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Aliases for SLC1A1 Gene

Aliases for SLC1A1 Gene

  • Solute Carrier Family 1 (Neuronal/Epithelial High Affinity Glutamate Transporter, System Xag), Member 1 2 3
  • Sodium-Dependent Glutamate/Aspartate Transporter 3 3 4
  • Neuronal And Epithelial Glutamate Transporter 3 4
  • Solute Carrier Family 1 Member 1 3 4
  • EAAC1 3 4
  • EAAT3 3 4
  • Excitatory Amino Acid Transporter 3 3
  • Excitatory Amino Acid Carrier 1) 6
  • Excitatory Amino Acid Carrier 1 3
  • Excitatory Amino-Acid Carrier 1 4
  • SCZD18 3
  • DCBXA 3

External Ids for SLC1A1 Gene

Summaries for SLC1A1 Gene

Entrez Gene Summary for SLC1A1 Gene

  • This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

GeneCards Summary for SLC1A1 Gene

SLC1A1 (Solute Carrier Family 1 (Neuronal/Epithelial High Affinity Glutamate Transporter, System Xag), Member 1) is a Protein Coding gene. Diseases associated with SLC1A1 include dicarboxylic aminoaciduria and schizophrenia susceptibility 18. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A1 Gene

  • Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).

Tocris Summary for SLC1A1 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.

Gene Wiki entry for SLC1A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A1 Gene

Genomics for SLC1A1 Gene

Genomic Location for SLC1A1 Gene

Start:
4,490,427 bp from pter
End:
4,587,469 bp from pter
Size:
97,043 bases
Orientation:
Plus strand

Genomic View for SLC1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A1 Gene

Regulatory Elements for SLC1A1 Gene

Proteins for SLC1A1 Gene

  • Protein details for SLC1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43005-EAA3_HUMAN
    Recommended name:
    Excitatory amino acid transporter 3
    Protein Accession:
    P43005
    Secondary Accessions:
    • O75587
    • Q5VZ24
    • Q8N199
    • Q9UEW2

    Protein attributes for SLC1A1 Gene

    Size:
    524 amino acids
    Molecular mass:
    57100 Da
    Quaternary structure:
    • Interacts with ARL6IP5/PRAF3.

neXtProt entry for SLC1A1 Gene

Proteomics data for SLC1A1 Gene at MOPED

Post-translational modifications for SLC1A1 Gene

Other Protein References for SLC1A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC1A1 Gene

Domains for SLC1A1 Gene

Gene Families for SLC1A1 Gene

Protein Domains for SLC1A1 Gene

UniProtKB/Swiss-Prot:

EAA3_HUMAN
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.:
    • P43005
genes like me logo Genes that share domains with SLC1A1: view

Function for SLC1A1 Gene

Molecular function for SLC1A1 Gene

GENATLAS Biochemistry: solute carrier family 1,member A1,glial high affinity glutamate transporter,expressed in neurons
UniProtKB/Swiss-Prot Function: Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).

Gene Ontology (GO) - Molecular Function for SLC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IDA 21123949
GO:0005515 protein binding IPI 25416956
GO:0015501 glutamate:sodium symporter activity IEA --
GO:0016595 glutamate binding IEA --
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A1: view
genes like me logo Genes that share phenotypes with SLC1A1: view

Animal Models for SLC1A1 Gene

MGI Knock Outs for SLC1A1:

miRNA for SLC1A1 Gene

miRTarBase miRNAs that target SLC1A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC1A1 Gene

Localization for SLC1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A1 Gene

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A1 Gene COMPARTMENTS Subcellular localization image for SLC1A1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7521911
GO:0016020 membrane TAS 7521911
GO:0016324 apical plasma membrane IDA 21123949
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC1A1: view

Pathways for SLC1A1 Gene

genes like me logo Genes that share pathways with SLC1A1: view

Pathways by source for SLC1A1 Gene

Gene Ontology (GO) - Biological Process for SLC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with SLC1A1: view

Compounds for SLC1A1 Gene

(5) Tocris Compounds for SLC1A1 Gene

Compound Action Cas Number
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake [52497-36-6]
DL-TBOA Selective non-transportable inhibitor of EAATs [205309-81-5]
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor [64769-66-0]
TFB-TBOA High affinity EAAT1 and EAAT2 blocker [480439-73-4]
WAY 213613 Potent, non-substrate EAAT2 inhibitor [868359-05-1]

(2) HMDB Compounds for SLC1A1 Gene

Compound Synonyms Cas Number PubMed IDs
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
Sodium
  • Sodium
7440-23-5

(3) Drugbank Compounds for SLC1A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Pregabalin
  • CI-1008
148553-50-8 transporter Other

(6) IUPHAR Ligand for SLC1A1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]ETB-TBOA None None 7.8
NBI-59159 Inhibitor Inhibition 7.6
DL-TBOA Inhibitor Inhibition 6.9
L-beta-BA Inhibitor Inhibition 6.1
[3H]L-aspartic acid None None
[3H]D-aspartic acid None None

(23) Novoseek inferred chemical compound relationships for SLC1A1 Gene

Compound -log(P) Hits PubMed IDs
dihydrokainate 85.7 1
glutamate 83.6 124
threo-beta-hydroxyaspartate 79.3 1
aspartate 64.6 18
chelerythrine 48.9 4
genes like me logo Genes that share compounds with SLC1A1: view

Transcripts for SLC1A1 Gene

Unigene Clusters for SLC1A1 Gene

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A1 Gene

No ASD Table

Relevant External Links for SLC1A1 Gene

GeneLoc Exon Structure for
SLC1A1
ECgene alternative splicing isoforms for
SLC1A1

