Aliases for CYP3A43 Gene
External Ids for CYP3A43 Gene
Previous GeneCards Identifiers for CYP3A43 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for CYP3A43 Gene
CYP3A43 (Cytochrome P450 Family 3 Subfamily A Member 43) is a Protein Coding gene. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Phase II conjugation. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.
UniProtKB/Swiss-Prot for CYP3A43 Gene
Exhibits low testosterone 6-beta-hydroxylase activity.