Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC15A2 Gene

Aliases for SLC15A2 Gene

  • Solute Carrier Family 15 Member 2 2 3
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 2 2 3 5
  • Solute Carrier Family 15 (H+/Peptide Transporter), Member 2 2 3
  • Oligopeptide Transporter, Kidney Isoform 3 4
  • Kidney H(+)/Peptide Cotransporter 3 4
  • Peptide Transporter 2 3 4
  • PEPT2 3 4

External Ids for SLC15A2 Gene

Previous GeneCards Identifiers for SLC15A2 Gene

  • GC03P118308
  • GC03P121254
  • GC03P122894
  • GC03P122934
  • GC03P123096
  • GC03P121612
  • GC03P118987

Summaries for SLC15A2 Gene

Entrez Gene Summary for SLC15A2 Gene

  • The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC15A2 Gene

SLC15A2 (Solute Carrier Family 15 Member 2) is a Protein Coding gene. Diseases associated with SLC15A2 include Cough Headache. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and peptide:proton symporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A2 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Gene Wiki entry for SLC15A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A2 Gene

Genomics for SLC15A2 Gene

Regulatory Elements for SLC15A2 Gene

Enhancers for SLC15A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC15A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A2 Gene

121,894,089 bp from pter
121,944,187 bp from pter
50,099 bases
Plus strand

Genomic View for SLC15A2 Gene

Genes around SLC15A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A2 Gene

Proteins for SLC15A2 Gene

  • Protein details for SLC15A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 15 member 2
    Protein Accession:
    Secondary Accessions:
    • A8K1A5
    • B4E2A7

    Protein attributes for SLC15A2 Gene

    729 amino acids
    Molecular mass:
    81783 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC15A2 Gene


neXtProt entry for SLC15A2 Gene

Proteomics data for SLC15A2 Gene at MOPED

Post-translational modifications for SLC15A2 Gene

  • Glycosylation at Asn 7, Asn 269, Asn 373, Asn 435, Asn 472, Asn 528, and Asn 567
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A2 Gene

Antibody Products

No data available for DME Specific Peptides for SLC15A2 Gene

Domains & Families for SLC15A2 Gene

Gene Families for SLC15A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A2: view

Function for SLC15A2 Gene

Molecular function for SLC15A2 Gene

UniProtKB/Swiss-Prot Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Gene Ontology (GO) - Molecular Function for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16738539
genes like me logo Genes that share ontologies with SLC15A2: view
genes like me logo Genes that share phenotypes with SLC15A2: view

Animal Models for SLC15A2 Gene

MGI Knock Outs for SLC15A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC15A2 Gene

Localization for SLC15A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC15A2 Gene COMPARTMENTS Subcellular localization image for SLC15A2 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC15A2: view

Pathways & Interactions for SLC15A2 Gene

genes like me logo Genes that share pathways with SLC15A2: view

Interacting Proteins for SLC15A2 Gene

Gene Ontology (GO) - Biological Process for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 7756356
GO:0006811 ion transport TAS --
GO:0055085 transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with SLC15A2: view

No data available for SIGNOR curated interactions for SLC15A2 Gene

Drugs & Compounds for SLC15A2 Gene

(49) Drugs for SLC15A2 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved Pharma Transporter, inhibitor 406
Ampicillin Approved Pharma Target, Transporter, inhibitor 53
Azidocillin Approved Pharma Transporter, inhibitor 0
Benazepril Approved, Investigational Pharma Transporter, substrate 45
Cefaclor Approved Pharma Transporter, inhibitor 5

(6) Additional Compounds for SLC15A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
genes like me logo Genes that share compounds with SLC15A2: view

Transcripts for SLC15A2 Gene

Unigene Clusters for SLC15A2 Gene

Solute carrier family 15 (H+/peptide transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A2 Gene

No ASD Table

Relevant External Links for SLC15A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC15A2 Gene

mRNA expression in normal human tissues for SLC15A2 Gene

Protein differential expression in normal tissues from HIPED for SLC15A2 Gene

This gene is overexpressed in Nasal epithelium (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC15A2 Gene

