Aliases for MRPS6 Gene
Aliases for MRPS6 Gene
External Ids for MRPS6 Gene
- HGNC: 14051
- Entrez Gene: 64968
- Ensembl: ENSG00000243927
- OMIM: 611973
- UniProtKB: P82932
Previous HGNC Symbols for MRPS6 Gene
- C21orf101
Previous GeneCards Identifiers for MRPS6 Gene
- GC21P032023
- GC21P034366
- GC21P034367
- GC21P035446
- GC21P035448
- GC21P020976
- GC21P035450
- GC21P035452
- GC21P035454
- GC21P035456
- GC21P035458
- GC21P035460
- GC21P034074
- GC21P034076
- GC21P034078
- GC21P034081
- GC21P034085
Summaries for MRPS6 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPS6 Gene
MRPS6 (Mitochondrial Ribosomal Protein S6) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and small ribosomal subunit rRNA binding.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS6 Gene
Genomics for MRPS6 Gene
Regulatory Elements for MRPS6 Gene
Enhancers for MRPS6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MRPS6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MRPS6 gene promoter:
Regulatory Element Products
Genomic Location for MRPS6 Gene
- Chromosome:
- 21
- Start:
- 34,073,224 bp from pter
- End:
- 34,143,034 bp from pter
- Size:
- 69,811 bases
- Orientation:
- Plus strand
Genomic View for MRPS6 Gene
Genes around MRPS6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by Ensembl
- 21q22.11 by Entrez Gene
- 21q22.11 by HGNC
MRPS6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPS6 Gene
Proteins for MRPS6 Gene
-
Protein details for MRPS6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P82932-RT06_HUMAN
- Recommended name:
- 28S ribosomal protein S6, mitochondrial
- Protein Accession:
- P82932
- B2R573
- Q96Q64
- Q9BSK8
- Q9BW89
Protein attributes for MRPS6 Gene
- Size:
- 125 amino acids
- Molecular mass:
- 14227 Da
- Quaternary structure:
-
- Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
- SequenceCaution:
-
- Sequence=BAB40995.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MRPS6 Gene
Post-translational modifications for MRPS6 Gene
Other Protein References for MRPS6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MRPS6
- Novus Biologicals Antibodies for MRPS6
- Invitrogen Antibodies for MRPS6
- antibodies-online Antibodies for MRPS6: See all 8
- GeneTex MRPS6 antibody for MRPS6
-
Santa Cruz Biotechnology (SCBT) Antibodies for MRPS6
Protein Products
-
OriGene Purified Proteins for MRPS6
- Search Origene for MassSpec and Protein Over-expression Lysates for MRPS6
- Origene Custom Protein Services for MRPS6
- antibodies-online Proteins for MRPS6: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MRPS6
Assay Products
- antibodies-online Kits for MRPS6: See all 8
No data available for DME Specific Peptides for MRPS6 Gene
Domains & Families for MRPS6 Gene
Gene Families for MRPS6 Gene
Protein Domains for MRPS6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPS6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P82932- Family:
-
- Belongs to the bacterial ribosomal protein bS6 family.
Function for MRPS6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | NAS | 11279123 |
| GO:0005515 | protein binding | IPI | 22458338 |
| GO:0019843 | rRNA binding | IEA | -- |
| GO:0070181 | small ribosomal subunit rRNA binding | IBA | -- |
Phenotypes for MRPS6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPS6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
- Search ViGene Biosciences for MRPS6
CRISPR Products
-
OriGene CRISPR knockouts for MRPS6
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS6
- GenScript: Design CRISPR guide RNA sequences for MRPS6
miRNA for MRPS6 Gene
- miRTarBase miRNAs that target MRPS6
miRNA Products
- Search ViGene Biosciences for MRPS6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MRPS6
- Browse OriGene Inhibitory RNA Products For MRPS6
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
Clone Products
-
OriGene ORF clones in human for MRPS6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for MRPS6
-
Horizon Cell Lines for MRPS6
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPS6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPS6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS6 Gene
Localization for MRPS6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPS6 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005763 | mitochondrial small ribosomal subunit | ISS | 11402041 |
| GO:0005840 | ribosome | IEA | -- |
| GO:0015935 | small ribosomal subunit | NAS | 11279123 |
Pathways & Interactions for MRPS6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Viral mRNA Translation |
.56
|
|
| 3 | Organelle biogenesis and maintenance | ||
Pathways by source for MRPS6 Gene
1 KEGG pathway for MRPS6 Gene
Interacting Proteins for MRPS6 Gene
Selected Interacting proteins:
P82932-RT06_HUMAN
ENSP00000382250
for MRPS6 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | NAS | 11279123 |
| GO:0032543 | mitochondrial translation | ISS | 11402041 |
| GO:0070125 | mitochondrial translational elongation | TAS | -- |
| GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPS6 Gene
Transcripts for MRPS6 Gene
mRNA/cDNA for MRPS6 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (460) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPS6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPS6
