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Aliases for SLC9A5 Gene

Aliases for SLC9A5 Gene

  • Solute Carrier Family 9, Subfamily A (NHE5, Cation Proton Antiporter 5), Member 5 2 3
  • NHE5 3 4 6
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 5 2 3
  • Solute Carrier Family 9 Member 5 3 4
  • Na(+)/H(+) Exchanger 5 3 4
  • NHE-5 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 5 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3
  • Sodium/Hydrogen Exchanger 5 3

External Ids for SLC9A5 Gene

Summaries for SLC9A5 Gene

GeneCards Summary for SLC9A5 Gene

SLC9A5 (Solute Carrier Family 9, Subfamily A (NHE5, Cation Proton Antiporter 5), Member 5) is a Protein Coding gene. Diseases associated with SLC9A5 include familial paroxysmal kinesigenic dyskinesia. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sodium:proton antiporter activity. An important paralog of this gene is SLC9A4.

UniProtKB/Swiss-Prot for SLC9A5 Gene

  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

Gene Wiki entry for SLC9A5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A5 Gene

Genomics for SLC9A5 Gene

Genomic Location for SLC9A5 Gene

Start:
67,237,683 bp from pter
End:
67,272,191 bp from pter
Size:
34,509 bases
Orientation:
Plus strand

Genomic View for SLC9A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC9A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A5 Gene

Regulatory Elements for SLC9A5 Gene

Proteins for SLC9A5 Gene

  • Protein details for SLC9A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14940-SL9A5_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 5
    Protein Accession:
    Q14940
    Secondary Accessions:
    • A5PKY7
    • Q9Y626

    Protein attributes for SLC9A5 Gene

    Size:
    896 amino acids
    Molecular mass:
    99011 Da
    Quaternary structure:
    • Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2.

neXtProt entry for SLC9A5 Gene

Proteomics data for SLC9A5 Gene at MOPED

Post-translational modifications for SLC9A5 Gene

Other Protein References for SLC9A5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC9A5 Gene

Domains for SLC9A5 Gene

Gene Families for SLC9A5 Gene

UniProtKB/Swiss-Prot:

SL9A5_HUMAN
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.:
    • Q14940
genes like me logo Genes that share domains with SLC9A5: view

Function for SLC9A5 Gene

Molecular function for SLC9A5 Gene

GENATLAS Biochemistry: solute carrier protein family 9 (sodium/hydrogen exchange),member 5,involved in intracellular pH regulation and cell volume,isoform 5,expressed in multiple regions of the brains including hippocampus
UniProtKB/Swiss-Prot Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

Gene Ontology (GO) - Molecular Function for SLC9A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity --
GO:0015385 sodium:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9A5: view

Phenotypes for SLC9A5 Gene

GenomeRNAi human phenotypes for SLC9A5:
genes like me logo Genes that share phenotypes with SLC9A5: view

miRNA for SLC9A5 Gene

miRTarBase miRNAs that target SLC9A5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC9A5 Gene

Localization for SLC9A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC9A5 Gene COMPARTMENTS Subcellular localization image for SLC9A5 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC9A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC9A5: view

Pathways for SLC9A5 Gene

genes like me logo Genes that share pathways with SLC9A5: view

Gene Ontology (GO) - Biological Process for SLC9A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9933641
GO:0006811 ion transport TAS --
GO:0006812 cation transport --
GO:0006814 sodium ion transport --
GO:0006885 regulation of pH IEA --
genes like me logo Genes that share ontologies with SLC9A5: view

Compounds for SLC9A5 Gene

(1) HMDB Compounds for SLC9A5 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(3) Novoseek inferred chemical compound relationships for SLC9A5 Gene

Compound -log(P) Hits PubMed IDs
amiloride 55.4 3
sodium 22.5 2
hydrogen 16.3 2
genes like me logo Genes that share compounds with SLC9A5: view

Transcripts for SLC9A5 Gene

Unigene Clusters for SLC9A5 Gene

Solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5:

Relevant External Links for SLC9A5 Gene

GeneLoc Exon Structure for
SLC9A5
ECgene alternative splicing isoforms for
SLC9A5

Expression for SLC9A5 Gene

mRNA expression in normal human tissues for SLC9A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC9A5 Gene

This gene is overexpressed in Spleen (7.6), Brain - Cerebellum (5.5), and Brain - Cerebellar Hemisphere (4.6).

