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Aliases for SLC1A5 Gene

Aliases for SLC1A5 Gene

  • Solute Carrier Family 1 Member 5 2 3 4
  • Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5 2 3 5
  • Sodium-Dependent Neutral Amino Acid Transporter Type 2 3 4
  • RD114/Simian Type D Retrovirus Receptor 3 4
  • Baboon M7 Virus Receptor 3 4
  • ATB(0) 3 4
  • ASCT2 3 4
  • M7V1 3 4
  • RDRC 3 4
  • Neutral Amino Acid Transporter B 3
  • RD114 Virus Receptor 3
  • M7VS1 3
  • AAAT 3
  • ATBO 3
  • R16 3
  • RDR 4

External Ids for SLC1A5 Gene

Previous HGNC Symbols for SLC1A5 Gene

  • RDRC
  • M7V1

Previous GeneCards Identifiers for SLC1A5 Gene

  • GC19M047922
  • GC19M047669
  • GC19M051954
  • GC19M051969
  • GC19M047278
  • GC19M043702

Summaries for SLC1A5 Gene

Entrez Gene Summary for SLC1A5 Gene

  • The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC1A5 Gene

SLC1A5 (Solute Carrier Family 1 Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include Cystinuria. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A5 Gene

  • Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene Wiki entry for SLC1A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A5 Gene

Genomics for SLC1A5 Gene

Regulatory Elements for SLC1A5 Gene

Enhancers for SLC1A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC1A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC1A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC1A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC1A5 Gene

Chromosome:
19
Start:
46,759,698 bp from pter
End:
46,788,649 bp from pter
Size:
28,952 bases
Orientation:
Minus strand

Genomic View for SLC1A5 Gene

Genes around SLC1A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A5 Gene

Proteins for SLC1A5 Gene

  • Protein details for SLC1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15758-AAAT_HUMAN
    Recommended name:
    Neutral amino acid transporter B(0)
    Protein Accession:
    Q15758
    Secondary Accessions:
    • A8K9H5
    • B4DR77
    • B4DWS4
    • B7ZB81
    • D0EYG6
    • E9PC01
    • O95720
    • Q96RL9
    • Q9BWQ3
    • Q9UNP2

    Protein attributes for SLC1A5 Gene

    Size:
    541 amino acids
    Molecular mass:
    56598 Da
    Quaternary structure:
    • Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.

    Alternative splice isoforms for SLC1A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A5 Gene

Proteomics data for SLC1A5 Gene at MOPED

Post-translational modifications for SLC1A5 Gene

  • Ubiquitination at Lys 372, Lys 502, Lys 522, and Lys 537
  • Glycosylation at Asn 163 and Asn 212
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A5 (SLC1A5)

No data available for DME Specific Peptides for SLC1A5 Gene

Domains & Families for SLC1A5 Gene

Protein Domains for SLC1A5 Gene

Graphical View of Domain Structure for InterPro Entry

Q15758

UniProtKB/Swiss-Prot:

AAAT_HUMAN :
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily.
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily.
genes like me logo Genes that share domains with SLC1A5: view

Function for SLC1A5 Gene

Molecular function for SLC1A5 Gene

GENATLAS Biochemistry:
solute carrier family 1 (glutamate/neutral amino acid transport),member 5
UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene Ontology (GO) - Molecular Function for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015175 neutral amino acid transmembrane transporter activity TAS 10051606
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A5: view
genes like me logo Genes that share phenotypes with SLC1A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC1A5

CRISPR Products

miRNA for SLC1A5 Gene

miRTarBase miRNAs that target SLC1A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC1A5 Gene

Localization for SLC1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A5 Gene

Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A5 Gene COMPARTMENTS Subcellular localization image for SLC1A5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

Pathways & Interactions for SLC1A5 Gene

genes like me logo Genes that share pathways with SLC1A5: view

Gene Ontology (GO) - Biological Process for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport IEA --
GO:0006868 glutamine transport TAS 21757002
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

No data available for SIGNOR curated interactions for SLC1A5 Gene

Drugs & Compounds for SLC1A5 Gene

(7) Drugs for SLC1A5 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 0
benzylcysteine Experimental Pharma Inhibition, Inhibitor 0
benzylserine Pharma Inhibition, Inhibitor 0

