Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST6GAL1 Gene

Aliases for ST6GAL1 Gene

  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1 2 3
  • ST6Gal I 2 3 4
  • SIAT1 3 4 6
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 1 3 4
  • B-Cell Antigen CD75 3 4
  • Alpha 2,6-ST 1 3 4
  • EC 2.4.99.1 4 64
  • ST6GalI 3 4
  • CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase) 3
  • Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialytransferase) 2
  • Beta-Galactoside Alpha-2,6-Sialyltransferase 1 3
  • Sialyltransferase 1 4
  • ST6N 3

External Ids for ST6GAL1 Gene

Previous Symbols for ST6GAL1 Gene

  • SIAT1

Summaries for ST6GAL1 Gene

Entrez Gene Summary for ST6GAL1 Gene

  • This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]

GeneCards Summary for ST6GAL1 Gene

ST6GAL1 (ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GAL2.

UniProtKB/Swiss-Prot for ST6GAL1 Gene

  • Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Gene Wiki entry for ST6GAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GAL1 Gene

Genomics for ST6GAL1 Gene

Genomic Location for ST6GAL1 Gene

Start:
186,930,485 bp from pter
End:
187,078,553 bp from pter
Size:
148,069 bases
Orientation:
Plus strand

Genomic View for ST6GAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST6GAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL1 Gene

Regulatory Elements for ST6GAL1 Gene

Proteins for ST6GAL1 Gene

  • Protein details for ST6GAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15907-SIAT1_HUMAN
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 1
    Protein Accession:
    P15907
    Secondary Accessions:
    • A8KA14
    • B2R513
    • D3DNV3

    Protein attributes for ST6GAL1 Gene

    Size:
    406 amino acids
    Molecular mass:
    46605 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ST6GAL1 Gene

    Alternative splice isoforms for ST6GAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GAL1 Gene

Proteomics data for ST6GAL1 Gene at MOPED

Selected DME Specific Peptides for ST6GAL1 Gene

Post-translational modifications for ST6GAL1 Gene

  • The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme
  • The soluble form derives from the membrane form by proteolytic processing
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr68, Asn149, and Asn161

Domains for ST6GAL1 Gene

Protein Domains for ST6GAL1 Gene

UniProtKB/Swiss-Prot:

SIAT1_HUMAN
Family:
  • Belongs to the glycosyltransferase 29 family.:
    • P15907
genes like me logo Genes that share domains with ST6GAL1: view

No data available for Gene Families for ST6GAL1 Gene

Function for ST6GAL1 Gene

Molecular function for ST6GAL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=530 uM for CMP-NeuAc {ECO:0000269 PubMed:21081508}; Vmax=1.074 pmol/min/ug enzyme {ECO:0000269 PubMed:21081508};
UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by CTP.
UniProtKB/Swiss-Prot Function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Enzyme Numbers (IUBMB) for ST6GAL1 Gene

Gene Ontology (GO) - Molecular Function for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity IDA 23999306
GO:0005515 protein binding IPI 16237761
GO:0008373 sialyltransferase activity IDA 21081508
genes like me logo Genes that share ontologies with ST6GAL1: view
genes like me logo Genes that share phenotypes with ST6GAL1: view

Animal Models for ST6GAL1 Gene

MGI Knock Outs for ST6GAL1:

miRNA for ST6GAL1 Gene

miRTarBase miRNAs that target ST6GAL1

No data available for Transcription Factor Targeting and HOMER Transcription for ST6GAL1 Gene

Localization for ST6GAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GAL1 Gene COMPARTMENTS Subcellular localization image for ST6GAL1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with ST6GAL1: view

Pathways for ST6GAL1 Gene

genes like me logo Genes that share pathways with ST6GAL1: view

UniProtKB/Swiss-Prot P15907-SIAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ST6GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006054 N-acetylneuraminate metabolic process IDA 23999306
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0006959 humoral immune response TAS 7786324
genes like me logo Genes that share ontologies with ST6GAL1: view

Compounds for ST6GAL1 Gene

(4) HMDB Compounds for ST6GAL1 Gene

Compound Synonyms Cas Number PubMed IDs
(N-acetylneuraminosyl(a2-6)lactosamine)
  • alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
64364-50-7
Cytidine monophosphate
  • 5'-CMP
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-acetylneuraminate
22-12-8
N-Acetyllactosamine
  • D-galactopyranosyl
32181-59-2

(10) Novoseek inferred chemical compound relationships for ST6GAL1 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 73.4 9
n-acetyllactosamine 68.3 5
ganglioside 42.2 2
polysaccharide 36.2 2
glycolipid 27.3 2
genes like me logo Genes that share compounds with ST6GAL1: view

Transcripts for ST6GAL1 Gene

Unigene Clusters for ST6GAL1 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - -
SP3:
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7:
SP8: - - - -
SP9:
SP10: - -
SP11: - - - - - - -
SP12: - - - - -
SP13: -
SP14: - -
SP15: - - -
SP16:

