Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SKP1 Gene

Aliases for SKP1 Gene

  • S-Phase Kinase-Associated Protein 1 2 3
  • TCEB1L 3 4 6
  • SKP1A 3 4 6
  • OCP2 3 4 6
  • Transcription Elongation Factor B Polypeptide 1-Like 3 4
  • Cyclin-A/CDK2-Associated Protein P19 3 4
  • Organ Of Corti Protein II 3 4
  • Organ Of Corti Protein 2 3 4
  • P19skp1 3 4
  • OCP-II 3 4
  • EMC19 3 4
  • OCP-2 3 4
  • SIII 3 4
  • P19A 3 4
  • RNA Polymerase II Elongation Factor-Like Protein OCP2 3
  • RNA Polymerase II Elongation Factor-Like Protein 4
  • S-Phase Kinase-Associated Protein 1A (P19A) 2
  • Cyclin A/CDK2-Associated Protein P19 3
  • Cyclin A/CDK2-Associated P19 3

External Ids for SKP1 Gene

Previous Symbols for SKP1 Gene

  • SKP1A

Summaries for SKP1 Gene

Entrez Gene Summary for SKP1 Gene

  • This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for SKP1 Gene

SKP1 (S-Phase Kinase-Associated Protein 1) is a Protein Coding gene. Diseases associated with SKP1 include corneal staphyloma and vitreoretinal dystrophy. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000272772.

UniProtKB/Swiss-Prot for SKP1 Gene

  • Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.

Gene Wiki entry for SKP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKP1 Gene

Genomics for SKP1 Gene

Genomic Location for SKP1 Gene

Start:
134,148,935 bp from pter
End:
134,177,038 bp from pter
Size:
28,104 bases
Orientation:
Minus strand

Genomic View for SKP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP1 Gene

Regulatory Elements for SKP1 Gene

Proteins for SKP1 Gene

  • Protein details for SKP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63208-SKP1_HUMAN
    Recommended name:
    S-phase kinase-associated protein 1
    Protein Accession:
    P63208
    Secondary Accessions:
    • D3DQ97
    • D3DQ98
    • P34991
    • Q8TAY2

    Protein attributes for SKP1 Gene

    Size:
    163 amino acids
    Molecular mass:
    18658 Da
    Quaternary structure:
    • Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7.

    Three dimensional structures from OCA and Proteopedia for SKP1 Gene

    Alternative splice isoforms for SKP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP1 Gene

Proteomics data for SKP1 Gene at MOPED

Post-translational modifications for SKP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys121, Lys130, Lys137, Lys142, and Lys155

No data available for DME Specific Peptides for SKP1 Gene

Domains for SKP1 Gene

Protein Domains for SKP1 Gene

Suggested Antigen Peptide Sequences for SKP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63208

UniProtKB/Swiss-Prot:

SKP1_HUMAN
Family:
  • Belongs to the SKP1 family.:
    • P63208
genes like me logo Genes that share domains with SKP1: view

No data available for Gene Families for SKP1 Gene

Function for SKP1 Gene

Molecular function for SKP1 Gene

UniProtKB/Swiss-Prot Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.

Gene Ontology (GO) - Molecular Function for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20347421
GO:0005515 protein binding IPI 11099048
genes like me logo Genes that share ontologies with SKP1: view
genes like me logo Genes that share phenotypes with SKP1: view

miRNA for SKP1 Gene

miRTarBase miRNAs that target SKP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SKP1 Gene

Localization for SKP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKP1 Gene COMPARTMENTS Subcellular localization image for SKP1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 15103331
GO:0031467 Cul7-RING ubiquitin ligase complex IDA 18498745
GO:0031519 colocalizes_with PcG protein complex IDA 16943429
genes like me logo Genes that share ontologies with SKP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SKP1 Gene

Pathways for SKP1 Gene

SuperPathways for SKP1 Gene

Superpath Contained pathways
1 Signaling by NOTCH1 PEST Domain Mutants in Cancer
2 CDK-mediated phosphorylation and removal of Cdc6
.78
3 Class I MHC mediated antigen processing and presentation
4 Cell cycle Role of SCF complex in cell cycle regulation
5 Regulation of PLK1 Activity at G2/M Transition
genes like me logo Genes that share pathways with SKP1: view

UniProtKB/Swiss-Prot P63208-SKP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with SKP1: view

Compounds for SKP1 Gene

(1) Novoseek inferred chemical compound relationships for SKP1 Gene

Compound -log(P) Hits PubMed IDs
atp 0 1
genes like me logo Genes that share compounds with SKP1: view

Transcripts for SKP1 Gene

Unigene Clusters for SKP1 Gene

S-phase kinase-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for SKP1 Gene

GeneLoc Exon Structure for
SKP1
ECgene alternative splicing isoforms for
SKP1

Expression for SKP1 Gene

mRNA expression in normal human tissues for SKP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKP1 Gene

SOURCE GeneReport for Unigene cluster for SKP1 Gene Hs.171626

genes like me logo Genes that share expressions with SKP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SKP1 Gene

