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Aliases for SLC15A2 Gene

Aliases for SLC15A2 Gene

  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 2 2 3
  • PEPT2 3 4 6
  • Solute Carrier Family 15 (H+/Peptide Transporter), Member 2 2 3
  • Oligopeptide Transporter, Kidney Isoform 3 4
  • Kidney H(+)/Peptide Cotransporter 3 4
  • Peptide Transporter 2 3 4
  • Solute Carrier Family 15 Member 2 3

External Ids for SLC15A2 Gene

Previous GeneCards Identifiers for SLC15A2 Gene

  • GC03P118308
  • GC03P121254
  • GC03P122894
  • GC03P122934
  • GC03P123096
  • GC03P121612
  • GC03P118987

Summaries for SLC15A2 Gene

Entrez Gene Summary for SLC15A2 Gene

  • The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC15A2 Gene

SLC15A2 (Solute Carrier Family 15 (Oligopeptide Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include peptide:proton symporter activity and high-affinity oligopeptide transporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A2 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

Gene Wiki entry for SLC15A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A2 Gene

Genomics for SLC15A2 Gene

Regulatory Elements for SLC15A2 Gene

Genomic Location for SLC15A2 Gene

Start:
121,894,089 bp from pter
End:
121,944,187 bp from pter
Size:
50,099 bases
Orientation:
Plus strand

Genomic View for SLC15A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC15A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A2 Gene

Proteins for SLC15A2 Gene

  • Protein details for SLC15A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16348-S15A2_HUMAN
    Recommended name:
    Solute carrier family 15 member 2
    Protein Accession:
    Q16348
    Secondary Accessions:
    • A8K1A5
    • B4E2A7

    Protein attributes for SLC15A2 Gene

    Size:
    729 amino acids
    Molecular mass:
    81783 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC15A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC15A2 Gene

Proteomics data for SLC15A2 Gene at MOPED

Post-translational modifications for SLC15A2 Gene

  • Glycosylation at Asn7, Asn269, Asn373, Asn435, Asn472, Asn528, and Asn567
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A2 Gene

Domains for SLC15A2 Gene

Gene Families for SLC15A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16348

UniProtKB/Swiss-Prot:

S15A2_HUMAN :
  • Q16348
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A2: view

Function for SLC15A2 Gene

Molecular function for SLC15A2 Gene

UniProtKB/Swiss-Prot Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

Gene Ontology (GO) - Molecular Function for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 16738539
GO:0015198 oligopeptide transporter activity --
GO:0015333 peptide:proton symporter activity TAS 7756356
GO:0015334 high-affinity oligopeptide transporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A2: view

Phenotypes for SLC15A2 Gene

genes like me logo Genes that share phenotypes with SLC15A2: view

Animal Model Products

CRISPR Products

miRNA for SLC15A2 Gene

miRTarBase miRNAs that target SLC15A2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC15A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC15A2 Gene

Localization for SLC15A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A2 Gene COMPARTMENTS Subcellular localization image for SLC15A2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC15A2: view

Pathways for SLC15A2 Gene

genes like me logo Genes that share pathways with SLC15A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC15A2 Gene

Gene Ontology (GO) - Biological Process for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7756356
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport --
GO:0015031 protein transport IEA --
GO:0015893 drug transport NAS 16738539
genes like me logo Genes that share ontologies with SLC15A2: view

Compounds for SLC15A2 Gene

(1) HMDB Compounds for SLC15A2 Gene

Compound Synonyms Cas Number PubMed IDs
Carnosine
  • Beta-Alanyl-L-histidine
305-84-0

(41) Drugbank Compounds for SLC15A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminolevulinic acid
  • 5-Aminolevulinic acid
106-60-5 transporter inhibitor
Amoxicillin
  • Amoxicilina [INN-Spanish]
26787-78-0 transporter inhibitor
Ampicillin
  • Aminobenzylpenicillin
69-53-4 transporter inhibitor
Azidocillin
17243-38-8 transporter inhibitor
Benazepril
  • Benazepril HCl
86541-75-5 transporter substrate

(5) IUPHAR Ligand for SLC15A2 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]GlySar None None
[3H]GlySar None None
[11C]GlySar None None
Lys[Z(NO2)]-Pro Inhibitor Inhibition
Lys[Z(NO2)]-Lys[Z(NO2)] Inhibitor Inhibition

(8) Novoseek inferred chemical compound relationships for SLC15A2 Gene

Compound -log(P) Hits PubMed IDs
glycylsarcosine 87.6 2
tripeptide s 83 3
valacyclovir 71.6 4
5-aminolevulinic acid 63.8 4
tripeptide 54.2 1
genes like me logo Genes that share compounds with SLC15A2: view

