Aliases for SLC6A4 Gene
External Ids for SLC6A4 Gene
Previous HGNC Symbols for SLC6A4 Gene
Previous GeneCards Identifiers for SLC6A4 Gene
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC6A4 Gene
SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC6A4 include obsessive-compulsive disorder and slc6a4-related behavior disorders. Among its related pathways are Circadian entrainment and SIDS Susceptibility Pathways. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is SLC6A13.
UniProtKB/Swiss-Prot for SLC6A4 Gene
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move one or more molecules per cycle. Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini, putative phosphorylation sites acting as potential targets for PKA and PKC and regions essential for 5-HT selective affinity. There is evidence to suggest that SERTs are linked to neuroticism, sexual behavior, alcoholism, clinical depression, hypertension and obsessive-compulsive disorder.