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Aliases for SLC13A3 Gene

Aliases for SLC13A3 Gene

  • Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3 2 3
  • NADC3 3 4 6
  • Sodium-Dependent High-Affinity Dicarboxylate Transporter 2 3 4
  • Na(+)/Dicarboxylate Cotransporter 3 3 4
  • NaDC-3 3 4
  • HNaDC3 3 4
  • SDCT2 3 4
  • Sodium-Dependent High Affinity Dicarboxylate Transporter 3 3
  • Solute Carrier Family 13 Member 3 3

External Ids for SLC13A3 Gene

Summaries for SLC13A3 Gene

Entrez Gene Summary for SLC13A3 Gene

  • Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC13A3 Gene

SLC13A3 (Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include high-affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A3 Gene

  • High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate

Gene Wiki entry for SLC13A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A3 Gene

Genomics for SLC13A3 Gene

Genomic Location for SLC13A3 Gene

Start:
46,557,823 bp from pter
End:
46,684,485 bp from pter
Size:
126,663 bases
Orientation:
Minus strand

Genomic View for SLC13A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A3 Gene

Regulatory Elements for SLC13A3 Gene

Proteins for SLC13A3 Gene

  • Protein details for SLC13A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWT9-S13A3_HUMAN
    Recommended name:
    Solute carrier family 13 member 3
    Protein Accession:
    Q8WWT9
    Secondary Accessions:
    • B4DIR8
    • E1P5U4
    • F6WI18
    • Q5JYC9
    • Q5JYD0
    • Q5JYD1
    • Q5TCQ2
    • Q8IVB1
    • Q8N8K4
    • Q96MM5
    • Q9BR25
    • Q9H1G1
    • Q9H3W4
    • Q9NQN5
    • Q9NS04

    Protein attributes for SLC13A3 Gene

    Size:
    602 amino acids
    Molecular mass:
    66841 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF73251.1; Type=Frameshift; Positions=188, 199; Evidence={ECO:0000305}; Sequence=CAC09447.2; Type=Miscellaneous discrepancy; Note=erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC13A3 Gene

neXtProt entry for SLC13A3 Gene

Proteomics data for SLC13A3 Gene at MOPED

Post-translational modifications for SLC13A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn586 and Asn596

No data available for DME Specific Peptides for SLC13A3 Gene

Domains for SLC13A3 Gene

Protein Domains for SLC13A3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S13A3_HUMAN
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.:
    • Q8WWT9
genes like me logo Genes that share domains with SLC13A3: view

Function for SLC13A3 Gene

Molecular function for SLC13A3 Gene

UniProtKB/Swiss-Prot Function: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate

Gene Ontology (GO) - Molecular Function for SLC13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015362 high-affinity sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC13A3: view

Phenotypes for SLC13A3 Gene

genes like me logo Genes that share phenotypes with SLC13A3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC13A3 Gene

Localization for SLC13A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A3 Gene COMPARTMENTS Subcellular localization image for SLC13A3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC13A3: view

Pathways for SLC13A3 Gene

genes like me logo Genes that share pathways with SLC13A3: view

Interacting Proteins for SLC13A3 Gene

Gene Ontology (GO) - Biological Process for SLC13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0006835 dicarboxylic acid transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC13A3: view

Compounds for SLC13A3 Gene

(2) HMDB Compounds for SLC13A3 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
Succinic acid
  • 1,2-Ethanedicarboxylate
110-15-6

(1) Drugbank Compounds for SLC13A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Succinic acid
  • 1,2-Ethanedicarboxylic acid
110-15-6 target

(6) Novoseek inferred chemical compound relationships for SLC13A3 Gene

Compound -log(P) Hits PubMed IDs
dicarboxylate 88.4 7
glutaric acid 82.3 4
succinate 66 3
alpha-ketoglutarate 64 1
citrate 49.7 2
genes like me logo Genes that share compounds with SLC13A3: view

Transcripts for SLC13A3 Gene

Unigene Clusters for SLC13A3 Gene

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:
SP15: -
SP16: - -
SP17:
SP18:

Relevant External Links for SLC13A3 Gene

GeneLoc Exon Structure for
SLC13A3
ECgene alternative splicing isoforms for
SLC13A3

Expression for SLC13A3 Gene

mRNA expression in normal human tissues for SLC13A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A3 Gene

This gene is overexpressed in Kidney - Cortex (30.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC13A3 Gene

