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Aliases for BMP7 Gene

Aliases for BMP7 Gene

  • Bone Morphogenetic Protein 7 2 3
  • Osteogenic Protein 1 2 3 4
  • OP-1 3 4
  • Eptotermin Alfa 4
  • BMP-7 4
  • OP1 4

External Ids for BMP7 Gene

Previous GeneCards Identifiers for BMP7 Gene

  • GC20M055473
  • GC20M056382
  • GC20M056430
  • GC20M055178
  • GC20M055743
  • GC20M052525

Summaries for BMP7 Gene

Entrez Gene Summary for BMP7 Gene

  • The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP7 Gene

BMP7 (Bone Morphogenetic Protein 7) is a Protein Coding gene. Diseases associated with BMP7 include spondylolisthesis and ureteral obstruction. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and growth factor activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP7 Gene

  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

Gene Wiki entry for BMP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP7 Gene

Genomics for BMP7 Gene

Regulatory Elements for BMP7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BMP7 Gene

57,168,748 bp from pter
57,266,651 bp from pter
97,904 bases
Minus strand

Genomic View for BMP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP7 Gene

Proteins for BMP7 Gene

  • Protein details for BMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone morphogenetic protein 7
    Protein Accession:
    Secondary Accessions:
    • Q9H512
    • Q9NTQ7

    Protein attributes for BMP7 Gene

    431 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for BMP7 Gene

neXtProt entry for BMP7 Gene

Proteomics data for BMP7 Gene at MOPED

Post-translational modifications for BMP7 Gene

  • Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
  • Glycosylation at Asn187, Asn302, Asn321, and Asn372
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BMP7 (BMP7)

Protein Products

No data available for DME Specific Peptides for BMP7 Gene

Domains for BMP7 Gene

Gene Families for BMP7 Gene

  • BMP :Bone morphogenetic proteins
  • ENDOLIG :Endogenous ligands

Graphical View of Domain Structure for InterPro Entry



  • P18075
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP7: view

Function for BMP7 Gene

Molecular function for BMP7 Gene

GENATLAS Biochemistry:
bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)
UniProtKB/Swiss-Prot Function:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

LifeMap Function Summary for BMP7 Gene

During embryonic development, BMP7 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding IPI 18184661
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with BMP7: view
genes like me logo Genes that share phenotypes with BMP7: view

Animal Models for BMP7 Gene

MGI Knock Outs for BMP7:

Animal Model Products

miRNA for BMP7 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BMP7 Gene

Localization for BMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP7 Gene


Subcellular locations from

Jensen Localization Image for BMP7 Gene COMPARTMENTS Subcellular localization image for BMP7 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 17977014
GO:0031012 extracellular matrix IEA --
GO:0031988 membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with BMP7: view

Pathways for BMP7 Gene

genes like me logo Genes that share pathways with BMP7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 2357959
GO:0001503 ossification IEA --
GO:0001654 eye development --
GO:0001656 metanephros development IEP 18437684
GO:0001657 ureteric bud development ISS --
genes like me logo Genes that share ontologies with BMP7: view

Compounds for BMP7 Gene


Pharmaceutical: Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible

(1) HMDB Compounds for BMP7 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(41) Novoseek inferred chemical compound relationships for BMP7 Gene

Compound -log(P) Hits PubMed IDs
ursinus 76.2 9
safran 65.8 2
alginate 61.3 17
safranin o 53.6 3
pirfenidone 49.2 2
genes like me logo Genes that share compounds with BMP7: view

Transcripts for BMP7 Gene

Unigene Clusters for BMP7 Gene

Bone morphogenetic protein 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP8: -

Relevant External Links for BMP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP7 Gene

mRNA expression in normal human tissues for BMP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BMP7 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BMP7 Gene

SOURCE GeneReport for Unigene cluster for BMP7 Gene Hs.473163

mRNA Expression by UniProt/SwissProt for BMP7 Gene

Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain
genes like me logo Genes that share expressions with BMP7: view

Expression partners for BMP7 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BMP7 Gene

