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Aliases for BMP8B Gene

Aliases for BMP8B Gene

  • Bone Morphogenetic Protein 8b 2 3
  • Osteogenic Protein 2 2 3 4
  • Bone Morphogenetic Protein 8 (Osteogenic Protein 2) 2 3
  • BMP-8B 3 4
  • BMP-8 3 4
  • BMP8 3 4
  • OP2 3 6
  • DJ118J21.1 (Bone Morphogenetic Protein 8 (Osteogenic Protein 2)) 3
  • OP-2 4

External Ids for BMP8B Gene

Previous HGNC Symbols for BMP8B Gene

  • BMP8

Previous GeneCards Identifiers for BMP8B Gene

  • GC01M039638
  • GC01M039639
  • GC01M039892
  • GC01M039996
  • GC01M040222
  • GC01M038342

Summaries for BMP8B Gene

Entrez Gene Summary for BMP8B Gene

  • The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP8B Gene

BMP8B (Bone Morphogenetic Protein 8b) is a Protein Coding gene. Diseases associated with BMP8B include blue color blindness and color blindness. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and growth factor activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP8B Gene

  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).

Gene Wiki entry for BMP8B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP8B Gene

Genomics for BMP8B Gene

Regulatory Elements for BMP8B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BMP8B Gene

39,757,182 bp from pter
39,788,861 bp from pter
31,680 bases
Minus strand

Genomic View for BMP8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP8B Gene

Proteins for BMP8B Gene

  • Protein details for BMP8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone morphogenetic protein 8B
    Protein Accession:
    Secondary Accessions:
    • E7EMY8
    • Q32NE5
    • Q53ZM7
    • Q9NUF0

    Protein attributes for BMP8B Gene

    402 amino acids
    Molecular mass:
    44768 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for BMP8B Gene


neXtProt entry for BMP8B Gene

Proteomics data for BMP8B Gene at MOPED

Post-translational modifications for BMP8B Gene

  • Glycosylation at Asn158 and Asn343
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BMP8B Gene

Domains for BMP8B Gene

Gene Families for BMP8B Gene

  • BMP :Bone morphogenetic proteins
  • ENDOLIG :Endogenous ligands

Suggested Antigen Peptide Sequences for BMP8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P34820
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP8B: view

Function for BMP8B Gene

Molecular function for BMP8B Gene

UniProtKB/Swiss-Prot Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).

LifeMap Function Summary for BMP8B Gene

During embryonic development, BMP8B as signaling molecule is secreted from the following cells
It affects the following cells:
BMP8B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for BMP8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
GO:0070700 BMP receptor binding IBA --
genes like me logo Genes that share ontologies with BMP8B: view
genes like me logo Genes that share phenotypes with BMP8B: view

Animal Models for BMP8B Gene

MGI Knock Outs for BMP8B:

Animal Model Products

CRISPR Products

miRNA for BMP8B Gene

miRTarBase miRNAs that target BMP8B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP8B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BMP8B Gene

Localization for BMP8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP8B Gene


Subcellular locations from

Jensen Localization Image for BMP8B Gene COMPARTMENTS Subcellular localization image for BMP8B gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BMP8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with BMP8B: view

Pathways for BMP8B Gene

genes like me logo Genes that share pathways with BMP8B: view

Pathways by source for BMP8B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Growth Factors in human,mouse,rat
    • Hedgehog Signaling Pathway in human,mouse,rat
    • Neurogenesis in human,mouse,rat

Gene Ontology (GO) - Biological Process for BMP8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 1460021
GO:0001503 ossification IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0030154 cell differentiation --
GO:0030509 BMP signaling pathway IBA --
genes like me logo Genes that share ontologies with BMP8B: view

Compounds for BMP8B Gene

(1) HMDB Compounds for BMP8B Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with BMP8B: view

Transcripts for BMP8B Gene

Unigene Clusters for BMP8B Gene

Bone morphogenetic protein 8b:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP8B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BMP8B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP8B Gene

No ASD Table

Relevant External Links for BMP8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP8B Gene

mRNA expression in normal human tissues for BMP8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMP8B Gene

This gene is overexpressed in Nerve - Tibial (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMP8B Gene

SOURCE GeneReport for Unigene cluster for BMP8B Gene Hs.734367

genes like me logo Genes that share expressions with BMP8B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BMP8B Gene

Orthologs for BMP8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BMP8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BMP8B 35
  • 98.67 (n)
  • 98.51 (a)
BMP8B 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 75 (a)
BMP8A 35
  • 88.64 (n)
  • 87.06 (a)
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
-- 36
  • 85 (a)
LOC100855618 35
  • 89.56 (n)
  • 88.16 (a)
(Mus musculus)
Mammalia Bmp8a 36
  • 83 (a)
Bmp8b 16
Bmp8b 36
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves -- 36
  • 67 (a)
BMP8B 35
  • 76.04 (n)
  • 73.51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp8b 35
  • 66.58 (n)
  • 68.85 (a)
(Danio rerio)
Actinopterygii bmp8a 35
  • 63.61 (n)
  • 61.39 (a)
bmp8a 36
  • 51 (a)
Species with no ortholog for BMP8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BMP8B Gene

Gene Tree for BMP8B (if available)
Gene Tree for BMP8B (if available)

Paralogs for BMP8B Gene

Paralogs for BMP8B Gene

Selected SIMAP similar genes for BMP8B Gene using alignment to 3 proteins: Pseudogenes for BMP8B Gene

genes like me logo Genes that share paralogs with BMP8B: view

Variants for BMP8B Gene

Sequence variations from dbSNP and Humsavar for BMP8B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs179472 -- 39,764,664(+) CGTTG(C/G)TTTTC missense, reference
rs182799 -- 39,768,569(+) AAAAA(C/T)GTTCA intron-variant
rs230313 -- 39,765,887(+) aaaaa(A/T)ataaa intron-variant
rs230315 -- 39,766,478(+) ACAGG(C/T)CAAGG intron-variant
rs230316 -- 39,766,606(-) GTCAC(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP8B Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855
dgv15n27 CNV Gain 19166990
dgv215n71 CNV Loss 21882294
dgv49e1 CNV Complex 17122850
nsv871927 CNV Loss 21882294

Relevant External Links for BMP8B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP8B Gene

Disorders for BMP8B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BMP8B Gene including...

Search for BMP8B Gene in MalaCards »

(1) University of Copenhagen DISEASES for BMP8B Gene

Relevant External Links for BMP8B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BMP8B: view

No data available for UniProtKB/Swiss-Prot for BMP8B Gene

Publications for BMP8B Gene

  1. Osteogenic protein-2. A new member of the transforming growth factor- beta superfamily expressed early in embryogenesis. (PMID: 1460021) Oezkaynak E. … Oppermann H. (J. Biol. Chem. 1992) 2 3 4 23
  2. The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. (PMID: 9070944) DiLeone R.J. … Kingsley D.M. (Genomics 1997) 2 3
  3. Genetic variations in humans associated with differences in the course of hepatitis C. (PMID: 15063762) Saito T. … Kawata S. (Biochem. Biophys. Res. Commun. 2004) 3 48
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for BMP8B Gene

Sources for BMP8B Gene

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