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Aliases for SLC4A2 Gene

Aliases for SLC4A2 Gene

  • Solute Carrier Family 4 (Anion Exchanger), Member 2 2 3
  • Erythrocyte Membrane Protein Band 3-Like 1 2 3
  • Non-Erythroid Band 3-Like Protein 3 4
  • Solute Carrier Family 4 Member 2 3 4
  • Anion Exchanger 2 Type B1 2 3
  • Anion Exchanger 2 Type B2 2 3
  • Anion Exchanger 2 Type A 2 3
  • EPB3L1 3 4
  • BND3L 3 4
  • AE 2 3 4
  • HKB3 3 4
  • AE2 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 2 (Erythrocyte Membrane Protein Band 3-Like 1) 2
  • Anion Exchanger 2 4
  • NBND3 3
  • MPB3L 4

External Ids for SLC4A2 Gene

Previous HGNC Symbols for SLC4A2 Gene

  • EPB3L1
  • AE2

Previous GeneCards Identifiers for SLC4A2 Gene

  • GC07P149003
  • GC07P150072
  • GC07P150148
  • GC07P150194
  • GC07P150387
  • GC07P150754
  • GC07P144569

Summaries for SLC4A2 Gene

GeneCards Summary for SLC4A2 Gene

SLC4A2 (Solute Carrier Family 4 (Anion Exchanger), Member 2) is a Protein Coding gene. Diseases associated with SLC4A2 include primary biliary cirrhosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. GO annotations related to this gene include transporter activity and anion transmembrane transporter activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A2 Gene

  • Plasma membrane anion exchange protein of wide distribution

Gene Wiki entry for SLC4A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A2 Gene

Genomics for SLC4A2 Gene

Regulatory Elements for SLC4A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC4A2 Gene

Chromosome:
7
Start:
151,057,210 bp from pter
End:
151,076,527 bp from pter
Size:
19,318 bases
Orientation:
Plus strand

Genomic View for SLC4A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A2 Gene

Proteins for SLC4A2 Gene

  • Protein details for SLC4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04920-B3A2_HUMAN
    Recommended name:
    Anion exchange protein 2
    Protein Accession:
    P04920
    Secondary Accessions:
    • B2R6T0
    • B4DIT0
    • D3DX05
    • F8W682
    • Q45EY5
    • Q969L3

    Protein attributes for SLC4A2 Gene

    Size:
    1241 amino acids
    Molecular mass:
    137009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A2 Gene

Proteomics data for SLC4A2 Gene at MOPED

Post-translational modifications for SLC4A2 Gene

  • Ubiquitination at Lys 658
  • Glycosylation at Asn 859, Asn 868, and Asn 882
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC4A2 Gene

Domains & Families for SLC4A2 Gene

Gene Families for SLC4A2 Gene

Graphical View of Domain Structure for InterPro Entry

P04920

UniProtKB/Swiss-Prot:

B3A2_HUMAN :
  • Belongs to the anion exchanger (TC 2.A.31) family.
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A2: view

Function for SLC4A2 Gene

Molecular function for SLC4A2 Gene

GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 2
UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution

Gene Ontology (GO) - Molecular Function for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity TAS 3015590
genes like me logo Genes that share ontologies with SLC4A2: view
genes like me logo Genes that share phenotypes with SLC4A2: view

Animal Models for SLC4A2 Gene

MGI Knock Outs for SLC4A2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC4A2 Gene

Localization for SLC4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A2 Gene COMPARTMENTS Subcellular localization image for SLC4A2 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC4A2: view

Pathways & Interactions for SLC4A2 Gene

genes like me logo Genes that share pathways with SLC4A2: view

Gene Ontology (GO) - Biological Process for SLC4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006820 anion transport TAS 3015590
GO:0015701 bicarbonate transport TAS --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC4A2: view

No data available for SIGNOR curated interactions for SLC4A2 Gene

Drugs & Compounds for SLC4A2 Gene

(3) Drugs for SLC4A2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker 45
ATP Pharma Activator 0
DIDS Pharma Channel blocker 0

(11) Additional Compounds for SLC4A2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonium
  • Ammonia ion
  • Ammonium
  • Ammonium chloride
  • AMMONIUM ION
  • Ammonium(1+)
14798-03-9
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
bicarbonate
Calmidazolium
chloride
genes like me logo Genes that share compounds with SLC4A2: view

