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Aliases for SLC7A4 Gene

Aliases for SLC7A4 Gene

  • Solute Carrier Family 7, Member 4 2 3
  • CAT4 3 4 6
  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 4 2 3
  • Solute Carrier Family 7 (Orphan Transporter), Member 4 2 3
  • Solute Carrier Family 7 Member 4 3 4
  • CAT-4 3 4
  • Cationic Amino Acid Transporter 4 3
  • Ig Heavy Chain Variable Region 3
  • VH 3 Family 3
  • HCAT3 3
  • VH 3

External Ids for SLC7A4 Gene

Summaries for SLC7A4 Gene

GeneCards Summary for SLC7A4 Gene

SLC7A4 (Solute Carrier Family 7, Member 4) is a Protein Coding gene. Diseases associated with SLC7A4 include chronic lymphocytic leukemia. GO annotations related to this gene include basic amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A3.

UniProtKB/Swiss-Prot for SLC7A4 Gene

  • Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

Gene Wiki entry for SLC7A4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A4 Gene

Genomics for SLC7A4 Gene

Genomic Location for SLC7A4 Gene

Start:
21,028,718 bp from pter
End:
21,032,874 bp from pter
Size:
4,157 bases
Orientation:
Minus strand

Genomic View for SLC7A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A4 Gene

Regulatory Elements for SLC7A4 Gene

Proteins for SLC7A4 Gene

  • Protein details for SLC7A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43246-CTR4_HUMAN
    Recommended name:
    Cationic amino acid transporter 4
    Protein Accession:
    O43246
    Secondary Accessions:
    • Q0P5U2
    • Q3KNQ6
    • Q4VC45
    • Q6IBY8
    • Q96H88

    Protein attributes for SLC7A4 Gene

    Size:
    635 amino acids
    Molecular mass:
    68268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC7A4 Gene

Proteomics data for SLC7A4 Gene at MOPED

Post-translational modifications for SLC7A4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn151, Asn195, Asn221, Asn500, and Asn601

Other Protein References for SLC7A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A4 Gene

Domains for SLC7A4 Gene

Gene Families for SLC7A4 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC7A4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CTR4_HUMAN
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.:
    • O43246
genes like me logo Genes that share domains with SLC7A4: view

Function for SLC7A4 Gene

Molecular function for SLC7A4 Gene

GENATLAS Biochemistry: solute carrier family 7,member A4,high affinity sodium independent,cationic amino-acid transporter,y+ type
UniProtKB/Swiss-Prot Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

Gene Ontology (GO) - Molecular Function for SLC7A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 L-ornithine transmembrane transporter activity IBA --
GO:0015171 amino acid transmembrane transporter activity --
GO:0015174 basic amino acid transmembrane transporter activity TAS 9598310
GO:0015181 arginine transmembrane transporter activity IBA --
GO:0015189 L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC7A4 Gene

Localization for SLC7A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A4 Gene COMPARTMENTS Subcellular localization image for SLC7A4 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC7A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 9598310
genes like me logo Genes that share ontologies with SLC7A4: view

Pathways for SLC7A4 Gene

SuperPathways for SLC7A4 Gene

No Data Available

Interacting Proteins for SLC7A4 Gene

Gene Ontology (GO) - Biological Process for SLC7A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport --
GO:0006520 cellular amino acid metabolic process TAS 9598310
GO:0006810 transport TAS 9598310
GO:0015802 basic amino acid transport --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC7A4: view

No data available for Pathways by source for SLC7A4 Gene

Compounds for SLC7A4 Gene

(3) Drugbank Compounds for SLC7A4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Arginine
  • (S)-2-Amino-5-guanidinovaleric acid
74-79-3 target
L-Lysine
  • (S)-2,6-diaminohexanoic acid
56-87-1 target
L-Ornithine
  • (S)-2,5-Diaminopentanoate
70-26-8 target
genes like me logo Genes that share compounds with SLC7A4: view

