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Aliases for CENPH Gene

Aliases for CENPH Gene

  • Centromere Protein H 2 3 5
  • Interphase Centromere Complex Protein 35 3 4
  • CENP-H 3 4
  • Kinetochore Protein CENP-H 3
  • ICEN35 4

External Ids for CENPH Gene

Previous GeneCards Identifiers for CENPH Gene

  • GC05P068637
  • GC05P070050
  • GC05P068455
  • GC05P068502
  • GC05P068503
  • GC05P068521
  • GC05P068486
  • GC05P065440
  • GC05P068488
  • GC05P068496
  • GC05P068508

Summaries for CENPH Gene

Entrez Gene Summary for CENPH Gene

  • Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPH Gene

CENPH (Centromere Protein H) is a Protein Coding gene. Diseases associated with CENPH include Hypopharynx Cancer. Among its related pathways are Chromosome Maintenance and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot for CENPH Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Wiki entry for CENPH Gene

Additional gene information for CENPH Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPH Gene

Genomics for CENPH Gene

GeneHancer (GH) Regulatory Elements for CENPH Gene

Promoters and enhancers for CENPH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I069188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 177 2.4 PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B CENPH ENSG00000280187 PIR38105 PIR48224 PIR41528 PIR42195 CCDC125 CDK7 CCNB1 SNORA50D
GH05I069233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 +45.4 45368 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CDK7 CCDC125 SLC30A5 GTF2H2C ENSG00000198237 ENSG00000254701 CENPH CCNB1 SNORA50D SMN2
GH05I069093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 -95.1 -95104 2.4 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 SLC30A5 SNORA50D CCNB1 CENPH GTF2H2C OCLN SMN2 ENSG00000248664
GH05I069236 Enhancer 0.9 Ensembl ENCODE 15.1 +48.6 48618 4.1 SCRT1 ZNF362 JUN EP300 FOSL1 MAFF GATA3 JUND POLR2A SCRT2 CCDC125 CENPH CDK7 ENSG00000198237 GC05P069260 GC05P069259
GH05I069334 Enhancer 1.1 Ensembl ENCODE 10.9 +146.1 146134 2.2 RB1 ARID4B ZNF48 RAD21 YY1 CHAMP1 ZNF335 ZNF366 SCRT2 ZNF143 CHCHD2P2 GC05P069334 CCDC125 GTF2H2C SLC30A5 MARVELD2 CENPH ENSG00000254701 NDUFB9P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CENPH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CENPH gene promoter:

Genomic Locations for CENPH Gene

Genomic Locations for CENPH Gene
chr5:69,189,548-69,210,357
(GRCh38/hg38)
Size:
20,810 bases
Orientation:
Plus strand
chr5:68,485,375-68,506,184
(GRCh37/hg19)

Genomic View for CENPH Gene

Genes around CENPH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPH Gene

Proteins for CENPH Gene

  • Protein details for CENPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R5-CENPH_HUMAN
    Recommended name:
    Centromere protein H
    Protein Accession:
    Q9H3R5
    Secondary Accessions:
    • A8K3Y1

    Protein attributes for CENPH Gene

    Size:
    247 amino acids
    Molecular mass:
    28481 Da
    Quaternary structure:
    • Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity).

neXtProt entry for CENPH Gene

Post-translational modifications for CENPH Gene

  • Ubiquitination at Lys76, Lys131, and Lys138

Other Protein References for CENPH Gene

No data available for DME Specific Peptides for CENPH Gene

Domains & Families for CENPH Gene

Gene Families for CENPH Gene

Protein Domains for CENPH Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3R5

UniProtKB/Swiss-Prot:

CENPH_HUMAN :
  • Belongs to the centromere protein H family.
Family:
  • Belongs to the centromere protein H family.
genes like me logo Genes that share domains with CENPH: view

Function for CENPH Gene

Molecular function for CENPH Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Ontology (GO) - Molecular Function for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11092768
GO:0043515 kinetochore binding IEA,IDA 11092768
genes like me logo Genes that share ontologies with CENPH: view
genes like me logo Genes that share phenotypes with CENPH: view

