Aliases for SLC1A2 Gene
External Ids for SLC1A2 Gene
Previous GeneCards Identifiers for SLC1A2 Gene
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
GeneCards Summary for SLC1A2 Gene
SLC1A2 (Solute Carrier Family 1 Member 2) is a Protein Coding gene. Diseases associated with SLC1A2 include Epileptic Encephalopathy, Early Infantile, 41 and Wernicke Encephalopathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neurotransmitter Release Cycle. GO annotations related to this gene include L-glutamate transmembrane transporter activity and glutamate:sodium symporter activity. An important paralog of this gene is SLC1A1.
UniProtKB/Swiss-Prot for SLC1A2 Gene
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.