Orthologs for BMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BMP7 35
  • 92.73 (n)
  • 97.91 (a)
BMP7 36
  • 98 (a)
(Canis familiaris)
Mammalia BMP7 35
  • 92.5 (n)
  • 95.82 (a)
BMP7 36
  • 97 (a)
(Mus musculus)
Mammalia Bmp7 35
  • 90.31 (n)
  • 96.98 (a)
Bmp7 16
Bmp7 36
  • 98 (a)
(Pan troglodytes)
Mammalia BMP7 35
  • 99.77 (n)
  • 100 (a)
BMP7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bmp7 35
  • 89.84 (n)
  • 96.98 (a)
(Monodelphis domestica)
Mammalia BMP7 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia BMP7 36
  • 91 (a)
(Gallus gallus)
Aves BMP7 35
  • 81.72 (n)
  • 89.81 (a)
BMP7 36
  • 90 (a)
(Anolis carolinensis)
Reptilia BMP7 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp7.1 35
  • 76.11 (n)
  • 85.47 (a)
MGC76016 35
African clawed frog
(Xenopus laevis)
Amphibia bmp7-prov 35
(Danio rerio)
Actinopterygii bmp7b 35
  • 77.45 (n)
  • 82.48 (a)
bmp7b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta gbb 37
  • 35 (a)
scw 37
  • 29 (a)
gbb 35
  • 54.7 (n)
  • 40.1 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000824 35
  • 50.86 (n)
  • 38.63 (a)
(Caenorhabditis elegans)
Secernentea dbl-1 37
  • 32 (a)
Species with no ortholog for BMP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP7 Gene

Gene Tree for BMP7 (if available)
Gene Tree for BMP7 (if available)

Paralogs for BMP7 Gene

Paralogs for BMP7 Gene

Selected SIMAP similar genes for BMP7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BMP7: view

Variants for BMP7 Gene

Sequence variations from dbSNP and Humsavar for BMP7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs10375 -- 57,170,625(-) GCGCC(C/T)ACCAG utr-variant-3-prime
rs12438 -- 57,168,849(-) CTCAC(A/G)GCTGT utr-variant-3-prime
rs12622 -- 57,170,588(-) GGGGC(A/G)TGGCA utr-variant-3-prime
rs46995 -- 57,219,693(-) CCTCA(C/T)CCTAG intron-variant
rs46997 -- 57,217,072(+) GGAGG(C/T)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP7 Gene

Variant ID Type Subtype PubMed ID
nsv912957 CNV Loss 21882294
nsv523091 CNV Loss 19592680
esv2722598 CNV Deletion 23290073
esv2722599 CNV Deletion 23290073
esv1010828 CNV Deletion 20482838
esv2722600 CNV Deletion 23290073
esv1062572 CNV Deletion 17803354
esv2668178 CNV Deletion 23128226
esv2673209 CNV Deletion 23128226
esv24660 CNV Loss 19812545

Relevant External Links for BMP7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP7 Gene

Disorders for BMP7 Gene

(5) University of Copenhagen DISEASES for BMP7 Gene

(68) Novoseek inferred disease relationships for BMP7 Gene

Disease -log(P) Hits PubMed IDs
renal fibrosis 72.6 12
degenerative spondylolisthesis 65.8 8
furcation defects 64.4 3
spondylolisthesis 43 3
arthrodesis 42.9 12

Relevant External Links for BMP7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BMP7: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for BMP7 Gene

Publications for BMP7 Gene

  1. Expression and characterization of a human BMP-7 variant with improved biochemical properties. (PMID: 17977014) Swencki-Underwood B. … Amegadzie B. (Protein Expr. Purif. 2008) 3 4 23
  2. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. (PMID: 19453255) Freedman B.I. … Carr J.J. (J. Bone Miner. Res. 2009) 3 23 48
  3. Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. (PMID: 20085912) Kodama A. … Taketani Y. (Hum. Reprod. 2010) 3 23
  4. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression. (PMID: 20093492) Luo D.D. … Fraser D. (Am. J. Pathol. 2010) 3 23
  5. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. (PMID: 20126477) Morrissey C. … Corey E. (Neoplasia 2010) 3 23

Products for BMP7 Gene

Sources for BMP7 Gene

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