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Aliases for BCL11B Gene

Aliases for BCL11B Gene

  • B-Cell CLL/Lymphoma 11B (Zinc Finger Protein) 2 3
  • CTIP2 3 4 6
  • Radiation-Induced Tumor Suppressor Gene 1 Protein 3 4
  • COUP-TF-Interacting Protein 2 3 4
  • BCL-11B 3 4
  • HRit1 3 4
  • RIT1 3 4
  • B-Cell CLL/Lymphoma 11B/T-Cell Receptor Delta Constant Region Fusion Protein 3
  • Zinc Finger Protein HRit1 Alpha 3
  • B-Cell Lymphoma/Leukaemia 11B 3
  • B-Cell Lymphoma/Leukemia 11B 3
  • B-Cell CLL/Lymphoma 11B 4
  • BCL11B/TRDC Fusion 3
  • HRIT1-Alpha 3
  • ATL1-Alpha 3
  • ATL1-Delta 3
  • ATL1-Gamma 3
  • ATL1-Beta 3
  • ZNF856B 3
  • CTIP-2 3
  • ATL1 3

External Ids for BCL11B Gene

Previous Symbols for BCL11B Gene

  • ZNF856B

Summaries for BCL11B Gene

Entrez Gene Summary for BCL11B Gene

  • This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for BCL11B Gene

BCL11B (B-Cell CLL/Lymphoma 11B (Zinc Finger Protein)) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF296.

UniProtKB/Swiss-Prot for BCL11B Gene

  • Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).

Gene Wiki entry for BCL11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL11B Gene

Genomics for BCL11B Gene

Genomic Location for BCL11B Gene

Start:
99,169,287 bp from pter
End:
99,271,713 bp from pter
Size:
102,427 bases
Orientation:
Minus strand

Genomic View for BCL11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL11B Gene

Regulatory Elements for BCL11B Gene

Proteins for BCL11B Gene

  • Protein details for BCL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K0-BC11B_HUMAN
    Recommended name:
    B-cell lymphoma/leukemia 11B
    Protein Accession:
    Q9C0K0
    Secondary Accessions:
    • Q9H162

    Protein attributes for BCL11B Gene

    Size:
    894 amino acids
    Molecular mass:
    95519 Da
    Quaternary structure:
    • Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.

    Alternative splice isoforms for BCL11B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL11B Gene

Proteomics data for BCL11B Gene at MOPED

Post-translational modifications for BCL11B Gene

  • Sumoylated with SUMO1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys585, Lys591, Lys597, Lys617, Lys672, Lys686, Lys790, Lys803, Lys806, Lys825, Lys838, Lys851, and Lys875

Other Protein References for BCL11B Gene

No data available for DME Specific Peptides for BCL11B Gene

Domains for BCL11B Gene

Gene Families for BCL11B Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for BCL11B Gene

UniProtKB/Swiss-Prot:

BC11B_HUMAN
Similarity:
  • Contains 6 C2H2-type zinc fingers.:
    • Q9C0K0
genes like me logo Genes that share domains with BCL11B: view

Function for BCL11B Gene

Molecular function for BCL11B Gene

UniProtKB/Swiss-Prot Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).

Gene Ontology (GO) - Molecular Function for BCL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 17245431
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with BCL11B: view
genes like me logo Genes that share phenotypes with BCL11B: view

Animal Models for BCL11B Gene

MGI Knock Outs for BCL11B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL11B Gene

Localization for BCL11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL11B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL11B Gene COMPARTMENTS Subcellular localization image for BCL11B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for BCL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BCL11B: view

Pathways for BCL11B Gene

genes like me logo Genes that share pathways with BCL11B: view

Gene Ontology (GO) - Biological Process for BCL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007409 axonogenesis --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with BCL11B: view

Transcripts for BCL11B Gene

Unigene Clusters for BCL11B Gene

B-cell CLL/lymphoma 11B (zinc finger protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL11B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for BCL11B Gene

GeneLoc Exon Structure for
BCL11B
ECgene alternative splicing isoforms for
BCL11B

Expression for BCL11B Gene

mRNA expression in normal human tissues for BCL11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL11B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.6), Brain - Putamen (basal ganglia) (5.8), Skin - Sun Exposed (Lower leg) (5.6), Skin - Not Sun Exposed (Suprapubic) (5.5), and Brain - Caudate (basal ganglia) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL11B Gene

