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Aliases for SLC1A4 Gene

Aliases for SLC1A4 Gene

  • Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 2 3
  • ASCT1 3 4 6
  • SATT 3 4 6
  • Alanine/Serine/Cysteine/Threonine Transporter 1 3 4
  • Solute Carrier Family 1 Member 4 3 4
  • ASCT-1 3 4
  • Alanine/Serine/Cysteine/Threonine Transporter 2
  • Glutamate/Neutral Amino Acid Transporter 3
  • Neutral Amino Acid Transporter A 3

External Ids for SLC1A4 Gene

Previous GeneCards Identifiers for SLC1A4 Gene

  • GC02P065350
  • GC02P065173
  • GC02P065191
  • GC02P065128
  • GC02P065070
  • GC02P065216

Summaries for SLC1A4 Gene

GeneCards Summary for SLC1A4 Gene

SLC1A4 (Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC1A4 include hartnup disorder and cystinuria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neuroscience. GO annotations related to this gene include chloride channel activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A4 Gene

  • Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

Gene Wiki entry for SLC1A4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A4 Gene

Genomics for SLC1A4 Gene

Regulatory Elements for SLC1A4 Gene

Genomic Location for SLC1A4 Gene

Start:
64,988,445 bp from pter
End:
65,023,865 bp from pter
Size:
35,421 bases
Orientation:
Plus strand

Genomic View for SLC1A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A4 Gene

Proteins for SLC1A4 Gene

  • Protein details for SLC1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43007-SATT_HUMAN
    Recommended name:
    Neutral amino acid transporter A
    Protein Accession:
    P43007
    Secondary Accessions:
    • B7Z3C0
    • D6W5F0

    Protein attributes for SLC1A4 Gene

    Size:
    532 amino acids
    Molecular mass:
    55723 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC1A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A4 Gene

Proteomics data for SLC1A4 Gene at MOPED

Post-translational modifications for SLC1A4 Gene

  • Glycosylation at Asn201 and Asn206
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A4 (SLC1A4)

No data available for DME Specific Peptides for SLC1A4 Gene

Domains for SLC1A4 Gene

Gene Families for SLC1A4 Gene

Protein Domains for SLC1A4 Gene

Suggested Antigen Peptide Sequences for SLC1A4 Gene

Graphical View of Domain Structure for InterPro Entry

P43007

UniProtKB/Swiss-Prot:

SATT_HUMAN :
  • P43007
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily.
genes like me logo Genes that share domains with SLC1A4: view

Function for SLC1A4 Gene

Molecular function for SLC1A4 Gene

GENATLAS Biochemistry: solute carrier family 1,member A4,glutamate/neutral amino acid transporter
UniProtKB/Swiss-Prot Function: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

Gene Ontology (GO) - Molecular Function for SLC1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IDA 8910405
GO:0015175 neutral amino acid transmembrane transporter activity --
GO:0015180 L-alanine transmembrane transporter activity IDA 8101838
GO:0015184 NOT L-cystine transmembrane transporter activity IDA 8340364
GO:0015186 L-glutamine transmembrane transporter activity TAS 21757002
genes like me logo Genes that share ontologies with SLC1A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC1A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC1A4 Gene

Localization for SLC1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A4 Gene

Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A4 Gene COMPARTMENTS Subcellular localization image for SLC1A4 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005882 intermediate filament ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 8910405
genes like me logo Genes that share ontologies with SLC1A4: view

Pathways for SLC1A4 Gene

genes like me logo Genes that share pathways with SLC1A4: view

Interacting Proteins for SLC1A4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000234256%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000419945%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000234256 P43007-SATT_HUMAN for SLC1A4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006821 chloride transport IDA 8910405
GO:0006835 dicarboxylic acid transport IEA --
GO:0006865 amino acid transport TAS --
GO:0006868 glutamine transport TAS 21757002
genes like me logo Genes that share ontologies with SLC1A4: view

Compounds for SLC1A4 Gene

(6) HMDB Compounds for SLC1A4 Gene

Compound Synonyms Cas Number PubMed IDs
Hydroxyproline
  • (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid
51-35-4
L-Alanine
  • (2S)-2-Aminopropanoate
56-41-7
L-Cystine
  • (-)-Cystine
56-89-3
L-Serine
  • (-)-Serine
56-45-1
L-Threonine
  • (2S,3R)-(-)-Threonine
72-19-5

(1) Drugbank Compounds for SLC1A4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Alanine
  • (2S)-2-Aminopropanoic acid
56-41-7 target

