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Aliases for MRPS6 Gene

Aliases for MRPS6 Gene

  • Mitochondrial Ribosomal Protein S6 2 3
  • C21orf101 3 4
  • MRP-S6 3 4
  • RPMS6 3 4
  • S6mt 3 4
  • Chromosome 21 Open Reading Frame 101 2

External Ids for MRPS6 Gene

Previous HGNC Symbols for MRPS6 Gene

  • C21orf101

Previous GeneCards Identifiers for MRPS6 Gene

  • GC21P032023
  • GC21P034366
  • GC21P034367
  • GC21P035446
  • GC21P035448
  • GC21P020976
  • GC21P035450
  • GC21P035452
  • GC21P035454
  • GC21P035456
  • GC21P035458
  • GC21P035460
  • GC21P034074

Summaries for MRPS6 Gene

Entrez Gene Summary for MRPS6 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS6 Gene

MRPS6 (Mitochondrial Ribosomal Protein S6) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and small ribosomal subunit rRNA binding.

Gene Wiki entry for MRPS6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS6 Gene

Genomics for MRPS6 Gene

Regulatory Elements for MRPS6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS6 Gene

34,073,224 bp from pter
34,143,034 bp from pter
69,811 bases
Plus strand

Genomic View for MRPS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS6 Gene

Proteins for MRPS6 Gene

  • Protein details for MRPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S6, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R573
    • Q96Q64
    • Q9BSK8
    • Q9BW89

    Protein attributes for MRPS6 Gene

    125 amino acids
    Molecular mass:
    14227 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    • Sequence=BAB40995.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS6 Gene

neXtProt entry for MRPS6 Gene

Proteomics data for MRPS6 Gene at MOPED

Post-translational modifications for MRPS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS6 Gene

Domains & Families for MRPS6 Gene

Gene Families for MRPS6 Gene

Protein Domains for MRPS6 Gene

Suggested Antigen Peptide Sequences for MRPS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S6P family.
  • Belongs to the ribosomal protein S6P family.
genes like me logo Genes that share domains with MRPS6: view

Function for MRPS6 Gene

Gene Ontology (GO) - Molecular Function for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0005515 protein binding IPI 22458338
GO:0019843 rRNA binding --
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with MRPS6: view
genes like me logo Genes that share phenotypes with MRPS6: view

Animal Model Products

miRNA for MRPS6 Gene

miRTarBase miRNAs that target MRPS6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS6 Gene

Localization for MRPS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS6 Gene


Subcellular locations from

Jensen Localization Image for MRPS6 Gene COMPARTMENTS Subcellular localization image for MRPS6 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS 11402041
GO:0005840 ribosome --
GO:0015935 small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS6: view

Pathways & Interactions for MRPS6 Gene

genes like me logo Genes that share pathways with MRPS6: view

Gene Ontology (GO) - Biological Process for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS6: view

No data available for SIGNOR curated interactions for MRPS6 Gene

Drugs & Compounds for MRPS6 Gene

No Compound Related Data Available

Transcripts for MRPS6 Gene

Unigene Clusters for MRPS6 Gene

Mitochondrial ribosomal protein S6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS6 Gene

No ASD Table

Relevant External Links for MRPS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS6 Gene

mRNA expression in normal human tissues for MRPS6 Gene

Protein differential expression in normal tissues from HIPED for MRPS6 Gene

This gene is overexpressed in Lung (25.5) and Breast (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS6 Gene

SOURCE GeneReport for Unigene cluster for MRPS6 Gene Hs.302742

genes like me logo Genes that share expression patterns with MRPS6: view

Protein tissue co-expression partners for MRPS6 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS6 Gene

Orthologs for MRPS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS6 35
  • 83.87 (n)
  • 85.48 (a)
MRPS6 36
  • 83 (a)
(Mus musculus)
Mammalia Mrps6 35
  • 84 (n)
  • 85.6 (a)
Mrps6 16
Mrps6 36
  • 86 (a)
(Pan troglodytes)
Mammalia MRPS6 35
  • 100 (n)
  • 100 (a)
SLC5A3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100360017 35
  • 84.27 (n)
  • 87.2 (a)
(Canis familiaris)
Mammalia MRPS6 36
  • 85 (a)
(Monodelphis domestica)
Mammalia MRPS6 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS6 36
  • 60 (a)
(Gallus gallus)
Aves MRPS6 35
  • 69.15 (n)
  • 66.94 (a)
MRPS6 36
  • 62 (a)
(Anolis carolinensis)
Reptilia MRPS6 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps6 35
  • 66.39 (n)
  • 67.21 (a)
(Danio rerio)
Actinopterygii mrps6 35
  • 55.56 (n)
  • 54.63 (a)
mrps6 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS6 36
  • 33 (a)
Species with no ortholog for MRPS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS6 Gene

Gene Tree for MRPS6 (if available)
Gene Tree for MRPS6 (if available)

Paralogs for MRPS6 Gene Pseudogenes for MRPS6 Gene

genes like me logo Genes that share paralogs with MRPS6: view

No data available for Paralogs for MRPS6 Gene

Variants for MRPS6 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPS6 Gene

Variant ID Type Subtype PubMed ID
esv28721 CNV Loss 19812545
nsv438323 CNV Loss 16468122
nsv3499 CNV Loss 18451855

Variation tolerance for MRPS6 Gene

Residual Variation Intolerance Score: 79.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MRPS6 Gene

Disorders for MRPS6 Gene

Relevant External Links for MRPS6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRPS6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS6 Gene

Publications for MRPS6 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67

Products for MRPS6 Gene

Sources for MRPS6 Gene

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