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Aliases for MRPL11 Gene

Aliases for MRPL11 Gene

  • Mitochondrial Ribosomal Protein L11 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL11m 3 4
  • MRP-L11 3 4
  • L11MT 3 4
  • 39S Ribosomal Protein L11, Mitochondrial 3
  • CGI-113 3

External Ids for MRPL11 Gene

Previous GeneCards Identifiers for MRPL11 Gene

  • GC11M068737
  • GC11M067883
  • GC11M065978
  • GC11M065959
  • GC11M066202
  • GC11M062530

Summaries for MRPL11 Gene

Entrez Gene Summary for MRPL11 Gene

  • This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

GeneCards Summary for MRPL11 Gene

MRPL11 (Mitochondrial Ribosomal Protein L11) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Translational Control. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL11 Gene

Additional gene information for MRPL11 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL11 Gene

Genomics for MRPL11 Gene

Regulatory Elements for MRPL11 Gene

Enhancers for MRPL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 74.3 +976.7 976655 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065851 1.4 ENCODE dbSUPER 28.9 +609.3 609254 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SART1 ENSG00000258297 RBM14 EIF1AD KAT5 POLA2 PCNX3 ZFPL1 SF3B2 SNX32
GH11H066342 1.8 FANTOM5 ENCODE dbSUPER 21 +118.2 118194 11 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ENSG00000258297 LOC105369352 RBM14 RIN1 EIF1AD ENSG00000255320 SCYL1 ACTN3 KAT5 RBM4
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 19.7 +571.3 571280 18 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
GH11H065609 1.7 FANTOM5 ENCODE dbSUPER 18.2 +852.7 852740 8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 MAP3K11 LOC105369352 EIF1AD MRPL11 SIPA1 RNASEH2C EHBP1L1 EFEMP2 SSSCA1 CTSF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL11 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040973 -162 1401 HDGF PKNOX1 ATF1 SIN3A ETS1 GLIS2 ZNF143 ATF7 KLF7 SP3

Genomic Location for MRPL11 Gene

Chromosome:
11
Start:
66,435,075 bp from pter
End:
66,466,738 bp from pter
Size:
31,664 bases
Orientation:
Minus strand

Genomic View for MRPL11 Gene

Genes around MRPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL11 Gene

Proteins for MRPL11 Gene

  • Protein details for MRPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B7-RM11_HUMAN
    Recommended name:
    39S ribosomal protein L11, mitochondrial
    Protein Accession:
    Q9Y3B7
    Secondary Accessions:
    • A6NLT0
    • A8K219
    • Q32P46
    • Q96Q73

    Protein attributes for MRPL11 Gene

    Size:
    192 amino acids
    Molecular mass:
    20683 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL11 Gene

    Alternative splice isoforms for MRPL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL11 Gene

Post-translational modifications for MRPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL11 Gene

No data available for DME Specific Peptides for MRPL11 Gene

Domains & Families for MRPL11 Gene

Gene Families for MRPL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3B7

UniProtKB/Swiss-Prot:

RM11_HUMAN :
  • Belongs to the universal ribosomal protein uL11 family.
Family:
  • Belongs to the universal ribosomal protein uL11 family.
genes like me logo Genes that share domains with MRPL11: view

Function for MRPL11 Gene

Phenotypes From GWAS Catalog for MRPL11 Gene

Gene Ontology (GO) - Molecular Function for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IBA 11543634
GO:0005515 protein binding IPI 22190034
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with MRPL11: view

Phenotypes for MRPL11 Gene

genes like me logo Genes that share phenotypes with MRPL11: view

Animal Model Products

CRISPR Products

miRNA for MRPL11 Gene

miRTarBase miRNAs that target MRPL11

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL11 Gene

Localization for MRPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL11 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL11 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL11: view

Pathways & Interactions for MRPL11 Gene

genes like me logo Genes that share pathways with MRPL11: view

Pathways by source for MRPL11 Gene

Gene Ontology (GO) - Biological Process for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IBA,NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL11: view

No data available for SIGNOR curated interactions for MRPL11 Gene

Drugs & Compounds for MRPL11 Gene

No Compound Related Data Available

Transcripts for MRPL11 Gene

Unigene Clusters for MRPL11 Gene

Mitochondrial ribosomal protein L11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for MRPL11 Gene

GeneLoc Exon Structure for
MRPL11
ECgene alternative splicing isoforms for
MRPL11

Expression for MRPL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL11 Gene

Protein differential expression in normal tissues from HIPED for MRPL11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Lung (7.4), and Breast (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL11 Gene



Protein tissue co-expression partners for MRPL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL11 Gene:

MRPL11

SOURCE GeneReport for Unigene cluster for MRPL11 Gene:

Hs.418450

Evidence on tissue expression from TISSUES for MRPL11 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MRPL11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL11 Gene

Orthologs for MRPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL11 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia MRPL11 33 34
  • 89.07 (n)
dog
(Canis familiaris)
Mammalia MRPL11 33 34
  • 89.07 (n)
mouse
(Mus musculus)
Mammalia Mrpl11 33 16 34
  • 85.24 (n)
rat
(Rattus norvegicus)
Mammalia mrpl11 33
  • 83.99 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL11 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL11 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl11 33
  • 63 (n)
Str.19345 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6453 33
zebrafish
(Danio rerio)
Actinopterygii mrpl11 33 34
  • 65.07 (n)
Dr.27215 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8314 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002332 33
  • 55.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL11 33 34
  • 54.22 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-11 33 34
  • 50.94 (n)
B0303.15 35
  • 46 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08437g 33
  • 49.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL19 33 34 36
  • 48.04 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL144C 33
  • 46.81 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MRPL11 33
  • 52.51 (n)
rice
(Oryza sativa)
Liliopsida Os10g0466200 33
  • 51.49 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04336 33
  • 51.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl19 33
  • 48.04 (n)
Species where no ortholog for MRPL11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL11 Gene

ENSEMBL:
Gene Tree for MRPL11 (if available)
TreeFam:
Gene Tree for MRPL11 (if available)

Paralogs for MRPL11 Gene

Pseudogenes.org Pseudogenes for MRPL11 Gene

genes like me logo Genes that share paralogs with MRPL11: view

No data available for Paralogs for MRPL11 Gene

Variants for MRPL11 Gene

Sequence variations from dbSNP and Humsavar for MRPL11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000105874 -- 66,439,966(+) CTTCC(A/T)TCTGG upstream-variant-2KB
rs1000237913 -- 66,438,998(+) AGGTA(C/T)ACACA upstream-variant-2KB
rs1000476721 -- 66,436,570(+) TCAAT(C/T)GTCAG intron-variant, downstream-variant-500B
rs1001080073 -- 66,440,770(+) GCGCC(A/G)TGCGC upstream-variant-2KB
rs1001795683 -- 66,439,355(+) GACCA(A/G)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL11 Gene

Variant ID Type Subtype PubMed ID
nsv832193 CNV loss 17160897

Variation tolerance for MRPL11 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL11 Gene

Disorders for MRPL11 Gene

Relevant External Links for MRPL11

Genetic Association Database (GAD)
MRPL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL11

No disorders were found for MRPL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL11 Gene

Publications for MRPL11 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4 60
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 60

Products for MRPL11 Gene

Sources for MRPL11 Gene

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