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Aliases for BMP7 Gene

Aliases for BMP7 Gene

  • Bone Morphogenetic Protein 7 2 3 5
  • Osteogenic Protein 1 2 3 4
  • OP-1 3 4
  • Eptotermin Alfa 4
  • BMP-7 4
  • OP1 4

External Ids for BMP7 Gene

Previous GeneCards Identifiers for BMP7 Gene

  • GC20M055473
  • GC20M056382
  • GC20M056430
  • GC20M055178
  • GC20M055743
  • GC20M052525

Summaries for BMP7 Gene

Entrez Gene Summary for BMP7 Gene

  • This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for BMP7 Gene

BMP7 (Bone Morphogenetic Protein 7) is a Protein Coding gene. Diseases associated with BMP7 include ureteral obstruction and renal fibrosis. Among its related pathways are Degradation of the extracellular matrix and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP7 Gene

  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Gene Wiki entry for BMP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP7 Gene

Genomics for BMP7 Gene

Regulatory Elements for BMP7 Gene

Genomic Location for BMP7 Gene

Chromosome:
20
Start:
57,168,748 bp from pter
End:
57,266,651 bp from pter
Size:
97,904 bases
Orientation:
Minus strand

Genomic View for BMP7 Gene

Genes around BMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP7 Gene

Proteins for BMP7 Gene

  • Protein details for BMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18075-BMP7_HUMAN
    Recommended name:
    Bone morphogenetic protein 7
    Protein Accession:
    P18075
    Secondary Accessions:
    • Q9H512
    • Q9NTQ7

    Protein attributes for BMP7 Gene

    Size:
    431 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for BMP7 Gene

neXtProt entry for BMP7 Gene

Proteomics data for BMP7 Gene at MOPED

Post-translational modifications for BMP7 Gene

  • Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
  • Glycosylation at Asn 187, Asn 302, Asn 321, and Asn 372
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BMP7 (BMP7)

No data available for DME Specific Peptides for BMP7 Gene

Domains & Families for BMP7 Gene

Graphical View of Domain Structure for InterPro Entry

P18075

UniProtKB/Swiss-Prot:

BMP7_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP7: view

Function for BMP7 Gene

Molecular function for BMP7 Gene

GENATLAS Biochemistry:
bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)
UniProtKB/Swiss-Prot Function:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

LifeMap Function Summary for BMP7 Gene

During embryonic development, BMP7 as signaling molecule is secreted from the following cells
It affects the following cells:
BMP7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with BMP7: view

Animal Models for BMP7 Gene

MGI Knock Outs for BMP7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BMP7 Gene

Localization for BMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP7 Gene COMPARTMENTS Subcellular localization image for BMP7 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for BMP7 Gene

Pathways & Interactions for BMP7 Gene

genes like me logo Genes that share pathways with BMP7: view

SIGNOR curated interactions for BMP7 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 2357959
GO:0001503 ossification IEA --
GO:0001654 eye development IEA --
GO:0001656 metanephros development IEP 18437684
GO:0001657 ureteric bud development IEA,ISS --
genes like me logo Genes that share ontologies with BMP7: view

Drugs & Compounds for BMP7 Gene

(17) Drugs for BMP7 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(24) Additional Compounds for BMP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BMP7: view

Transcripts for BMP7 Gene

Unigene Clusters for BMP7 Gene

Bone morphogenetic protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for BMP7 Gene

GeneLoc Exon Structure for
BMP7
ECgene alternative splicing isoforms for
BMP7

Expression for BMP7 Gene

mRNA expression in normal human tissues for BMP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BMP7 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BMP7 Gene



SOURCE GeneReport for Unigene cluster for BMP7 Gene Hs.473163

mRNA Expression by UniProt/SwissProt for BMP7 Gene

P18075-BMP7_HUMAN
Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain.
genes like me logo Genes that share expression patterns with BMP7: view

Protein tissue co-expression partners for BMP7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BMP7 Gene

