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Aliases for RTN4R Gene

Aliases for RTN4R Gene

  • Reticulon 4 Receptor 2 3 5
  • Nogo-66 Receptor 3 4
  • Nogo Receptor 3 4
  • NOGOR 3 4
  • NGR 3 4
  • Reticulon-4 Receptor 3
  • UNQ330/PRO526 3

External Ids for RTN4R Gene

Previous GeneCards Identifiers for RTN4R Gene

  • GC22M017169
  • GC22M018603
  • GC22M003848

Summaries for RTN4R Gene

Entrez Gene Summary for RTN4R Gene

  • This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4R Gene

RTN4R (Reticulon 4 Receptor) is a Protein Coding gene. Diseases associated with RTN4R include Schizophrenia and Spinal Cord Injury. Among its related pathways are Spinal Cord Injury and p75(NTR)-mediated signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL1.

UniProtKB/Swiss-Prot for RTN4R Gene

  • Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).

Tocris Summary for RTN4R Gene

Gene Wiki entry for RTN4R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4R Gene

Genomics for RTN4R Gene

Regulatory Elements for RTN4R Gene

Enhancers for RTN4R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G020221 0.8 dbSUPER 12.7 +61.3 61325 0.9 HDAC1 KLF1 HDAC6 AGO1 SAP30 MAX RBBP5 RAD21 YY1 SCRT2 RTN4R LOC284865 LOC105372863 PIR42310
GH22G020219 0.8 FANTOM5 12.7 +63.3 63314 0.2 PKNOX1 ATF1 CBX3 USF1 AGO1 CBX5 POLR2A NFYB NFYA MIER1 RTN4R PIR42310 LOC105372863
GH22G020180 0.8 ENCODE 12.5 +100.1 100060 4.7 PKNOX1 AGO1 RAD21 GLIS2 EGR1 SCRT2 MCM3 ZBTB2 USF2 GATAD2B RTN4R TRMT2A ZDHHC8 ARVCF CCDC188 GC22P020198
GH22G020220 0.7 dbSUPER 12.7 +62.5 62539 0.9 BCOR SMARCA5 ATF1 MCM3 AGO1 USF2 ZIC2 ZBTB7A GLIS2 HDAC2 RTN4R LOC105372863 PIR42310
GH22G020217 0.7 dbSUPER 12.7 +65.8 65793 0.9 PKNOX1 KLF1 AGO1 ZFP64 RBBP5 ZIC2 ZNF433 ZBTB20 SP2 CEBPB RTN4R DGCR8 THAP7 LOC284865 PIR42310 LOC105372863
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN4R on UCSC Golden Path with GeneCards custom track

Genomic Location for RTN4R Gene

Chromosome:
22
Start:
20,241,415 bp from pter
End:
20,283,246 bp from pter
Size:
41,832 bases
Orientation:
Minus strand

Genomic View for RTN4R Gene

Genes around RTN4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4R Gene

Proteins for RTN4R Gene

  • Protein details for RTN4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZR6-RTN4R_HUMAN
    Recommended name:
    Reticulon-4 receptor
    Protein Accession:
    Q9BZR6
    Secondary Accessions:
    • D3DX28

    Protein attributes for RTN4R Gene

    Size:
    473 amino acids
    Molecular mass:
    50708 Da
    Quaternary structure:
    • Homodimer (PubMed:18411262). Interacts with MAG (PubMed:12089450, PubMed:12839991, PubMed:18411262). Interacts with RTN4 (By similarity). Interacts with NGFR (PubMed:12426574, PubMed:18411262). Interacts with LINGO1 (PubMed:14966521). Interacts with KIAA0319L (PubMed:20697954). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity).

    Three dimensional structures from OCA and Proteopedia for RTN4R Gene

neXtProt entry for RTN4R Gene

Post-translational modifications for RTN4R Gene

  • N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
  • Glycosylation at isoforms=82, Asn179, and Asn372

Other Protein References for RTN4R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for RTN4R (Nogo Receptor/NgR)

Protein Products

No data available for DME Specific Peptides for RTN4R Gene

Domains & Families for RTN4R Gene

Suggested Antigen Peptide Sequences for RTN4R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZR6

UniProtKB/Swiss-Prot:

RTN4R_HUMAN :
  • Belongs to the Nogo receptor family.
Family:
  • Belongs to the Nogo receptor family.
genes like me logo Genes that share domains with RTN4R: view

No data available for Gene Families for RTN4R Gene

Function for RTN4R Gene

Molecular function for RTN4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).

Gene Ontology (GO) - Molecular Function for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0004872 receptor activity NAS,IEA 11201742
GO:0005515 protein binding IPI 20463223
GO:0008201 heparin binding IEA,ISS --
GO:0035374 chondroitin sulfate binding IEA,ISS --
genes like me logo Genes that share ontologies with RTN4R: view
genes like me logo Genes that share phenotypes with RTN4R: view

Animal Models for RTN4R Gene

MGI Knock Outs for RTN4R:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4R

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4R Gene

Localization for RTN4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4R Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250 UniProtKB:Q99PI8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN4R gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 3
mitochondrion 2
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS,IEA --
GO:0009986 cell surface IDA 16712417
genes like me logo Genes that share ontologies with RTN4R: view

Pathways & Interactions for RTN4R Gene

genes like me logo Genes that share pathways with RTN4R: view

Pathways by source for RTN4R Gene

2 BioSystems pathways for RTN4R Gene
1 GeneGo (Thomson Reuters) pathway for RTN4R Gene

Gene Ontology (GO) - Biological Process for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007166 cell surface receptor signaling pathway IEA,ISS --
GO:0007409 axonogenesis IEA --
GO:0010977 negative regulation of neuron projection development ISS,IEA --
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with RTN4R: view

