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Aliases for SLC5A3 Gene

Aliases for SLC5A3 Gene

  • Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter), Member 3 2 3
  • Sodium/Myo-Inositol Transporter 1 3 4
  • Na(+)/Myo-Inositol Cotransporter 3 4
  • SMIT1 3 4
  • Solute Carrier Family 5 (Inositol Transporters), Member 3 3
  • Solute Carrier Family 5 (Inositol Transporter), Member 3 2
  • Sodium/Myo-Inositol Cotransporter 1 3
  • Sodium/Myo-Inositol Cotransporter 3
  • Solute Carrier Family 5 Member 3 4
  • SMIT2 3
  • BCW2 3
  • SMIT 3

External Ids for SLC5A3 Gene

Summaries for SLC5A3 Gene

GeneCards Summary for SLC5A3 Gene

SLC5A3 (Solute Carrier Family 5 (Sodium/Myo-Inositol Cotransporter), Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and MPS VI - Maroteaux-Lamy syndrome. GO annotations related to this gene include myo-inositol:sodium symporter activity. An important paralog of this gene is SLC5A10.

UniProtKB/Swiss-Prot for SLC5A3 Gene

  • Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function

Gene Wiki entry for SLC5A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC5A3 Gene

Genomics for SLC5A3 Gene

Genomic Location for SLC5A3 Gene

34,073,570 bp from pter
34,106,262 bp from pter
32,693 bases
Plus strand

Genomic View for SLC5A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC5A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC5A3 Gene

Regulatory Elements for SLC5A3 Gene

Proteins for SLC5A3 Gene

  • Protein details for SLC5A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/myo-inositol cotransporter
    Protein Accession:
    Secondary Accessions:
    • O43489

    Protein attributes for SLC5A3 Gene

    718 amino acids
    Molecular mass:
    79694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC5A3 Gene

Proteomics data for SLC5A3 Gene at MOPED

Post-translational modifications for SLC5A3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys290 and Lys596
  • Glycosylation at Asn232

Other Protein References for SLC5A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC5A3 Gene

Domains for SLC5A3 Gene

Gene Families for SLC5A3 Gene

Protein Domains for SLC5A3 Gene

Suggested Antigen Peptide Sequences for SLC5A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.:
    • P53794
genes like me logo Genes that share domains with SLC5A3: view

Function for SLC5A3 Gene

Molecular function for SLC5A3 Gene

GENATLAS Biochemistry: solute carrier family 5 (inositol transport),member 3,expressed predominantly in brain,kidney,placenta,involved in cellular osmoregulation
UniProtKB/Swiss-Prot Function: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function

Gene Ontology (GO) - Molecular Function for SLC5A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005367 myo-inositol:sodium symporter activity TAS 1372904
GO:0005524 ATP binding --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances --
genes like me logo Genes that share ontologies with SLC5A3: view
genes like me logo Genes that share phenotypes with SLC5A3: view

Animal Models for SLC5A3 Gene

MGI Knock Outs for SLC5A3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC5A3 Gene

Localization for SLC5A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC5A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC5A3 Gene COMPARTMENTS Subcellular localization image for SLC5A3 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC5A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1372904
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 7789985
genes like me logo Genes that share ontologies with SLC5A3: view

Pathways for SLC5A3 Gene

genes like me logo Genes that share pathways with SLC5A3: view

Interacting Proteins for SLC5A3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000370543 P53794-SC5A3_HUMAN for SLC5A3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC5A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IEA --
GO:0006810 transport TAS 1372904
GO:0006814 sodium ion transport IEA --
GO:0007422 peripheral nervous system development IEA --
GO:0015798 myo-inositol transport IEA --
genes like me logo Genes that share ontologies with SLC5A3: view

Compounds for SLC5A3 Gene

(1) HMDB Compounds for SLC5A3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(1) IUPHAR Ligand for SLC5A3 Gene

Ligand Type Action Affinity Pubmed IDs
phlorizin Inhibitor Inhibition

(15) Novoseek inferred chemical compound relationships for SLC5A3 Gene

Compound -log(P) Hits PubMed IDs
inositol 87.5 45
betaine 68.5 6
inositol monophosphate 62.3 1
aldose 55.6 3
carbamazepine 54.6 1
genes like me logo Genes that share compounds with SLC5A3: view

Transcripts for SLC5A3 Gene

mRNA/cDNA for SLC5A3 Gene

(1) REFSEQ mRNAs :
(460) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b

Relevant External Links for SLC5A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC5A3 Gene

mRNA expression in normal human tissues for SLC5A3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC5A3 Gene

genes like me logo Genes that share expressions with SLC5A3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC5A3 Gene

Orthologs for SLC5A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC5A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC5A3 35
  • 99.63 (n)
  • 99.72 (a)
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
SLC5A3 35
  • 91.92 (n)
  • 95.68 (a)
(Canis familiaris)
Mammalia LOC100856716 35
  • 94.43 (n)
  • 96.66 (a)
SLC5A3 36
  • 97 (a)
(Mus musculus)
Mammalia Slc5a3 35
  • 90.71 (n)
  • 93.59 (a)
Slc5a3 16
Slc5a3 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Slc5a3 35
  • 89.32 (n)
  • 92.48 (a)
(Gallus gallus)
Aves -- 36
  • 87 (a)
SLC5A3 35
  • 79.15 (n)
  • 87.24 (a)
(Danio rerio)
Actinopterygii LOC568338 35
  • 65.85 (n)
  • 68.58 (a)
si:ch211-125e6.9 36
  • 67 (a)
si:ch211-132g1.5 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
-- 36
  • 53 (a)
-- 36
  • 53 (a)
Species with no ortholog for SLC5A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC5A3 Gene

Gene Tree for SLC5A3 (if available)
Gene Tree for SLC5A3 (if available)

Paralogs for SLC5A3 Gene

Selected SIMAP similar genes for SLC5A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC5A3: view

Variants for SLC5A3 Gene

Sequence variations from dbSNP and Humsavar for SLC5A3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_061875 -
VAR_061876 -

Structural Variations from Database of Genomic Variants (DGV) for SLC5A3 Gene

Variant ID Type Subtype PubMed ID
esv28721 CNV Loss 19812545

Relevant External Links for SLC5A3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC5A3 Gene

Disorders for SLC5A3 Gene

(1) University of Copenhagen DISEASES for SLC5A3 Gene

(1) Novoseek inferred disease relationships for SLC5A3 Gene

Disease -log(P) Hits PubMed IDs
down syndrome 33.3 2

Relevant External Links for SLC5A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC5A3: view

No data available for UniProtKB/Swiss-Prot for SLC5A3 Gene

Publications for SLC5A3 Gene

  1. The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. (PMID: 7789985) Berry G.T. … Spinner N.B. (Genomics 1995) 2 3 4 23
  2. The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. (PMID: 9441750) Mallee J.J. … Berry G.T. (Genomics 1997) 3 4 23
  3. Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. (PMID: 9612208) Porcellati F. … Killen P.D. (Am. J. Physiol. 1998) 3 23
  4. The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. (PMID: 8646889) Berry G.T. … Antonarakis S.E. (Cytogenet. Cell Genet. 1996) 3 23
  5. Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. (PMID: 19032932) Lin X. … Ostlund R.E. (Arch. Biochem. Biophys. 2009) 3 23

Products for SLC5A3 Gene

Sources for SLC5A3 Gene

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