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Aliases for ASAH2B Gene

Aliases for ASAH2B Gene

  • N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2B 2 3
  • ASAH2L 3 4 6
  • Putative Inactive N-Acylsphingosine Amidohydrolase 2B 3 4
  • Putative Inactive Non-Lysosomal Ceramidase B 3 4
  • ASAH2-Like Protein 3 4
  • ASAH2C 3 6
  • N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2C 2
  • Putative Inactive Neutral Ceramidase B 3
  • EC 3.5.1.23 63
  • BA449O16.3 3
  • BA98I6.3 3

External Ids for ASAH2B Gene

Previous HGNC Symbols for ASAH2B Gene

  • ASAH2C

Previous GeneCards Identifiers for ASAH2B Gene

  • GC00U914492
  • GC10U900594
  • GC10P052169
  • GC10P052499
  • GC10P046471

Summaries for ASAH2B Gene

GeneCards Summary for ASAH2B Gene

ASAH2B (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2B) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. An important paralog of this gene is ASAH2.

Gene Wiki entry for ASAH2B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASAH2B Gene

Genomics for ASAH2B Gene

Regulatory Elements for ASAH2B Gene

Genomic Location for ASAH2B Gene

Start:
50,739,318 bp from pter
End:
50,816,495 bp from pter
Size:
77,178 bases
Orientation:
Plus strand

Genomic View for ASAH2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASAH2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASAH2B Gene

Proteins for ASAH2B Gene

  • Protein details for ASAH2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7U1-ASA2B_HUMAN
    Recommended name:
    Putative inactive neutral ceramidase B
    Protein Accession:
    P0C7U1
    Secondary Accessions:
    • B7Z261

    Protein attributes for ASAH2B Gene

    Size:
    165 amino acids
    Molecular mass:
    19025 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs

    Alternative splice isoforms for ASAH2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASAH2B Gene

Proteomics data for ASAH2B Gene at MOPED

Selected DME Specific Peptides for ASAH2B Gene

Post-translational modifications for ASAH2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASAH2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ASAH2B Gene

Protein Domains for ASAH2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ASAH2B Gene

Graphical View of Domain Structure for InterPro Entry

P0C7U1

UniProtKB/Swiss-Prot:

ASA2B_HUMAN :
  • P0C7U1
Family:
  • Belongs to the neutral ceramidase family.
genes like me logo Genes that share domains with ASAH2B: view

No data available for Gene Families for ASAH2B Gene

Function for ASAH2B Gene

Enzyme Numbers (IUBMB) for ASAH2B Gene

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASAH2B Gene

Localization for ASAH2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASAH2B Gene COMPARTMENTS Subcellular localization image for ASAH2B gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASAH2B Gene

Pathways for ASAH2B Gene

genes like me logo Genes that share pathways with ASAH2B: view

Pathways by source for ASAH2B Gene

Interacting Proteins for ASAH2B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363118%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000363118 for ASAH2B Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ASAH2B Gene

None

Transcripts for ASAH2B Gene

mRNA/cDNA for ASAH2B Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASAH2B Gene

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASAH2B Gene

No ASD Table

Relevant External Links for ASAH2B Gene

GeneLoc Exon Structure for
ASAH2B
ECgene alternative splicing isoforms for
ASAH2B

Expression for ASAH2B Gene

mRNA expression in normal human tissues for ASAH2B Gene

SOURCE GeneReport for Unigene cluster for ASAH2B Gene Hs.710005

mRNA Expression by UniProt/SwissProt for ASAH2B Gene

P0C7U1-ASA2B_HUMAN
Tissue specificity: Ubiquitous. Expression is reduced with increasing age and in late-onset Alzheimer disease (LOAD) patients. This reduction is even more pronounced in patients with an affected mother.
genes like me logo Genes that share expressions with ASAH2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for ASAH2B Gene

Orthologs for ASAH2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ASAH2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 15 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 47 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Asah2 36
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 12 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii asah2 36
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CDase 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 6 (a)
ManyToMany
-- 36
  • 7 (a)
ManyToMany
-- 36
  • 6 (a)
ManyToMany
Species with no ortholog for ASAH2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASAH2B Gene

ENSEMBL:
Gene Tree for ASAH2B (if available)
TreeFam:
Gene Tree for ASAH2B (if available)

Paralogs for ASAH2B Gene

Paralogs for ASAH2B Gene

Selected SIMAP similar genes for ASAH2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASAH2B: view

Variants for ASAH2B Gene

Sequence variations from dbSNP and Humsavar for ASAH2B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs13189 -- 50,757,005(+) TTTCT(C/T)ATGTT utr-variant-3-prime
rs1133222 -- 50,756,905(+) GCTCA(C/T)TGGAG utr-variant-3-prime
rs1513250 -- 50,756,029(-) TCAGA(C/T)TGTCA utr-variant-3-prime
rs2259978 -- 50,745,848(+) aaaaa(A/T)tttta intron-variant
rs2259980 -- 50,745,818(+) TAGAA(C/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASAH2B Gene

Variant ID Type Subtype PubMed ID
nsv895393 CNV Gain 21882294

Relevant External Links for ASAH2B Gene

HapMap Linkage Disequilibrium report
ASAH2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASAH2B Gene

Disorders for ASAH2B Gene

No disorders were found for ASAH2B Gene.

No data available for UniProtKB/Swiss-Prot for ASAH2B Gene

Publications for ASAH2B Gene

  1. A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. (PMID: 17334805) Avramopoulos D. … Bassett S.S. (Neurogenetics 2007) 2 3 4
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for ASAH2B Gene

Sources for ASAH2B Gene

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