No data available for SIGNOR curated interactions for RTN4R Gene

Drugs & Compounds for RTN4R Gene

(3) Drugs for RTN4R Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MOG (35-55) Pharma Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment 0

(4) Additional Compounds for RTN4R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
C3bot (154-182)
1246280-79-4
Nogo-66 (1-40)
475221-20-6
ONO 2506
185517-21-9
PLP (139-151)
122018-58-0

(5) Tocris Compounds for RTN4R Gene

Compound Action Cas Number
C3bot (154-182) Neurotrophic fragment of clostridial C3 protein 1246280-79-4
MOG (35-55) Encephalitogenic myelin oligodendrocyte glycoprotein fragment 149635-73-4
Nogo-66 (1-40) Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration 475221-20-6
ONO 2506 Inhibits S-100beta synthesis; neuroprotective 185517-21-9
PLP (139-151) Encephalitogenic myelin proteolipid fragment 122018-58-0
genes like me logo Genes that share compounds with RTN4R: view

Transcripts for RTN4R Gene

Unigene Clusters for RTN4R Gene

Reticulon 4 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4R Gene

No ASD Table

Relevant External Links for RTN4R Gene

GeneLoc Exon Structure for
RTN4R
ECgene alternative splicing isoforms for
RTN4R

Expression for RTN4R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTN4R Gene

mRNA differential expression in normal tissues according to GTEx for RTN4R Gene

This gene is overexpressed in Brain - Cerebellum (x7.3), Brain - Cerebellar Hemisphere (x6.8), Brain - Cortex (x6.8), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for RTN4R Gene

This gene is overexpressed in Cerebrospinal fluid (54.3) and Fetal Brain (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4R Gene



Protein tissue co-expression partners for RTN4R Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RTN4R Gene:

RTN4R

SOURCE GeneReport for Unigene cluster for RTN4R Gene:

Hs.30868

mRNA Expression by UniProt/SwissProt for RTN4R Gene:

Q9BZR6-RTN4R_HUMAN
Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).

Evidence on tissue expression from TISSUES for RTN4R Gene

  • Nervous system(4.7)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with RTN4R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4R Gene

Orthologs for RTN4R Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTN4R 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia RTN4R 34
  • 85.61 (n)
cow
(Bos Taurus)
Mammalia RTN4R 34 35
  • 84.11 (n)
mouse
(Mus musculus)
Mammalia Rtn4r 34 16 35
  • 82.66 (n)
rat
(Rattus norvegicus)
Mammalia Rtn4r 34
  • 82.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RTN4R 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RTN4R 34 35
  • 59.74 (n)
lizard
(Anolis carolinensis)
Reptilia RTN4R 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485966 34
  • 49.65 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332374 34
  • 54.34 (n)
rtn4r 35 35
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1504 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-12 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for RTN4R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4R Gene

ENSEMBL:
Gene Tree for RTN4R (if available)
TreeFam:
Gene Tree for RTN4R (if available)

Paralogs for RTN4R Gene

(3) SIMAP similar genes for RTN4R Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RTN4R: view

Variants for RTN4R Gene

Sequence variations from dbSNP and Humsavar for RTN4R Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs74315508 other 20,242,778(-) AGCTC(C/G/T)GGTCT reference, missense
rs74315509 other 20,242,546(-) CGAGC(A/G)CGCCT reference, missense
rs1000005339 -- 20,248,509(+) GGACA(C/T)ATCAA intron-variant
rs1000197364 -- 20,262,268(+) AGCTG(G/T)GTGTG intron-variant
rs1000416789 -- 20,258,512(+) GAGTG(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4R Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv4482n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
dgv7986n54 CNV loss 21841781
esv1003446 CNV deletion 20482838
esv2758825 CNV loss 17122850
esv3310500 CNV novel sequence insertion 20981092
esv3441142 CNV duplication 20981092
esv3893434 CNV gain 25118596
esv3893435 CNV gain 25118596
nsv1060294 CNV gain 25217958
nsv1064701 CNV gain 25217958
nsv1117315 CNV tandem duplication 24896259
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834134 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for RTN4R Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4R Gene

Human Gene Mutation Database (HGMD)
RTN4R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTN4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4R Gene

Disorders for RTN4R Gene

MalaCards: The human disease database

(2) MalaCards diseases for RTN4R Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
spinal cord injury
  • spinal cord injuries
- elite association - COSMIC cancer census association via MalaCards
Search RTN4R in MalaCards View complete list of genes associated with diseases

Relevant External Links for RTN4R

Genetic Association Database (GAD)
RTN4R
Human Genome Epidemiology (HuGE) Navigator
RTN4R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4R
genes like me logo Genes that share disorders with RTN4R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4R Gene

Publications for RTN4R Gene

  1. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PMID: 11201742) Fournier A.E. … Strittmatter S.M. (Nature 2001) 2 3 4 22 64
  2. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. (PMID: 19052207) Budel S. … Strittmatter S.M. (J. Neurosci. 2008) 3 22 46 64
  3. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. (PMID: 16897606) Meng J. … He L. (J Neural Transm 2007) 3 22 46 64
  4. A high-content screening assay for the Nogo receptor based on cellular Rho activation. (PMID: 16712417) Teusch N. … Kiefer C. (Assay Drug Dev Technol 2006) 3 4 22 64
  5. Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. (PMID: 15532024) Sinibaldi L. … Dallapiccola B. (Hum. Mutat. 2004) 3 22 46 64

Products for RTN4R Gene

Sources for RTN4R Gene

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