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Aliases for SLC1A5 Gene

Aliases for SLC1A5 Gene

  • Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5 2 3
  • M7V1 3 4 6
  • RDRC 3 4 6
  • Sodium-Dependent Neutral Amino Acid Transporter Type 2 3 4
  • RD114/Simian Type D Retrovirus Receptor 3 4
  • Solute Carrier Family 1 Member 5 3 4
  • Baboon M7 Virus Receptor 3 4
  • ATB(0) 3 4
  • M7VS1 3 6
  • ASCT2 3 4
  • Neutral Amino Acid Transporter B(0) 3
  • Neutral Amino Acid Transporter B 3
  • RD114 Virus Receptor 3
  • AAAT 3
  • ATBO 3
  • R16 3
  • RDR 4

External Ids for SLC1A5 Gene

Previous HGNC Symbols for SLC1A5 Gene

  • RDRC
  • M7V1

Previous GeneCards Identifiers for SLC1A5 Gene

  • GC19M047922
  • GC19M047669
  • GC19M051954
  • GC19M051969
  • GC19M047278
  • GC19M043702

Summaries for SLC1A5 Gene

Entrez Gene Summary for SLC1A5 Gene

  • The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC1A5 Gene

SLC1A5 (Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include hartnup disorder and pellagra. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and neutral amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A5 Gene

  • Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene Wiki entry for SLC1A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A5 Gene

Genomics for SLC1A5 Gene

Regulatory Elements for SLC1A5 Gene

Genomic Location for SLC1A5 Gene

Start:
46,760,328 bp from pter
End:
46,789,019 bp from pter
Size:
28,692 bases
Orientation:
Minus strand

Genomic View for SLC1A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A5 Gene

Proteins for SLC1A5 Gene

  • Protein details for SLC1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15758-AAAT_HUMAN
    Recommended name:
    Neutral amino acid transporter B(0)
    Protein Accession:
    Q15758
    Secondary Accessions:
    • A8K9H5
    • B4DR77
    • B4DWS4
    • B7ZB81
    • D0EYG6
    • E9PC01
    • O95720
    • Q96RL9
    • Q9BWQ3
    • Q9UNP2

    Protein attributes for SLC1A5 Gene

    Size:
    541 amino acids
    Molecular mass:
    56598 Da
    Quaternary structure:
    • Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.

    Alternative splice isoforms for SLC1A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A5 Gene

Proteomics data for SLC1A5 Gene at MOPED

Post-translational modifications for SLC1A5 Gene

  • Ubiquitination at Lys372, Lys502, Lys522, and Lys537
  • Glycosylation at Asn163 and Asn212
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A5 Gene

No data available for DME Specific Peptides for SLC1A5 Gene

Domains for SLC1A5 Gene

Gene Families for SLC1A5 Gene

Protein Domains for SLC1A5 Gene

Graphical View of Domain Structure for InterPro Entry

Q15758

UniProtKB/Swiss-Prot:

AAAT_HUMAN :
  • Q15758
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily.
genes like me logo Genes that share domains with SLC1A5: view

Function for SLC1A5 Gene

Molecular function for SLC1A5 Gene

GENATLAS Biochemistry: solute carrier family 1 (glutamate/neutral amino acid transport),member 5
UniProtKB/Swiss-Prot Function: Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene Ontology (GO) - Molecular Function for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 10051606
GO:0005515 protein binding IPI 23492904
GO:0015171 amino acid transmembrane transporter activity --
GO:0015175 neutral amino acid transmembrane transporter activity TAS 10051606
genes like me logo Genes that share ontologies with SLC1A5: view

Phenotypes for SLC1A5 Gene

GenomeRNAi human phenotypes for SLC1A5:
genes like me logo Genes that share phenotypes with SLC1A5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC1A5 Gene

Localization for SLC1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A5 Gene

Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A5 Gene COMPARTMENTS Subcellular localization image for SLC1A5 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8702519
GO:0016020 membrane IDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

Pathways for SLC1A5 Gene

genes like me logo Genes that share pathways with SLC1A5: view

Gene Ontology (GO) - Biological Process for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport IEA --
GO:0006860 extracellular amino acid transport IEA --
GO:0006865 amino acid transport TAS --
genes like me logo Genes that share ontologies with SLC1A5: view

Compounds for SLC1A5 Gene

(3) HMDB Compounds for SLC1A5 Gene

Compound Synonyms Cas Number PubMed IDs
L-Asparagine
  • (-)-Asparagine
70-47-3
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9
Sodium
  • Sodium
7440-23-5

(2) Drugbank Compounds for SLC1A5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Asparagine
  • (-)-Asparagine
70-47-3 target
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 transporter substrate