(10) Novoseek inferred chemical compound relationships for SLC1A4 Gene

Compound -log(P) Hits PubMed IDs
glutamate 57.2 15
glutamine 54.6 3
alanine 50.4 5
serine 46.5 4
phenylalanine 43 2
genes like me logo Genes that share compounds with SLC1A4: view

Transcripts for SLC1A4 Gene

Unigene Clusters for SLC1A4 Gene

Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC1A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A4 Gene

No ASD Table

Relevant External Links for SLC1A4 Gene

GeneLoc Exon Structure for
SLC1A4
ECgene alternative splicing isoforms for
SLC1A4

Expression for SLC1A4 Gene

mRNA expression in normal human tissues for SLC1A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC1A4 Gene

SOURCE GeneReport for Unigene cluster for SLC1A4 Gene Hs.654352

mRNA Expression by UniProt/SwissProt for SLC1A4 Gene

P43007-SATT_HUMAN
Tissue specificity: Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined
genes like me logo Genes that share expressions with SLC1A4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC1A4 Gene

Orthologs for SLC1A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A4 35
  • 99.5 (n)
  • 100 (a)
SLC1A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A4 35
  • 88.24 (n)
  • 92.45 (a)
SLC1A4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A4 35
  • 90.3 (n)
  • 93.19 (a)
SLC1A4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a4 35
  • 86.15 (n)
  • 89.85 (a)
Slc1a4 16
Slc1a4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc1a4 35
  • 84.25 (n)
  • 88.05 (a)
chicken
(Gallus gallus)
Aves SLC1A4 35
  • 76.25 (n)
  • 80.84 (a)
SLC1A4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a4 35
  • 70.78 (n)
  • 75.9 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a4 35
  • 72.06 (n)
  • 79.21 (a)
slc1a4 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 36
  • 35 (a)
OneToMany
Eaat1 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-4 36
  • 36 (a)
OneToMany
T22E5.2 37
  • 39 (a)
W03G1.1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SLC1A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A4 Gene

ENSEMBL:
Gene Tree for SLC1A4 (if available)
TreeFam:
Gene Tree for SLC1A4 (if available)

Paralogs for SLC1A4 Gene

Paralogs for SLC1A4 Gene

Selected SIMAP similar genes for SLC1A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC1A4: view

Variants for SLC1A4 Gene

Sequence variations from dbSNP and Humsavar for SLC1A4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7850 -- 65,022,788(+) CCAGC(A/C)ACTGT utr-variant-3-prime
rs759458 - 65,018,231(-) CTCTA(C/T)GTTGT missense, reference
rs1008617 -- 64,987,658(-) TGGGG(A/G)GGGGG upstream-variant-2KB
rs1056703 -- 64,994,462(+) CCATC(A/T)TGCAG intron-variant
rs1058922 -- 65,023,407(+) GGGGA(A/T)CTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC1A4 Gene

Variant ID Type Subtype PubMed ID
nsv834246 CNV Loss 17160897
esv275563 CNV Loss 21479260

Relevant External Links for SLC1A4 Gene

HapMap Linkage Disequilibrium report
SLC1A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A4 Gene

Disorders for SLC1A4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SLC1A4 Gene including...

Search for SLC1A4 Gene in MalaCards »

(3) Novoseek inferred disease relationships for SLC1A4 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 8.31 7
cancer 4.42 1
tumors 0 1

Relevant External Links for SLC1A4

Genetic Association Database (GAD)
SLC1A4
Human Genome Epidemiology (HuGE) Navigator
SLC1A4
genes like me logo Genes that share disorders with SLC1A4: view

No data available for UniProtKB/Swiss-Prot for SLC1A4 Gene

Publications for SLC1A4 Gene

  1. Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. (PMID: 7896285) Hofmann K. … Stoffel W. (Genomics 1994) 2 3 4 23
  2. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PMID: 18638388) Deng X. … Fukumaki Y. (BMC Psychiatry 2008) 3 23 48
  3. ASCT-1 is a neutral amino acid exchanger with chloride channel activity. (PMID: 8910405) Zerangue N. … Kavanaugh M.P. (J. Biol. Chem. 1996) 2 3 23
  4. No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample. (PMID: 17106422) Skowronek M.H. … Rietschel M. (Psychiatr. Genet. 2006) 3 23 48
  5. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. (PMID: 8340364) Shafqat S. … Fremeau R.T. Jr. (J. Biol. Chem. 1993) 3 4 23

Products for SLC1A4 Gene

Sources for SLC1A4 Gene

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