Expression for SLC1A1 Gene

mRNA expression in normal human tissues for SLC1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC1A1 Gene

This gene is overexpressed in Liver (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC1A1 Gene

SOURCE GeneReport for Unigene cluster for SLC1A1 Gene Hs.444915

mRNA Expression by UniProt/SwissProt for SLC1A1 Gene

P43005-EAA3_HUMAN
Tissue specificity: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
genes like me logo Genes that share expressions with SLC1A1: view

Orthologs for SLC1A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A1 36
  • 99.36 (n)
  • 99.05 (a)
SLC1A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A1 36
  • 89.06 (n)
  • 90.84 (a)
SLC1A1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A1 36
  • 89.95 (n)
  • 93.32 (a)
SLC1A1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a1 36
  • 85.79 (n)
  • 90.25 (a)
Slc1a1 16
Slc1a1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A1 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a1 36
  • 86.42 (n)
  • 91.2 (a)
chicken
(Gallus gallus)
Aves SLC1A1 36
  • 77.61 (n)
  • 84.16 (a)
SLC1A1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A1 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a1 36
  • 76.4 (n)
  • 83.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9753 36
zebrafish
(Danio rerio)
Actinopterygii slc1a1 36
  • 69.03 (n)
  • 74.28 (a)
slc1a1 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006718 36
  • 56.77 (n)
  • 55.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 38
  • 45 (a)
Eaat2 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-2 38
  • 52 (a)
K08F4.4 38
  • 44 (a)
T22E5.2 38
  • 47 (a)
R05G6.6 38
  • 43 (a)
W03G1.1 38
  • 35 (a)
Y53C12A.2 38
  • 47 (a)
Species with no ortholog for SLC1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A1 Gene

ENSEMBL:
Gene Tree for SLC1A1 (if available)
TreeFam:
Gene Tree for SLC1A1 (if available)

Paralogs for SLC1A1 Gene

Paralogs for SLC1A1 Gene

Selected SIMAP similar genes for SLC1A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC1A1: view

Variants for SLC1A1 Gene

Sequence variations from dbSNP and Humsavar for SLC1A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs884931 -- 4,488,898(+) gtctc(A/G/T)ctctg upstream-variant-2KB
rs913991 -- 4,493,141(+) AAAGG(A/G)AAGTC intron-variant
rs928209 -- 4,542,890(+) CTACA(A/G)TTTGG intron-variant
rs951458 -- 4,504,384(-) TATCA(A/T)AGAAA intron-variant
rs972519 -- 4,492,098(+) AAGTA(C/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A1 Gene

Variant ID Type Subtype PubMed ID
nsv524574 CNV Gain 19592680
dgv8014n71 CNV Gain 21882294
nsv892120 CNV Gain 21882294
nsv892121 CNV Gain 21882294
nsv818673 CNV Loss 17921354
esv22769 CNV Loss 19812545
esv2656609 CNV Deletion 23128226
nsv515747 CNV Loss 19592680
dgv8015n71 CNV Loss 21882294
nsv8407 CNV Loss 18304495
nsv466095 CNV Loss 19166990
nsv517270 CNV Loss 19592680
nsv818674 CNV Loss 17921354
esv2422074 CNV Deletion 20811451
esv2678426 CNV Deletion 23128226
nsv824822 CNV Loss 20364138
dgv2276e1 CNV Complex 17122850
nsv442536 CNV CNV 18776908
nsv892124 CNV Gain 21882294
esv2051616 CNV Deletion 18987734
esv2738154 CNV Deletion 23290073
nsv528488 CNV Loss 19592680
nsv819362 CNV Loss 19587683

Relevant External Links for SLC1A1 Gene

HapMap Linkage Disequilibrium report
SLC1A1
Human Gene Mutation Database (HGMD)
SLC1A1

Disorders for SLC1A1 Gene

(1) OMIM Diseases for SLC1A1 Gene (133550)

UniProtKB/Swiss-Prot

EAA3_HUMAN
  • Dicarboxylic aminoaciduria (DCBXA) [MIM:222730]: An autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation. {ECO:0000269 PubMed:21123949}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Schizophrenia 18 (SCZD18) [MIM:615232]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:21982423, ECO:0000269 PubMed:23341099}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099). {ECO:0000269 PubMed:21982423, ECO:0000269 PubMed:23341099}.

(10) Novoseek inferred disease relationships for SLC1A1 Gene

Disease -log(P) Hits PubMed IDs
glioma 50.3 15
neurodegeneration 36.6 1
epilepsy temporal lobe 34.2 1
neurological disorders 26.6 1
astrocytoma 21.3 1

Relevant External Links for SLC1A1

Genetic Association Database (GAD)
SLC1A1
Human Genome Epidemiology (HuGE) Navigator
SLC1A1
genes like me logo Genes that share disorders with SLC1A1: view

Publications for SLC1A1 Gene

  1. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. (PMID: 7521911) Arriza J.L. … Amara S.G. (J. Neurosci. 1994) 3 4 23
  2. Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. (PMID: 11317217) Veenstra-VanderWeele J. … Cook E.H. Jr. (Mol. Psychiatry 2001) 3 4 23
  3. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. (PMID: 16818867) Dickel D.E. … Hanna G.L. (Arch. Gen. Psychiatry 2006) 3 23 49
  4. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. (PMID: 18096700) Liu Y. … Rothstein J.D. (J. Biol. Chem. 2008) 3 23
  5. Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane. (PMID: 17646425) Watabe M. … Nakaki T. (Mol. Pharmacol. 2007) 3 23

Products for SLC1A1 Gene

Sources for SLC1A1 Gene

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