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Aliases for SLC1A2 Gene

Aliases for SLC1A2 Gene

  • Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 2 3
  • EAAT2 3 4 6
  • Sodium-Dependent Glutamate/Aspartate Transporter 2 3 4
  • Glutamate/Aspartate Transporter II 3 4
  • Excitotoxic Amino Acid Transporter 2 3
  • Excitatory Amino Acid Transporter 2 3
  • Solute Carrier Family 1 Member 2 4
  • GLT-1 3
  • GLT1 4

External Ids for SLC1A2 Gene

Previous GeneCards Identifiers for SLC1A2 Gene

  • GC11M036834
  • GC11M035960
  • GC11M035315
  • GC11M035246
  • GC11M035237
  • GC11M035229
  • GC11M034972

Summaries for SLC1A2 Gene

Entrez Gene Summary for SLC1A2 Gene

  • This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for SLC1A2 Gene

SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC1A2 include brain injury and traumatic brain injury. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and glutamate:sodium symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A2 Gene

  • Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

Tocris Summary for SLC1A2 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.

Gene Wiki entry for SLC1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A2 Gene

Genomics for SLC1A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC1A2 Gene

Start:
35,251,205 bp from pter
End:
35,420,063 bp from pter
Size:
168,859 bases
Orientation:
Minus strand

Genomic View for SLC1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A2 Gene

Proteins for SLC1A2 Gene

  • Protein details for SLC1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43004-EAA2_HUMAN
    Recommended name:
    Excitatory amino acid transporter 2
    Protein Accession:
    P43004
    Secondary Accessions:
    • B4DQE9
    • Q14417
    • Q541G6
    • U3KQQ4

    Protein attributes for SLC1A2 Gene

    Size:
    574 amino acids
    Molecular mass:
    62104 Da
    Quaternary structure:
    • Homotrimer. Isoform 3 can oligomerize with isoform 1. Interacts with AJUBA (By similarity).

    Alternative splice isoforms for SLC1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A2 Gene

Proteomics data for SLC1A2 Gene at MOPED

Post-translational modifications for SLC1A2 Gene

  • Glycosylated
  • Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.
  • Glycosylation at Asn206 and Asn216
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A2 (GLT1)

No data available for DME Specific Peptides for SLC1A2 Gene

Domains for SLC1A2 Gene

Gene Families for SLC1A2 Gene

Protein Domains for SLC1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P43004

UniProtKB/Swiss-Prot:

EAA2_HUMAN :
  • P43004
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily.
genes like me logo Genes that share domains with SLC1A2: view

Function for SLC1A2 Gene

Molecular function for SLC1A2 Gene

GENATLAS Biochemistry: solute carrier family 1,member A2,glial high affinity glutamate transporter,expressed in brain and pancreas,located in astrocytes,with five transcripts alternatively spliced from 5utr and a variant acting as a putative modifier for the spastic paraplegia phenotype
UniProtKB/Swiss-Prot Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

Gene Ontology (GO) - Molecular Function for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IDA 7521911
GO:0005515 protein binding IPI 19527721
GO:0015501 glutamate:sodium symporter activity IEA --
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A2: view
genes like me logo Genes that share phenotypes with SLC1A2: view

Animal Models for SLC1A2 Gene

MGI Knock Outs for SLC1A2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC1A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC1A2 Gene

Localization for SLC1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A2 Gene COMPARTMENTS Subcellular localization image for SLC1A2 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 7521911
GO:0016021 integral component of membrane IEA --
GO:0030424 axon --
GO:0030673 axolemma IEA --
genes like me logo Genes that share ontologies with SLC1A2: view

Pathways for SLC1A2 Gene

genes like me logo Genes that share pathways with SLC1A2: view

Pathways by source for SLC1A2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007399 nervous system development --
genes like me logo Genes that share ontologies with SLC1A2: view

Compounds for SLC1A2 Gene

(5) Tocris Compounds for SLC1A2 Gene

Compound Action Cas Number
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor [64769-66-0]
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) [1263094-00-3]
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake [52497-36-6]
DL-TBOA Selective non-transportable inhibitor of EAATs [205309-81-5]
TFB-TBOA High affinity EAAT1 and EAAT2 blocker [480439-73-4]

(1) HMDB Compounds for SLC1A2 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC1A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(9) IUPHAR Ligand for SLC1A2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]ETB-TBOA None None 7.8
WAY-213613 Inhibitor Inhibition 6.9
DL-TBOA Inhibitor Inhibition 6.9
SYM2081 Inhibitor Inhibition 5.5
dihydrokainate Inhibitor Inhibition 5
threo-3-methylglutamate Inhibitor Inhibition 4.7
[3H]L-aspartic acid None None
[3H]D-aspartic acid None None
[3H](2S,4R)-4-methylglutamate None None

(43) Novoseek inferred chemical compound relationships for SLC1A2 Gene

Compound -log(P) Hits PubMed IDs
dihydrokainate 90.6 20
glutamate 89 202
l-serine o-sulfate 72.1 1
dl-threo-beta-benzyloxyaspartate 68.8 3
l-trans-pyrrolidine-2,4-dicarboxylic acid 66 1
genes like me logo Genes that share compounds with SLC1A2: view

Transcripts for SLC1A2 Gene

Unigene Clusters for SLC1A2 Gene

Solute carrier family 1 (glial high affinity glutamate transporter), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC1A2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC1A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -

Relevant External Links for SLC1A2 Gene

GeneLoc Exon Structure for
SLC1A2
ECgene alternative splicing isoforms for
SLC1A2

Expression for SLC1A2 Gene

mRNA expression in normal human tissues for SLC1A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC1A2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (8.3), Brain - Nucleus accumbens (basal ganglia) (7.7), Brain - Amygdala (7.5), Brain - Putamen (basal ganglia) (7.2), Brain - Frontal Cortex (BA9) (4.9), Brain - Cortex (4.6), and Brain - Anterior cingulate cortex (BA24) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC1A2 Gene

SOURCE GeneReport for Unigene cluster for SLC1A2 Gene Hs.502338

genes like me logo Genes that share expressions with SLC1A2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC1A2 Gene

Orthologs for SLC1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A2 35
  • 99.59 (n)
  • 100 (a)
SLC1A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A2 35
  • 90.71 (n)
  • 97.04 (a)
SLC1A2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A2 35
  • 91.37 (n)
  • 96.63 (a)
SLC1A2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a2 35
  • 88.64 (n)
  • 95.45 (a)
Slc1a2 16
Slc1a2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a2 35
  • 88.77 (n)
  • 95.64 (a)
chicken
(Gallus gallus)
Aves SLC1A2 35
  • 78.76 (n)
  • 88.77 (a)
SLC1A2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a2 35
  • 75.91 (n)
  • 85.16 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a2a 36
  • 78 (a)
OneToMany
slc1a2b 35
  • 72.1 (n)
  • 79.93 (a)
slc1a2b 36
  • 78 (a)
OneToMany
slc1a9 36
  • 49 (a)
OneToMany
wufj34b12 35
fruit fly
(Drosophila melanogaster)
Insecta Eaat2 36
  • 39 (a)
OneToOne
Eaat1 37
  • 43 (a)
Eaat2 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-1 35
  • 58.47 (n)
  • 61.46 (a)
glt-1 36
  • 58 (a)
OneToMany
glt-3 36
  • 46 (a)
OneToMany
glt-5 36
  • 50 (a)
OneToMany
glt-6 36
  • 43 (a)
OneToMany
glt-7 36
  • 36 (a)
OneToMany
glt-2 37
  • 62 (a)
K08F4.4 37
  • 50 (a)
T22E5.2 37
  • 44 (a)
R05G6.6 37
  • 43 (a)
W03G1.1 37
  • 34 (a)
Y53C12A.2 37
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5947 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.317 36
  • 43 (a)
OneToOne
Species with no ortholog for SLC1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A2 Gene

ENSEMBL:
Gene Tree for SLC1A2 (if available)
TreeFam:
Gene Tree for SLC1A2 (if available)

Paralogs for SLC1A2 Gene

Paralogs for SLC1A2 Gene

Selected SIMAP similar genes for SLC1A2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A2: view

Variants for SLC1A2 Gene

Sequence variations from dbSNP and Humsavar for SLC1A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs752949 -- 35,306,201(+) TCGTC(C/T)GGCGG synonymous-codon, reference
rs764750 -- 35,391,683(-) TAAAA(C/G)AGCAG intron-variant
rs911561 -- 35,377,563(+) TGGCT(A/G)TGTCA intron-variant
rs911562 -- 35,377,806(+) GAACA(A/G)AAAGA intron-variant
rs927352 -- 35,355,967(+) TCATA(C/T)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A2 Gene

Variant ID Type Subtype PubMed ID
nsv7733 CNV Insertion 18451855
nsv832120 CNV Gain 17160897
esv269007 CNV Insertion 20981092
essv13578 CNV CNV 17122850
esv2602066 CNV Insertion 19546169

Relevant External Links for SLC1A2 Gene

HapMap Linkage Disequilibrium report
SLC1A2
Human Gene Mutation Database (HGMD)
SLC1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A2 Gene

Disorders for SLC1A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for SLC1A2 Gene including...

Search for SLC1A2 Gene in MalaCards »

(28) Novoseek inferred disease relationships for SLC1A2 Gene

Disease -log(P) Hits PubMed IDs
amyotrophic lateral sclerosis 79.2 24
neurodegeneration 58.5 6
neurological disorders 54.1 4
gliosis 49 1
neurodegenerative diseases 48.5 4

Relevant External Links for SLC1A2

Genetic Association Database (GAD)
SLC1A2
Human Genome Epidemiology (HuGE) Navigator
SLC1A2
genes like me logo Genes that share disorders with SLC1A2: view

No data available for UniProtKB/Swiss-Prot for SLC1A2 Gene

Publications for SLC1A2 Gene

  1. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. (PMID: 7521911) Arriza J.L. … Amara S.G. (J. Neurosci. 1994) 3 4 23
  2. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. (PMID: 9463476) Shimamoto K. … Nakajima T. (Mol. Pharmacol. 1998) 3 4 23
  3. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. (PMID: 15296513) Deng X. … Fukumaki Y. (BMC Psychiatry 2004) 3 23 48
  4. No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia. (PMID: 19660525) Nagai Y. … Arai H. (Neurosci. Lett. 2009) 3 23 48
  5. Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium. (PMID: 19283393) Beschorner R. … Schittenhelm J. (Acta Neuropathol. 2009) 3 23

Products for SLC1A2 Gene

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