Animal Models for CENPH Gene

MGI Knock Outs for CENPH:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPH

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPH Gene

Localization for CENPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPH Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPH gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA,NAS 11092768
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 11092768
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPH: view

Pathways & Interactions for CENPH Gene

genes like me logo Genes that share pathways with CENPH: view

Gene Ontology (GO) - Biological Process for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051382 kinetochore assembly IEA --
GO:0051383 kinetochore organization TAS 11092768
genes like me logo Genes that share ontologies with CENPH: view

No data available for SIGNOR curated interactions for CENPH Gene

Drugs & Compounds for CENPH Gene

No Compound Related Data Available

Transcripts for CENPH Gene

Unigene Clusters for CENPH Gene

Centromere protein H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPH

Alternative Splicing Database (ASD) splice patterns (SP) for CENPH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CENPH Gene

GeneLoc Exon Structure for
CENPH
ECgene alternative splicing isoforms for
CENPH

Expression for CENPH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPH Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CENPH Gene

This gene is overexpressed in Fetal ovary (20.7), Amniocyte (15.7), Testis (10.6), Islet of Langerhans (10.4), and Plasma (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPH Gene



Protein tissue co-expression partners for CENPH Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPH Gene:

CENPH

SOURCE GeneReport for Unigene cluster for CENPH Gene:

Hs.631967
genes like me logo Genes that share expression patterns with CENPH: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPH Gene

Orthologs for CENPH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPH 33 34
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia CENPH 33 34
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia CENPH 33 34
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia LOC681185 33
  • 78.5 (n)
mouse
(Mus musculus)
Mammalia Cenph 33 16 34
  • 76.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPH 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPH 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPH 33 34
  • 51.97 (n)
lizard
(Anolis carolinensis)
Reptilia CENPH 34
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenph 33
  • 56.45 (n)
zebrafish
(Danio rerio)
Actinopterygii cenph 34
  • 24 (a)
OneToOne
Species where no ortholog for CENPH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPH Gene

ENSEMBL:
Gene Tree for CENPH (if available)
TreeFam:
Gene Tree for CENPH (if available)

Paralogs for CENPH Gene

No data available for Paralogs for CENPH Gene

Variants for CENPH Gene

Sequence variations from dbSNP and Humsavar for CENPH Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs777698677 A colorectal cancer sample 69,189,638(+) G/A coding_sequence_variant, missense_variant
rs1000100692 -- 69,197,994(+) C/T intron_variant
rs1000265076 -- 69,199,844(+) G/A intron_variant
rs1000318035 -- 69,200,053(+) C/T intron_variant
rs1000455875 -- 69,206,565(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CENPH Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
esv3452028 CNV insertion 20981092
nsv478671 CNV novel sequence insertion 20440878
nsv509066 CNV insertion 20534489

Variation tolerance for CENPH Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPH Gene

Human Gene Mutation Database (HGMD)
CENPH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPH Gene

Disorders for CENPH Gene

MalaCards: The human disease database

(1) MalaCards diseases for CENPH Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hypopharynx cancer
  • hypopharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards
Search CENPH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CENPH

genes like me logo Genes that share disorders with CENPH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPH Gene

Publications for CENPH Gene

  1. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. (PMID: 11092768) Sugata N … Todokoro K (Human molecular genetics 2000) 2 3 4 22 58
  2. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PMID: 17651496) Alonso A … Warburton PE (Genome biology 2007) 3 4 22 58
  3. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 3 4 22 58
  4. RNAi knockdown of human kinetochore protein CENP-H. (PMID: 16875666) Orthaus S … Diekmann S (Biochemical and biophysical research communications 2006) 3 4 22 58
  5. Transcription within a functional human centromere. (PMID: 14536089) Saffery R … Choo KH (Molecular cell 2003) 3 4 22 58

Products for CENPH Gene

Sources for CENPH Gene

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