Aliases for P2RY12 Gene
External Ids for P2RY12 Gene
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for P2RY12 Gene
P2RY12 (Purinergic Receptor P2Y, G-Protein Coupled, 12) is a Protein Coding gene. Diseases associated with P2RY12 include resistance to clopidogrel and bleeding disorder, platelet-type, 8. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and ADP receptor activity. An important paralog of this gene is P2RY14.
UniProtKB/Swiss-Prot for P2RY12 Gene
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.