SOURCE GeneReport for Unigene cluster for SLC9A5 Gene Hs.439650

mRNA Expression by UniProt/SwissProt for SLC9A5 Gene

Q14940-SL9A5_HUMAN
Tissue specificity: Expressed in brain, testis, spleen, and skeletal muscle
genes like me logo Genes that share expressions with SLC9A5: view

Orthologs for SLC9A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC9A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC9A5 36
  • 98.01 (n)
  • 97.41 (a)
SLC9A5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC9A5 36
  • 92.67 (n)
  • 96.01 (a)
SLC9A5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9A5 36
  • 92.93 (n)
  • 95.55 (a)
SLC9A5 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9a5 36
  • 90.31 (n)
  • 95.78 (a)
Slc9a5 16
Slc9a5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9A5 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A5 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9a5 36
  • 90.19 (n)
  • 95.67 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 75 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
SLC9A5 36
  • 74.2 (n)
  • 76.92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a5 36
  • 66.55 (n)
  • 71.14 (a)
zebrafish
(Danio rerio)
Actinopterygii slc9a5 36
  • 64.3 (n)
  • 64.01 (a)
slc9a5 37
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009036 36
  • 53.64 (n)
  • 47.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nhe2 36
  • 53.26 (n)
  • 45.47 (a)
worm
(Caenorhabditis elegans)
Secernentea nhx-4 37
  • 24 (a)
ManyToMany
pbo-4 37
  • 28 (a)
ManyToMany
nhx-9 38
  • 43 (a)
nhx-7 38
  • 35 (a)
nhx-6 38
  • 38 (a)
nhx-3 38
  • 44 (a)
nhx-2 38
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHX1 37
  • 21 (a)
OneToMany
Species with no ortholog for SLC9A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A5 Gene

ENSEMBL:
Gene Tree for SLC9A5 (if available)
TreeFam:
Gene Tree for SLC9A5 (if available)

Paralogs for SLC9A5 Gene

Paralogs for SLC9A5 Gene

Selected SIMAP similar genes for SLC9A5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC9A5: view

Variants for SLC9A5 Gene

Sequence variations from dbSNP and Humsavar for SLC9A5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs786358 -- 67,272,160(+) CTTGA(A/C)CCTAA utr-variant-3-prime
rs1061356 -- 67,271,012(+) CACCT(A/G)CCTTC reference, synonymous-codon
rs1061357 -- 67,271,087(+) AGCAG(C/T)GCTGA reference, synonymous-codon
rs1061358 -- 67,272,031(+) ACAGA(G/T)AAGGA utr-variant-3-prime
rs1061359 -- 67,272,042(+) ACCCA(G/T)CATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC9A5 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990
esv2668436 CNV Deletion 23128226
esv9318 CNV Gain 19470904
nsv819753 CNV Gain 19587683

Relevant External Links for SLC9A5 Gene

HapMap Linkage Disequilibrium report
SLC9A5

Disorders for SLC9A5 Gene

(1) University of Copenhagen DISEASES for SLC9A5 Gene

Relevant External Links for SLC9A5

Genetic Association Database (GAD)
SLC9A5
genes like me logo Genes that share disorders with SLC9A5: view

No data available for UniProtKB/Swiss-Prot for SLC9A5 Gene

Publications for SLC9A5 Gene

  1. Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. (PMID: 9933641) Baird N.R. … Shull G.E. (J. Biol. Chem. 1999) 3 4 23
  2. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. (PMID: 9933642) Attaphitaya S. … Melvin J.E. (J. Biol. Chem. 1999) 2 3 23
  3. Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. (PMID: 7759094) Klanke C.A. … Menon A.G. (Genomics 1995) 2 3 4
  4. beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. (PMID: 15699339) Szabo E.Z. … Orlowski J. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4
  5. RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. (PMID: 16920332) Onishi I. … Numata M. (Cell. Signal. 2007) 3 23

Products for SLC9A5 Gene

Sources for SLC9A5 Gene

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