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS6
- GenScript: Design CRISPR guide RNA sequences for MRPS6
miRNA Products
- Search ViGene Biosciences for MRPS6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MRPS6
- Browse OriGene Inhibitory RNA Products For MRPS6
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS6 gene
Clone Products
-
OriGene ORF clones in human for MRPS6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for MRPS6 Gene
This gene is overexpressed in Lung (25.5) and Breast (19.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS6 Gene
NURSA nuclear receptor signaling pathways regulating expression of MRPS6 Gene:
MRPS6SOURCE GeneReport for Unigene cluster for MRPS6 Gene:
Hs.302742Evidence on tissue expression from TISSUES for MRPS6 Gene
- Nervous system(4.9)
- Kidney(4.4)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for MRPS6
-
OriGene qPCR primer pairs and template standards for MRPS6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS6 Gene
Orthologs for MRPS6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRPS6 34 |
|
||
| SLC5A3 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MRPS6 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC100360017 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrps6 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MRPS6 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MRPS6 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MRPS6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MRPS6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MRPS6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mrps6 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mrps6 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mRpS6 35 |
|
OneToOne |
- Species where no ortholog for MRPS6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MRPS6 Gene
Pseudogenes.org Pseudogenes for MRPS6 Gene
No data available for Paralogs for MRPS6 Gene
Variants for MRPS6 Gene
| SNP ID | Clin | Chr 21 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000064656 | -- | 34,079,990(+) | TCTTT(C/T)CCTGC | intron-variant | |
| rs1000090050 | -- | 34,093,571(+) | AAGGA(A/G)AATGC | intron-variant | |
| rs1000156894 | -- | 34,079,854(+) | TCCCC(G/T)TGGCA | intron-variant | |
| rs1000190074 | -- | 34,105,135(+) | GGTAT(A/G)GAATT | intron-variant, utr-variant-3-prime | |
| rs1000196042 | -- | 34,101,557(+) | CTGGT(C/G)TTTCT | intron-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7820n54 | CNV | loss | 21841781 |
| dgv7821n54 | CNV | loss | 21841781 |
| dgv7822n54 | CNV | gain+loss | 21841781 |
| dgv7823n54 | CNV | gain | 21841781 |
| esv28721 | CNV | loss | 19812545 |
| esv3646915 | CNV | loss | 21293372 |
| esv3646916 | CNV | loss | 21293372 |
| esv3646917 | CNV | loss | 21293372 |
| nsv1073127 | CNV | deletion | 25765185 |
| nsv3499 | CNV | deletion | 18451855 |
| nsv438323 | CNV | loss | 16468122 |
| nsv587408 | CNV | loss | 21841781 |
| nsv587417 | CNV | loss | 21841781 |
| nsv587419 | CNV | loss | 21841781 |
| nsv953355 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.22;
24.44% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MRPS6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPS6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS6 Gene
Disorders for MRPS6 Gene
Relevant External Links for MRPS6
No disorders were found for MRPS6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS6 Gene
Publications for MRPS6 Gene
- Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A. … Ramakrishnan V. (Science 2015) 3 4 64
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S. … Kathiresan S. (Lancet 2010) 3 46 64
- Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) LluA-s-Ganella C. … Elosua R. (Rev Esp Cardiol 2010) 3 46 64
- Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PMID: 19198609) . … Altshuler D. (Nat. Genet. 2009) 3 46 64
Products for MRPS6 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for MRPS6
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- Custom Assay Services
- OriGene Purified Proteins for MRPS6
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- OriGene qPCR primer pairs and template standards for MRPS6
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- GenScript: Design CRISPR guide RNA sequences for MRPS6
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for MRPS6
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for MRPS6
- antibodies-online Antibodies for MRPS6: See all 8
- antibodies-online Kits for MRPS6: See all 8
- antibodies-online Proteins for MRPS6: See all 6
- Search antibodies-online for peptides
- GeneTex MRPS6 antibody for MRPS6
- Search GeneTex for Proteins for MRPS6
- ViGene Biosciences adenoviral particle packaged cDNA for MRPS6 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for MRPS6
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- Horizon Cell Lines for MRPS6
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRPS6
- VectorBuilder custom plasmid, inducible vectors for MRPS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MRPS6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer