Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC6A6 Gene

Aliases for SLC6A6 Gene

  • Solute Carrier Family 6 (Neurotransmitter Transporter), Member 6 2 3
  • Solute Carrier Family 6 (Neurotransmitter Transporter, Taurine), Member 6 2 3
  • TAUT 3 6
  • Sodium- And Chloride-Dependent Taurine Transporter 3
  • Solute Carrier Family 6 Member 6 4
  • Taurine Transporter 2

External Ids for SLC6A6 Gene

Previous GeneCards Identifiers for SLC6A6 Gene

  • GC03P014373
  • GC03P014419
  • GC03P014444
  • GC03P014380

Summaries for SLC6A6 Gene

Entrez Gene Summary for SLC6A6 Gene

  • This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for SLC6A6 Gene

SLC6A6 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 6) is a Protein Coding gene. Diseases associated with SLC6A6 include myofascial pain syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neurotransmitter:sodium symporter activity and taurine:sodium symporter activity. An important paralog of this gene is SLC6A4.

UniProtKB/Swiss-Prot for SLC6A6 Gene

  • Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.

Gene Wiki entry for SLC6A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC6A6 Gene

Genomics for SLC6A6 Gene

Regulatory Elements for SLC6A6 Gene

Genomic Location for SLC6A6 Gene

14,402,576 bp from pter
14,489,349 bp from pter
86,774 bases
Plus strand

Genomic View for SLC6A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC6A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC6A6 Gene

Proteins for SLC6A6 Gene

  • Protein details for SLC6A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium- and chloride-dependent taurine transporter
    Protein Accession:
    Secondary Accessions:
    • B2RNU7
    • Q9BRI2
    • Q9BXB0

    Protein attributes for SLC6A6 Gene

    620 amino acids
    Molecular mass:
    69830 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC6A6 Gene


neXtProt entry for SLC6A6 Gene

Proteomics data for SLC6A6 Gene at MOPED

Post-translational modifications for SLC6A6 Gene

Other Protein References for SLC6A6 Gene

No data available for DME Specific Peptides for SLC6A6 Gene

Domains for SLC6A6 Gene

Gene Families for SLC6A6 Gene

  • SLC :Solute carriers

Protein Domains for SLC6A6 Gene

Suggested Antigen Peptide Sequences for SLC6A6 Gene

Graphical View of Domain Structure for InterPro Entry



  • P31641
  • Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
genes like me logo Genes that share domains with SLC6A6: view

Function for SLC6A6 Gene

Molecular function for SLC6A6 Gene

GENATLAS Biochemistry: solute carrier family 6,member A6,neurotansmitter transporter,taurine
UniProtKB/Swiss-Prot Function: Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.

Gene Ontology (GO) - Molecular Function for SLC6A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005328 neurotransmitter:sodium symporter activity IEA --
GO:0005368 taurine transmembrane transporter activity --
GO:0005369 taurine:sodium symporter activity IEA --
GO:0030977 taurine binding IEA --
genes like me logo Genes that share ontologies with SLC6A6: view
genes like me logo Genes that share phenotypes with SLC6A6: view

Animal Models for SLC6A6 Gene

MGI Knock Outs for SLC6A6:

miRNA for SLC6A6 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC6A6 Gene

Localization for SLC6A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC6A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC6A6 Gene COMPARTMENTS Subcellular localization image for SLC6A6 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC6A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane TAS 8010975
genes like me logo Genes that share ontologies with SLC6A6: view

Pathways for SLC6A6 Gene

genes like me logo Genes that share pathways with SLC6A6: view

Interacting Proteins for SLC6A6 Gene

Gene Ontology (GO) - Biological Process for SLC6A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process TAS 8010975
GO:0006810 transport TAS 8010975
GO:0006811 ion transport TAS --
GO:0006836 neurotransmitter transport IEA --
GO:0006865 amino acid transport TAS --
genes like me logo Genes that share ontologies with SLC6A6: view

Compounds for SLC6A6 Gene

(3) HMDB Compounds for SLC6A6 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-Carboxyethylamine
  • Sodium
  • 1-Aminoethane-2-sulfonate

(14) Novoseek inferred chemical compound relationships for SLC6A6 Gene

Compound -log(P) Hits PubMed IDs
taurine 90.3 62
cysteine sulfinic acid 81.1 4
beta-alanine 75.7 2
betaine 64.9 6
inositol 59.8 7
genes like me logo Genes that share compounds with SLC6A6: view

Transcripts for SLC6A6 Gene

Unigene Clusters for SLC6A6 Gene

Solute carrier family 6 (neurotransmitter transporter, taurine), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for SLC6A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC6A6 Gene

mRNA expression in normal human tissues for SLC6A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC6A6 Gene