Transcripts for SLC4A2 Gene

Unigene Clusters for SLC4A2 Gene

Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - -

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17: -
SP18:
SP19:

ExUns: 30a · 30b ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for SLC4A2 Gene

GeneLoc Exon Structure for
SLC4A2
ECgene alternative splicing isoforms for
SLC4A2

Expression for SLC4A2 Gene

mRNA expression in normal human tissues for SLC4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC4A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.6), Stomach (12.1), and Placenta (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC4A2 Gene



SOURCE GeneReport for Unigene cluster for SLC4A2 Gene Hs.647069

genes like me logo Genes that share expression patterns with SLC4A2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC4A2 Gene

Orthologs for SLC4A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC4A2 35
  • 89.81 (n)
  • 95.15 (a)
SLC4A2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A2 35
  • 90.35 (n)
  • 95.23 (a)
SLC4A2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a2 35
  • 87.57 (n)
  • 94.73 (a)
Slc4a2 16
Slc4a2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC4A2 35
  • 99.49 (n)
  • 99.68 (a)
SLC4A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a2 35
  • 87.91 (n)
  • 94.32 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC4A2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC4A2 35
  • 78.09 (n)
  • 81.01 (a)
SLC4A2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A2 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc4a2b 35
  • 67.46 (n)
  • 70.78 (a)
slc4a2a 36
  • 65 (a)
OneToMany
slc4a2b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8177 37
  • 44 (a)
CG8177 35
  • 54.07 (n)
  • 47.83 (a)
CG8177 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006115 35
  • 57.13 (n)
  • 49.23 (a)
worm
(Caenorhabditis elegans)
Secernentea R03E9.3 37
  • 26 (a)
abts-4 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06450 35
  • 42.36 (n)
  • 29.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for SLC4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC4A2 Gene

ENSEMBL:
Gene Tree for SLC4A2 (if available)
TreeFam:
Gene Tree for SLC4A2 (if available)

Paralogs for SLC4A2 Gene

Paralogs for SLC4A2 Gene

genes like me logo Genes that share paralogs with SLC4A2: view

Variants for SLC4A2 Gene

Sequence variations from dbSNP and Humsavar for SLC4A2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10245199 -- 151,061,395(+) CCTGC(A/G)GGGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10155938 -- 151,069,651(+) ATGCT(C/T)CCTGG intron-variant
rs7807812 -- 151,068,471(+) AAAGG(C/T)CTGTT intron-variant
rs6464122 -- 151,064,063(+) GGGGG(C/G)ATATA intron-variant
rs6464120 -- 151,060,310(+) GCGGG(A/G)AGTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC4A2 Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv526410 CNV Loss 19592680
nsv889476 CNV Loss 21882294
nsv524928 CNV Gain 19592680
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv517508 CNV Loss 19592680
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294

Variation tolerance for SLC4A2 Gene

Residual Variation Intolerance Score: 3.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC4A2 Gene

HapMap Linkage Disequilibrium report
SLC4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A2 Gene

Disorders for SLC4A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC4A2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • chronic nonsuppurative destructive cholangitis
- elite association

Relevant External Links for SLC4A2

Genetic Association Database (GAD)
SLC4A2
Human Genome Epidemiology (HuGE) Navigator
SLC4A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC4A2
genes like me logo Genes that share disorders with SLC4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC4A2 Gene

Publications for SLC4A2 Gene

  1. Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway. (PMID: 20180022) Huang Q.R. … He M. (Apoptosis 2010) 23 67
  2. When lightning strikes twice: the plot thickens for a dual role of the anion exchanger 2 (AE2/SLC4A2) in the pathogenesis and treatment of primary biliary cirrhosis. (PMID: 19157624) Fickert P. … Trauner M. (J. Hepatol. 2009) 23 67
  3. HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization. (PMID: 19823673) Zhou C. … Baltz J.M. (PLoS ONE 2009) 23 67
  4. Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy. (PMID: 19882051) Cui T. … Xing A. (Saudi Med J 2009) 23 67
  5. The pathogenesis of primary biliary cirrhosis. (PMID: 19630465) SolA-s Herruzo J.A. … MuA+oz YagA1e T. (Rev Esp Enferm Dig 2009) 23 67

Products for SLC4A2 Gene

Sources for SLC4A2 Gene

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