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Aliases for SLC4A3 Gene

Aliases for SLC4A3 Gene

  • Solute Carrier Family 4 (Anion Exchanger), Member 3 2 3
  • AE3 3 4 6
  • Cardiac/Brain Band 3-Like Protein 3 4
  • Solute Carrier Family 4 Member 3 3 4
  • Neuronal Band 3-Like Protein 3 4
  • Anion Exchanger 3 2 4
  • CAE3/BAE3 3 4
  • SLC2C 3 6
  • AE 3 3 4
  • Solute Carrier Family 4, Anion Exchanger, Member 3 2
  • Anion Exchanger 3 Cardiac Isoform 3
  • Anion Exchanger 3, Neuronal 3
  • Anion Exchange Protein 3 3
  • Neuronal 2

External Ids for SLC4A3 Gene

Previous GeneCards Identifiers for SLC4A3 Gene

  • GC02P218515
  • GC02P219214
  • GC02P220456
  • GC02P220695
  • GC02P220694
  • GC02P220317
  • GC02P220200
  • GC02P220492
  • GC02P212345

Summaries for SLC4A3 Gene

GeneCards Summary for SLC4A3 Gene

SLC4A3 (Solute Carrier Family 4 (Anion Exchanger), Member 3) is a Protein Coding gene. Diseases associated with SLC4A3 include epithelial malignant thymoma and thymoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A8.

UniProtKB/Swiss-Prot for SLC4A3 Gene

  • Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-)

Gene Wiki entry for SLC4A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A3 Gene

Genomics for SLC4A3 Gene

Regulatory Elements for SLC4A3 Gene

Transcription factor binding sites by QIAGEN in the SLC4A3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC4A3 Gene

Start:
219,627,327 bp from pter
End:
219,641,980 bp from pter
Size:
14,654 bases
Orientation:
Plus strand

Genomic View for SLC4A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A3 Gene

Proteins for SLC4A3 Gene

  • Protein details for SLC4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48751-B3A3_HUMAN
    Recommended name:
    Anion exchange protein 3
    Protein Accession:
    P48751
    Secondary Accessions:
    • A6H8L2
    • A8K1Q9
    • B7ZVX6
    • B9EGD1
    • Q6YIQ9

    Protein attributes for SLC4A3 Gene

    Size:
    1232 amino acids
    Molecular mass:
    135791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC4A3 Gene

Proteomics data for SLC4A3 Gene at MOPED

Post-translational modifications for SLC4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A3 Gene

No data available for DME Specific Peptides for SLC4A3 Gene

Domains for SLC4A3 Gene

Gene Families for SLC4A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48751

UniProtKB/Swiss-Prot:

B3A3_HUMAN :
  • P48751
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.
genes like me logo Genes that share domains with SLC4A3: view

Function for SLC4A3 Gene

Molecular function for SLC4A3 Gene

GENATLAS Biochemistry:
solute carrier family 4 (chloride-bicarbonate,anion exchange),member 3,expressed in human heart,isoform 3c in brain and stomach,containing an intronic CGG repeat
UniProtKB/Swiss-Prot Function:
Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-)

Gene Ontology (GO) - Molecular Function for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity --
GO:0015301 anion:anion antiporter activity --
genes like me logo Genes that share ontologies with SLC4A3: view
genes like me logo Genes that share phenotypes with SLC4A3: view

Animal Models for SLC4A3 Gene

MGI Knock Outs for SLC4A3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC4A3 Gene

Localization for SLC4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A3 Gene COMPARTMENTS Subcellular localization image for SLC4A3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7923606
GO:0016020 membrane TAS 7923606
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC4A3: view

Pathways for SLC4A3 Gene

genes like me logo Genes that share pathways with SLC4A3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7923606
GO:0006811 ion transport TAS --
GO:0006820 anion transport --
GO:0015701 bicarbonate transport TAS --
GO:0051453 regulation of intracellular pH IBA --
genes like me logo Genes that share ontologies with SLC4A3: view

Compounds for SLC4A3 Gene

(2) Novoseek inferred chemical compound relationships for SLC4A3 Gene

Compound -log(P) Hits PubMed IDs
bicarbonate 59.6 6
chloride 42.6 2
genes like me logo Genes that share compounds with SLC4A3: view

Transcripts for SLC4A3 Gene

Unigene Clusters for SLC4A3 Gene

Solute carrier family 4, anion exchanger, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC4A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A3 Gene

No ASD Table

Relevant External Links for SLC4A3 Gene

GeneLoc Exon Structure for
SLC4A3
ECgene alternative splicing isoforms for
SLC4A3

Expression for SLC4A3 Gene

mRNA expression in normal human tissues for SLC4A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC4A3 Gene

This gene is overexpressed in Heart - Left Ventricle (11.1), Heart - Atrial Appendage (7.9), and Ovary (5.8).

