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Aliases for SLC11A1 Gene

Aliases for SLC11A1 Gene

  • Solute Carrier Family 11 Member 1 2 3 4
  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1 2 3 5
  • NRAMP 1 3 4
  • NRAMP1 3 4
  • NRAMP 3 4
  • LSH 3 4
  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 3
  • Solute Carrier Family 11 (Sodium/Phosphate Symporters), Member 1 3
  • Natural Resistance-Associated Macrophage Protein 1 2

External Ids for SLC11A1 Gene

Previous HGNC Symbols for SLC11A1 Gene

  • LSH
  • NRAMP
  • NRAMP1

Previous GeneCards Identifiers for SLC11A1 Gene

  • GC02P217262
  • GC02P217968
  • GC02P219210
  • GC02P219450
  • GC02P219449
  • GC02P219072
  • GC02P218955
  • GC02P219246
  • GC02P211100

Summaries for SLC11A1 Gene

Entrez Gene Summary for SLC11A1 Gene

  • This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC11A1 Gene

SLC11A1 (Solute Carrier Family 11 Member 1) is a Protein Coding gene. Diseases associated with SLC11A1 include buruli ulcer and tuberculosis. Among its related pathways are Immune System and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and manganese ion transmembrane transporter activity. An important paralog of this gene is SLC11A2.

UniProtKB/Swiss-Prot for SLC11A1 Gene

  • Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Gene Wiki entry for SLC11A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC11A1 Gene

Genomics for SLC11A1 Gene

Regulatory Elements for SLC11A1 Gene

Promoters for SLC11A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC11A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC11A1 Gene

Chromosome:
2
Start:
218,381,766 bp from pter
End:
218,396,894 bp from pter
Size:
15,129 bases
Orientation:
Plus strand

Genomic View for SLC11A1 Gene

Genes around SLC11A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC11A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC11A1 Gene

Proteins for SLC11A1 Gene

  • Protein details for SLC11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49279-NRAM1_HUMAN
    Recommended name:
    Natural resistance-associated macrophage protein 1
    Protein Accession:
    P49279
    Secondary Accessions:
    • C0H5Y3

    Protein attributes for SLC11A1 Gene

    Size:
    550 amino acids
    Molecular mass:
    59872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC11A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC11A1 Gene

Proteomics data for SLC11A1 Gene at MOPED

Post-translational modifications for SLC11A1 Gene

  • Glycosylation at Asn 324 and Asn 338
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC11A1 Gene

Antibody Products

  • R&D Systems Antibodies for SLC11A1 (NRAMP1/SLC11A1)

No data available for DME Specific Peptides for SLC11A1 Gene

Domains & Families for SLC11A1 Gene

Gene Families for SLC11A1 Gene

Protein Domains for SLC11A1 Gene

Graphical View of Domain Structure for InterPro Entry

P49279

UniProtKB/Swiss-Prot:

NRAM1_HUMAN :
  • Belongs to the NRAMP family.
Family:
  • Belongs to the NRAMP family.
genes like me logo Genes that share domains with SLC11A1: view

Function for SLC11A1 Gene

Molecular function for SLC11A1 Gene

GENATLAS Biochemistry:
solute carrier family 11,member A1,proton-coupled divalent metal ion transporter family,natural resistance-associated macrophage protein 1,also expressed in liver,spleen with a polymorphism in the promoter region correlating with autoimmune versus infectious disease susceptibility
UniProtKB/Swiss-Prot Function:
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
UniProtKB/Swiss-Prot Induction:
In response to lymphokine or bacterial products.
genes like me logo Genes that share phenotypes with SLC11A1: view

Animal Models for SLC11A1 Gene

MGI Knock Outs for SLC11A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC11A1 Gene

Localization for SLC11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC11A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC11A1 Gene COMPARTMENTS Subcellular localization image for SLC11A1 gene
Compartment Confidence
endosome 5
plasma membrane 5
lysosome 4
vacuole 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009279 cell outer membrane IEA --
GO:0010008 endosome membrane IEA --
GO:0031902 late endosome membrane TAS --
genes like me logo Genes that share ontologies with SLC11A1: view

Pathways & Interactions for SLC11A1 Gene

genes like me logo Genes that share pathways with SLC11A1: view

Gene Ontology (GO) - Biological Process for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0001818 negative regulation of cytokine production IEA,ISS --
GO:0001819 positive regulation of cytokine production IEA,ISS --
GO:0002369 T cell cytokine production IEA,ISS --
GO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA,ISS --
genes like me logo Genes that share ontologies with SLC11A1: view

No data available for SIGNOR curated interactions for SLC11A1 Gene

Drugs & Compounds for SLC11A1 Gene

(8) Drugs for SLC11A1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32

(8) Additional Compounds for SLC11A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC11A1: view

Transcripts for SLC11A1 Gene

Unigene Clusters for SLC11A1 Gene

Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC11A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for SLC11A1 Gene

GeneLoc Exon Structure for
SLC11A1
ECgene alternative splicing isoforms for
SLC11A1

Expression for SLC11A1 Gene

mRNA expression in normal human tissues for SLC11A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC11A1 Gene

This gene is overexpressed in Whole Blood (x34.2).

Protein differential expression in normal tissues from HIPED for SLC11A1 Gene

This gene is overexpressed in Kidney (60.6) and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC11A1 Gene



SOURCE GeneReport for Unigene cluster for SLC11A1 Gene Hs.591607

mRNA Expression by UniProt/SwissProt for SLC11A1 Gene

P49279-NRAM1_HUMAN
Tissue specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver.
genes like me logo Genes that share expression patterns with SLC11A1: view

Protein tissue co-expression partners for SLC11A1 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC11A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC11A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC11A1 35
  • 99.64 (n)
  • 99.45 (a)
NRAMP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC11A1 36
  • 88 (a)
OneToOne
SLC11A1 35
  • 88.6 (n)
  • 89.58 (a)
dog
(Canis familiaris)
Mammalia SLC11A1 35
  • 88.85 (n)
  • 88.3 (a)
SLC11A1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc11a1 16
Slc11a1 35
  • 83.49 (n)
  • 87.66 (a)
Slc11a1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC11A1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC11A1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc11a1 35
  • 83.14 (n)
  • 86.76 (a)
chicken
(Gallus gallus)
Aves SLC11A1 36
  • 67 (a)
OneToOne
SLC11A1 35
  • 74.35 (n)
  • 72.96 (a)
lizard
(Anolis carolinensis)
Reptilia SLC11A1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc11a1 35
  • 69.11 (n)
  • 68.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mvl 36
  • 49 (a)
OneToMany
Mvl 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea smf-1 37
  • 53 (a)
smf-2 37
  • 52 (a)
smf-1 36
  • 46 (a)
ManyToMany
smf-2 36
  • 48 (a)
ManyToMany
smf-3 36
  • 49 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMF1 36
  • 25 (a)
ManyToMany
SMF2 36
  • 27 (a)
ManyToMany
SMF3 36
  • 29 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRAMP4 35
  • 54.36 (n)
  • 55.4 (a)
rice
(Oryza sativa)
Liliopsida Os03g0208500 35
  • 56.67 (n)
  • 54.68 (a)
Species with no ortholog for SLC11A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC11A1 Gene

ENSEMBL:
Gene Tree for SLC11A1 (if available)
TreeFam:
Gene Tree for SLC11A1 (if available)

Paralogs for SLC11A1 Gene

Paralogs for SLC11A1 Gene

(2) SIMAP similar genes for SLC11A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC11A1: view

Variants for SLC11A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC11A1 Gene

P49279-NRAM1_HUMAN
Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM:610446].

Sequence variations from dbSNP and Humsavar for SLC11A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_004629 -
rs201565523 - 218,390,027(+) GGCTG(C/T)GGTGA nc-transcript-variant, reference, missense
rs17235409 - 218,395,009(+) AAGAG(A/C/G)ACCAG reference, missense
rs1059824 -- 218,395,237(+) gagaC(A/G)CCACC utr-variant-3-prime
rs2045433 -- 218,392,965(-) GGTGA(A/G)CTCCT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC11A1 Gene

Variant ID Type Subtype PubMed ID
nsv519829 CNV Loss 19592680
nsv875855 CNV Loss 21882294
nsv3166 CNV Insertion 18451855
dgv4435n71 CNV Loss 21882294
nsv875858 CNV Loss 21882294

Variation tolerance for SLC11A1 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC11A1 Gene

HapMap Linkage Disequilibrium report
SLC11A1
Human Gene Mutation Database (HGMD)
SLC11A1

Disorders for SLC11A1 Gene

MalaCards: The human disease database

(23) MalaCards diseases for SLC11A1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
buruli ulcer
  • buruli ulcer disease
tuberculosis
  • tuberculosis of mother, with delivery
brucellosis
  • bang's disease
typhoid fever
  • diverticulosis of colon with hemorrhage
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC11A1

Genetic Association Database (GAD)
SLC11A1
Human Genome Epidemiology (HuGE) Navigator
SLC11A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC11A1
genes like me logo Genes that share disorders with SLC11A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC11A1 Gene

Publications for SLC11A1 Gene

  1. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. (PMID: 16103355) Malik S. … Schurr E. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23 48 67
  2. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. (PMID: 7964458) Cellier M. … Gros P. (J. Exp. Med. 1994) 2 3 23
  3. NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. (PMID: 19055603) Ates O. … Topal-Sarikaya A. (Int. J. Immunogenet. 2009) 3 23
  4. Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction. (PMID: 19474129) McDermid J.M. … Prentice A.M. (Am. J. Clin. Nutr. 2009) 3 23
  5. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. (PMID: 19723394) Velez D.R. … Scott W.K. (Int. J. Tuberc. Lung Dis. 2009) 3 23

Products for SLC11A1 Gene

Sources for SLC11A1 Gene

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