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Aliases for MRPS11 Gene

Aliases for MRPS11 Gene

  • Mitochondrial Ribosomal Protein S11 2 3
  • Cervical Cancer Proto-Oncogene 2 Protein 3 4
  • MRP-S11 3 4
  • HCC-2 3 4
  • S11mt 3 4
  • Cervical Cancer Proto-Oncogene 2 2
  • RPMS11 4

External Ids for MRPS11 Gene

Previous GeneCards Identifiers for MRPS11 Gene

  • GC15P085107
  • GC15P082295
  • GC15P086597
  • GC15P086740
  • GC15P086811
  • GC15P089010
  • GC15P065122

Summaries for MRPS11 Gene

Entrez Gene Summary for MRPS11 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS11 Gene

MRPS11 (Mitochondrial Ribosomal Protein S11) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS11 Gene

Genomics for MRPS11 Gene

Regulatory Elements for MRPS11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS11 Gene

Chromosome:
15
Start:
88,467,453 bp from pter
End:
88,480,773 bp from pter
Size:
13,321 bases
Orientation:
Plus strand

Genomic View for MRPS11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS11 Gene

Proteins for MRPS11 Gene

  • Protein details for MRPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82912-RT11_HUMAN
    Recommended name:
    28S ribosomal protein S11, mitochondrial
    Protein Accession:
    P82912
    Secondary Accessions:
    • B2RD52
    • Q969D7
    • Q96GI3
    • Q9BYC3

    Protein attributes for MRPS11 Gene

    Size:
    194 amino acids
    Molecular mass:
    20616 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Three dimensional structures from OCA and Proteopedia for MRPS11 Gene

    Alternative splice isoforms for MRPS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS11 Gene

Proteomics data for MRPS11 Gene at MOPED

Post-translational modifications for MRPS11 Gene

  • Ubiquitination at Lys 59, Lys 79, Lys 122, and Lys 152
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS11 Gene

No data available for DME Specific Peptides for MRPS11 Gene

Domains & Families for MRPS11 Gene

Gene Families for MRPS11 Gene

Protein Domains for MRPS11 Gene

Suggested Antigen Peptide Sequences for MRPS11 Gene

Graphical View of Domain Structure for InterPro Entry

P82912

UniProtKB/Swiss-Prot:

RT11_HUMAN :
  • Belongs to the ribosomal protein S11P family.
Family:
  • Belongs to the ribosomal protein S11P family.
genes like me logo Genes that share domains with MRPS11: view

Function for MRPS11 Gene

Gene Ontology (GO) - Molecular Function for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0048027 mRNA 5-UTR binding IBA --
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with MRPS11: view

Phenotypes for MRPS11 Gene

GenomeRNAi human phenotypes for MRPS11:
genes like me logo Genes that share phenotypes with MRPS11: view

Animal Model Products

miRNA for MRPS11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS11

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS11 Gene

Localization for MRPS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS11 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS11 Gene COMPARTMENTS Subcellular localization image for MRPS11 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS11: view

Pathways & Interactions for MRPS11 Gene

genes like me logo Genes that share pathways with MRPS11: view

Gene Ontology (GO) - Biological Process for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006412 translation IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPS11: view

No data available for SIGNOR curated interactions for MRPS11 Gene

Drugs & Compounds for MRPS11 Gene

No Compound Related Data Available

Transcripts for MRPS11 Gene

Unigene Clusters for MRPS11 Gene

Mitochondrial ribosomal protein S11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:
SP12:

Relevant External Links for MRPS11 Gene

GeneLoc Exon Structure for
MRPS11
ECgene alternative splicing isoforms for
MRPS11

Expression for MRPS11 Gene

mRNA expression in normal human tissues for MRPS11 Gene

Protein differential expression in normal tissues from HIPED for MRPS11 Gene

This gene is overexpressed in Lung (23.6) and Cervix (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS11 Gene



SOURCE GeneReport for Unigene cluster for MRPS11 Gene Hs.111286

genes like me logo Genes that share expression patterns with MRPS11: view

Protein tissue co-expression partners for MRPS11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS11 Gene

Orthologs for MRPS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS11 35
  • 84.11 (n)
  • 79.27 (a)
MRPS11 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS11 35
  • 82.04 (n)
  • 76.68 (a)
MRPS11 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps11 35
  • 79.41 (n)
  • 72.77 (a)
Mrps11 16
Mrps11 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS11 35
  • 98.45 (n)
  • 98.97 (a)
MRPS11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps11 35
  • 79.23 (n)
  • 75.39 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS11 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS11 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS11 35
  • 67.74 (n)
  • 66.67 (a)
MRPS11 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS11 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps11 35
  • 59.2 (n)
  • 61.75 (a)
Str.14691 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6598 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15752 35
mrps11 35
  • 61.52 (n)
  • 58.02 (a)
mrps11 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpS11 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-11 36
  • 31 (a)
OneToOne
Species with no ortholog for MRPS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS11 Gene

ENSEMBL:
Gene Tree for MRPS11 (if available)
TreeFam:
Gene Tree for MRPS11 (if available)

Paralogs for MRPS11 Gene

Pseudogenes.org Pseudogenes for MRPS11 Gene

genes like me logo Genes that share paralogs with MRPS11: view

No data available for Paralogs for MRPS11 Gene

Variants for MRPS11 Gene

Sequence variations from dbSNP and Humsavar for MRPS11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2289416 -- 88,472,519(-) CTTCT(G/T)AAGTG intron-variant, utr-variant-3-prime
rs7176195 -- 88,471,780(+) AGACA(A/G)TGGAA intron-variant
rs7176734 -- 88,472,055(+) ctgtt(G/T)ttggg intron-variant
rs7176939 -- 88,472,179(+) TCTGG(G/T)TTTTT intron-variant
rs7177526 -- 88,471,837(+) ATTTG(A/C)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS11 Gene

Variant ID Type Subtype PubMed ID
nsv904476 CNV Gain 21882294
nsv833085 CNV Gain+Loss 17160897

Variation tolerance for MRPS11 Gene

Residual Variation Intolerance Score: 54.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS11 Gene

HapMap Linkage Disequilibrium report
MRPS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS11 Gene

Disorders for MRPS11 Gene

Relevant External Links for MRPS11

Genetic Association Database (GAD)
MRPS11
Human Genome Epidemiology (HuGE) Navigator
MRPS11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS11
genes like me logo Genes that share disorders with MRPS11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS11 Gene

Publications for MRPS11 Gene

  1. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. (PMID: 15300802) Ishiguchi H. … Kohno K. (Int. J. Cancer 2004) 23 67
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 2 67
  3. Targeting presequence acquisition after mitochondrial gene transfer to the nucleus occurs by duplication of existing targeting signals. (PMID: 8978691) Kadowaki K. … Hirai A. (EMBO J. 1996) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for MRPS11 Gene

Sources for MRPS11 Gene

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