SOURCE GeneReport for Unigene cluster for SLC13A3 Gene Hs.655498

mRNA Expression by UniProt/SwissProt for SLC13A3 Gene

Q8WWT9-S13A3_HUMAN
Tissue specificity: Expression is highest in kidney. Detected in placenta, brain, liver and pancreas
genes like me logo Genes that share expressions with SLC13A3: view

Orthologs for SLC13A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC13A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC13A3 36
  • 99.45 (n)
  • 99.83 (a)
SLC13A3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC13A3 36
  • 88.76 (n)
  • 88.87 (a)
SLC13A3 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A3 36
  • 89.85 (n)
  • 90.52 (a)
SLC13A3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a3 36
  • 85.98 (n)
  • 88.15 (a)
Slc13a3 16
Slc13a3 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC13A3 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A3 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a3 36
  • 86.83 (n)
  • 87.83 (a)
chicken
(Gallus gallus)
Aves SLC13A3 36
  • 74.97 (n)
  • 79.97 (a)
SLC13A3 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A3 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a3 36
  • 66.28 (n)
  • 69.36 (a)
zebrafish
(Danio rerio)
Actinopterygii slc13a3 36
  • 66.08 (n)
  • 69.2 (a)
slc13a3 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7309 37
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nac-1 37
  • 36 (a)
ManyToMany
nac-2 36
  • 45.89 (n)
  • 39.81 (a)
nac-3 37
  • 37 (a)
ManyToMany
R107.1 38
  • 33 (a)
B0285.6 38
  • 34 (a)
F31F6.6 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO87 39
rice
(Oryza sativa)
Liliopsida Os.15092 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for SLC13A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A3 Gene

ENSEMBL:
Gene Tree for SLC13A3 (if available)
TreeFam:
Gene Tree for SLC13A3 (if available)

Paralogs for SLC13A3 Gene

Paralogs for SLC13A3 Gene

Selected SIMAP similar genes for SLC13A3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC13A3: view

Variants for SLC13A3 Gene

Sequence variations from dbSNP and Humsavar for SLC13A3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3583 -- 46,557,891(+) CAAAA(C/T)AGACC utr-variant-3-prime
rs3585 -- 46,557,940(+) GAGCA(C/G)attca utr-variant-3-prime
rs8149 -- 46,558,602(+) TGCTC(A/G)CTTGG utr-variant-3-prime
rs9873 -- 46,681,999(+) tcagt(C/T)tccaa intron-variant
rs10218 -- 46,558,866(-) CTCAG(G/T)CCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC13A3 Gene

Variant ID Type Subtype PubMed ID
nsv833994 CNV Gain 17160897
esv2722460 CNV Deletion 23290073
esv2722462 CNV Deletion 23290073
nsv912900 CNV Loss 21882294
esv34663 CNV Gain 17911159
nsv509771 CNV Insertion 20534489
esv6676 CNV Gain 19470904
nsv828733 CNV Gain 20364138
dgv1331e1 CNV Complex 17122850
nsv9812 CNV Gain 18304495
esv32661 CNV Gain 17666407
esv2722463 CNV Deletion 23290073
nsv179106 CNV Loss 16902084
esv2722464 CNV Deletion 23290073
nsv179609 CNV Loss 16902084
nsv912901 CNV Loss 21882294

Relevant External Links for SLC13A3 Gene

HapMap Linkage Disequilibrium report
SLC13A3

Disorders for SLC13A3 Gene

(2) University of Copenhagen DISEASES for SLC13A3 Gene

Relevant External Links for SLC13A3

Genetic Association Database (GAD)
SLC13A3
Human Genome Epidemiology (HuGE) Navigator
SLC13A3
genes like me logo Genes that share disorders with SLC13A3: view

No data available for UniProtKB/Swiss-Prot for SLC13A3 Gene

Publications for SLC13A3 Gene

  1. Structure, function, and genomic organization of human Na(+)- dependent high-affinity dicarboxylate transporter. (PMID: 10794676) Wang H. … Ganapathy V. (Am. J. Physiol. 2000) 2 3 4 23
  2. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PMID: 18602983) Bento J.L. … Mychaleckyj J.C. (Genomics 2008) 3 23 49
  3. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. (PMID: 15561973) Burckhardt B.C. … Burckhardt G. (Am. J. Physiol. Renal Physiol. 2005) 3 23 25
  4. Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. (PMID: 10992006) Huang W. … Ganapathy V. (J. Pharmacol. Exp. Ther. 2000) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for SLC13A3 Gene

Sources for SLC13A3 Gene

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