Aliases for MRPS6 Gene
Aliases for MRPS6 Gene
External Ids for MRPS6 Gene
- HGNC: 14051
- Entrez Gene: 64968
- Ensembl: ENSG00000243927
- OMIM: 611973
- UniProtKB: P82932
Previous HGNC Symbols for MRPS6 Gene
- C21orf101
Previous GeneCards Identifiers for MRPS6 Gene
- GC21P032023
- GC21P034366
- GC21P034367
- GC21P035446
- GC21P035448
- GC21P020976
- GC21P035450
- GC21P035452
- GC21P035454
- GC21P035456
- GC21P035458
- GC21P035460
- GC21P034074
- GC21P034076
- GC21P034078
- GC21P034081
- GC21P034085
- GC21P034087
- GC21P034089
Summaries for MRPS6 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPS6 Gene
MRPS6 (Mitochondrial Ribosomal Protein S6) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome and small ribosomal subunit rRNA binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS6 Gene
Genomics for MRPS6 Gene
GeneHancer (GH) Regulatory Elements for MRPS6 Gene
- Top Transcription factor binding sites by QIAGEN in the MRPS6 gene promoter:
Regulatory Element Products
Genomic Locations for MRPS6 Gene
- chr21:34,073,224-34,143,034
- (GRCh38/hg38)
- Size:
- 69,811 bases
- Orientation:
- Plus strand
- chr21:35,445,524-35,515,334
- (GRCh37/hg19)
Genomic View for MRPS6 Gene
- Cytogenetic band:
-
- 21q22.11 by Ensembl
- 21q22.11 by Entrez Gene
- 21q22.11 by HGNC


RefSeq DNA sequence for MRPS6 Gene
Proteins for MRPS6 Gene
-
Protein details for MRPS6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P82932-RT06_HUMAN
- Recommended name:
- 28S ribosomal protein S6, mitochondrial
- Protein Accession:
- P82932
- B2R573
- Q96Q64
- Q9BSK8
- Q9BW89
Protein attributes for MRPS6 Gene
- Size:
- 125 amino acids
- Molecular mass:
- 14227 Da
- Quaternary structure:
-
- Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
- SequenceCaution:
-
- Sequence=BAB40995.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MRPS6 Gene
Post-translational modifications for MRPS6 Gene
Other Protein References for MRPS6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Invitrogen Antibodies for MRPS6
- GeneTex MRPS6 antibody for MRPS6
-
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Protein Products
-
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-
Quality Products:
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Assay Products
No data available for DME Specific Peptides for MRPS6 Gene
Domains & Families for MRPS6 Gene
Gene Families for MRPS6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPS6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPS6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P82932- Family:
-
- Belongs to the bacterial ribosomal protein bS6 family.
Function for MRPS6 Gene
Phenotypes From GWAS Catalog for MRPS6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003735 | structural constituent of ribosome | NAS | 11279123 |
GO:0005515 | protein binding | IPI | 22458338 |
GO:0019843 | rRNA binding | IEA | -- |
GO:0070181 | small ribosomal subunit rRNA binding | IBA | -- |
Phenotypes for MRPS6 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPS6 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for MRPS6
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for MRPS6 Gene
- miRTarBase miRNAs that target MRPS6
miRNA Products
- Search ViGene Biosciences for MRPS6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRPS6
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- genomics-online: shRNA clones - Search results for available MRPS6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MRPS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPS6 gene related products
- orf clones - Search results for available MRPS6 gene related products
- Applied Biological Materials Clones for MRPS6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for MRPS6
-
Horizon Cell Lines for MRPS6
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPS6 gene
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS6 Gene
Localization for MRPS6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPS6 Gene
- Mitochondrion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005763 | mitochondrial small ribosomal subunit | ISS | 11402041 |
GO:0005840 | ribosome | IEA | -- |
GO:0015935 | small ribosomal subunit | NAS | 11279123 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS6 Gene
Pathways & Interactions for MRPS6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Viral mRNA Translation |
.55
|
|
3 | Organelle biogenesis and maintenance |
Pathways by source for MRPS6 Gene
1 KEGG pathway for MRPS6 Gene
Interacting Proteins for MRPS6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | NAS,IEA | 11279123 |
GO:0032543 | mitochondrial translation | ISS | 11402041 |
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPS6 Gene
Transcripts for MRPS6 Gene
mRNA/cDNA for MRPS6 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (460) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPS6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPS6
