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Aliases for MRPS11 Gene

Aliases for MRPS11 Gene

  • Mitochondrial Ribosomal Protein S11 2 3
  • Cervical Cancer Proto-Oncogene 2 Protein 3 4
  • MRP-S11 3 4
  • HCC-2 3 4
  • S11mt 3 4
  • 28S Ribosomal Protein S11, Mitochondrial 3
  • Cervical Cancer Proto-Oncogene 2 2
  • RPMS11 4

External Ids for MRPS11 Gene

Previous GeneCards Identifiers for MRPS11 Gene

  • GC15P085107
  • GC15P082295
  • GC15P086597
  • GC15P086740
  • GC15P086811
  • GC15P089010
  • GC15P065122

Summaries for MRPS11 Gene

Entrez Gene Summary for MRPS11 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS11 Gene

MRPS11 (Mitochondrial Ribosomal Protein S11) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS11 Gene

Genomics for MRPS11 Gene

Regulatory Elements for MRPS11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS11 Gene

88,467,453 bp from pter
88,480,773 bp from pter
13,321 bases
Plus strand

Genomic View for MRPS11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS11 Gene

Proteins for MRPS11 Gene

  • Protein details for MRPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S11, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RD52
    • Q969D7
    • Q96GI3
    • Q9BYC3

    Protein attributes for MRPS11 Gene

    194 amino acids
    Molecular mass:
    20616 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Alternative splice isoforms for MRPS11 Gene


neXtProt entry for MRPS11 Gene

Proteomics data for MRPS11 Gene at MOPED

Post-translational modifications for MRPS11 Gene

  • Ubiquitination at Lys59, Lys79, Lys121, Lys122, and Lys152
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS11 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS11 Gene

Domains for MRPS11 Gene

Gene Families for MRPS11 Gene

Protein Domains for MRPS11 Gene

Suggested Antigen Peptide Sequences for MRPS11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S11P family.
  • Belongs to the ribosomal protein S11P family.
genes like me logo Genes that share domains with MRPS11: view

Function for MRPS11 Gene

Gene Ontology (GO) - Molecular Function for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS11: view

Phenotypes for MRPS11 Gene

GenomeRNAi human phenotypes for MRPS11:
genes like me logo Genes that share phenotypes with MRPS11: view

Animal Model Products

miRNA for MRPS11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS11

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS11 Gene

Localization for MRPS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS11 Gene


Subcellular locations from

Jensen Localization Image for MRPS11 Gene COMPARTMENTS Subcellular localization image for MRPS11 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS11: view

Pathways for MRPS11 Gene

SuperPathways for MRPS11 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS11: view

Pathways by source for MRPS11 Gene

1 KEGG pathway for MRPS11 Gene

Gene Ontology (GO) - Biological Process for MRPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS11: view

Transcripts for MRPS11 Gene

Unigene Clusters for MRPS11 Gene

Mitochondrial ribosomal protein S11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -

Relevant External Links for MRPS11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS11 Gene

mRNA expression in normal human tissues for MRPS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS11 Gene

This gene is overexpressed in Lung (23.6) and Cervix (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS11 Gene

SOURCE GeneReport for Unigene cluster for MRPS11 Gene Hs.111286

genes like me logo Genes that share expressions with MRPS11: view

Expression partners for MRPS11 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS11 Gene

Orthologs for MRPS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS11 35
  • 84.11 (n)
  • 79.27 (a)
MRPS11 36
  • 78 (a)
(Canis familiaris)
Mammalia MRPS11 35
  • 82.04 (n)
  • 76.68 (a)
MRPS11 36
  • 75 (a)
(Mus musculus)
Mammalia Mrps11 35
  • 79.41 (n)
  • 72.77 (a)
Mrps11 16
Mrps11 36
  • 73 (a)
(Pan troglodytes)
Mammalia MRPS11 35
  • 98.45 (n)
  • 98.97 (a)
MRPS11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps11 35
  • 79.23 (n)
  • 75.39 (a)
(Monodelphis domestica)
Mammalia MRPS11 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS11 36
  • 68 (a)
(Gallus gallus)
Aves MRPS11 35
  • 67.74 (n)
  • 66.67 (a)
MRPS11 36
  • 56 (a)
(Anolis carolinensis)
Reptilia MRPS11 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps11 35
  • 59.2 (n)
  • 61.75 (a)
Str.14691 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6598 35
(Danio rerio)
Actinopterygii Dr.15752 35
mrps11 35
  • 61.52 (n)
  • 58.02 (a)
mrps11 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS11 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrps-11 36
  • 31 (a)
Species with no ortholog for MRPS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS11 Gene

Gene Tree for MRPS11 (if available)
Gene Tree for MRPS11 (if available)

Paralogs for MRPS11 Gene Pseudogenes for MRPS11 Gene

genes like me logo Genes that share paralogs with MRPS11: view

No data available for Paralogs for MRPS11 Gene

Variants for MRPS11 Gene

Sequence variations from dbSNP and Humsavar for MRPS11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2289416 -- 88,472,519(-) CTTCT(G/T)AAGTG intron-variant
rs7176195 -- 88,471,780(+) AGACA(A/G)TGGAA intron-variant
rs7176734 -- 88,472,055(+) ctgtt(G/T)ttggg intron-variant
rs7176939 -- 88,472,179(+) TCTGG(G/T)TTTTT intron-variant
rs7177526 -- 88,471,837(+) ATTTG(A/C)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS11 Gene

Variant ID Type Subtype PubMed ID
nsv904476 CNV Gain 21882294
nsv833085 CNV Gain+Loss 17160897

Relevant External Links for MRPS11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS11 Gene

Disorders for MRPS11 Gene

Relevant External Links for MRPS11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS11 Gene

Publications for MRPS11 Gene

  1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 2 3 4
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPS11 Gene

Sources for MRPS11 Gene

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