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Aliases for UCA1 Gene

Subcategory (RNA class) for UCA1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for UCA1 Gene

  • Urothelial Cancer Associated 1 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 178 2 3
  • Cancer Up-Regulated Drug Resistant 2 3
  • Onco-LncRNA-36 3
  • NCRNA00178 3
  • LINC00178 3
  • UCAT1 3
  • CUDR 3

External Ids for UCA1 Gene

Previous GeneCards Identifiers for UCA1 Gene

  • GC19U900573
  • GC19P015939
  • GC19P015511

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene represents a long non-coding RNA. It plays a regulatory role in bladder cancer cell proliferation. Several genes can be regulated by this gene, and the most important one is the CREB (cAMP responsive element binding protein) gene, which encodes a transcriptional factor and affects the oncogenesis. [provided by RefSeq, Mar 2012]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

Regulatory Elements for UCA1 Gene

Enhancers for UCA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G015826 2 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +3.8 3818 12.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000269578 AKAP8 CYP4F24P UCA1 OR10H4 OR10H5 ENSG00000268087 CYP4F12 CYP4F11 ENSG00000267904
GH19G015844 1.2 ENCODE dbSUPER 8.3 +15.7 15714 1.0 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 NCOA1 MEF2D MBD2 SMARCA4 CYP4F24P UCA1 GC19M015845 GC19M015836
GH19G015824 0.9 dbSUPER 10.5 -4.0 -3991 1.7 PKNOX1 NFIB ARID4B ZNF48 YY1 ZNF766 KLF13 THAP11 ZBTB11 NFYC CYP4F24P OR10H5 CYP4F11 OR10H4 UCA1 ZNF861P GC19P015826
GH19G015841 0.5 dbSUPER 7.2 +13.4 13397 0.9 CTCF ZBTB33 REST ZBTB7A ZKSCAN1 UCA1 CYP4F11 GC19M015845 GC19M015836
GH19G015842 0.5 dbSUPER 7.2 +13.4 13397 0.9 CTCF ZBTB33 REST ZBTB7A ZKSCAN1 UCA1 CYP4F11 GC19M015845 GC19M015836
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UCA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCA1 Gene

Chromosome:
19
Start:
15,828,947 bp from pter
End:
15,836,321 bp from pter
Size:
7,375 bases
Orientation:
Plus strand

Genomic View for UCA1 Gene

Genes around UCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q2VCE5
    Recommended name:
    UCA1 protein
    Protein Accession:
    Q2VCE5

    Protein attributes for UCA1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains & Families for UCA1 Gene

Protein Domains for UCA1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UCA1: view

No data available for UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Pathways & Interactions for UCA1 Gene

genes like me logo Genes that share pathways with UCA1: view

Pathways by source for UCA1 Gene

1 BioSystems pathway for UCA1 Gene

Interacting Proteins for UCA1 Gene

Gene Ontology (GO) - Biological Process for UCA1 Gene

None

No data available for SIGNOR curated interactions for UCA1 Gene

Transcripts for UCA1 Gene

mRNA/cDNA for UCA1 Gene

(20) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCA1 Gene

Urothelial cancer associated 1 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
UCA1
ECgene alternative splicing isoforms for
UCA1

Expression for UCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).

NURSA nuclear receptor signaling pathways regulating expression of UCA1 Gene:

UCA1

SOURCE GeneReport for Unigene cluster for UCA1 Gene:

Hs.644234
genes like me logo Genes that share expression patterns with UCA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

ENSEMBL:
Gene Tree for UCA1 (if available)
TreeFam:
Gene Tree for UCA1 (if available)

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

Sequence variations from dbSNP and Humsavar for UCA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000154015 -- 15,832,624(+) CCTTT(C/T)CCCAT intron-variant
rs1000178231 -- 15,834,944(+) TCCAC(A/G)CCCAA intron-variant, nc-transcript-variant
rs1000267710 -- 15,827,226(+) CACTC(G/T)GGAAA upstream-variant-2KB, splice-acceptor-variant
rs1000476101 -- 15,836,794(+) ACCGA(A/G)GGCCG downstream-variant-500B, upstream-variant-2KB
rs1000488880 -- 15,834,055(+) TTCAC(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897
nsv960799 CNV duplication 23825009

Relevant External Links for UCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UCA1 Gene

Disorders for UCA1 Gene

Relevant External Links for UCA1

Human Genome Epidemiology (HuGE) Navigator
UCA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCA1

No disorders were found for UCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene

Publications for UCA1 Gene

  1. lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y. … Zhang Z. (DNA Cell Biol. 2016) 2 3 64
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3 64
  3. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F. … Chen W. (FEBS Lett. 2008) 2 3 64
  4. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang W.P. … Kwok T.T. (RNA 2007) 2 3 64
  5. Expression of Long Noncoding RNA Urothelial Cancer Associated 1 Promotes Cisplatin Resistance in Cervical Cancer. (PMID: 28414550) Wang B. … Zhou S. (Cancer Biother. Radiopharm. 2017) 3 64

Products for UCA1 Gene

Sources for UCA1 Gene

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