(3) Additional Compounds for SLC1A5 Gene - From: IUPHAR, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
p-nitrophenyl glutamyl anilide
Inhibition, Inhibitor
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC1A5: view

Transcripts for SLC1A5 Gene

Unigene Clusters for SLC1A5 Gene

Solute carrier family 1 (neutral amino acid transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for SLC1A5 Gene

GeneLoc Exon Structure for
SLC1A5
ECgene alternative splicing isoforms for
SLC1A5

Expression for SLC1A5 Gene

mRNA expression in normal human tissues for SLC1A5 Gene

Protein differential expression in normal tissues from HIPED for SLC1A5 Gene

This gene is overexpressed in Nasal epithelium (29.9), Bone (11.7), and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC1A5 Gene



SOURCE GeneReport for Unigene cluster for SLC1A5 Gene Hs.631582

mRNA Expression by UniProt/SwissProt for SLC1A5 Gene

Q15758-AAAT_HUMAN
Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
genes like me logo Genes that share expression patterns with SLC1A5: view

Protein tissue co-expression partners for SLC1A5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC1A5 Gene

Orthologs for SLC1A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC1A5 35
  • 84.88 (n)
  • 87.17 (a)
SLC1A5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A5 35
  • 86.17 (n)
  • 88.7 (a)
SLC1A5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a5 35
  • 81.29 (n)
  • 83.83 (a)
Slc1a5 16
Slc1a5 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC1A5 35
  • 99.5 (n)
  • 100 (a)
SLC1A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a5 35
  • 79.38 (n)
  • 80.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC1A5 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A5 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a5 35
  • 69.29 (n)
  • 75.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535841 35
  • 67.18 (n)
  • 69.8 (a)
slc1a5 36
  • 62 (a)
OneToMany
slc1a5 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 37
  • 38 (a)
Eaat1 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W03G1.1 37
  • 32 (a)
glt-4 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLC1A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A5 Gene

ENSEMBL:
Gene Tree for SLC1A5 (if available)
TreeFam:
Gene Tree for SLC1A5 (if available)

Paralogs for SLC1A5 Gene

Paralogs for SLC1A5 Gene

(6) SIMAP similar genes for SLC1A5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC1A5: view

Variants for SLC1A5 Gene

Sequence variations from dbSNP and Humsavar for SLC1A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3027961 - 46,775,602(-) TGCCA(C/G)TCCCC intron-variant, reference, missense
rs3027956 - 46,787,917(-) CGGAG(C/G)CCACC upstream-variant-2KB, reference, missense
rs7257942 -- 46,773,772(+) accca(C/G)cctgt intron-variant
rs12982560 -- 46,790,201(+) ggctg(C/T)agtga upstream-variant-2KB
rs12985039 -- 46,770,709(+) acccg(C/G)ctcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A5 Gene

Variant ID Type Subtype PubMed ID
dgv3961n71 CNV Loss 21882294
nsv833850 CNV Loss 17160897
esv1008167 CNV Deletion 20482838
nsv912190 CNV Gain 21882294

Variation tolerance for SLC1A5 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC1A5 Gene

Disorders for SLC1A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC1A5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cystinuria
  • csnu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC1A5

Genetic Association Database (GAD)
SLC1A5
Human Genome Epidemiology (HuGE) Navigator
SLC1A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A5
genes like me logo Genes that share disorders with SLC1A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC1A5 Gene

Publications for SLC1A5 Gene

  1. The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. (PMID: 10051606) Rasko J.E.J. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. (PMID: 16516348) Gegelashvili M. … Gegelashvili G. (Neurochem. Int. 2006) 3 25 26
  3. Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. (PMID: 16197915) Bungard C.I. … McGivan J.D. (Arch. Biochem. Biophys. 2005) 3 25 26
  4. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (PMID: 8702519) Kekuda R. … Ganapathy V. (J. Biol. Chem. 1996) 2 3 23
  5. Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts. (PMID: 19321927) Wich C. … Knerr I. (Gynecol. Obstet. Invest. 2009) 3 23

Products for SLC1A5 Gene

Sources for SLC1A5 Gene

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