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Aliases for UCA1 Gene

Subcategory (RNA class) for UCA1 Gene


Quality Score for this RNA gene is


Aliases for UCA1 Gene

  • Urothelial Cancer Associated 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 178 2 3
  • Cancer Up-Regulated Drug Resistant 2 3
  • NCRNA00178 3
  • LINC00178 3
  • GUCA1B 6
  • UCAT1 3
  • GCAP2 6
  • GUCA2 6
  • CUDR 3
  • RP48 6

External Ids for UCA1 Gene

Previous GeneCards Identifiers for UCA1 Gene

  • GC19U900573
  • GC19P015939
  • GC19P015511

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene represents a long non-coding RNA. It plays a regulatory role in bladder cancer cell proliferation. Several genes can be regulated by this gene, and the most important one is the CREB (cAMP responsive element binding protein) gene, which encodes a transcriptional factor and affects the oncogenesis. [provided by RefSeq, Mar 2012]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with UCA1 include retinitis pigmentosa 48. Among its related pathways are Signaling by GPCR and Disease.

fRNAdb sequence ontologies for UCA1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

  • mature_transcript: A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

Genomic Location for UCA1 Gene

15,828,947 bp from pter
15,836,321 bp from pter
7,375 bases
Plus strand

Genomic View for UCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

No data available for Regulatory Elements for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    UCA1 protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for UCA1 Gene

    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Proteomics data for UCA1 Gene at MOPED

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains for UCA1 Gene

Gene Families for UCA1 Gene

Protein Domains for UCA1 Gene


Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UCA1: view

No data available for UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

Subcellular locations from

Jensen Localization Image for UCA1 Gene COMPARTMENTS Subcellular localization image for UCA1 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Transcripts for UCA1 Gene

mRNA/cDNA for UCA1 Gene

(20) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCA1 Gene

Urothelial cancer associated 1 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCA1 Gene

mRNA expression in normal human tissues for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (23.4) and Cervix - Endocervix (8.6).

SOURCE GeneReport for Unigene cluster for UCA1 Gene Hs.644234

genes like me logo Genes that share expressions with UCA1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

Gene Tree for UCA1 (if available)
Gene Tree for UCA1 (if available)

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

Sequence variations from dbSNP and Humsavar for UCA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs145477339 -- 15,827,451(+) ACACG(C/T)CATCT upstream-variant-2KB
rs145097151 -- 15,827,960(+) CACAC(C/T)TGTAA upstream-variant-2KB
rs145032336 -- 15,830,573(+) CTTGA(C/T)GGGAA intron-variant
rs145026157 -- 15,833,714(+) CTCAG(A/G)GCAAG intron-variant
rs144066565 -- 15,828,843(+) AACAA(-/CAA)GGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
esv2718244 CNV Deletion 23290073
nsv833766 CNV Loss 17160897
esv2671181 CNV Deletion 23128226

Relevant External Links for UCA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCA1 Gene

Disorders for UCA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UCA1 Gene in MalaCards »

(1) Disease for UCA1 Gene

(1) OMIM Diseases for UCA1 Gene (602275)

(1) University of Copenhagen DISEASES for UCA1 Gene

Relevant External Links for UCA1

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UCA1: view

No data available for UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for UCA1 Gene

Publications for UCA1 Gene

  1. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3
  2. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F. … Chen W. (FEBS Lett. 2008) 2 3
  3. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang W.P. … Kwok T.T. (RNA 2007) 2 3
  4. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. (PMID: 16914571) Wang X.S. … Chen W.F. (Clin. Cancer Res. 2006) 3
  5. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. (PMID: 22285928) Yang C. … Chen W. (Gene 2012) 3

Products for UCA1 Gene

Sources for UCA1 Gene

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