 Gene

Chromosome:
6
Start:
25,781,454 bp from pter
End:
25,832,070 bp from pter
Size:
50,617 bases
Orientation:
Minus strand

Genomic View for SLC17A1 Gene

Genes around SLC17A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A1 Gene

Proteins for SLC17A1 Gene

  • Protein details for SLC17A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14916-NPT1_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 1
    Protein Accession:
    Q14916
    Secondary Accessions:
    • A8K418
    • O60761
    • Q13783
    • Q3MIP5
    • Q5MJP8
    • Q5TB83
    • Q96KL8

    Protein attributes for SLC17A1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51132 Da
    Quaternary structure:
    • Interacts with PDZK1.
    SequenceCaution:
    • Sequence=BAA05888.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19543.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC17A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A1 Gene

Proteomics data for SLC17A1 Gene at MOPED

Post-translational modifications for SLC17A1 Gene

  • Glycosylation at Asn 41, Asn 49, and Asn 58
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A1 Gene

No data available for DME Specific Peptides for SLC17A1 Gene

Domains & Families for SLC17A1 Gene

Gene Families for SLC17A1 Gene

Protein Domains for SLC17A1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14916

UniProtKB/Swiss-Prot:

NPT1_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A1: view

Function for SLC17A1 Gene

Molecular function for SLC17A1 Gene

GENATLAS Biochemistry:
solute carrier family 17 (sodium/phosphate cotransport),member 1,expressed in kidney
UniProtKB/Swiss-Prot Function:
Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.
genes like me logo Genes that share phenotypes with SLC17A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A1

CRISPR Products

miRNA for SLC17A1 Gene

miRTarBase miRNAs that target SLC17A1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A1 Gene

Localization for SLC17A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A1 Gene COMPARTMENTS Subcellular localization image for SLC17A1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC17A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 8288239
genes like me logo Genes that share ontologies with SLC17A1: view

Pathways & Interactions for SLC17A1 Gene

genes like me logo Genes that share pathways with SLC17A1: view

Interacting Proteins for SLC17A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244527%0d%0a9606.ENSP00000262613%0d%0a
Selected Interacting proteins: Q14916-NPT1_HUMAN ENSP00000244527 for SLC17A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SLC17A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035435 phosphate ion transmembrane transport IEA --
GO:0035725 sodium ion transmembrane transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC17A1: view

No data available for SIGNOR curated interactions for SLC17A1 Gene

Drugs & Compounds for SLC17A1 Gene

(2) Additional Compounds for SLC17A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A1: view

Transcripts for SLC17A1 Gene

Unigene Clusters for SLC17A1 Gene

Solute carrier family 17 (sodium phosphate), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3:

Relevant External Links for SLC17A1 Gene

GeneLoc Exon Structure for
SLC17A1
ECgene alternative splicing isoforms for
SLC17A1

Expression for SLC17A1 Gene

mRNA expression in normal human tissues for SLC17A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A1 Gene

This gene is overexpressed in Kidney - Cortex (x40.8) and Liver (x10.6).

Protein differential expression in normal tissues from HIPED for SLC17A1 Gene

This gene is overexpressed in Urine (37.0) and Kidney (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A1 Gene



SOURCE GeneReport for Unigene cluster for SLC17A1 Gene Hs.205816

mRNA Expression by UniProt/SwissProt for SLC17A1 Gene

Q14916-NPT1_HUMAN
Tissue specificity: Expressed in kidney cortex, liver and brain but not in other tissues.
genes like me logo Genes that share expression patterns with SLC17A1: view

Protein tissue co-expression partners for SLC17A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC17A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC17A1 35
  • 78.37 (n)
  • 62.53 (a)
SLC17A1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A1 35
  • 79.3 (n)
  • 69.81 (a)
SLC17A1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a1 35
  • 74.98 (n)
  • 65.59 (a)
Slc17a1 16
Slc17a1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC17A1 35
  • 99.36 (n)
  • 98.5 (a)
SLC17A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc17a1 35
  • 75.91 (n)
  • 66.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F21F8.11 37
  • 24 (a)
T09B9.2 37
  • 25 (a)
Species with no ortholog for SLC17A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC17A1 Gene

ENSEMBL:
Gene Tree for SLC17A1 (if available)
TreeFam:
Gene Tree for SLC17A1 (if available)

Paralogs for SLC17A1 Gene

Paralogs for SLC17A1 Gene

(7) SIMAP similar genes for SLC17A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC17A1: view

Variants for SLC17A1 Gene

Sequence variations from dbSNP and Humsavar for SLC17A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6933573 - 25,819,896(+) CTGGG(C/T)TCCAA reference, missense
rs1165196 - 25,812,922(-) TTCCA(C/T)TGGTA intron-variant, reference, missense
rs3923 -- 25,783,087(-) GGGCC(A/G)GTTTT reference, missense, utr-variant-3-prime
rs765284 -- 25,828,113(-) GTTCC(A/C)CCATT intron-variant
rs765285 -- 25,828,014(-) taggc(C/G)cctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A1 Gene

Variant ID Type Subtype PubMed ID
nsv883489 CNV Gain 21882294

Variation tolerance for SLC17A1 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC17A1 Gene

HapMap Linkage Disequilibrium report
SLC17A1
Human Gene Mutation Database (HGMD)
SLC17A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A1 Gene

Disorders for SLC17A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC17A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gout
  • articular gout
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC17A1

Genetic Association Database (GAD)
SLC17A1
Human Genome Epidemiology (HuGE) Navigator
SLC17A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC17A1
genes like me logo Genes that share disorders with SLC17A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A1 Gene

Publications for SLC17A1 Gene

  1. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. (PMID: 8288239) Chong S.S. … Hughes M.R. (Genomics 1993) 2 3 4 23 67
  2. Generation of a transcription map of a 1 Mbase region containing the HFE gene (6p22). (PMID: 9781053) Totaro A. … Gasparini P. (Eur. J. Hum. Genet. 1998) 3 23
  3. Cloning and functional expression of a Na(+)-dependent phosphate co- transporter from human kidney: cDNA cloning and functional expression. (PMID: 7826357) Miyamoto K. … Takeda E. (Biochem. J. 1995) 3 23
  4. Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts. (PMID: 8867793) Li H. … Xie Z. (Cell. Mol. Biol. Res. 1995) 3 23
  5. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. (PMID: 25252215) Chiba T. … Shinomiya N. ( 2015) 3

Products for SLC17A1 Gene

Sources for SLC17A1 Gene

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