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Aliases for SLC2A4 Gene

Aliases for SLC2A4 Gene

  • Solute Carrier Family 2 Member 4 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 2 3 5
  • Glucose Transporter Type 4, Insulin-Responsive 3 4
  • GLUT-4 3 4
  • GLUT4 3 4
  • Insulin-Responsive Glucose Transporter Type 4 3

External Ids for SLC2A4 Gene

Previous HGNC Symbols for SLC2A4 Gene

  • GLUT4

Previous GeneCards Identifiers for SLC2A4 Gene

  • GC17P007543
  • GC17P007914
  • GC17P007127
  • GC17P007385
  • GC17P007125
  • GC17P007186
  • GC17P007076

Summaries for SLC2A4 Gene

Entrez Gene Summary for SLC2A4 Gene

  • This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A4 Gene

SLC2A4 (Solute Carrier Family 2 Member 4) is a Protein Coding gene. Diseases associated with SLC2A4 include diabetes mellitus, noninsulin-dependent and metabolic syndrome x. Among its related pathways are Adipocytokine signaling pathway and AMPK signaling pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A4 Gene

  • Insulin-regulated facilitative glucose transporter.

Gene Wiki entry for SLC2A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A4 Gene

Genomics for SLC2A4 Gene

Regulatory Elements for SLC2A4 Gene

Enhancers for SLC2A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC2A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A4 Gene

Chromosome:
17
Start:
7,281,667 bp from pter
End:
7,288,257 bp from pter
Size:
6,591 bases
Orientation:
Plus strand

Genomic View for SLC2A4 Gene

Genes around SLC2A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A4 Gene

Proteins for SLC2A4 Gene

  • Protein details for SLC2A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14672-GTR4_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 4
    Protein Accession:
    P14672
    Secondary Accessions:
    • Q05BQ3
    • Q14CX2

    Protein attributes for SLC2A4 Gene

    Size:
    509 amino acids
    Molecular mass:
    54787 Da
    Quaternary structure:
    • Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1.
    Miscellaneous:
    • Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

    Alternative splice isoforms for SLC2A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A4 Gene

Proteomics data for SLC2A4 Gene at MOPED

Post-translational modifications for SLC2A4 Gene

Other Protein References for SLC2A4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC2A4 (GLUT4)

No data available for DME Specific Peptides for SLC2A4 Gene

Domains & Families for SLC2A4 Gene

Gene Families for SLC2A4 Gene

Suggested Antigen Peptide Sequences for SLC2A4 Gene

Graphical View of Domain Structure for InterPro Entry

P14672

UniProtKB/Swiss-Prot:

GTR4_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A4: view

Function for SLC2A4 Gene

Molecular function for SLC2A4 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A4,facilitated glucose transporter,associated to susceptibility to NIDDM with a polymorphic variant
UniProtKB/Swiss-Prot Function:
Insulin-regulated facilitative glucose transporter.
genes like me logo Genes that share phenotypes with SLC2A4: view

Animal Models for SLC2A4 Gene

MGI Knock Outs for SLC2A4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A4 Gene

Localization for SLC2A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A4 Gene

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A4 Gene COMPARTMENTS Subcellular localization image for SLC2A4 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 3
extracellular 3
golgi apparatus 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005905 coated pit IEA --
GO:0012505 endomembrane system ISS --
GO:0012506 vesicle membrane IDA 14562105
GO:0016020 membrane IEA,TAS 2649253
genes like me logo Genes that share ontologies with SLC2A4: view

Pathways & Interactions for SLC2A4 Gene

genes like me logo Genes that share pathways with SLC2A4: view

SIGNOR curated interactions for SLC2A4 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008645 hexose transport TAS --
GO:0032869 cellular response to insulin stimulus IDA 12556481
GO:0044281 small molecule metabolic process TAS --
GO:0055085 transmembrane transport IEA --
GO:1904659 glucose transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A4: view

Drugs & Compounds for SLC2A4 Gene

(61) Drugs for SLC2A4 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]2-deoxyglucose Pharma 0
Glufosfamide Pharma inhibitor 0

(49) Additional Compounds for SLC2A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A4: view

Transcripts for SLC2A4 Gene

Unigene Clusters for SLC2A4 Gene

Solute carrier family 2 (facilitated glucose transporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for SLC2A4 Gene

GeneLoc Exon Structure for
SLC2A4
ECgene alternative splicing isoforms for
SLC2A4

Expression for SLC2A4 Gene

mRNA expression in normal human tissues for SLC2A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.5), Heart - Left Ventricle (x5.9), Esophagus - Muscularis (x5.3), and Esophagus - Gastroesophageal Junction (x5.2).