Transcripts for SLC7A4 Gene

mRNA/cDNA for SLC7A4 Gene

Unigene Clusters for SLC7A4 Gene

Solute carrier family 7 (orphan transporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A4 Gene

No ASD Table

Relevant External Links for SLC7A4 Gene

GeneLoc Exon Structure for
SLC7A4
ECgene alternative splicing isoforms for
SLC7A4

Expression for SLC7A4 Gene

mRNA expression in normal human tissues for SLC7A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A4 Gene

This gene is overexpressed in Testis (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC7A4 Gene

SOURCE GeneReport for Unigene cluster for SLC7A4 Gene Hs.197116

genes like me logo Genes that share expressions with SLC7A4: view

Orthologs for SLC7A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A4 36
  • 99.27 (n)
  • 99.21 (a)
SLC7A4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC7A4 36
  • 80.44 (n)
  • 74.96 (a)
SLC7A4 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A4 36
  • 83.79 (n)
  • 80.06 (a)
SLC7A4 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a4 36
  • 81.63 (n)
  • 81.42 (a)
Slc7a4 16
Slc7a4 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A4 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a4 36
  • 81.63 (n)
  • 81.73 (a)
chicken
(Gallus gallus)
Aves SLC7A4 36
  • 73.11 (n)
  • 71.95 (a)
SLC7A4 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A4 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a4 36
  • 67.58 (n)
  • 76.76 (a)
zebrafish
(Danio rerio)
Actinopterygii slc7a4 36
slc7a4 36
  • 64.74 (n)
  • 66.4 (a)
slc7a4 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010567 36
  • 55.38 (n)
  • 48.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13248 36
  • 54.38 (n)
  • 45.16 (a)
CG7255 37
  • 22 (a)
ManyToMany
CG13248 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.12 37
  • 16 (a)
OneToOne
F23F1.6 38
  • 37 (a)
C50D2.2 38
  • 40 (a)
B0454.6 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HIP1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
Species with no ortholog for SLC7A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A4 Gene

ENSEMBL:
Gene Tree for SLC7A4 (if available)
TreeFam:
Gene Tree for SLC7A4 (if available)

Paralogs for SLC7A4 Gene

Paralogs for SLC7A4 Gene

Selected SIMAP similar genes for SLC7A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC7A4: view

Variants for SLC7A4 Gene

Sequence variations from dbSNP and Humsavar for SLC7A4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs402931 -- 21,031,696(+) TCCAG(C/T)GTGGA synonymous-codon, reference, intron-variant
rs1061255 -- 21,031,579(-) GTGGC(A/C/T)GCTGT synonymous-codon, reference, intron-variant
rs2072549 -- 21,031,554(+) GCATA(A/G)GGCTG reference, synonymous-codon, intron-variant
rs2072550 - 21,031,730(+) CCATG(A/G)TGGAG reference, missense, intron-variant
rs2075279 -- 21,029,023(+) CAGGT(A/G)TGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC7A4 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
nsv914423 CNV Gain 21882294
nsv828960 CNV Loss 20364138
nsv471185 CNV Loss 18288195
nsv834142 CNV Gain 17160897
nsv3563 CNV Loss 18451855
nsv914429 CNV Gain 21882294

Relevant External Links for SLC7A4 Gene

HapMap Linkage Disequilibrium report
SLC7A4

Disorders for SLC7A4 Gene

Relevant External Links for SLC7A4

Human Genome Epidemiology (HuGE) Navigator
SLC7A4
genes like me logo Genes that share disorders with SLC7A4: view

No data available for UniProtKB/Swiss-Prot for SLC7A4 Gene

Publications for SLC7A4 Gene

  1. The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome. (PMID: 9598310) Sperandeo M.P. … Sebastio G. (Genomics 1998) 2 3 4 23
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4. (PMID: 11665818) Hammermann R. … RackAc K. (Amino Acids 2001) 2 3
  5. Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity. (PMID: 12049641) Wolf S. … Closs E.I. (Biochem. J. 2002) 3

Products for SLC7A4 Gene

Sources for SLC7A4 Gene

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