Orthologs for SKP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SKP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
OneToMany
SKP1 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
ManyToMany
SKP1 35
  • 92.84 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SKP1 35
  • 97.14 (n)
  • 100 (a)
SKP1 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Skp1a 35
  • 94.48 (n)
  • 99.39 (a)
Skp1a 16
Skp1a 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Skp1 35
  • 94.48 (n)
  • 99.39 (a)
chicken
(Gallus gallus)
Aves SKP1 35
  • 88.55 (n)
  • 100 (a)
SKP1 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia skp1a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia skp1 35
  • 84.25 (n)
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11291 35
zebrafish
(Danio rerio)
Actinopterygii skp1 35
  • 84.05 (n)
  • 98.77 (a)
skp1 36
  • 99 (a)
OneToMany
zgc73186 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008719 35
  • 70.16 (n)
  • 84.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta skpA 35
  • 69.96 (n)
  • 77.16 (a)
skpA 36
  • 77 (a)
ManyToMany
skpB 36
  • 69 (a)
ManyToMany
skpC 36
  • 54 (a)
ManyToMany
skpD 36
  • 51 (a)
ManyToMany
skpE 36
  • 44 (a)
ManyToMany
skpF 36
  • 54 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea skr-1 35
  • 65.2 (n)
  • 71.7 (a)
skr-1 36
  • 65 (a)
ManyToMany
skr-10 36
  • 35 (a)
ManyToMany
skr-12 36
  • 38 (a)
ManyToMany
skr-13 36
  • 38 (a)
ManyToMany
skr-14 36
  • 32 (a)
ManyToMany
skr-15 36
  • 29 (a)
ManyToMany
skr-16 36
  • 29 (a)
ManyToMany
skr-17 36
  • 33 (a)
ManyToMany
skr-18 36
  • 30 (a)
ManyToMany
skr-19 36
  • 34 (a)
ManyToMany
skr-2 36
  • 56 (a)
ManyToMany
skr-20 36
  • 30 (a)
ManyToMany
skr-21 36
  • 25 (a)
ManyToMany
skr-3 36
  • 54 (a)
ManyToMany
skr-4 36
  • 52 (a)
ManyToMany
skr-5 36
  • 53 (a)
ManyToMany
skr-6 36
  • 45 (a)
ManyToMany
skr-7 36
  • 35 (a)
ManyToMany
skr-8 36
  • 35 (a)
ManyToMany
skr-9 36
  • 34 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR295C 35
  • 53.75 (n)
  • 51.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKP1 35
  • 59.49 (n)
  • 56.96 (a)
SKP1 36
  • 42 (a)
OneToMany
SKP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16941g 35
  • 61.6 (n)
  • 58.23 (a)
rice
(Oryza sativa)
Liliopsida Os11g0456300 35
  • 62.34 (n)
  • 59.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08991 35
  • 64.36 (n)
  • 59.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes skp1 35
  • 57.02 (n)
  • 58.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3812 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11317 36
  • 90 (a)
OneToMany
Species with no ortholog for SKP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKP1 Gene

ENSEMBL:
Gene Tree for SKP1 (if available)
TreeFam:
Gene Tree for SKP1 (if available)

Paralogs for SKP1 Gene

Paralogs for SKP1 Gene

genes like me logo Genes that share paralogs with SKP1: view

Variants for SKP1 Gene

Sequence variations from dbSNP and Humsavar for SKP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1181319 -- 134,160,326(+) cacca(A/C)agcct intron-variant
rs1558610 -- 134,175,898(+) CTCCA(C/T)GGCCA intron-variant
rs2110585 -- 134,176,930(+) AAAAC(A/C)GAAGA utr-variant-5-prime
rs2160154 -- 134,175,533(+) GTACT(A/G)AAATG intron-variant
rs2267933 -- 134,173,401(+) tggga(A/G)gactg intron-variant

Relevant External Links for SKP1 Gene

HapMap Linkage Disequilibrium report
SKP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SKP1 Gene

Disorders for SKP1 Gene

(1) Novoseek inferred disease relationships for SKP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for SKP1

Genetic Association Database (GAD)
SKP1
Human Genome Epidemiology (HuGE) Navigator
SKP1
genes like me logo Genes that share disorders with SKP1: view

No data available for UniProtKB/Swiss-Prot for SKP1 Gene

Publications for SKP1 Gene

  1. Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13- 12qter. (PMID: 9031623) Liang Y. … Friedman T.B. (Gene 1997) 3 4 23
  2. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PMID: 8646875) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. Insights into SCF ubiquitin ligases from the structure of the Skp1- Skp2 complex. (PMID: 11099048) Schulman B.A. … Pavletich N.P. (Nature 2000) 3 4 23
  4. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PMID: 12481031) Dias D.C. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  5. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. (PMID: 7553852) Zhang H. … Beach D. (Cell 1995) 2 3 4

Products for SKP1 Gene

Sources for SKP1 Gene

Back to Top

Content