Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC15A1 Gene

Aliases for SLC15A1 Gene

  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 2 3
  • Oligopeptide Transporter, Small Intestine Isoform 3 4
  • Peptide Transporter 1 3 4
  • HPECT1 3 6
  • PEPT1 3 4
  • BA551M18.1.1 (Solute Carrier Family 15 (Oligopeptide Transporter) Member 1) 2
  • Solute Carrier Family 15 Oligopeptide Transporter Member 1 2
  • Macrophage Oligopeptide Transporter PEPT1 3
  • Intestinal H(+)/Peptide Cotransporter 4
  • Intestinal H+/Peptide Cotransporter 3
  • Solute Carrier Family 15 Member 1 3
  • Caco-2 Oligopeptide Transporter 3
  • Peptide Transporter HPEPT1 2
  • HPEPT1 3

External Ids for SLC15A1 Gene

Previous GeneCards Identifiers for SLC15A1 Gene

  • GC13M097696
  • GC13M093724
  • GC13M098172
  • GC13M097034
  • GC13M098134
  • GC13M099336
  • GC13M079930

Summaries for SLC15A1 Gene

Entrez Gene Summary for SLC15A1 Gene

  • This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

GeneCards Summary for SLC15A1 Gene

SLC15A1 (Solute Carrier Family 15 (Oligopeptide Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Protein digestion and absorption. GO annotations related to this gene include proton-dependent oligopeptide secondary active transmembrane transporter activity and peptide:proton symporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A1 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products

Gene Wiki entry for SLC15A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A1 Gene

Genomics for SLC15A1 Gene

Regulatory Elements for SLC15A1 Gene

Genomic Location for SLC15A1 Gene

Start:
98,683,801 bp from pter
End:
98,752,675 bp from pter
Size:
68,875 bases
Orientation:
Minus strand

Genomic View for SLC15A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC15A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A1 Gene

Proteins for SLC15A1 Gene

  • Protein details for SLC15A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46059-S15A1_HUMAN
    Recommended name:
    Solute carrier family 15 member 1
    Protein Accession:
    P46059
    Secondary Accessions:
    • Q5VW82

    Protein attributes for SLC15A1 Gene

    Size:
    708 amino acids
    Molecular mass:
    78806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A1 Gene

Proteomics data for SLC15A1 Gene at MOPED

Post-translational modifications for SLC15A1 Gene

  • Glycosylation at Asn50, Asn404, Asn408, Asn439, Asn509, Asn514, and Asn562
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A1 Gene

Domains for SLC15A1 Gene

Gene Families for SLC15A1 Gene

Suggested Antigen Peptide Sequences for SLC15A1 Gene

Graphical View of Domain Structure for InterPro Entry

P46059

UniProtKB/Swiss-Prot:

S15A1_HUMAN :
  • P46059
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A1: view

Function for SLC15A1 Gene

Molecular function for SLC15A1 Gene

GENATLAS Biochemistry: solute carrier family 15 (oligopeptide transport),member 1,expressed in small intestine
UniProtKB/Swiss-Prot Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products

Gene Ontology (GO) - Molecular Function for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity IEA --
GO:0015198 oligopeptide transporter activity --
GO:0015333 peptide:proton symporter activity TAS 7896779
genes like me logo Genes that share ontologies with SLC15A1: view

Phenotypes for SLC15A1 Gene

MGI mutant phenotypes for SLC15A1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC15A1: view

Animal Model Products

CRISPR Products

miRNA for SLC15A1 Gene

miRTarBase miRNAs that target SLC15A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC15A1 Gene

Localization for SLC15A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A1 Gene COMPARTMENTS Subcellular localization image for SLC15A1 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7896779
GO:0016020 membrane TAS 7896779
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC15A1: view

Pathways for SLC15A1 Gene

genes like me logo Genes that share pathways with SLC15A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC15A1 Gene

Gene Ontology (GO) - Biological Process for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7896779
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport --
GO:0007586 digestion TAS 7896779
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SLC15A1: view

Compounds for SLC15A1 Gene

(50) Drugbank Compounds for SLC15A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminolevulinic acid
  • 5-Aminolevulinic acid
106-60-5 transporter inhibitor
Amoxicillin
  • Amoxicilina [INN-Spanish]
26787-78-0 transporter inhibitor
Ampicillin
  • Aminobenzylpenicillin
69-53-4 transporter inhibitor
Azidocillin
17243-38-8 transporter inhibitor
Benazepril
  • Benazepril HCl
86541-75-5 transporter substrate

(5) IUPHAR Ligand for SLC15A1 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]GlySar None None
[3H]GlySar None None
[11C]GlySar None None
Lys[Z(NO2)]-Pro Inhibitor Inhibition
4-AMBA Inhibitor Inhibition

(52) Novoseek inferred chemical compound relationships for SLC15A1 Gene

Compound -log(P) Hits PubMed IDs
glycylsarcosine 97.7 38
tripeptide s 91 26
cephalexin 86.1 26
tripeptide 84.1 24
cefadroxil 83.1 4
genes like me logo Genes that share compounds with SLC15A1: view

Transcripts for SLC15A1 Gene

mRNA/cDNA for SLC15A1 Gene

(13) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC15A1 Gene

Solute carrier family 15 (oligopeptide transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC15A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC15A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A1 Gene

No ASD Table

Relevant External Links for SLC15A1 Gene

GeneLoc Exon Structure for
SLC15A1
ECgene alternative splicing isoforms for
SLC15A1

Expression for SLC15A1 Gene

mRNA expression in normal human tissues for SLC15A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (22.8), Skin - Not Sun Exposed (Suprapubic) (7.2), Skin - Sun Exposed (Lower leg) (6.2), and Liver (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC15A1 Gene

SOURCE GeneReport for Unigene cluster for SLC15A1 Gene Hs.436893

genes like me logo Genes that share expressions with SLC15A1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC15A1 Gene

Orthologs for SLC15A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A1 35
  • 99.15 (n)
  • 98.73 (a)
SLC15A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEPT-1 36
  • 83 (a)
OneToOne
SLC15A1 35
  • 83.12 (n)
  • 83.03 (a)
dog
(Canis familiaris)
Mammalia SLC15A1 35
  • 85.05 (n)
  • 83.17 (a)
SLC15A1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a1 35
  • 83.24 (n)
  • 85.17 (a)
Slc15a1 16
Slc15a1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC15A1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC15A1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a1 35
  • 82.34 (n)
  • 83.76 (a)
chicken
(Gallus gallus)
Aves SLC15A1 35
  • 67.6 (n)
  • 66.32 (a)
SLC15A1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC15A1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a1 35
  • 64.86 (n)
  • 65.74 (a)
zebrafish
(Danio rerio)
Actinopterygii slc15a1 35
slc15a1a 36
  • 55 (a)
OneToMany
slc15a1b 35
  • 64.19 (n)
  • 62.17 (a)
slc15a1b 36
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010383 35
  • 50.94 (n)
  • 42.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2930 35
  • 52.14 (n)
  • 44.06 (a)
CG2930 36
  • 32 (a)
ManyToMany
yin 36
  • 35 (a)
ManyToMany
CG9444 37
  • 31 (a)
BcDNA:GH06717 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea pept-1 35
  • 54.74 (n)
  • 45.06 (a)
pept-1 36
  • 30 (a)
ManyToMany
pept-2 36
  • 33 (a)
ManyToMany
pept-3 36
  • 34 (a)
ManyToMany
opt-1 37
  • 44 (a)
opt-2 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 35
  • 47.01 (n)
  • 32.68 (a)
PTR2 36
  • 19 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12915g 35
  • 45.52 (n)
  • 31.48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTR2 35
  • 47.41 (n)
  • 37.03 (a)
rice
(Oryza sativa)
Liliopsida Os03g0719900 35
  • 48.48 (n)
  • 35.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.04c 35
  • 45.49 (n)
  • 29.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
Species with no ortholog for SLC15A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A1 Gene

ENSEMBL:
Gene Tree for SLC15A1 (if available)
TreeFam:
Gene Tree for SLC15A1 (if available)

Paralogs for SLC15A1 Gene

Paralogs for SLC15A1 Gene

Selected SIMAP similar genes for SLC15A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC15A1: view

Variants for SLC15A1 Gene

Sequence variations from dbSNP and Humsavar for SLC15A1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs809536 -- 98,739,732(+) cccgg(G/T)ttcat intron-variant
rs812231 -- 98,728,908(+) cctgg(A/G)aggtg intron-variant
rs883962 -- 98,748,029(-) TGTCT(A/G)AGCAG intron-variant
rs914300 -- 98,751,448(-) CTGAA(A/C)TATTT intron-variant
rs914301 -- 98,740,731(-) GTCCC(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A1 Gene

Variant ID Type Subtype PubMed ID
esv2747861 CNV Deletion 23290073
nsv518082 CNV Gain 19592680
nsv900946 CNV Loss 21882294

Relevant External Links for SLC15A1 Gene

HapMap Linkage Disequilibrium report
SLC15A1
Human Gene Mutation Database (HGMD)
SLC15A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A1 Gene

Disorders for SLC15A1 Gene

(8) Novoseek inferred disease relationships for SLC15A1 Gene

Disease -log(P) Hits PubMed IDs
inflammatory bowel diseases 30.2 4
colitis ulcerative 13.8 3
inflammation 8.99 15
tumors 2.3 3
atrophy 0 1

Relevant External Links for SLC15A1

Genetic Association Database (GAD)
SLC15A1
Human Genome Epidemiology (HuGE) Navigator
SLC15A1
genes like me logo Genes that share disorders with SLC15A1: view

No data available for UniProtKB/Swiss-Prot for SLC15A1 Gene

Publications for SLC15A1 Gene

  1. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. (PMID: 7896779) Liang R. … Leibach F.H. (J. Biol. Chem. 1995) 2 3 4 25
  2. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (PMID: 19462432) Zucchelli M. … D'Amato M. (Inflamm. Bowel Dis. 2009) 3 23 48
  3. Oseltamivir (tamiflu) is a substrate of peptide transporter 1. (PMID: 19439487) Ogihara T. … Tamai I. (Drug Metab. Dispos. 2009) 3 23 25
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) KnA1tter I. … Brandsch M. (J. Pharmacol. Exp. Ther. 2008) 3 23 25
  5. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. (PMID: 16627568) Sala-Rabanal M. … Wright E.M. (J. Physiol. (Lond.) 2006) 3 23 25

Products for SLC15A1 Gene

Sources for SLC15A1 Gene

Back to Top

Content