Aliases for SIM1 Gene
External Ids for SIM1 Gene
Previous GeneCards Identifiers for SIM1 Gene
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIM1 Gene
SIM1 (Single-Minded Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with SIM1 include Obesity Due To Sim1 Deficiency and Prader-Willi-Like Syndrome Due To Point Mutation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is SIM2.
UniProtKB/Swiss-Prot for SIM1 Gene
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.