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Aliases for CENPH Gene

Aliases for CENPH Gene

  • Centromere Protein H 2 3
  • Interphase Centromere Complex Protein 35 3 4
  • CENP-H 3 4
  • Kinetochore Protein CENP-H 3
  • ICEN35 4

External Ids for CENPH Gene

Previous GeneCards Identifiers for CENPH Gene

  • GC05P068637
  • GC05P070050
  • GC05P068455
  • GC05P068502
  • GC05P068503
  • GC05P068521
  • GC05P068486
  • GC05P065440
  • GC05P068488
  • GC05P068496
  • GC05P068508

Summaries for CENPH Gene

Entrez Gene Summary for CENPH Gene

  • Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPH Gene

CENPH (Centromere Protein H) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot for CENPH Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Wiki entry for CENPH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPH Gene

Genomics for CENPH Gene

Regulatory Elements for CENPH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CENPH Gene

Start:
69,189,548 bp from pter
End:
69,210,357 bp from pter
Size:
20,810 bases
Orientation:
Plus strand

Genomic View for CENPH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPH Gene

Proteins for CENPH Gene

  • Protein details for CENPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R5-CENPH_HUMAN
    Recommended name:
    Centromere protein H
    Protein Accession:
    Q9H3R5
    Secondary Accessions:
    • A8K3Y1

    Protein attributes for CENPH Gene

    Size:
    247 amino acids
    Molecular mass:
    28481 Da
    Quaternary structure:
    • Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity).

neXtProt entry for CENPH Gene

Proteomics data for CENPH Gene at MOPED

Post-translational modifications for CENPH Gene

  • Ubiquitination at Lys76, Lys131, and Lys138
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CENPH Gene

Domains for CENPH Gene

Protein Domains for CENPH Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3R5

UniProtKB/Swiss-Prot:

CENPH_HUMAN :
  • Q9H3R5
Family:
  • Belongs to the centromere protein H family.
genes like me logo Genes that share domains with CENPH: view

No data available for Gene Families for CENPH Gene

Function for CENPH Gene

Molecular function for CENPH Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Ontology (GO) - Molecular Function for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11092768
GO:0043515 kinetochore binding IDA 11092768
genes like me logo Genes that share ontologies with CENPH: view

Phenotypes for CENPH Gene

genes like me logo Genes that share phenotypes with CENPH: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CENPH Gene

Localization for CENPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPH Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPH Gene COMPARTMENTS Subcellular localization image for CENPH gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore NAS 11092768
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 11092768
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPH: view

Pathways for CENPH Gene

genes like me logo Genes that share pathways with CENPH: view

Pathways by source for CENPH Gene

Gene Ontology (GO) - Biological Process for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051382 kinetochore assembly IEA --
genes like me logo Genes that share ontologies with CENPH: view

Transcripts for CENPH Gene

Unigene Clusters for CENPH Gene

Centromere protein H:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CENPH Gene

GeneLoc Exon Structure for
CENPH
ECgene alternative splicing isoforms for
CENPH

Expression for CENPH Gene

mRNA expression in normal human tissues for CENPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPH Gene

This gene is overexpressed in Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPH Gene

SOURCE GeneReport for Unigene cluster for CENPH Gene Hs.631967

genes like me logo Genes that share expressions with CENPH: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CENPH Gene

Orthologs for CENPH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPH 35
  • 99.33 (n)
  • 98.79 (a)
CENPH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPH 35
  • 88.39 (n)
  • 83.2 (a)
CENPH 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPH 35
  • 85.52 (n)
  • 77.37 (a)
CENPH 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenph 35
  • 76.01 (n)
  • 67.78 (a)
Cenph 16
Cenph 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPH 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPH 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681185 35
  • 78.5 (n)
  • 76 (a)
chicken
(Gallus gallus)
Aves CENPH 35
  • 51.97 (n)
  • 35.91 (a)
CENPH 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPH 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenph 35
  • 56.45 (n)
  • 46.73 (a)
zebrafish
(Danio rerio)
Actinopterygii cenph 36
  • 24 (a)
OneToOne
Species with no ortholog for CENPH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPH Gene

ENSEMBL:
Gene Tree for CENPH (if available)
TreeFam:
Gene Tree for CENPH (if available)

Paralogs for CENPH Gene

No data available for Paralogs for CENPH Gene

Variants for CENPH Gene

Sequence variations from dbSNP and Humsavar for CENPH Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs100192 -- 69,192,347(-) TGGAA(C/T)GTAAA intron-variant
rs171211 -- 69,199,256(+) tcact(A/G)ccacc intron-variant
rs191572 -- 69,204,665(-) ttgca(C/G)cactg intron-variant
rs239591 -- 69,197,946(+) gagac(A/C)gtctt intron-variant
rs350092 -- 69,207,026(-) ATGAA(A/T)CATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPH Gene

Variant ID Type Subtype PubMed ID
nsv509066 CNV Insertion 20534489

Relevant External Links for CENPH Gene

HapMap Linkage Disequilibrium report
CENPH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPH Gene

Disorders for CENPH Gene

(1) Novoseek inferred disease relationships for CENPH Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for CENPH

Human Genome Epidemiology (HuGE) Navigator
CENPH
genes like me logo Genes that share disorders with CENPH: view

No data available for UniProtKB/Swiss-Prot for CENPH Gene

Publications for CENPH Gene

  1. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes. (PMID: 11092768) Sugata N. … Todokoro K. (Hum. Mol. Genet. 2000) 2 3 4 23
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 23
  3. RNAi knockdown of human kinetochore protein CENP-H. (PMID: 16875666) Orthaus S. … Diekmann S. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  4. Transcription within a functional human centromere. (PMID: 14536089) Saffery R. … Choo K.H.A. (Mol. Cell 2003) 3 4 23
  5. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PMID: 17651496) Alonso A. … Warburton P.E. (Genome Biol. 2007) 3 4 23

Products for CENPH Gene

Sources for CENPH Gene

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