- genomics-online: gRNA clones - Search results for available MRPS6 gene related products
- Applied Biological Materials CRISPR for MRPS6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS6
- GenScript: Design CRISPR guide RNA sequences for MRPS6
miRNA Products
- Search ViGene Biosciences for MRPS6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRPS6
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- genomics-online: shRNA clones - Search results for available MRPS6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MRPS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPS6 gene related products
- orf clones - Search results for available MRPS6 gene related products
- Applied Biological Materials Clones for MRPS6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MRPS6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS6 Gene
NURSA nuclear receptor signaling pathways regulating expression of MRPS6 Gene:
MRPS6SOURCE GeneReport for Unigene cluster for MRPS6 Gene:
Hs.302742Evidence on tissue expression from TISSUES for MRPS6 Gene
- Nervous system(4.9)
- Kidney(4.4)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for MRPS6
-
OriGene qPCR primer pairs and template standards for MRPS6
- genomics-online: primer clones - Search results for available MRPS6 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS6 Gene
Orthologs for MRPS6 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MRPS6 33 |
|
||
SLC5A3 34 |
|
OneToOne | |||
dog (Canis familiaris) |
Mammalia | MRPS6 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | LOC100360017 33 |
|
||
mouse (Mus musculus) |
Mammalia | Mrps6 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | MRPS6 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MRPS6 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MRPS6 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MRPS6 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MRPS6 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mrps6 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | mrps6 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | mRpS6 34 |
|
OneToOne |
- Species where no ortholog for MRPS6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MRPS6 Gene
Pseudogenes.org Pseudogenes for MRPS6 Gene
No data available for Paralogs for MRPS6 Gene
Variants for MRPS6 Gene
SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000064656 | -- | 34,079,990(+) | T/C | intron_variant | |
rs1000090050 | -- | 34,093,571(+) | A/G | intron_variant | |
rs1000156894 | -- | 34,079,854(+) | T/G | intron_variant | |
rs1000190074 | -- | 34,105,135(+) | G/A | intron_variant | |
rs1000196042 | -- | 34,101,557(+) | C/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7820n54 | CNV | loss | 21841781 |
dgv7821n54 | CNV | loss | 21841781 |
dgv7822n54 | CNV | gain+loss | 21841781 |
dgv7823n54 | CNV | gain | 21841781 |
esv28721 | CNV | loss | 19812545 |
esv3646915 | CNV | loss | 21293372 |
esv3646916 | CNV | loss | 21293372 |
esv3646917 | CNV | loss | 21293372 |
nsv1073127 | CNV | deletion | 25765185 |
nsv3499 | CNV | deletion | 18451855 |
nsv438323 | CNV | loss | 16468122 |
nsv587408 | CNV | loss | 21841781 |
nsv587417 | CNV | loss | 21841781 |
nsv587419 | CNV | loss | 21841781 |
nsv953355 | CNV | deletion | 24416366 |
Additional Variant Information for MRPS6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPS6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS6 Gene
Disorders for MRPS6 Gene
Additional Disease Information for MRPS6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MRPS6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS6 Gene
Publications for MRPS6 Gene
- Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A … Ramakrishnan V (Science (New York, N.Y.) 2015) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) Lluís-Ganella C … Elosua R (Revista espanola de cardiologia 2010) 3 44 58
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S … Kathiresan S (Lancet (London, England) 2010) 3 44 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
Products for MRPS6 Gene
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- VectorBuilder custom plasmid, inducible vectors for MRPS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available MRPS6 Antibodies ranked by validation data
- Compare Top MRPS6 Antibodies
- antibodies-online: Search results for available MRPS6 related products ranked by validation data
- antibodies-online: Search results for 6 available MRPS6 Proteins ranked by validation data
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- Quality Products:
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- genomics-online: cdna clones - Search results for available MRPS6 gene related products
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Sources for MRPS6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew