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Aliases for SLC2A2 Gene

Aliases for SLC2A2 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2 2 3
  • GLUT2 3 4 6
  • Glucose Transporter Type 2, Liver 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 2 3
  • GLUT-2 4

External Ids for SLC2A2 Gene

Previous HGNC Symbols for SLC2A2 Gene

  • GLUT2

Previous GeneCards Identifiers for SLC2A2 Gene

  • GC03M167856
  • GC03M171763
  • GC03M172116
  • GC03M172035
  • GC03M172196
  • GC03M170714
  • GC03M168084

Summaries for SLC2A2 Gene

Entrez Gene Summary for SLC2A2 Gene

  • This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC2A2 Gene

SLC2A2 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC2A2 include fanconi-bickel syndrome and renal glucosuria. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include dehydroascorbic acid transporter activity and hexose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A2 Gene

  • Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A2 Gene

Genomics for SLC2A2 Gene

Regulatory Elements for SLC2A2 Gene

Genomic Location for SLC2A2 Gene

Start:
170,996,348 bp from pter
End:
171,026,979 bp from pter
Size:
30,632 bases
Orientation:
Minus strand

Genomic View for SLC2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A2 Gene

Proteins for SLC2A2 Gene

  • Protein details for SLC2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11168-GTR2_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
    Protein Accession:
    P11168
    Secondary Accessions:
    • A8K481
    • B2R936
    • B7Z547
    • F8W8V8
    • Q9UCW9

    Protein attributes for SLC2A2 Gene

    Size:
    524 amino acids
    Molecular mass:
    57490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A2 Gene

Proteomics data for SLC2A2 Gene at MOPED

Post-translational modifications for SLC2A2 Gene

  • N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
  • Glycosylation at Asn62
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC2A2 Gene

Domains for SLC2A2 Gene

Gene Families for SLC2A2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P11168

UniProtKB/Swiss-Prot:

GTR2_HUMAN :
  • P11168
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A2: view

Function for SLC2A2 Gene

Molecular function for SLC2A2 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A2,facilitated glucose transporter
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney

Gene Ontology (GO) - Molecular Function for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity EXP --
GO:0015149 hexose transmembrane transporter activity TAS --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A2: view
genes like me logo Genes that share phenotypes with SLC2A2: view

Animal Models for SLC2A2 Gene

MGI Knock Outs for SLC2A2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC2A2 Gene

Localization for SLC2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A2 Gene COMPARTMENTS Subcellular localization image for SLC2A2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8027028
GO:0005903 brush border IEA --
GO:0016020 membrane TAS 8027028
genes like me logo Genes that share ontologies with SLC2A2: view

Pathways for SLC2A2 Gene

genes like me logo Genes that share pathways with SLC2A2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0008645 hexose transport TAS --
GO:0015758 glucose transport TAS --
GO:0015992 proton transport IBA --
genes like me logo Genes that share ontologies with SLC2A2: view

Compounds for SLC2A2 Gene

(1) ApexBio Compounds for SLC2A2 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes [864070-44-0]

(1) Drugbank Compounds for SLC2A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Streptozocin
18883-66-4 target ligand

(1) IUPHAR Ligand for SLC2A2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]2-deoxyglucose None None

(34) Novoseek inferred chemical compound relationships for SLC2A2 Gene

Compound -log(P) Hits PubMed IDs
glucose 79.1 179
preproinsulin 70.4 5
3-o-methylglucose 67.9 4
2-deoxyglucose 66.6 9
cytochalasin b 65.4 6
genes like me logo Genes that share compounds with SLC2A2: view

Transcripts for SLC2A2 Gene

Unigene Clusters for SLC2A2 Gene

Solute carrier family 2 (facilitated glucose transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -

Relevant External Links for SLC2A2 Gene

GeneLoc Exon Structure for
SLC2A2
ECgene alternative splicing isoforms for
SLC2A2

Expression for SLC2A2 Gene

mRNA expression in normal human tissues for SLC2A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A2 Gene

This gene is overexpressed in Liver (46.4).

