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Aliases for SLC15A1 Gene

Aliases for SLC15A1 Gene

  • Solute Carrier Family 15 Member 1 2 3 5
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 2 3
  • Oligopeptide Transporter, Small Intestine Isoform 3 4
  • Peptide Transporter 1 3 4
  • PEPT1 3 4
  • BA551M18.1.1 (Solute Carrier Family 15 (Oligopeptide Transporter) Member 1) 2
  • Solute Carrier Family 15 Oligopeptide Transporter Member 1 2
  • Macrophage Oligopeptide Transporter PEPT1 3
  • Intestinal H(+)/Peptide Cotransporter 4
  • Intestinal H+/Peptide Cotransporter 3
  • Caco-2 Oligopeptide Transporter 3
  • Peptide Transporter HPEPT1 2
  • HPECT1 3
  • HPEPT1 3

External Ids for SLC15A1 Gene

Previous GeneCards Identifiers for SLC15A1 Gene

  • GC13M097696
  • GC13M093724
  • GC13M098172
  • GC13M097034
  • GC13M098134
  • GC13M099336
  • GC13M079930

Summaries for SLC15A1 Gene

Entrez Gene Summary for SLC15A1 Gene

  • This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

GeneCards Summary for SLC15A1 Gene

SLC15A1 (Solute Carrier Family 15 Member 1) is a Protein Coding gene. Diseases associated with SLC15A1 include Short Bowel Syndrome. Among its related pathways are Collagen chain trimerization and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and oligopeptide transporter activity. An important paralog of this gene is SLC15A2.

UniProtKB/Swiss-Prot for SLC15A1 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

Gene Wiki entry for SLC15A1 Gene

Additional gene information for SLC15A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A1 Gene

Genomics for SLC15A1 Gene

Regulatory Elements for SLC15A1 Gene

Enhancers for SLC15A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H098775 1.1 ENCODE dbSUPER 20.5 -23.8 -23754 1 RARA POLR3A FOS CEBPB PPARG ZFP69B NFIL3 MIER3 RCOR2 ETV4 SLC15A1 DOCK9-AS1 DOCK9 LOC105370330
GH13H098737 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +7.3 7317 15 PKNOX1 ZFP64 ZSCAN4 ZNF133 ZBTB40 RAD21 RARA YY1 SCRT2 FOS STK24-AS1 SLC15A1 DOCK9-AS2 RN7SL60P
GH13H098908 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -157.3 -157282 3 POLR2A JUN ETV1 MYC NR2F2 GABPA DOCK9 SLC15A1 GPR183 STK24 GC13M098916 GC13P098878
GH13H098812 1 ENCODE dbSUPER 10.9 -61.6 -61617 2 PKNOX1 OVOL3 FEZF1 ZNF384 ZBTB8A ZNF843 OSR2 CTBP1 PRDM6 BCL11A SLC15A1 DOCK9-AS2 DOCK9-AS1 LOC105370330
GH13H098730 0.7 ENCODE dbSUPER 12.8 +20.5 20493 3 ZNF2 MAFK SLC15A1 DOCK9-AS1 DOCK9 RN7SL60P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC15A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A1 Gene

Chromosome:
13
Start:
98,683,801 bp from pter
End:
98,752,675 bp from pter
Size:
68,875 bases
Orientation:
Minus strand

Genomic View for SLC15A1 Gene

Genes around SLC15A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A1 Gene

Proteins for SLC15A1 Gene

  • Protein details for SLC15A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46059-S15A1_HUMAN
    Recommended name:
    Solute carrier family 15 member 1
    Protein Accession:
    P46059
    Secondary Accessions:
    • Q5VW82

    Protein attributes for SLC15A1 Gene

    Size:
    708 amino acids
    Molecular mass:
    78806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A1 Gene

Post-translational modifications for SLC15A1 Gene

  • Glycosylation at isoforms=50, Asn404, isoforms=408, isoforms=439, isoforms=509, isoforms=514, and isoforms=562
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SLC15A1
  • Cloud-Clone Corp. Antibodies for SLC15A1
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC15A1

No data available for DME Specific Peptides for SLC15A1 Gene

Domains & Families for SLC15A1 Gene

Gene Families for SLC15A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

P46059

UniProtKB/Swiss-Prot:

S15A1_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A1: view

Function for SLC15A1 Gene

Molecular function for SLC15A1 Gene

GENATLAS Biochemistry:
solute carrier family 15 (oligopeptide transport),member 1,expressed in small intestine
UniProtKB/Swiss-Prot Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

Phenotypes From GWAS Catalog for SLC15A1 Gene

Gene Ontology (GO) - Molecular Function for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity IEA --
GO:0015198 oligopeptide transporter activity IEA --
GO:0015252 hydrogen ion channel activity IEA --
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity TAS --
genes like me logo Genes that share ontologies with SLC15A1: view
genes like me logo Genes that share phenotypes with SLC15A1: view

Animal Models for SLC15A1 Gene

MGI Knock Outs for SLC15A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC15A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC15A1 Gene

Localization for SLC15A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7896779
GO:0005903 brush border IEA --
GO:0016020 membrane TAS 7896779
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC15A1: view

Pathways & Interactions for SLC15A1 Gene

genes like me logo Genes that share pathways with SLC15A1: view

Gene Ontology (GO) - Biological Process for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7896779
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0007586 digestion TAS 7896779
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SLC15A1: view

