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Aliases for SLC7A1 Gene

Aliases for SLC7A1 Gene

  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 1 2 3
  • ATRC1 3 4 6
  • Ecotropic Retroviral Leukemia Receptor Homolog 3 4
  • System Y+ Basic Amino Acid Transporter 3 4
  • Ecotropic Retrovirus Receptor Homolog 3 4
  • Solute Carrier Family 7 Member 1 3 4
  • Ecotropic Retroviral Receptor 2 3
  • CAT-1 3 4
  • REC1L 3 4
  • CAT1 3 4
  • ERR 3 4
  • High Affinity Cationic Amino Acid Transporter 1 3
  • Amino Acid Transporter, Cationic 1 3
  • Amino Acid Transporter 2
  • Cationic 1 2
  • HCAT1 3

External Ids for SLC7A1 Gene

Previous HGNC Symbols for SLC7A1 Gene

  • ERR
  • ATRC1

Previous GeneCards Identifiers for SLC7A1 Gene

  • GC13M028068
  • GC13M024068
  • GC13M029016
  • GC13M027886
  • GC13M027884
  • GC13M028984
  • GC13M030083
  • GC13M010903

Summaries for SLC7A1 Gene

GeneCards Summary for SLC7A1 Gene

SLC7A1 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 1) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and MicroRNAs in cancer. GO annotations related to this gene include arginine transmembrane transporter activity. An important paralog of this gene is SLC7A3.

UniProtKB/Swiss-Prot for SLC7A1 Gene

  • High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

Gene Wiki entry for SLC7A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A1 Gene

Genomics for SLC7A1 Gene

Regulatory Elements for SLC7A1 Gene

Genomic Location for SLC7A1 Gene

Start:
29,509,410 bp from pter
End:
29,595,688 bp from pter
Size:
86,279 bases
Orientation:
Minus strand

Genomic View for SLC7A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A1 Gene

Proteins for SLC7A1 Gene

  • Protein details for SLC7A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30825-CTR1_HUMAN
    Recommended name:
    High affinity cationic amino acid transporter 1
    Protein Accession:
    P30825
    Secondary Accessions:
    • Q5JR50

    Protein attributes for SLC7A1 Gene

    Size:
    629 amino acids
    Molecular mass:
    67638 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC7A1 Gene

Proteomics data for SLC7A1 Gene at MOPED

Post-translational modifications for SLC7A1 Gene

  • Ubiquitination at Lys4 and Lys484
  • Glycosylation at Asn216, Asn226, and Asn235
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC7A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A1 Gene

Domains for SLC7A1 Gene

Gene Families for SLC7A1 Gene

Protein Domains for SLC7A1 Gene

Suggested Antigen Peptide Sequences for SLC7A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30825

UniProtKB/Swiss-Prot:

CTR1_HUMAN :
  • P30825
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
genes like me logo Genes that share domains with SLC7A1: view

Function for SLC7A1 Gene

Molecular function for SLC7A1 Gene

GENATLAS Biochemistry: solute carrier family 7,member A1,high affinity sodium independent,cationic amino-acid transporter,y+ type
UniProtKB/Swiss-Prot Function: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

Gene Ontology (GO) - Molecular Function for SLC7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 L-ornithine transmembrane transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0015171 amino acid transmembrane transporter activity --
GO:0015181 arginine transmembrane transporter activity IBA --
GO:0015189 L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A1: view

Phenotypes for SLC7A1 Gene

genes like me logo Genes that share phenotypes with SLC7A1: view

Animal Models for SLC7A1 Gene

MGI Knock Outs for SLC7A1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC7A1 Gene

Localization for SLC7A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A1 Gene COMPARTMENTS Subcellular localization image for SLC7A1 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1718082
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC7A1: view

Pathways for SLC7A1 Gene

genes like me logo Genes that share pathways with SLC7A1: view

Gene Ontology (GO) - Biological Process for SLC7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport --
GO:0006810 transport NAS 1348489
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015809 arginine transport --
genes like me logo Genes that share ontologies with SLC7A1: view

Compounds for SLC7A1 Gene

(1) HMDB Compounds for SLC7A1 Gene

Compound Synonyms Cas Number PubMed IDs
L-Arginine
  • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
74-79-3

(3) Drugbank Compounds for SLC7A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Arginine
  • (S)-2-Amino-5-guanidinovaleric acid
74-79-3 target
L-Lysine
  • (S)-2,6-diaminohexanoic acid
56-87-1 target
L-Ornithine
  • (S)-2,5-Diaminopentanoate
70-26-8 target

(13) Novoseek inferred chemical compound relationships for SLC7A1 Gene

Compound -log(P) Hits PubMed IDs
arginine 77.5 53
adma 69.2 3
citrulline 66 1
ornithine 60.4 12
lysine 58.7 11
genes like me logo Genes that share compounds with SLC7A1: view

Transcripts for SLC7A1 Gene

mRNA/cDNA for SLC7A1 Gene

Unigene Clusters for SLC7A1 Gene

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A1 Gene

No ASD Table

Relevant External Links for SLC7A1 Gene

GeneLoc Exon Structure for
SLC7A1
ECgene alternative splicing isoforms for
SLC7A1

Expression for SLC7A1 Gene

mRNA expression in normal human tissues for SLC7A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A1 Gene

This gene is overexpressed in Esophagus - Mucosa (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC7A1 Gene

SOURCE GeneReport for Unigene cluster for SLC7A1 Gene Hs.14846

mRNA Expression by UniProt/SwissProt for SLC7A1 Gene

P30825-CTR1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SLC7A1: view

Orthologs for SLC7A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC7A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A1 35
  • 99.36 (n)
  • 99.84 (a)
SLC7A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC7A1 35
  • 86.06 (n)
  • 91.26 (a)
SLC7A1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A1 35
  • 87.76 (n)
  • 91.41 (a)
SLC7A1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a1 35
  • 84.46 (n)
  • 87.62 (a)
Slc7a1 16
Slc7a1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a1 35
  • 85.52 (n)
  • 88.46 (a)
chicken
(Gallus gallus)
Aves CAT-1 36
  • 77 (a)
OneToOne
SLC7A1 35
  • 72.2 (n)
  • 77.26 (a)
lizard
(Anolis carolinensis)
Reptilia SLC7A1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a1 35
  • 68.3 (n)
  • 74.18 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26583 35
slc7a1 35
  • 67.67 (n)
  • 72.21 (a)
slc7a1 36
  • 67 (a)
OneToMany
SLC7A1 (2 of 2) 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta slif 35
  • 56.16 (n)
  • 49.12 (a)
CG13248 37
  • 39 (a)
CG11128 37
  • 45 (a)
CG7255 37
  • 45 (a)
CG5535 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea F23F1.6 37
  • 35 (a)
C50D2.2 37
  • 39 (a)
B0454.6 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAT4 35
  • 47.54 (n)
  • 39.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for SLC7A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A1 Gene

ENSEMBL:
Gene Tree for SLC7A1 (if available)
TreeFam:
Gene Tree for SLC7A1 (if available)

Paralogs for SLC7A1 Gene

Paralogs for SLC7A1 Gene

Selected SIMAP similar genes for SLC7A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC7A1: view

Variants for SLC7A1 Gene

Sequence variations from dbSNP and Humsavar for SLC7A1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs15376 -- 29,512,165(+) TATGC(A/G)AGGCA utr-variant-3-prime
rs175973 -- 29,542,246(-) aactc(C/T)tgacc intron-variant
rs280946 -- 29,553,043(-) CATAA(A/G)AGCCA intron-variant
rs280947 -- 29,550,591(-) TTGGC(C/G/T)GACAT intron-variant
rs280950 -- 29,545,888(+) AAAAG(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A1 Gene

Variant ID Type Subtype PubMed ID
nsv899960 CNV Gain 21882294
esv1006674 CNV Deletion 20482838
nsv979 CNV Loss 18451855
esv2671622 CNV Deletion 23128226
esv2661963 CNV Deletion 23128226
esv2747210 CNV Deletion 23290073
esv2747211 CNV Deletion 23290073
esv1071553 CNV Deletion 17803354

Relevant External Links for SLC7A1 Gene

HapMap Linkage Disequilibrium report
SLC7A1
Human Gene Mutation Database (HGMD)
SLC7A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A1 Gene

Disorders for SLC7A1 Gene

(3) Novoseek inferred disease relationships for SLC7A1 Gene

Disease -log(P) Hits PubMed IDs
leukemia 22.1 4
glioblastoma 12.3 1
tumors 0 1

Relevant External Links for SLC7A1

Genetic Association Database (GAD)
SLC7A1
Human Genome Epidemiology (HuGE) Navigator
SLC7A1
genes like me logo Genes that share disorders with SLC7A1: view

No data available for UniProtKB/Swiss-Prot for SLC7A1 Gene

Publications for SLC7A1 Gene

  1. The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14. (PMID: 1348489) Albritton L.M. … Cunningham J.M. (Genomics 1992) 2 3 4 23
  2. Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. (PMID: 15491978) Rotmann A. … Closs E.I. (J. Biol. Chem. 2004) 3 23 25
  3. Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. (PMID: 17325243) Yang Z. … Kaye D.M. (Circulation 2007) 3 25 48
  4. Stable polarized expression of hCAT-1 in an epithelial cell line. (PMID: 11891586) Cariappa R. … Smith C.H. (J. Membr. Biol. 2002) 3 23
  5. The importance of cationic amino acid transporter expression in human skin. (PMID: 12787129) Schnorr O. … Kolb-Bachofen V. (J. Invest. Dermatol. 2003) 3 23

Products for SLC7A1 Gene

Sources for SLC7A1 Gene

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