This gene is overexpressed in Whole Blood (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC6A6 Gene

SOURCE GeneReport for Unigene cluster for SLC6A6 Gene Hs.529488

mRNA Expression by UniProt/SwissProt for SLC6A6 Gene

Tissue specificity: Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
genes like me logo Genes that share expressions with SLC6A6: view

Orthologs for SLC6A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC6A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC6A6 35
  • 99.35 (n)
  • 99.68 (a)
SLC6A6 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC6A6 35
  • 88.6 (n)
  • 90.32 (a)
SLC6A6 36
  • 90 (a)
(Canis familiaris)
Mammalia SLC6A6 35
  • 91.18 (n)
  • 94.68 (a)
SLC6A6 36
  • 95 (a)
(Mus musculus)
Mammalia Slc6a6 35
  • 90.16 (n)
  • 93.39 (a)
Slc6a6 16
Slc6a6 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SLC6A6 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SLC6A6 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Slc6a6 35
  • 90.27 (n)
  • 93.87 (a)
(Gallus gallus)
Aves SLC6A6 35
  • 81.22 (n)
  • 85.62 (a)
SLC6A6 36
  • 81 (a)
(Anolis carolinensis)
Reptilia SLC6A6 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc6a6 35
  • 77.65 (n)
  • 82.63 (a)
(Danio rerio)
Actinopterygii slc6a6a 36
  • 78 (a)
slc6a6b 35
  • 75.43 (n)
  • 79.19 (a)
slc6a6b 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1732 36
  • 47 (a)
ine 37
  • 42 (a)
CG1732 37
  • 54 (a)
CG10804 37
  • 36 (a)
CG1698 37
  • 38 (a)
(Caenorhabditis elegans)
Secernentea snf-11 36
  • 47 (a)
snf-8 37
  • 24 (a)
snf-3 37
  • 40 (a)
snf-5 37
  • 30 (a)
snf-12 37
  • 32 (a)
snf-11 37
  • 48 (a)
snf-1 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for SLC6A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC6A6 Gene

Gene Tree for SLC6A6 (if available)
Gene Tree for SLC6A6 (if available)

Paralogs for SLC6A6 Gene Pseudogenes for SLC6A6 Gene

genes like me logo Genes that share paralogs with SLC6A6: view

Variants for SLC6A6 Gene

Sequence variations from dbSNP and Humsavar for SLC6A6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs732606 -- 14,416,774(-) CACGG(C/G)AGACT intron-variant
rs745185 -- 14,416,773(-) ACGGC(A/G)GACTT intron-variant
rs748098 -- 14,429,403(+) TGGCT(A/G)TTGGG intron-variant
rs748099 -- 14,429,531(+) GTCAT(C/G)AGCCA intron-variant
rs893084 -- 14,439,766(-) CTTCC(A/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC6A6 Gene

Variant ID Type Subtype PubMed ID
nsv876550 CNV Loss 21882294
esv2724945 CNV Deletion 23290073
nsv834619 CNV Gain+Loss 17160897
esv2724957 CNV Deletion 23290073
esv2724958 CNV Deletion 23290073
nsv3712 CNV Insertion 18451855
nsv876571 CNV Loss 21882294

Relevant External Links for SLC6A6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC6A6 Gene

Disorders for SLC6A6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC6A6 Gene including...

Search for SLC6A6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC6A6 Gene

(4) Novoseek inferred disease relationships for SLC6A6 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 31.3 1
necrosis 0 1
shock 0 2
tumors 0 3

Relevant External Links for SLC6A6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC6A6: view

No data available for UniProtKB/Swiss-Prot for SLC6A6 Gene

Publications for SLC6A6 Gene

  1. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. (PMID: 8010975) Ramamoorthy S. … Ganapathy V. (Biochem. J. 1994) 2 3 4
  2. Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. (PMID: 8382624) Jhiang S.M. … Mazzaferri E.L. (FEBS Lett. 1993) 2 3 4
  3. Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. (PMID: 8654117) Miyamoto Y. … Sprinkle T.J. (Curr. Eye Res. 1996) 3 4
  4. Osmosensitive gene expression of taurine transporter and cyclin C in embryonic fibroblast cells. (PMID: 17153588) Oh C. … Lee D.H. (Adv. Exp. Med. Biol. 2006) 3 23
  5. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl(-)-dependent TauT (SLC6A6). (PMID: 19074966) Anderson C.M. … Thwaites D.T. (J. Physiol. (Lond.) 2009) 3 23

Products for SLC6A6 Gene

Sources for SLC6A6 Gene

Back to Top