Protein differential expression in normal tissues for SLC4A3 Gene

This gene is overexpressed in Heart (43.2) and Retina (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC4A3 Gene

SOURCE GeneReport for Unigene cluster for SLC4A3 Gene Hs.1176

mRNA Expression by UniProt/SwissProt for SLC4A3 Gene

P48751-B3A3_HUMAN
Tissue specificity: Both BAE3 and CAE3 are expressed in failing ventricle
genes like me logo Genes that share expressions with SLC4A3: view

Expression partners for SLC4A3 Gene

In Situ Assay Products

Orthologs for SLC4A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC4A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC4A3 35
  • 89.09 (n)
  • 94.33 (a)
SLC4A3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC4A3 35
  • 89.94 (n)
  • 94.98 (a)
SLC4A3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc4a3 35
  • 88.18 (n)
  • 96.17 (a)
Slc4a3 16
Slc4a3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC4A3 35
  • 99.36 (n)
  • 99.76 (a)
SLC4A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a3 35
  • 88.24 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC4A3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A3 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC4A3 35
  • 70.77 (n)
  • 72.3 (a)
SLC4A3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC4A3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495394 35
  • 68.88 (n)
  • 71.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333073 35
  • 64.3 (n)
  • 65.89 (a)
SLC4A3 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8177 37
  • 48 (a)
CG8177 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03E9.3 37
  • 26 (a)
abts-4 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOR1 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BOR1 35
  • 44.55 (n)
  • 33.64 (a)
rice
(Oryza sativa)
Liliopsida Os12g0566000 35
  • 45.88 (n)
  • 29.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A3 Gene

ENSEMBL:
Gene Tree for SLC4A3 (if available)
TreeFam:
Gene Tree for SLC4A3 (if available)

Paralogs for SLC4A3 Gene

Paralogs for SLC4A3 Gene

Selected SIMAP similar genes for SLC4A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC4A3: view

Variants for SLC4A3 Gene

Sequence variations from dbSNP and Humsavar for SLC4A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs589767 -- 219,635,701(+) TCTGA(A/G)GCAAC synonymous-codon, reference, nc-transcript-variant
rs597306 - 219,629,396(+) CCCCC(A/C)CTCAG reference, missense, upstream-variant-2KB
rs612078 -- 219,630,445(+) CTGCT(A/C)AGGGC intron-variant, upstream-variant-2KB
rs621515 -- 219,637,415(-) ACACA(A/G)AACAC intron-variant
rs623851 -- 219,637,321(+) TGTTG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A3 Gene

Variant ID Type Subtype PubMed ID
dgv4438n71 CNV Loss 21882294
nsv875876 CNV Loss 21882294
esv1005415 CNV Deletion 20482838

Relevant External Links for SLC4A3 Gene

HapMap Linkage Disequilibrium report
SLC4A3
Human Gene Mutation Database (HGMD)
SLC4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A3 Gene

Disorders for SLC4A3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC4A3 Gene in MalaCards »

(2) Diseases for SLC4A3 Gene including...

(1) University of Copenhagen DISEASES for SLC4A3 Gene

Relevant External Links for SLC4A3

Genetic Association Database (GAD)
SLC4A3
Human Genome Epidemiology (HuGE) Navigator
SLC4A3
genes like me logo Genes that share disorders with SLC4A3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SLC4A3 Gene

Publications for SLC4A3 Gene

  1. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. (PMID: 7923606) Yannoukakos D. … Alper S.L. (Circ. Res. 1994) 3 4 23
  2. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. (PMID: 8001971) Su Y.R. … Menon A.G. (Genomics 1994) 2 3 23
  3. Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. (PMID: 11248201) Alrefai W.A. … Dudeja P.K. (Biochim. Biophys. Acta 2001) 3 23
  4. Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. (PMID: 12399075) Sander T. … NA1rnberg P. (Epilepsy Res. 2002) 23 48
  5. Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3. (PMID: 19605733) Vilas G.L. … Casey J.R. (Am. J. Physiol., Cell Physiol. 2009) 3 23

Products for SLC4A3 Gene

Sources for SLC4A3 Gene

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