(3) IUPHAR Ligand for SLC1A5 Gene

Ligand Type Action Affinity Pubmed IDs
p-nitrophenyl glutamyl anilide Inhibitor Inhibition
benzylcysteine Inhibitor Inhibition
benzylserine Inhibitor Inhibition

(4) Novoseek inferred chemical compound relationships for SLC1A5 Gene

Compound -log(P) Hits PubMed IDs
glutamine 35.1 3
alanine 34.2 4
glutamate 32.8 2
serine 8.26 1
genes like me logo Genes that share compounds with SLC1A5: view

Transcripts for SLC1A5 Gene

Unigene Clusters for SLC1A5 Gene

Solute carrier family 1 (neutral amino acid transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for SLC1A5 Gene

GeneLoc Exon Structure for
SLC1A5
ECgene alternative splicing isoforms for
SLC1A5

Expression for SLC1A5 Gene

mRNA expression in normal human tissues for SLC1A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC1A5 Gene

SOURCE GeneReport for Unigene cluster for SLC1A5 Gene Hs.631582

mRNA Expression by UniProt/SwissProt for SLC1A5 Gene

Q15758-AAAT_HUMAN
Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine
genes like me logo Genes that share expressions with SLC1A5: view

No data available for mRNA differential expression in normal tissues for SLC1A5 Gene

Orthologs for SLC1A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A5 35
  • 99.5 (n)
  • 100 (a)
SLC1A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A5 35
  • 84.88 (n)
  • 87.17 (a)
SLC1A5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A5 35
  • 86.17 (n)
  • 88.7 (a)
SLC1A5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a5 35
  • 81.29 (n)
  • 83.83 (a)
Slc1a5 16
Slc1a5 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A5 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A5 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a5 35
  • 79.38 (n)
  • 80.93 (a)
lizard
(Anolis carolinensis)
Reptilia SLC1A5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a5 35
  • 69.29 (n)
  • 75.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535841 35
  • 67.18 (n)
  • 69.8 (a)
slc1a5 36
  • 62 (a)
OneToMany
slc1a5 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 36
  • 35 (a)
OneToMany
Eaat1 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-4 36
  • 35 (a)
OneToMany
W03G1.1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLC1A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A5 Gene

ENSEMBL:
Gene Tree for SLC1A5 (if available)
TreeFam:
Gene Tree for SLC1A5 (if available)

Paralogs for SLC1A5 Gene

Paralogs for SLC1A5 Gene

Selected SIMAP similar genes for SLC1A5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC1A5: view

Variants for SLC1A5 Gene

Sequence variations from dbSNP and Humsavar for SLC1A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs313835 -- 46,777,532(+) CCACC(C/T)AGTGG intron-variant
rs313836 -- 46,779,373(+) GAGCC(A/G)AGATC intron-variant
rs313851 -- 46,783,234(+) taagg(C/T)gggca intron-variant
rs313852 -- 46,783,912(+) CCTGG(A/G)CACCT intron-variant
rs313853 -- 46,784,682(+) GCAAA(C/T)ACAGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC1A5 Gene

Variant ID Type Subtype PubMed ID
dgv3961n71 CNV Loss 21882294
nsv833850 CNV Loss 17160897
esv1008167 CNV Deletion 20482838
nsv912190 CNV Gain 21882294

Relevant External Links for SLC1A5 Gene

HapMap Linkage Disequilibrium report
SLC1A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A5 Gene

Disorders for SLC1A5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SLC1A5 Gene including...

Search for SLC1A5 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SLC1A5 Gene

(1) Novoseek inferred disease relationships for SLC1A5 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 1

Relevant External Links for SLC1A5

Genetic Association Database (GAD)
SLC1A5
Human Genome Epidemiology (HuGE) Navigator
SLC1A5
genes like me logo Genes that share disorders with SLC1A5: view

No data available for UniProtKB/Swiss-Prot for SLC1A5 Gene

Publications for SLC1A5 Gene

  1. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (PMID: 8702519) Kekuda R. … Ganapathy V. (J. Biol. Chem. 1996) 2 3 4 23
  2. The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. (PMID: 10051606) Rasko J.E.J. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  3. Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. (PMID: 11350958) Tailor C.S. … Kabat D. (J. Biol. Chem. 2001) 3 4 23
  4. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PMID: 18638388) Deng X. … Fukumaki Y. (BMC Psychiatry 2008) 3 23 48
  5. Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts. (PMID: 19321927) Wich C. … Knerr I. (Gynecol. Obstet. Invest. 2009) 3 23

Products for SLC1A5 Gene

  • antibodies-online peptides for SLC1A5
  • antibodies-online antibodies for SLC1A5
  • antibodies-online kits for SLC1A5

Sources for SLC1A5 Gene

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