Transcripts for SLC15A2 Gene

Unigene Clusters for SLC15A2 Gene

Solute carrier family 15 (H+/peptide transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC15A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A2 Gene

No ASD Table

Relevant External Links for SLC15A2 Gene

GeneLoc Exon Structure for
SLC15A2
ECgene alternative splicing isoforms for
SLC15A2

Expression for SLC15A2 Gene

mRNA expression in normal human tissues for SLC15A2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC15A2 Gene

SOURCE GeneReport for Unigene cluster for SLC15A2 Gene Hs.518089

genes like me logo Genes that share expressions with SLC15A2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC15A2 Gene

Orthologs for SLC15A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A2 35
  • 99.54 (n)
  • 99.59 (a)
SLC15A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
OneToMany
SLC15A2 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC15A2 35
  • 90.53 (n)
  • 88.34 (a)
SLC15A2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a2 35
  • 85.23 (n)
  • 82.72 (a)
Slc15a2 16
Slc15a2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC15A2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc15a2 35
  • 85.14 (n)
  • 82.85 (a)
chicken
(Gallus gallus)
Aves SLC15A2 35
  • 64.92 (n)
  • 61.43 (a)
SLC15A2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC15A2 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia slc15a2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a2 35
  • 61.65 (n)
  • 59.12 (a)
zebrafish
(Danio rerio)
Actinopterygii slc15a2 35
  • 61.9 (n)
  • 57 (a)
slc15a2 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012154 35
  • 49.95 (n)
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2930 36
  • 35 (a)
ManyToMany
yin 36
  • 38 (a)
ManyToMany
yin 37
  • 40 (a)
CG9444 37
  • 31 (a)
BcDNA:GH06717 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pept-1 36
  • 29 (a)
ManyToMany
pept-2 36
  • 31 (a)
ManyToMany
pept-3 35
  • 48.75 (n)
  • 38.16 (a)
pept-3 36
  • 34 (a)
ManyToMany
opt-1 37
  • 42 (a)
opt-2 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0235700 35
  • 46.41 (n)
  • 35.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for SLC15A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A2 Gene

ENSEMBL:
Gene Tree for SLC15A2 (if available)
TreeFam:
Gene Tree for SLC15A2 (if available)

Paralogs for SLC15A2 Gene

Paralogs for SLC15A2 Gene

Selected SIMAP similar genes for SLC15A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A2: view

Variants for SLC15A2 Gene

Sequence variations from dbSNP and Humsavar for SLC15A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13860 -- 121,942,564(+) AGCAT(C/T)TCAGA utr-variant-3-prime
rs866926 -- 121,913,414(+) ATAGA(A/T)GCTGG intron-variant, upstream-variant-2KB
rs866927 -- 121,913,585(+) GTGAT(A/G)AGTAG intron-variant, upstream-variant-2KB
rs866928 -- 121,913,455(+) TGAGT(A/G)AAAGC intron-variant, upstream-variant-2KB
rs866929 -- 121,913,660(+) GAAAC(A/G)TAATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC15A2 Gene

Variant ID Type Subtype PubMed ID
nsv516233 CNV Gain+Loss 19592680
nsv877383 CNV Loss 21882294
esv33139 CNV Loss 17666407
nsv877384 CNV Gain 21882294

Relevant External Links for SLC15A2 Gene

HapMap Linkage Disequilibrium report
SLC15A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A2 Gene

Disorders for SLC15A2 Gene

(1) Novoseek inferred disease relationships for SLC15A2 Gene

Disease -log(P) Hits PubMed IDs
lung tumor 24.1 1

Relevant External Links for SLC15A2

Genetic Association Database (GAD)
SLC15A2
Human Genome Epidemiology (HuGE) Navigator
SLC15A2
genes like me logo Genes that share disorders with SLC15A2: view

No data available for UniProtKB/Swiss-Prot for SLC15A2 Gene

Publications for SLC15A2 Gene

  1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PMID: 7756356) Liu W. … Leibach F.H. (Biochim. Biophys. Acta 1995) 2 3 4 25
  2. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. (PMID: 18766334) Liu R. … Lee E.J. (Eur. J. Clin. Pharmacol. 2009) 3 23 48
  3. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. (PMID: 19723536) Sobin C. … Alterio H. (Neurotoxicology 2009) 3 23 48
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) KnA1tter I. … Brandsch M. (J. Pharmacol. Exp. Ther. 2008) 3 23 25
  5. The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters. (PMID: 20067523) Geissler S. … Brandsch M. (FEBS J. 2010) 3 23

Products for SLC15A2 Gene

  • antibodies-online peptides for SLC15A2
  • antibodies-online antibodies for SLC15A2
  • antibodies-online kits for SLC15A2

Sources for SLC15A2 Gene

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