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Aliases for ST6GAL1 Gene

Aliases for ST6GAL1 Gene

  • ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 2
  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1 2 3 5
  • ST6Gal I 2 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 1 3 4
  • B-Cell Antigen CD75 3 4
  • Alpha 2,6-ST 1 3 4
  • EC 4 63
  • ST6GalI 3 4
  • SIAT1 3 4
  • CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase) 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialytransferase) 2
  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2
  • Sialyltransferase 1 4
  • ST6N 3

External Ids for ST6GAL1 Gene

Previous HGNC Symbols for ST6GAL1 Gene

  • SIAT1

Previous GeneCards Identifiers for ST6GAL1 Gene

  • GC03P188132
  • GC03P186648
  • GC03P184054

Summaries for ST6GAL1 Gene

Entrez Gene Summary for ST6GAL1 Gene

  • This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]

GeneCards Summary for ST6GAL1 Gene

ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Diseases associated with ST6GAL1 include Colon Adenocarcinoma and Colorectal Cancer. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot for ST6GAL1 Gene

  • Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Gene Wiki entry for ST6GAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GAL1 Gene

Genomics for ST6GAL1 Gene

Regulatory Elements for ST6GAL1 Gene

Enhancers for ST6GAL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST6GAL1 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST6GAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST6GAL1 Gene

186,930,343 bp from pter
187,078,553 bp from pter
148,211 bases
Plus strand

Genomic View for ST6GAL1 Gene

Genes around ST6GAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL1 Gene

Proteins for ST6GAL1 Gene

  • Protein details for ST6GAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • A8KA14
    • B2R513
    • D3DNV3

    Protein attributes for ST6GAL1 Gene

    406 amino acids
    Molecular mass:
    46605 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ST6GAL1 Gene

    Alternative splice isoforms for ST6GAL1 Gene


neXtProt entry for ST6GAL1 Gene

Proteomics data for ST6GAL1 Gene at MOPED

Selected DME Specific Peptides for ST6GAL1 Gene

Post-translational modifications for ST6GAL1 Gene

  • The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Thr 68, Asn 149, and Asn 161
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ST6GAL1 (ST6 Gal Sialyltransferase 1/ST6GAL1)
  • Abcam antibodies for CD75

Domains & Families for ST6GAL1 Gene

Protein Domains for ST6GAL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GAL1: view

No data available for Gene Families for ST6GAL1 Gene

Function for ST6GAL1 Gene

Molecular function for ST6GAL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=530 uM for CMP-NeuAc {ECO:0000269 PubMed:21081508}; Vmax=1.074 pmol/min/ug enzyme {ECO:0000269 PubMed:21081508};
UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CTP.
UniProtKB/Swiss-Prot Function:
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Enzyme Numbers (IUBMB) for ST6GAL1 Gene

genes like me logo Genes that share phenotypes with ST6GAL1: view

Animal Models for ST6GAL1 Gene

MGI Knock Outs for ST6GAL1:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST6GAL1 Gene

Localization for ST6GAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

Jensen Localization Image for ST6GAL1 Gene COMPARTMENTS Subcellular localization image for ST6GAL1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with ST6GAL1: view

Pathways & Interactions for ST6GAL1 Gene

genes like me logo Genes that share pathways with ST6GAL1: view

UniProtKB/Swiss-Prot P15907-SIAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018279 protein N-linked glycosylation via asparagine IDA,TAS 23999306
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ST6GAL1: view

No data available for SIGNOR curated interactions for ST6GAL1 Gene

Drugs & Compounds for ST6GAL1 Gene

(1) Drugs for ST6GAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for ST6GAL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (N-acetylneuraminosyl(alpha2-6)lactosamine)
  • 6'-Sialyllactosamine
  • a-N-Acetylneuraminyl-2,6-b-D-galactosyl-1,4-N-acetyl-b-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-delta-galactosyl-1,4-N-acetyl-beta-delta-glucosamine
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST6GAL1: view

Transcripts for ST6GAL1 Gene

Unigene Clusters for ST6GAL1 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP8: - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - -
SP13: -
SP14: - -
SP15: - - -

ExUns: 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -

Relevant External Links for ST6GAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GAL1 Gene

mRNA expression in normal human tissues for ST6GAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GAL1 Gene

This gene is overexpressed in Liver (x15.8).