ExUns: 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ST6GAL1 Gene

GeneLoc Exon Structure for
ST6GAL1
ECgene alternative splicing isoforms for
ST6GAL1

Expression for ST6GAL1 Gene

mRNA expression in normal human tissues for ST6GAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GAL1 Gene

This gene is overexpressed in Liver (15.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST6GAL1 Gene

SOURCE GeneReport for Unigene cluster for ST6GAL1 Gene Hs.207459

genes like me logo Genes that share expressions with ST6GAL1: view

Orthologs for ST6GAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIAT1 37
  • 100 (a)
OneToOne
ST6GAL1 36
  • 99.51 (n)
  • 99.51 (a)
cow
(Bos Taurus)
Mammalia ST6GAL1 36
  • 85.49 (n)
  • 83.08 (a)
ST6GAL1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GAL1 36
  • 88.64 (n)
  • 90.23 (a)
ST6GAL1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6gal1 36
  • 82.46 (n)
  • 80.15 (a)
St6gal1 16
St6gal1 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GAL1 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia St6gal1 36
  • 82.46 (n)
  • 81.14 (a)
chicken
(Gallus gallus)
Aves ST6GAL1 36
  • 65.01 (n)
  • 63.03 (a)
ST6GAL1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GAL1 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal1 36
  • 58.89 (n)
  • 53.99 (a)
zebrafish
(Danio rerio)
Actinopterygii st6gal1 36
  • 56.79 (n)
  • 53.29 (a)
st6gal1 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 37
  • 25 (a)
OneToMany
Species with no ortholog for ST6GAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL1 Gene

ENSEMBL:
Gene Tree for ST6GAL1 (if available)
TreeFam:
Gene Tree for ST6GAL1 (if available)

Paralogs for ST6GAL1 Gene

Paralogs for ST6GAL1 Gene

genes like me logo Genes that share paralogs with ST6GAL1: view

Variants for ST6GAL1 Gene

Sequence variations from dbSNP and Humsavar for ST6GAL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7559 -- 187,078,265(+) TAAAA(C/T)GCAAA utr-variant-3-prime
rs9716 -- 187,077,428(+) AGGGG(A/G)TCTAA utr-variant-3-prime
rs257099 -- 187,065,244(-) GGCAG(A/G)TGGAT intron-variant
rs257100 -- 187,065,211(-) ACTAG(C/T)CTGGC intron-variant
rs257101 -- 187,061,040(-) ttttg(G/T)gtgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL1 Gene

Variant ID Type Subtype PubMed ID
esv34136 CNV Loss 18971310
dgv1542e1 CNV Complex 17122850
nsv508975 CNV Insertion 20534489
esv2726343 CNV Deletion 23290073
esv2726344 CNV Deletion 23290073
esv1985985 CNV Deletion 18987734
esv2726345 CNV Deletion 23290073
esv1371504 CNV Deletion 17803354
nsv878072 CNV Gain 21882294
nsv519618 CNV Loss 19592680
nsv4156 CNV Loss 18451855

Relevant External Links for ST6GAL1 Gene

HapMap Linkage Disequilibrium report
ST6GAL1

Disorders for ST6GAL1 Gene

(13) Novoseek inferred disease relationships for ST6GAL1 Gene

Disease -log(P) Hits PubMed IDs
colon adenocarcinoma 49.4 3
colon cancer 34.7 8
cervical carcinoma 27.5 2
metastasis 15.3 3
carcinoma 15.1 2

Relevant External Links for ST6GAL1

Genetic Association Database (GAD)
ST6GAL1
Human Genome Epidemiology (HuGE) Navigator
ST6GAL1
genes like me logo Genes that share disorders with ST6GAL1: view

No data available for UniProtKB/Swiss-Prot for ST6GAL1 Gene

Publications for ST6GAL1 Gene

  1. The B cell antigen CD75 is a cell surface sialyltransferase. (PMID: 2373995) Stamenkovic I. … Funderud S. (J. Exp. Med. 1990) 3 4 23
  2. Complete cDNA sequence encoding human beta-galactoside alpha-2,6- sialyltransferase. (PMID: 2408023) Grundmann U.G. … Zettlmeissl G. (Nucleic Acids Res. 1990) 2 3 4
  3. Isolation and characterization of a partial cDNA for a human sialyltransferase. (PMID: 2803295) Lance P. … Lau J.T.Y. (Biochem. Biophys. Res. Commun. 1989) 3 4
  4. Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo. (PMID: 19150807) Kitazume S. … Hashimoto Y. (Glycobiology 2009) 3 23
  5. Liver Galbeta1,4GlcNAc alpha2,6-sialyltransferase is down-regulated in human alcoholics: possible cause for the appearance of asialoconjugates. (PMID: 17697868) Gong M. … Lakshman M.R. (Metab. Clin. Exp. 2007) 3 23

Products for ST6GAL1 Gene

Sources for ST6GAL1 Gene

Back to Top

Content