SOURCE GeneReport for Unigene cluster for SLC15A2 Gene Hs.518089

genes like me logo Genes that share expression patterns with SLC15A2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC15A2 Gene

Orthologs for SLC15A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLC15A2 35
  • 90.53 (n)
  • 88.34 (a)
SLC15A2 36
  • 87 (a)
(Mus musculus)
Mammalia Slc15a2 35
  • 85.23 (n)
  • 82.72 (a)
Slc15a2 16
Slc15a2 36
  • 81 (a)
(Pan troglodytes)
Mammalia SLC15A2 35
  • 99.54 (n)
  • 99.59 (a)
SLC15A2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc15a2 35
  • 85.14 (n)
  • 82.85 (a)
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
SLC15A2 36
  • 87 (a)
(Monodelphis domestica)
Mammalia SLC15A2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves SLC15A2 35
  • 64.92 (n)
  • 61.43 (a)
SLC15A2 36
  • 61 (a)
(Anolis carolinensis)
Reptilia SLC15A2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a2 35
  • 61.65 (n)
  • 59.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia slc15a2-prov 35
(Danio rerio)
Actinopterygii slc15a2 35
  • 61.9 (n)
  • 57 (a)
slc15a2 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06717 37
  • 42 (a)
CG9444 37
  • 31 (a)
yin 37
  • 40 (a)
CG2930 36
  • 35 (a)
yin 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012154 35
  • 49.95 (n)
  • 44 (a)
(Caenorhabditis elegans)
Secernentea opt-1 37
  • 42 (a)
opt-2 37
  • 41 (a)
pept-3 35
  • 48.75 (n)
  • 38.16 (a)
pept-1 36
  • 29 (a)
pept-2 36
  • 31 (a)
pept-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 19 (a)
(Oryza sativa)
Liliopsida Os03g0235700 35
  • 46.41 (n)
  • 35.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
-- 36
  • 36 (a)
-- 36
  • 41 (a)
Species with no ortholog for SLC15A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A2 Gene

Gene Tree for SLC15A2 (if available)
Gene Tree for SLC15A2 (if available)

Paralogs for SLC15A2 Gene

Paralogs for SLC15A2 Gene

(3) SIMAP similar genes for SLC15A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A2: view

Variants for SLC15A2 Gene

Sequence variations from dbSNP and Humsavar for SLC15A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1920305 - 121,896,470(-) AAAAG(C/T)GCTCG reference, missense
rs1143667 - 121,897,412(+) CCTGT(A/G)TTTCC reference, missense
rs2257212 - 121,924,957(-) CAGAA(A/G)GGGAT reference, missense
rs1143671 - 121,928,439(+) CCCAG(C/T)CAGGT reference, missense
rs1143672 - 121,929,321(+) AAGCA(A/G)AACAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC15A2 Gene

Variant ID Type Subtype PubMed ID
nsv516233 CNV Gain+Loss 19592680
nsv877383 CNV Loss 21882294
esv33139 CNV Loss 17666407
nsv877384 CNV Gain 21882294

Variation tolerance for SLC15A2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.04; 98.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC15A2 Gene

Disorders for SLC15A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC15A2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cough headache
  • primary cough headache
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC15A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC15A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A2 Gene

Publications for SLC15A2 Gene

  1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PMID: 7756356) Liu W. … Leibach F.H. (Biochim. Biophys. Acta 1995) 2 3 4 25 26 67
  2. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) KnA1tter I. … Brandsch M. (J. Pharmacol. Exp. Ther. 2008) 3 23 25 26
  3. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. (PMID: 10636865) Ganapathy M.E. … Ganapathy V. (J. Biol. Chem. 2000) 23 25 26
  4. Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. (PMID: 10748266) Terada T. … Inui K. (Eur. J. Pharmacol. 2000) 23 25 26
  5. Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. (PMID: 9610386) Ganapathy M.E. … Leibach F.H. (Biochem. Biophys. Res. Commun. 1998) 23 25 26

Products for SLC15A2 Gene

Sources for SLC15A2 Gene