Protein differential expression in normal tissues from HIPED for ST6GAL1 Gene

This gene is overexpressed in Liver (20.9), Serum (20.8), Plasma (9.2), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST6GAL1 Gene

SOURCE GeneReport for Unigene cluster for ST6GAL1 Gene Hs.207459

genes like me logo Genes that share expression patterns with ST6GAL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ST6GAL1 Gene

Orthologs for ST6GAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ST6GAL1 35
  • 85.49 (n)
  • 83.08 (a)
ST6GAL1 36
  • 83 (a)
(Canis familiaris)
Mammalia ST6GAL1 35
  • 88.64 (n)
  • 90.23 (a)
ST6GAL1 36
  • 90 (a)
(Mus musculus)
Mammalia St6gal1 35
  • 82.46 (n)
  • 80.15 (a)
St6gal1 16
St6gal1 36
  • 80 (a)
(Pan troglodytes)
Mammalia ST6GAL1 35
  • 99.51 (n)
  • 99.51 (a)
SIAT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia St6gal1 35
  • 82.46 (n)
  • 81.14 (a)
(Monodelphis domestica)
Mammalia ST6GAL1 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves ST6GAL1 35
  • 65.01 (n)
  • 63.03 (a)
ST6GAL1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ST6GAL1 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal1 35
  • 58.89 (n)
  • 53.99 (a)
(Danio rerio)
Actinopterygii st6gal1 35
  • 56.79 (n)
  • 53.29 (a)
st6gal1 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 36
  • 25 (a)
Species with no ortholog for ST6GAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL1 Gene

Gene Tree for ST6GAL1 (if available)
Gene Tree for ST6GAL1 (if available)

Paralogs for ST6GAL1 Gene

Paralogs for ST6GAL1 Gene

genes like me logo Genes that share paralogs with ST6GAL1: view

Variants for ST6GAL1 Gene

Sequence variations from dbSNP and Humsavar for ST6GAL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7559 -- 187,078,265(+) TAAAA(C/T)GCAAA utr-variant-3-prime
rs9716 -- 187,077,428(+) AGGGG(A/G)TCTAA utr-variant-3-prime
rs736341 -- 187,067,001(+) GTGAG(C/T)TAGAC intron-variant
rs1042642 -- 187,075,941(+) TGGGG(A/G)CTTCA downstream-variant-500B, utr-variant-3-prime
rs1042643 -- 187,076,614(+) AACTG(A/T)GTTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL1 Gene

Variant ID Type Subtype PubMed ID
esv34136 CNV Loss 18971310
dgv1542e1 CNV Complex 17122850
nsv508975 CNV Insertion 20534489
esv2726343 CNV Deletion 23290073
esv2726344 CNV Deletion 23290073
esv1985985 CNV Deletion 18987734
esv2726345 CNV Deletion 23290073
esv1371504 CNV Deletion 17803354
nsv878072 CNV Gain 21882294
nsv519618 CNV Loss 19592680
nsv4156 CNV Loss 18451855

Variation tolerance for ST6GAL1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST6GAL1 Gene

Disorders for ST6GAL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ST6GAL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colon adenocarcinoma
  • adenocarcinoma of colon
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST6GAL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ST6GAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST6GAL1 Gene

Publications for ST6GAL1 Gene

  1. Complete cDNA sequence encoding human beta-galactoside alpha-2,6- sialyltransferase. (PMID: 2408023) Grundmann U.G. … Zettlmeissl G. (Nucleic Acids Res. 1990) 2 3 4 67
  2. Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. (PMID: 19709745) Mondal S. … Mandal C. (Leuk. Res. 2010) 3 23
  3. Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation. (PMID: 20127017) Lee M. … Lee Y.S. (Oncol. Rep. 2010) 3 23
  4. Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo. (PMID: 19150807) Kitazume S. … Hashimoto Y. (Glycobiology 2009) 3 23
  5. Synthesis and expression of CDw75 antigen in human colorectal cancer. (PMID: 20003255) Costa-Nogueira C. … FernA!ndez-Briera A. (BMC Cancer 2009) 3 23

Products for ST6GAL1 Gene

Sources for ST6GAL1 Gene