Protein differential expression in normal tissues from HIPED for SLC2A4 Gene

This gene is overexpressed in Heart (32.0), Urinary Bladder (16.6), and Adipocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A4 Gene



SOURCE GeneReport for Unigene cluster for SLC2A4 Gene Hs.380691

mRNA Expression by UniProt/SwissProt for SLC2A4 Gene

P14672-GTR4_HUMAN
Tissue specificity: Skeletal and cardiac muscles; brown and white fat.
genes like me logo Genes that share expression patterns with SLC2A4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SLC2A4 Gene

Orthologs for SLC2A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC2A4 35
  • 89.39 (n)
  • 93.32 (a)
SLC2A4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A4 35
  • 90.18 (n)
  • 95.87 (a)
SLC2A4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a4 35
  • 87.88 (n)
  • 95.28 (a)
Slc2a4 16
Slc2a4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC2A4 35
  • 99.61 (n)
  • 99.8 (a)
SLC2A4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a4 35
  • 87.88 (n)
  • 95.28 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC2A4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A4 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01043017.1 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7882 37
  • 34 (a)
Glut1 37
  • 51 (a)
sut1 37
  • 36 (a)
sut2 37
  • 33 (a)
sut3 37
  • 31 (a)
sut4 37
  • 33 (a)
Glut1 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 37
  • 39 (a)
H17B01.1b 37
  • 39 (a)
K08F9.1 37
  • 24 (a)
R09B5.11 37
  • 36 (a)
Y37A1A.3 37
  • 26 (a)
F53H8.3 36
  • 27 (a)
ManyToMany
fgt-1 36
  • 36 (a)
ManyToMany
R09B5.11 36
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
ManyToMany
VPS73 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 36
  • 45 (a)
OneToMany
Species with no ortholog for SLC2A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A4 Gene

ENSEMBL:
Gene Tree for SLC2A4 (if available)
TreeFam:
Gene Tree for SLC2A4 (if available)

Paralogs for SLC2A4 Gene

(10) SIMAP similar genes for SLC2A4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC2A4: view

Variants for SLC2A4 Gene

Sequence variations from dbSNP and Humsavar for SLC2A4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121434581 Diabetes mellitus, non-insulin-dependent (NIDDM) 7,285,729(+) GCTAC(A/C/G)TCTCC reference, missense
VAR_007171 -
rs5434 - 7,283,555(+) CCTCA(C/G)CACCC reference, missense
rs8192702 - 7,285,140(+) CCTGG(C/T)GGGCA reference, missense
rs35198331 - 7,283,487(-) TTGTA(G/T)CTCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC2A4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1963 CNV Loss 18451855

Variation tolerance for SLC2A4 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.60; 78.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A4 Gene

HapMap Linkage Disequilibrium report
SLC2A4
Human Gene Mutation Database (HGMD)
SLC2A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A4 Gene

Disorders for SLC2A4 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SLC2A4 Gene - From: Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
metabolic syndrome x
  • abdominal obesity-metabolic syndrome
glucose intolerance
  • fatty stool
gestational diabetes
  • gdm
glucose metabolism disease
  • disorder of glucose metabolism
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GTR4_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:1521731, ECO:0000269 PubMed:1756912, ECO:0000269 PubMed:1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC2A4

Genetic Association Database (GAD)
SLC2A4
Human Genome Epidemiology (HuGE) Navigator
SLC2A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A4
genes like me logo Genes that share disorders with SLC2A4: view

No data available for Genatlas for SLC2A4 Gene

Publications for SLC2A4 Gene

  1. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. (PMID: 1756912) Choi W.H. … Moller D.E. (Diabetes 1991) 3 4 48 67
  2. Effects of testosterone and metformin on glucose metabolism in endometrium. (PMID: 19328476) Zhang L. … Liao Q. (Fertil. Steril. 2010) 3 23
  3. Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue. (PMID: 19955252) Colomiere M. … Lappas M. (J. Mol. Endocrinol. 2010) 3 23
  4. Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. (PMID: 20103707) Griesel B.A. … Olson A.L. (Diabetes 2010) 3 23
  5. Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes. (PMID: 20173759) Feng L. … Zhao J.J. (Acta Pharmacol. Sin. 2010) 3 23

Products for SLC2A4 Gene

Sources for SLC2A4 Gene

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