Orthologs for BMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP7 36
  • 100 (a)
OneToOne
BMP7 35
  • 99.77 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia BMP7 35
  • 92.73 (n)
  • 97.91 (a)
BMP7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP7 36
  • 97 (a)
OneToOne
BMP7 35
  • 92.5 (n)
  • 95.82 (a)
mouse
(Mus musculus)
Mammalia Bmp7 36
  • 98 (a)
OneToOne
Bmp7 16
Bmp7 35
  • 90.31 (n)
  • 96.98 (a)
oppossum
(Monodelphis domestica)
Mammalia BMP7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp7 35
  • 89.84 (n)
  • 96.98 (a)
chicken
(Gallus gallus)
Aves BMP7 35
  • 81.72 (n)
  • 89.81 (a)
BMP7 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMP7 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia bmp7-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp7.1 35
  • 76.11 (n)
  • 85.47 (a)
MGC76016 35
zebrafish
(Danio rerio)
Actinopterygii bmp7b 36
  • 80 (a)
OneToOne
bmp7b 35
  • 77.45 (n)
  • 82.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000824 35
  • 50.86 (n)
  • 38.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta gbb 37
  • 35 (a)
scw 37
  • 29 (a)
gbb 35
  • 54.7 (n)
  • 40.1 (a)
worm
(Caenorhabditis elegans)
Secernentea dbl-1 37
  • 32 (a)
Species with no ortholog for BMP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP7 Gene

ENSEMBL:
Gene Tree for BMP7 (if available)
TreeFam:
Gene Tree for BMP7 (if available)

Paralogs for BMP7 Gene

Paralogs for BMP7 Gene

(10) SIMAP similar genes for BMP7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BMP7: view

Variants for BMP7 Gene

Sequence variations from dbSNP and Humsavar for BMP7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_064058 -
rs61733438 - 57,175,004(+) TGCTG(C/T)TCTCT reference, missense
rs12622 -- 57,170,588(-) GGGGC(A/G)TGGCA utr-variant-3-prime
rs230202 -- 57,216,402(+) GAGAT(C/T)GTCAA intron-variant
rs230203 -- 57,216,559(+) GGCTG(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP7 Gene

Variant ID Type Subtype PubMed ID
nsv912957 CNV Loss 21882294
nsv523091 CNV Loss 19592680
esv2722598 CNV Deletion 23290073
esv2722599 CNV Deletion 23290073
esv1010828 CNV Deletion 20482838
esv2722600 CNV Deletion 23290073
esv1062572 CNV Deletion 17803354
esv2668178 CNV Deletion 23128226
esv2673209 CNV Deletion 23128226
esv24660 CNV Loss 19812545

Variation tolerance for BMP7 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMP7 Gene

HapMap Linkage Disequilibrium report
BMP7
Human Gene Mutation Database (HGMD)
BMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP7 Gene

Disorders for BMP7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for BMP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ureteral obstruction
renal fibrosis
osteochondritis dissecans
  • obsessive-compulsive disorder
keshan disease
  • caused by deficiency of selenium in the diet
blue color blindness
  • tritan defect
- elite association - COSMIC cancer census association via MalaCards
Search BMP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMP7

Genetic Association Database (GAD)
BMP7
Human Genome Epidemiology (HuGE) Navigator
BMP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMP7
genes like me logo Genes that share disorders with BMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP7 Gene

Publications for BMP7 Gene

  1. Expression and characterization of a human BMP-7 variant with improved biochemical properties. (PMID: 17977014) Swencki-Underwood B. … Amegadzie B. (Protein Expr. Purif. 2008) 3 4 23 67
  2. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. (PMID: 20126477) Morrissey C. … Corey E. (Neoplasia 2010) 3 23
  3. Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells. (PMID: 19108831) Shi J. … Taketani Y. (Fertil. Steril. 2010) 3 23
  4. The role of BMP-7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro. (PMID: 19950204) Shen B. … Diwan A.D. (J. Cell. Biochem. 2010) 3 23
  5. Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. (PMID: 20085912) Kodama A. … Taketani Y. (Hum. Reprod. 2010) 3 23

Products for BMP7 Gene

Sources for BMP7 Gene

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