No data available for SIGNOR curated interactions for SLC15A1 Gene

Drugs & Compounds for SLC15A1 Gene

(81) Drugs for SLC15A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved, Vet_approved Pharma Transporter, inhibitor 487
Ampicillin Approved, Vet_approved Pharma Target, Transporter, inhibitor 61
Cefaclor Approved Pharma Transporter, inhibitor 5
Cefadroxil Approved, Vet_approved, Withdrawn Pharma Transporter, substrate, inhibitor 10
Cefepime Approved Pharma Transporter, inhibitor 39

(17) Additional Compounds for SLC15A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
36892-36-1
genes like me logo Genes that share compounds with SLC15A1: view

Transcripts for SLC15A1 Gene

mRNA/cDNA for SLC15A1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC15A1 Gene

Solute carrier family 15 (oligopeptide transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC15A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A1 Gene

No ASD Table

Relevant External Links for SLC15A1 Gene

GeneLoc Exon Structure for
SLC15A1
ECgene alternative splicing isoforms for
SLC15A1

Expression for SLC15A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC15A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.8), Skin - Not Sun Exposed (Suprapubic) (x7.2), Skin - Sun Exposed (Lower leg) (x6.2), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for SLC15A1 Gene

This gene is overexpressed in Fetal gut (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC15A1 Gene



Protein tissue co-expression partners for SLC15A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC15A1 Gene:

SLC15A1

SOURCE GeneReport for Unigene cluster for SLC15A1 Gene:

Hs.436893

Evidence on tissue expression from TISSUES for SLC15A1 Gene

  • Intestine(4.6)
  • Kidney(2.6)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with SLC15A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A1 Gene

Orthologs for SLC15A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A1 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia SLC15A1 33 34
  • 85.05 (n)
mouse
(Mus musculus)
Mammalia Slc15a1 33 16 34
  • 83.24 (n)
cow
(Bos Taurus)
Mammalia SLC15A1 33
  • 83.12 (n)
PEPT-1 34
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a1 33
  • 82.34 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC15A1 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC15A1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC15A1 33 34
  • 67.6 (n)
lizard
(Anolis carolinensis)
Reptilia SLC15A1 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a1 33
  • 64.86 (n)
zebrafish
(Danio rerio)
Actinopterygii slc15a1b 33 34
  • 64.19 (n)
slc15a1a 34
  • 55 (a)
OneToMany
slc15a1 33
fruit fly
(Drosophila melanogaster)
Insecta CG2930 33 34
  • 52.14 (n)
BcDNA:GH06717 35
  • 40 (a)
yin 34
  • 35 (a)
ManyToMany
CG9444 35
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010383 33
  • 50.94 (n)
worm
(Caenorhabditis elegans)
Secernentea pept-1 33 34
  • 54.74 (n)
opt-1 35
  • 44 (a)
opt-2 35
  • 44 (a)
pept-3 34
  • 34 (a)
ManyToMany
pept-2 34
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 33 34
  • 47.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12915g 33
  • 45.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTR2 33
  • 47.41 (n)
rice
(Oryza sativa)
Liliopsida Os03g0719900 33
  • 48.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.04c 33
  • 45.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for SLC15A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A1 Gene

ENSEMBL:
Gene Tree for SLC15A1 (if available)
TreeFam:
Gene Tree for SLC15A1 (if available)

Paralogs for SLC15A1 Gene

Paralogs for SLC15A1 Gene

(3) SIMAP similar genes for SLC15A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC15A1: view

Variants for SLC15A1 Gene

Sequence variations from dbSNP and Humsavar for SLC15A1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000066284 -- 98,707,469(+) AAGTA(C/G)AATGG intron-variant
rs1000099451 -- 98,728,312(+) TCAGG(A/G)TGACT intron-variant
rs1000326544 -- 98,690,057(+) AGGAC(G/T)GTGTT intron-variant
rs1000457721 -- 98,742,116(+) AACAC(A/C)AGAGA intron-variant
rs1000476521 -- 98,684,142(+) ACCAA(C/T)GTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC15A1 Gene

Variant ID Type Subtype PubMed ID
esv2747861 CNV deletion 23290073
esv3391339 CNV insertion 20981092
nsv1038016 CNV gain 25217958
nsv518082 CNV gain 19592680

Variation tolerance for SLC15A1 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC15A1 Gene

Human Gene Mutation Database (HGMD)
SLC15A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A1 Gene

Disorders for SLC15A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC15A1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
short bowel syndrome
  • acquired short bowel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC15A1

Genetic Association Database (GAD)
SLC15A1
Human Genome Epidemiology (HuGE) Navigator
SLC15A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC15A1
genes like me logo Genes that share disorders with SLC15A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A1 Gene

Publications for SLC15A1 Gene

  1. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. (PMID: 7896779) Liang R … Leibach FH (The Journal of biological chemistry 1995) 2 3 4 25 60
  2. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (PMID: 19462432) Zucchelli M … D'Amato M (Inflammatory bowel diseases 2009) 3 22 45 60
  3. Oseltamivir (tamiflu) is a substrate of peptide transporter 1. (PMID: 19439487) Ogihara T … Tamai I (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 22 25 60
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) Knütter I … Brandsch M (The Journal of pharmacology and experimental therapeutics 2008) 3 22 25 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for SLC15A1 Gene

Sources for SLC15A1 Gene

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