Protein differential expression in normal tissues for SLC2A2 Gene

This gene is overexpressed in Liver (20.5), Uterus (17.1), Fetal Liver (15.8), and Gallbladder (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A2 Gene

SOURCE GeneReport for Unigene cluster for SLC2A2 Gene Hs.167584

mRNA Expression by UniProt/SwissProt for SLC2A2 Gene

P11168-GTR2_HUMAN
Tissue specificity: Liver, insulin-producing beta cell, small intestine and kidney
genes like me logo Genes that share expressions with SLC2A2: view

Expression partners for SLC2A2 Gene

In Situ Assay Products

Orthologs for SLC2A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC2A2 35
  • 85.68 (n)
  • 82.57 (a)
SLC2A2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A2 35
  • 86.83 (n)
  • 86.26 (a)
SLC2A2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a2 35
  • 81.77 (n)
  • 82.03 (a)
Slc2a2 16
Slc2a2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC2A2 35
  • 99.43 (n)
  • 99.81 (a)
SLC2A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a2 35
  • 81.29 (n)
  • 82.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC2A2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A2 35
  • 66.54 (n)
  • 66.02 (a)
SLC2A2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A2 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a2 35
  • 69.05 (n)
  • 67.89 (a)
Str.10072 35
zebrafish
(Danio rerio)
Actinopterygii slc2a2 35
  • 62.05 (n)
  • 61.45 (a)
slc2a2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7882 37
  • 30 (a)
Glut1 37
  • 41 (a)
sut1 37
  • 31 (a)
sut2 37
  • 28 (a)
sut3 37
  • 29 (a)
Glut1 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 37
  • 39 (a)
H17B01.1b 37
  • 39 (a)
R09B5.11 37
  • 35 (a)
F53H8.3 36
  • 26 (a)
ManyToMany
fgt-1 36
  • 39 (a)
ManyToMany
R09B5.11 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
ManyToMany
VPS73 36
  • 26 (a)
ManyToMany
SNF3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 36
  • 41 (a)
OneToMany
Species with no ortholog for SLC2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A2 Gene

ENSEMBL:
Gene Tree for SLC2A2 (if available)
TreeFam:
Gene Tree for SLC2A2 (if available)

Paralogs for SLC2A2 Gene

genes like me logo Genes that share paralogs with SLC2A2: view

Variants for SLC2A2 Gene

Sequence variations from dbSNP and Humsavar for SLC2A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2544 -- 171,018,346(+) CCCCC(C/T)GTGAT intron-variant
rs5393 -- 171,027,131(-) TAATT(A/C)TCTGT upstream-variant-2KB
rs5394 -- 171,027,104(-) TGCCT(C/T)CCATG upstream-variant-2KB
rs5395 -- 171,027,031(-) TCTTT(C/T)CACCG upstream-variant-2KB
rs5396 -- 171,027,026(-) TCACC(A/G)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC2A2 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
dgv5347n71 CNV Loss 21882294
nsv236991 CNV Loss 16902084
esv259438 OTHER Complex 20981092
esv259965 OTHER Complex 20981092
nsv509866 CNV Loss 20534489

Relevant External Links for SLC2A2 Gene

HapMap Linkage Disequilibrium report
SLC2A2
Human Gene Mutation Database (HGMD)
SLC2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A2 Gene

Disorders for SLC2A2 Gene

(2) OMIM Diseases for SLC2A2 Gene (138160)

UniProtKB/Swiss-Prot

GTR2_HUMAN
  • Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO:0000269 PubMed:10987651, ECO:0000269 PubMed:11044475}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for SLC2A2 Gene

(23) Novoseek inferred disease relationships for SLC2A2 Gene

Disease -log(P) Hits PubMed IDs
fanconi-bickel syndrome 96.9 21
renal tubular disorder 70.5 1
insulinoma 61.4 10
glycogen storage disease 58.5 4
niddm 58.2 40

Genatlas disease for SLC2A2 Gene

glycogen storage disease,hepatorenal with tubular nephropathy and impaired utilization of glucose and galactose,Fanconi-Bickel syndrome

Relevant External Links for SLC2A2

Genetic Association Database (GAD)
SLC2A2
Human Genome Epidemiology (HuGE) Navigator
SLC2A2
genes like me logo Genes that share disorders with SLC2A2: view

Publications for SLC2A2 Gene

  1. Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus. (PMID: 7593414) Matsubara A. … Kaku K. (J. Clin. Endocrinol. Metab. 1995) 4 23 48
  2. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. (PMID: 8027028) Mueckler M. … Permutt M.A. (J. Biol. Chem. 1994) 3 4 23
  3. A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato- renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity. (PMID: 10987651) Burwinkel B. … Kilimann M.W. (Hum. Genet. 1999) 3 4 23
  4. Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome. (PMID: 11044475) Sakamoto O. … Iinuma K. (Pediatr. Res. 2000) 3 4 23
  5. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. (PMID: 11344224) MA … Pedersen O. (J. Clin. Endocrinol. Metab. 2001) 3 23 48

Products for SLC2A2 Gene

Sources for SLC2A2 Gene

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