SOURCE GeneReport for Unigene cluster for BCL11B Gene Hs.709690

mRNA Expression by UniProt/SwissProt for BCL11B Gene

Q9C0K0-BC11B_HUMAN
Tissue specificity: Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma
genes like me logo Genes that share expressions with BCL11B: view

Orthologs for BCL11B Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL11B 36
  • 99.74 (n)
  • 99.89 (a)
BCL11B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL11B 36
  • 94.33 (n)
  • 96.42 (a)
BCL11B 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL11B 36
  • 96.31 (n)
  • 97.54 (a)
BCL11B 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl11b 36
  • 89.08 (n)
  • 93.63 (a)
Bcl11b 16
Bcl11b 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL11B 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL11B 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl11b 36
  • 88.8 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 85 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
BCL11B 36
  • 76.66 (n)
  • 84.67 (a)
lizard
(Anolis carolinensis)
Reptilia BCL11B 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl11b 36
  • 70.58 (n)
  • 81.64 (a)
Str.12510 36
zebrafish
(Danio rerio)
Actinopterygii BCL11B (2 of 2) 37
  • 60 (a)
OneToMany
bcl11ba 37
  • 76 (a)
OneToMany
LOC100330974 36
  • 70.2 (n)
  • 71.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9650 37
  • 17 (a)
OneToMany
CG9650 38
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea F13H6.1 37
  • 16 (a)
OneToMany
F13H6.1 38
  • 65 (a)
Species with no ortholog for BCL11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCL11B Gene

ENSEMBL:
Gene Tree for BCL11B (if available)
TreeFam:
Gene Tree for BCL11B (if available)

Paralogs for BCL11B Gene

Paralogs for BCL11B Gene

genes like me logo Genes that share paralogs with BCL11B: view

Variants for BCL11B Gene

Sequence variations from dbSNP and Humsavar for BCL11B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs710304 -- 99,176,472(+) CAAAG(A/G)AAAGG intron-variant
rs710305 -- 99,177,950(+) CCAAA(C/T)ACCCT intron-variant
rs710306 -- 99,181,553(+) CAATG(A/C)AAATG intron-variant
rs710307 -- 99,182,727(+) GCCAC(C/T)GCCCC intron-variant
rs710308 -- 99,183,170(+) ACTCA(A/C)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL11B Gene

Variant ID Type Subtype PubMed ID
nsv827039 CNV Gain 20364138
nsv827040 CNV Gain 20364138
dgv385n67 CNV Gain 20364138
dgv386n67 CNV Gain 20364138
esv2671501 CNV Deletion 23128226
dgv387n67 CNV Gain 20364138
esv23236 CNV Loss 19812545
esv275067 CNV Gain+Loss 21479260
nsv470666 CNV Gain 18288195
nsv832871 CNV Gain 17160897
nsv832872 CNV Loss 17160897
nsv528741 CNV Loss 19592680
esv2658925 CNV Deletion 23128226
nsv827049 CNV Gain 20364138

Relevant External Links for BCL11B Gene

HapMap Linkage Disequilibrium report
BCL11B

Disorders for BCL11B Gene

(1) University of Copenhagen DISEASES for BCL11B Gene

(2) Novoseek inferred disease relationships for BCL11B Gene

Disease -log(P) Hits PubMed IDs
lymphoma 24.7 2
tumors 0 1
genes like me logo Genes that share disorders with BCL11B: view

No data available for UniProtKB/Swiss-Prot for BCL11B Gene

Publications for BCL11B Gene

  1. Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. (PMID: 12565905) Wakabayashi Y. … Kominami R. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. (PMID: 11719382) Satterwhite E. … Dyer M.J. (Blood 2001) 2 3 4
  3. A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. (PMID: 15104287) Bezrookove V. … Rosenberg C. (Cancer Genet. Cytogenet. 2004) 3 23
  4. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. (PMID: 15849318) Marban C. … Rohr O. (Nucleic Acids Res. 2005) 3 23
  5. Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. (PMID: 17369851) Kamimura K. … Kominami R. (Oncogene 2007) 3 23

Products for BCL11B Gene

  • antibodies-online peptides for BCL11B
  • antibodies-online antibodies for BCL11B
  • antibodies-online kits for BCL11B

Sources for BCL11B Gene

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